Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241181EnglishN2026January15Healthcare Home Sleep Apnea Tests for Obstructive Sleep Apnea: Advances, Clinical Utility, Technological Limitations, and the Arising Role of Artificial Intelligence     English0104Aleksandra TlakEnglish Katarzyna BielawskaEnglish Wiktoria Julia AuguscikEnglish Home Sleep Apnea Tests (HSAT) for the home-based assessment of Obstructive Sleep Apnea (OSA) may constitute a signifi cant alternative to polysomnography (PSG), which is conventionally performed in sleep laboratories. In recent years, there has been an increasing demand for out-of-laboratory sleep testing, driven by improved accessibility, enhanced patient comfort, and economic considerations. In this systematic review, we analyze the available scientific literature published between 2015 and 2025 concerning diagnostic devices intended for home-based OSA assessment, including specific device subtypes and software solutions utilizing artificial intelligence (AI) algorithms. The results of the analyzed studies indicate that many HSAT devices demonstrate sensitivity and specificity comparable to standard PSG in the detection of moderate and severe OSA. However, persistent limitations must be emphasized, including restricted measurement capabilities such as the absence of full electroen cephalography (EEG), electrocardiography (ECG), electromyography (EMG), or electrooculography (EOG) recordings in certain devices, as well as overall variability in the parameters recorded across different systems. Although HSAT devices are currently unable to fully replace conventional polysomnography, this review highlights their substantial potential in OSA diagnostics, par ticularly in settings with limited access to sleep laboratories. We also underscore the need for further research in this field and for standardization, especially regarding device specifications and measured parameters. EnglishHome sleep tests (HSAT), Obstructive sleep apnea (OSA), Otolaryngology, Sleep medicine, Wearable devices, Artificial intelligencehttp://ijcrr.com/abstract.php?article_id=4885http://ijcrr.com/article_html.php?did=4885 1. Lyne CJ, Hamilton GS, Turton ARE, Stupar D, Mansfield DR. Validation of a single-use and reusable home sleep apnea test based on peripheral arterial tonometry compared to laboratory polysomnography for the diagnosis of obstructive sleep apnea. J Clin Sleep Med. 2023;19: 1429-1435. https://jcsm.aasm.org/ doi/10.5664/jcsm.10568 2. Gottlieb DJ, Punjabi NM. Diagnosis and Management of Ob structive Sleep Apnea: A Review. JAMA. 2020;323: 1389 1400. https://jamanetwork.com/journals/jama/article-ab stract/2764461 3. Espinosa MA, Ponce P, Molina A, Borja V, Torres MG, Rojas M. Advancements in Home-Based Devices for Detecting Obstruc tive Sleep Apnea: A Comprehensive Study. Sensors (Basel). 2023;23: 9512. https://www.mdpi.com/1424-8220/23/23/9512 4. Hussein O, Alkhader A, Gohar A, Bhat A. Home Sleep Apnea Testing for Obstructive Sleep Apnea. Mo Med. 2024;121: 60-65. https://pmc.ncbi.nlm.nih.gov/articles/PMC10887466/ 5. Park JH, Wang C, Shin H. FDA-cleared home sleep apnea test ing devices. NPJ Digit Med. 2024;7: 123. https://www.nature. com/articles/s41746-024-01112-w 6. Chiang AA, Jerkins E, Holfinger S, Schutte-Rodin S, Chandra kantan A, Mong L, et al. OSA diagnosis goes wearable: are the latest devices ready to shine? J Clin Sleep Med. 2024;20: 1823 1838. https://jcsm.aasm.org/doi/10.5664/jcsm.11290 7. Kwon S, Kim H, Yeo WH. Recent advances in wearable sen sors and portable electronics for sleep monitoring. iScience. 2021;24: 102461. https://www.cell.com/iscience/fulltext/ S2589-0042(21)00429-6?_returnURL=https%3A%2F%2Flink inghub.elsevier.com%2Fretrieve%2Fpii%2FS25890042210042 96%3Fshowall%3Dtrue 8. Abd-Alrazaq A, Aslam H, AlSaad R, Alsahli M, Ahmed A, Damseh R, et al. Detection of Sleep Apnea Using Wearable AI: Systematic Review and Meta-Analysis. J Med Internet Res. 2024;26: e58187. https://www.jmir.org/2024/1/e58187

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241181EnglishN2026January15Healthcare Synthesis, Spectral Analysis and Biological Evaluation of a Novel Schiff Base [N-(2-hydroxy 1-naphthylmethylene)-5-acetyl-2-amino-4 methylthiazole] and its Complex       English0510Indu SolankyEnglish Suman MalikEnglish Archana SinghEnglish Anjul DadoriaEnglish Introduction: Schiff base ligands containing Thiazole and naphthalene groups are important in coordination chemistry and medicinal research due to their strong metal binding ability and biological potential. Aim/Objectives: To synthesize a novel Schiff base ligand and its Fe (III) complex and evaluate their antibacterial activity. Methods: The ligand was prepared by condensation of 2-hydroxy-1-naphthaldehyde with 5-acetyl-2-amino-4-methylthiazole. The Fe (III) complex was synthesized in ethanolic medium under controlled pH. Characterization was carried out using elemental analysis, UV–Visible, FT-IR, mass, magnetic and XRD studies. Antibacterial activity was tested by agar well diffusion method. Results: Spectral data confirmed tridentate coordination through azomethine nitrogen, phenolic oxygen and Thiazole nitrogen. Magnetic studies supported an octahedral geometry. The metal complex showed better antibacterial activity than the free ligand. Conclusion: The Schiff base forms a stable octahedral Fe (III) complex with enhanced antibacterial activity, indicating its poten tial for further pharmaceutical applications. EnglishSchiff base ligand, Fe (III) complex, Tridentate coordination, Spectroscopic analysis, Octahedral geometry, Antibacterial activityhttp://ijcrr.com/abstract.php?article_id=4888http://ijcrr.com/article_html.php?did=4888 1. Patai S. The chemistry of the carbon–nitrogen double bond. New York: Wiley-Interscience; 1970. 2. Mukherjee GN. Recent developments in coordination chemistry of metal complexes of Schiff bases. Coord Chem Rev. 2000; 203(1):1-42. https://doi.org/10.1016/S0010-8545(99)00154-5 3. Raman N, Kulandaisamy A, Thangaraja C. Synthesis, struc ture and spectral studies of Schiff base transition metal com plexes. J Coord Chem. 2009;62(5):691-709. https://doi. org/10.1080/00958970802351025 4. Dadoria A, Malik S, Singh A. Therapeutic and anticorrosive prospects of Schiff base metal complexes: a comprehensive review. Int J Creat Res Thoughts. 2025;13(10):70-76. https://doi. org/10.56975/ijcrt.v13i10.295962 5. Jain R, Sharma P, Vaidya A. Synthesis and biological evaluation of Thiazole derivatives. Bioorg Med Chem. 2015; 23(15):4143 4152. https://doi.org/10.1016/j.bmc.2015.05.042 6. Malik S, Jain B, Mirza AS, Singh A. Review study on metal complexes synthesized from therapeutically important Schiff bases. Pharm Chem J. 2016; 3(4):119-124. 7. Wipf P, Halter RJ. Thiazole-based inhibitors: synthesis and bio logical studies. J Med Chem. 2004; 47(13):3242-3250. https:// doi.org/10.1021/jm049860z 8. Rollas S, Küçükgüzel SG. Biological activities of hydrazone and Schiff base derivatives of heterocycles. Molecules. 2007; 12(8):1910-1939. https://doi.org/10.3390/12081910 9. Baruah A, Roy ML, Nath BC. Metal complexes of Thiazole derived Schiff bases: spectroscopic and structural studies. J Mol Struct. 2005; 744-747:1-7. https://doi.org/10.1016/j.mol struc.2004.11.029 10. Patel RN, Patel DK. Spectroscopic and antimicrobial studies of Thiazole-based Schiff base complexes. Spectrochim Acta A Mol Biomol Spectrosc. 2012; 86:431-438. https://doi.org/10.1016/j. saa.2011.10.060 11. Malik S, Singh A, Ahmed N. Spectral characterization and ther mal behaviour of Schiff base metal complex derived from 2-am inobenzimidazole. Adv Appl Sci Res. 2015;6(8):199-204. 12. Avaji PG, Kumar CH, Patil SA. Synthesis and characteri zation of naphthalene-based Schiff base metal complex es. J Coord Chem. 2008;61(12):1881-1892. https://doi. org/10.1080/00958970801968941 13. Cimerman Z, Miljani? S, Gali? N. Schiff bases derived from o-hydroxy aromatic aldehydes: spectroscopic characterization. Anal Chim Acta. 1997;343(2):145-153. https://doi.org/10.1016/ S0003-2670(96)00572-5 14. Chandra S, Gupta LK. Spectral analysis and structural investiga tions of transition metal complexes of Schiff bases. Spectrochim Acta A Mol Biomol Spectrosc. 2005;61(2):269-275. https://doi. org/10.1016/j.saa.2004.03.012. 15. Kovala-Demertzi D, Varadinova T. Biological applications of metal-Schiff base complexes. J Inorg Biochem. 2000;78(3):347 354. https://doi.org/10.1016/S0162-0134(99)00200-6 16. Tweedy BG. Chelation in biological systems: antimicrobial ac tivity of metal complexes. Phytopathology. 1964;55(8):910-914. 17. Chohan ZH, Sumrra SH, Youssoufi MH. Metal-based phar macologically active Schiff bases. Appl Organomet Chem. 2006;20(3):195-201. https://doi.org/10.1002/aoc.1039 18. Singh DP, Kumar R, Tyagi P. Transition metal complexes of N,O-donor Schiff bases and their antimicrobial activity. Eur J Med Chem. 2009;44(4):1731-1738. https://doi.org/10.1016/j. ejmech.2008.09.018 19. Raj DS, Raju M, Krishnan S. Spectral and biological studies of Schiff base complexes incorporating heterocycles. Spectrochim Acta A Mol Biomol Spectrosc. 2014;133:494-501. https://doi. org/10.1016/j.saa.2014.05.043 20. Jha NN, Ray IP. Synthesis and characterization of metal com plexes derived from 4-hydroxybenzaldehyde Schiff bases. Asian J Chem. 2000;12(3):703-706. 21. Rai BK, Sharma KK. Spectral and biological studies of some transition metal complexes with Schiff base ligands. Orient J Chem. 2011;27:143-148. 22. Raman N, Raja JD. Synthesis, structural characterization and antibacterial studies of some biosensitive mixed-ligand copper (II) complexes. Indian J Chem A. 2007;46A:1611-1614. 23. Angelusiu MV, Almajan GL, Illes DC, Rosu T, Negoiu M. Cop per (II), cobalt (II), nickel (II) and zinc (II) complexes with Schiff bases derived from 2-hydroxy-1-naphthaldehyde: syn thesis, characterization and antimicrobial activity. Chem Bull Politehnica Univ Timisoara. 2008;53:1-2. 24. Kapadnis KH, Jadhav SP, Patil AP, Hiray AP. Synthesis, char acterization and antimicrobial evaluation of some Schiff base metal complexes. World J Pharm Sci. 2016;5:1055-1063. 25. Alaghaz AMN, Ammar RA. Synthesis, potentiometric and anti microbial studies on metal complexes of a Thiazole Schiff base. Al-Azhar Bull Sci. 2010; 17:233-248. 26. Joshi KT, Pancholi AM, Pandya KS, Thakar AS. Synthesis, char acterization and antimicrobial activity of novel Schiff base and its transition metal complexes derived from 2-amino-4-phenyl Thiazole. J Chem Pharm Res. 2012;4(10):4389-4397. 27. Khan SJ, Marufa SS, Sultan MI, Aurora AT, Debnath JR, Eas min S. Novel thiophene–thiazole Schiff base hybrids: design, synthesis, antimicrobial and antioxidant activity with ADMET prediction, molecular docking and dynamics study. RSC Adv. 2025;15:45690-45706. https://doi.org/10.1039/D5RA04569A 28. Jiang GQ, Lu YZ. Synthesis and structure of Fe (III) complex derived from an octadentate Schiff base ligand. Asian J Chem. 2013;25:5107-5108. 29. Feng X, Chen JL, Luo GY, Wanfog LY, Guo JZ. A binuclear iron (III) Schiff base complex doubly bridged by hydroxyl groups: synthesis, structure and characterization. Russ J Coord Chem. 2015;41:101-107. https://doi.org/10.1134/S1070328415020043 30. Mehta BH, Salunke AS. Synthesis, characterization and X-ray diffraction studies of some transition metal complexes of Schiff base ligands. Asian J Chem. 2016;17:1103-1110. 31. More PG, Bhalvankar RB. Thermal and powder X-ray diffrac tion studies of copper (II) complexes of Schiff bases. Asian J Chem. 2010;13:1484-1488. 32. Nagajothi A, Kiruthika A, Chitra S, Parameswari K. Synthesis, characterization and antimicrobial studies of Fe(III) Schiff base complexes. Res J Chem Sci. 2013; 3:35-43.