Maintenance of skeletal muscle integrity is a very important concern for certain occupational workers such as athletes, sportsmen and military personnel. A number of published reports suggest that heat stress in a potent activator of muscle hypertrophy and can be used as a powerful tool to prevent muscle atrophy during conditions of bed rest due to injury or illness as well muscle inactivity due to any other reason. Therefore, application of heat to muscle can be very beneficial not only for soldiers and athletes, but patients during habilitation for gaining muscle mass and force generation. This review attempts to summarize the recent advances in understanding of mechanisms by which heat stress causes skeletal muscle hypertrophy with an emphasis on the signal transduction pathways that play detrimental roles in regulating muscle hypertrophy in response to heat stress.