To evaluate the correlation between breast cancer and many risk factors which include family history of breast cancer, history of benign breast disease, obesity, age at menarche, menopause, abortions, older ladies at first full-term pregnancy, parity, lactation. 328 females, all originating from the Sudanese, were eligible for analysis. An age-stratified random sample of 100 women was used as a control group. The interview followed a structured questionnaire. 153 (47%) of patients their age __ampersandsignlt;50 years, 175 (53%) age __ampersandsigngt;50 years, 148 (45%) of the patients from rural areas, while 180 (55%) from urban areas. There is association between breast cancer and residence. Premenopausal patients were 158 (48%) and postmenopausal patients were 170 (52%), there is statistically significant difference. There is no statistically significant difference observed between patients approaching menopause at an age of __ampersandsigngt;50 years and those approach it at age __ampersandsignlt;50 years. The study revealed statistically significant difference between breast cancer and age at menarche less than 12 years, history of breast cancer in a first degree relative, parity and body mass index, whereas, no significant difference was noticed with history of abortion or miscarriage, lactation, use of medication to suppress lactation. The study confirmed an etiological association between breast cancer and Many risk factors have been identified either genetic factor which include family history of breast cancer, obesity and high fat diet or hormonal factors which include female sex, risk increasing with age, long interval between menarche and menopause and older ladies at first full-term pregnancy have resulted in several aetiological hypotheses.