Background: Phytochemicals are a large group of plant-derived compounds responsible for several physiological functions including defence. Polyphenols are ubiquitous in plants. Aim: Formulation of a plant based control in sesame against Alternaria leaf spot disease. Methodology: Methodologies include culturing of pathogen, aqueous extraction of Mikkania scadens by hydrodistillation, quantification of phenols and IR finger printing of infected plants. Results: Inoculation of 20 __ampersandsignmu;l conidial suspension of Altenaria sesami followed by treatment of sesame plants with 7.5% M. scandens extract delayed the disease outbreak and increased the resistance. Remarkable level of free and cell wall-bound phenolics was noticed in the M. Scadens treated sesame plants. Subsequently, the total phenol was fractionated revealed the presence of a pool of phenolic acids and were identified by comparing with the peaks of the internal standards. Infra-red spectral analysis showed the bands around 3370 cm-1 represent O-H and N-H stretching vibrations that are mainly generated by alkaloids. The bands between 3000 and 2800 cm-1 represent C-H stretching vibrations of triglycerides. Bands between 1800 and 1500 cm-1 contained amide-I, amide-II bands, but overlapped with other absorption bands within this region. Amide-III, the functional group of nucleic acids also contributed to these absorption bands in the leaves. Conclusion: Plant based control measures are an eco-friendly method that effectively induce resistance in the plants.