<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="healthcare" lang="en"><front><journal-meta><journal-id journal-id-type="publisher">IJCRR</journal-id><journal-id journal-id-type="nlm-ta">I Journ Cur Res Re</journal-id><journal-title-group><journal-title>International Journal of Current Research and Review</journal-title><abbrev-journal-title abbrev-type="pubmed">I Journ Cur Res Re</abbrev-journal-title></journal-title-group><issn pub-type="ppub">2231-2196</issn><issn pub-type="opub">0975-5241</issn><publisher><publisher-name>Radiance Research Academy</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1080</article-id><article-id pub-id-type="doi"/><article-id pub-id-type="doi-url"/><article-categories><subj-group subj-group-type="heading"><subject>Healthcare</subject></subj-group></article-categories><title-group><article-title>EFFECT OF CHRONIC ADMINISTRATION OF ATORVASTATIN, SIMVASTATIN AND LOVASTATIN ON ANIMAL MODELS OF EPILEPSY&#13;
</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>V.</surname><given-names>Nayak</given-names></name></contrib><contrib contrib-type="author"><name><surname>S.</surname><given-names>Adiga</given-names></name></contrib><contrib contrib-type="author"><name><surname>B.M.</surname><given-names>Poornima</given-names></name></contrib><contrib contrib-type="author"><name><surname>R.</surname><given-names>Sharma</given-names></name></contrib><contrib contrib-type="author"><name><surname>A.</surname><given-names>Garg</given-names></name></contrib><contrib contrib-type="author"><name><surname>M.</surname><given-names>Shetty</given-names></name></contrib><contrib contrib-type="author"><name><surname>S.</surname><given-names>Kamath</given-names></name></contrib><contrib contrib-type="author"><name><surname>M.</surname><given-names>Hegde</given-names></name></contrib><contrib contrib-type="author"><name><surname>S.S.</surname><given-names>Koshy</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><day>19</day><month>10</month><year>2013</year></pub-date><volume>)</volume><issue/><fpage>61</fpage><lpage>65</lpage><permissions><copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement><copyright-year>2009</copyright-year><license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p></license></permissions><abstract><p>Introduction: Statins, the widely used hypolipidemics drugs have a number of pleotropic effects. Objective: To study the effect of chronic administration of atorvastatin, simvastatin and lovastatin on maximal electroshock and pentylenetetrazole induced seizures in Wistar rats. Material and Methods: After obtaining institutional animal ethics committee clearance the study was conducted in male wistar rats. The animals were dosed with the various statins for 30 days. The effect of statins on maximal electroshock and pentylenetetrazole induced seizures was then studied. The animals were then sacrificed and the brain tissue was used for antioxidant estimation. Results: Statins showed a protective effect against seizures in both the models. The levels of glutathione were increased and malonadialdehyde decreased in the brain tissue in statin treated groups. The present study confirms the anticonvulsant action of statins, their antioxidant action being the possible mechanism.&#13;
</p></abstract><kwd-group><kwd>statins</kwd><kwd> seizures </kwd><kwd> antioxidant action</kwd></kwd-group></article-meta></front></article>
