Introduction: It is a well established fact that __ampersandsignldquo;vagotomy__ampersandsignrdquo; in varying degrees is a decisively relieving surgical procedure in peptic ulcer patients. Failure of vagotomy or recurrence of paptic ulcer symptoms is due to the variations in the pattern of distribution of the gastric nerves to stomach. Complexity of varying pattern of the gastric nerves supplying the stomach compels a thorough investigation in this context. Materials and Methods: Total of 30 Stomachs with lower part of esophagus and pylorus were utilized for the study from the department of anatomy of Narayana Medical College, Nellore, and Andhra Pradesh. Each specimen was labeled soon after collection and then preserved in a small tank containing 10% formalin. The nerve trunks and their branches were traced by standard dissection methods. Results and Conclusion: In the present study of 30 specimens in 20% of gastric nerves variation were found in its course, pattern and communication; which can produce secretion of acid inspite of conventional vagotomy. It could be suggested that high selective vagotomy can a method of choice for treatment of specific cases of paptic ulcer because of the variations found in the distribution of vagi to the stomach.