Objectives: To study the commonest cancers encountered in both male and female sexes in the regional population of Andhra Pradesh in south Indian region. Methods: The study was conducted on total number of 450 patients, who were admitted in Mehdi Nawaz Jung (MNJ) government central cancer hospital, Hyderabad, Andhra Pradesh after histologically confirmed various cancers. Results: the study revealed that Breast cancer (57 cases, 12.6%), Lung cancer (47 cases, 10.4%), Cervical cancer (41 cases, 9.1%), Oral cancer (41 cases, 9.1%), (264 cases, 58.8%) constitute remaining cancers. Males constitute 48. 8% (220 cases) out of 450 cases and Females constitute 51.2% (230 cases) out of of (450 cases). Age and sex distribution revealed maximum number of cancer patients were present between 40 to 50 years (23.3%). Males, majority of cases are present in 40-50 years age group (11.1%) and females majority of cases are seen in 30-40 year age group (12.8%). Distribution of study sample revealed 55.7% cancer cases (251 patients) residing in urban areas and 44.2% cases (199 patients) were found in rural areas and following data discussed in results. Conclusion: Cancer is projected to become a leading cause of death worldwide in low and middle income countries. This will have the impact of high cancer incidence and death rates more sharply than developed countries.