Introduction: Due to rapid technological development, shift workers are continuously increasing. Shift workers are subjected to altered circadian rhythm which might make them prone to cardiovascular disorders. Aim: To examine whether longer duration of shift work increases the risk factors for cardiovascular disorders and also to compare it with day workers. Materials __ampersandsignamp; Methods: 50 male industrial workers and security guards at Burla, who did night shift for atleast 1 year and 50 day workers who did not do night shift in the last 2 yrs were involved in the study. The various risk factors such as body mass index, blood pressure, lipid profile, atherogenic indices were estimated at the beginning of the study in both night and dayshift workers. Dietary pattern was not altered during the period of the study. Result: Study revealed that shift work significantly increase the risk of cardiovascular diseases. BMI, BP __ampersandsignamp; atherogenic indices were found to be significantly increased in night shift workers when compared to day workers. Among the night shift workers, at the end of 3 years follow up, risk further increased to higher level. Conclusion: Night shift workers are at higher risk for developing cardiovascular diseases.