Background: There is not much study done in our population group on the various types of breast tumours and the molecular profile (ER/PR status). Since Breast carcinoma incidence is increasing in our population the study was done to evaluate the different histopathological types, the hormone receptor status and there correlation with various clinicomorphological features in our population. Material and Methods: A two year prospective study was carried out on 50 patients with histologically confirmed invasive breast carcinomas which were further subjected to immunohistochemical assay (ER/ PR). Correlation with established risk factors age, tumour size, grade and histopathology were analysed. Results: ER and PR receptors determined by immunohistochemical method revealed ER+/PR+ in 52 %, ER+/PR- in 4 %, ER-/PR+ in 8% and ER-/PR- in 36% of the cases. Postmenopausal women showed a higher incidence of receptor positivity (77.27%) with increasing age. T2 tumours were more common (72%) as compared to T1 and T3 tumours. Receptor status was noted to be comparatively increased in larger sized tumours (88.9%). Infiltrating ductal carcinoma (NOS) was the commonest type (80%) with receptor positivity of 57.5%. Maximum tumours in the study were grade II (50%) which also showed maximum receptor positivity (64%) and the reactivity for the receptors was observed to decrease with increasing grade. Conclusion: ER/PR expression in breast cancers in the current study was found to be higher than the studies done in India/ Asia but still lower than studies done in west, even on Indian/ Asian immigrants to US and other western countries. This markedly lower receptor expression in Indian/ Asian studies is more likely due to preanalytic variables, threshold for positivity and interpretation criteria rather than genetic differences. So it is suggested that these variables need to be further identified and measures taken to rectify them so that a definite assessment of the receptor status can be done.