Background: Self medication is defined as the use or intake of any medication by a Patient on his own initiative or on the advice of a Pharmacist or a lay person instead of consulting a medical practitioner. This may generate more economic benefit for patient because of saving in travel, consultation time and direct financial cost of treatment. Objective: To study self medication habits among people in Nagpur part of central India. Research methodology: Samples of 280 patients were selected. Data was collected via face to face structured interview of respondents using the questionnaire. The inclusion criteria for selection of patients were those came to retail pharmacy to buy OTC drugs. Each individual was given explanation about the purpose of study. Results: An inclusion criterion to select the patient was 15 to above 60 year of age. About 89% people had a positive trust in allopathic medicines, 17% people learn self medication from doctors prescriptions provided during their prior illness. 1% were alcoholic, 6% were smokers, 61% people with chronic problems, who were considered in danger findings. Only 27% people were aware about drug interaction. Conclusion: This descriptive study shows, the majority of population had a poor knowledge about appropriate self-medication while the knowledge of the benefits and risks was not adequate. Thus to avoid or minimize the danger of self medication, there is a need to carry out educational campaign to alert population about the use of many OTC medicines available in market. Active participation of health care professionals, specially Physicians and pharmacist, pharmaceutical industry, government regulations and continuous inspection by the competent authorities is important.