Introduction: The sciatic nerve is the largest nerve of the body. Not only does it have the largest number of nerve fibers, but it also supplies a vast region. Compression of sciatic nerve any where during its course may contribute to clinical conditions like sciatica and pyriformis syndrome. Anomalous sciatic nerve and its branches can often be damaged by wrongly placed intra-muscular injections and during pelvic and total hip replacement surgeries. The present study was conducted to highlight different variations in course and branching pattern of the sciatic nerve in Andhra Pradesh population. Materials and Methods: The present study was carried out on gluteal regions of 100 lower extremities of 50 embalmed cadavers during routine dissection practices for undergraduates in the dissection hall of Gandhi medical college and Osmania medical colleges of Andhra Pradesh, India. Results and Conclusion: In the present study 92 out of 100 specimens sciatic nerve passed below pyriformis into gluteal region then descended downwards in the back of thigh, which terminated in to common peroneal nerve and tibial nerve in the popliteal fossa as usual. In 3% cases common peroneal nerve pierced pyriformis and tibial nerve passed below the muscle. Common peroneal nerveand tibial nerve passed above and below the pyriformis respectively in 4% cases. Unsplit sciatic nerve piercing the piriformis is found in 1 case only.