Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411723EnglishN2025December13Healthcare Cytohistomorphological Features of Superficial CD34-Positive Fibroblastic Tumor       English0104Neelam SoodEnglish KaminiEnglish Introduction: SCPFT is a rare, low-grade mesenchymal neoplasm first described by Carter et al. in 2014. Clinically, it presents as a slow-growing, painless, well-circumscribed mass in superficial soft tissue over lower extremities and trunk of adults. It is characterized by spindle to epithelioid cells with eosinophilic cytoplasm, mild nuclear atypia, and rare mitotic activity. The tumor shows diffuse and characteristic strong CD34, while being negative for S100, Desmin, and smooth muscle actin (SMA). Cytologi cal descriptions of SCPFT are scarce in the literature, posing a diagnostic challenge on fine-needle aspiration. Aim/Objective: To describe the cytomorphological features of a rare case of Superficial CD34-positive fibroblastic tumor (SCP FT) and emphasize its diagnostic considerations on fine needle aspiration cytology. Case Report: A 16-year-old girl presented with a slow-growing, painless swelling over the posterior aspect of the right arm for two years. Clinical examination revealed a mobile, well-circumscribed mass measuring 3 cm x 3 cm. Fine needle aspiration cytology was performed, followed by histopathological examination and immunohistochemical analysis for confirmation. Results: Cytology smears were moderately cellular, showing loose cohesive clusters and scattered singly dispersed spindle to epithelioid cells. The tumor cells exhibited moderate to abundant eosinophilic cytoplasm, occasional vacuolation, vesicular nuclei, and prominent nucleoli. Focal nuclear pleomorphism was observed, with occasional bizarre and multinucleated cells, but no mitotic figures. The background showed a mixed inflammatory infiltrate. Differential diagnoses considered were solitary reticulohistiocytoma, atypical fibrous histiocytoma, alveolar soft part sarcoma, and atypical fibroxanthoma. Histopathological examination and immunohistochemistry confirmed the diagnosis of Superficial CD34-positive fibroblastic tumor. Conclusion: Superficial CD34-positive fibroblastic tumor is a rare, low-grade neoplasm of mesenchymal neoplasm with overlap ping cytological features. Recognition of its characteristic cytomorphology, along with histopathology and immunohistochemistry, is crucial for accurate diagnosis and appropriate patient management. EnglishLow-grade mesenchymal neoplasm, Fibroblastic, Epithelioid cells, CD34 positive, FNA, Histopathology, Immunohistochemistryhttp://ijcrr.com/abstract.php?article_id=4882http://ijcrr.com/article_html.php?did=4882 1. Carter JM, Weiss SW, Linos K, DiCaudo DJ, Folpe AL. Super ficial CD34-positive fibroblastic tumor: Report of 18 cases of a distinctive low-grade mesenchymal neoplasm of intermediate (borderline) malignancy. Mod Pathol 2014; 27:294-302. 2. Li SY, Zhang HL, Bai YZ. Superficial CD34-Positive Fibroblas tic Tumor on the chest wall of an 8-Year-Old Girl: A Case Re port and Literature Review. Pediatr Hematol Oncol. 2021 Sep; 38(6):602-608. 3. Sood N, Khandelia BK. Superficial CD34-positive fibroblastic tumor: A new entity; case report and review of literature. Indian J Pathol Microbiol. 2017; 60(3):377-380. 4. WHO Classification Soft Tissue and Bone Tumors. 5th ed. IARC; 2020. 5. Mao X, Sun YY, Deng ML, Ma T, Yu L. Superficial CD34-posi tive fibroblastic tumor: report of two cases and review of litera ture. Int J Clin Exp Pathol. 2020 Jan 1; 13(1):38-43. 6. Li W, Molnar SL, Mott M, White E, De Las Casas LE. Super ficial CD34-positive fibroblastic tumor: Cytologic features, tis sue correlation, ancillary studies, and differential diagnosis of a recently described soft tissue neoplasm. Diagn Cytopathol. 2016 Nov; 44(11):926-930. 7. Yim JE, Kwon HM, Kim HR, Shin DH, Choi JS, Choi JH, et al. Superficial CD34-Positive Fibroblastic Tumor: Two Case Re ports. Ann Dermatol. 2023 May; 35 (Suppl 1):S25-S29.

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411723EnglishN2025December28Healthcare Hydrogen-Rich Water and Molecular Hydrogen in Sports Science: A Review of Physiological Effects, Recovery Mechanisms, and Performance Outcomes   English0510Julia CharkotEnglish Wojciech Jedrzej BienkowskiEnglish Katarzyna BielawskaEnglish Mikolaj CharkotEnglish Michal BienkowskiEnglish Molecular hydrogen (H2 ), particularly in the form of hydrogen-rich water (HRW), has gained increasing attention for its potential antioxidative, anti-inflammatory, and ergogenic properties in physically active populations. The aim of this narrative review was to synthesize and critically evaluate current evidence on the physiological effects, recovery mechanisms, and performance outcomes associated with molecular hydrogen supplementation in sport and exercise science. A literature search was con ducted for studies published between 2000 and 2024 using PubMed, Scopus, Web of Science, and Google Scholar. The review included studies investigating the effects of H2 administered via hydrogen-rich water, inhalation, or intravenous infusion on oxidative stress, inflammation, fatigue, and physical performance. Current evidence indicates that molecular hydrogen may at tenuate exercise-induced oxidative stress, reduce inflammatory biomarkers, improve lactate metabolism, and alleviate delayed onset muscle soreness. Hydrogen-rich water appears to confer benefits in both acute and chronic exercise contexts; however, study findings remain heterogeneous. Molecular hydrogen shows potential as a supportive intervention in sports medicine and exercise recovery. Nevertheless, variability in study design, limited sample sizes, and inconsistent performance metrics restrict definitive conclusions. Further well-designed, large-scale randomized controlled trials are needed to establish optimal dosing, administration strategies, and long-term effectiveness. EnglishMolecular hydrogen, Hydrogen-rich water, Oxidative stress, Athletic recovery, Antioxidant therapy, Randomized controlled trialshttp://ijcrr.com/abstract.php?article_id=4884http://ijcrr.com/article_html.php?did=4884 1. Alharbi AAD, Alhussain MH, Alharthi AS, Alshahrani MS, Alqarni A. Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments During Incremental Exercise in Humans. Nutrients. 2021;13(2):459. doi: 10.3390/nu13020459. Accessed on: 16 September 2025; 20:00. 2. Alharbi AAD, Alhussain MH, Alharthi AS, Alshahrani MS, Alqarni A. The Acute Effects of a Single Dose of Molecular Hydrogen Supplements on Responses to Ergogenic Adjustments During High-Intensity Intermittent Exercise in Humans. Nutri ents. 2022;14(19):3974. doi: 10.3390/nu14193974. 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