Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241179EnglishN2025May14Healthcare Review of Various Microbiota Modifications Due to Environmental Pollutant Exposure Causing Type 2 Diabetes in Rodent Model Experiments         English0110Buvaneswari GajendranEnglish Frankline Noah KanagarajEnglish G. SarirekaEnglish Vanitha KrishnanEnglish Parthiban KaruppiahEnglish Santhosh Kumar VEnglish Introduction: In recent years, chemical-induced diabetes especially some endocrine disrupting chemicals (EDCs) are classified as diabetogen. Aim/Objectives: The present meta-analysis aimed to investigate the diabetogenic nature and its resultant gut microbiome changes in mice exposed to EDCs. Methods: This study was done by searching online database, PubMed using MesH terms; and gut microbiome/microbiota. Articles with EDC induced hyperglycemia and those performed meta-genomics analysis were included. All parameters includ ing experimental set-up, biochemical tests, 16SrRNA sequencing were tabulated and grouped based on the type of EDC used. Results: Out of 13 studies selected based on inclusion criteria, four administered POPs and three used emulsifiers. The meta genomics analysis reported a total of 13 phylum and 64 genera. Only four studies reported F/B ratio in which two showed increased pattern. Some unique OTUs of 58/66, 42/38 and 43/38 were observed in diabetes mice when induced with glycerol monolaurate, PCB126 and PCB77 as compared to the control mice respectively. In induction group, majority of the studies have reported enhanced Gram’s negative bacteria in which frequently documented organisms were Akkermansia and Lactobacillus, followed by Bifidobacterium, Bacteriodes and Helicobacter. Conclusion: The outcome of this meta-analysis clearly indicated the diabetogenic nature of EDCs and its role in altering the gut microbiome. 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Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241179EnglishN2025May14Healthcare Comparison of the Effectiveness of Maitland Spinal Mobilization Versus Mckenzie Exercise Combined with Core Stability Exercise on Pain, Range of Motion and Functional Activities in Mechanical Low Back Pain           English1115Manikandan MEnglish Parthiban SEnglish Ashraf YEnglish Introduction: Mechanical low back pain (LBP) is low back pain associated with the spine, intervertebral disks, or surrounding soft tissues. It generally results from an acute traumatic event but may also be caused by cumulative trauma. The severity of an acute traumatic event varies widely, from twisting ones back to being involved in a motor vehicle collision. Mechanical LBP due to cumulative trauma tends to occur more commonly in the workplace. Aim/Objectives: To find out the effects of Maitland Spinal Mobilization versus McKenzie Exercise combined with core stability exercise on pain, range of motion and functional activities in subjects with Mechanical Low Back Pain. Methods: Among 40 patients, 12 were excluded. The remaining 28 patient’s age group of 20 to 45 years were recruited. The study was a quasi-experimental comparative design. This was conducted at Department of Orthopaedics & department of physi cal medicine rehabilitation, PSG Hospitals, Coimbatore. By simple random sampling method, 14 patients were selected in each group of intervention. Group A received Maitland Spinal Mobilization & Group B McKenzie Exercises. The core stability exercises were a common treatment for both groups. The treatment given for groups were 3 session/week for 2 weeks. The treatment outcome was assessed using Numerical Pain Rating Scale, Range of Motion and Oswestry Disability Index. Data were analyzed by SPSS 20 to determine the effects of both the treatment regimens and compared with each other. Results: Data analysis revealed that within group statistically significant difference within group Maitland Spinal Mobilization with Core stability exercises and McKenzie exercise with Core stability exercises both groups showed significant (p0.05) for all parameters. Conclusion: This study shows that Maitland Spinal Mobilization combined with Core stability exercises improves functional activities largely than McKenzie exercises combined with Core stability exercises in the treatment of patients with mechanical low back pain. EnglishMechanical Low Back Pain, Maitland Mobilization, McKenzie, Core Stability Exercise, Numerical Pain Rating Scale, ODI. Range of motionhttp://ijcrr.com/abstract.php?article_id=4856http://ijcrr.com/article_html.php?did=4856 1. Hills EC. Mechanical Low Back Pain. Medscape. Updated April 10, 2025. Available at: https://emedicine.medscape.com/ article/310353-overview [Accessed July 15, 2025] 2. Lam OT, Strenger DM, Chan-Fee M, Feret A, Ho P, Pham PT. Effectiveness of the McKenzie Method of Mechanical Diagnosis and Therapy for Treating Low Back Pain: Literature Review with Meta-analysis. J Orthop Sports Phys Ther. 2018;Jun;48(6):476 490. doi:10.2519/jospt.2018.7562 3. Will JS, Bury DC, Miller JA. Mechanical Low Back Pain. Am Fam Physician. 2018 Oct 1;98(7):421-428 4. Chiradejnant A, Maher C, Latimer J, Stepkovitch N. Efficacy of ‘therapist-selected’ versus ‘randomly selected’ mobilisation techniques for the treatment of low back pain: A randomised controlled trial. Aust J Physiother. 2003;49(3):233-241. doi:10.1016/S0004-9514(14)60139-2. 5. Seema S. Effect of Grade II and Grade III Mobilization by Mait land Technique in Low Back Pain. Indian J Physiother Occup Ther. 2012;6(4):91-95. 6. Naik VC, Chitra J, Khatri S. Effectiveness of Maitland versus Mulligan mobilization technique following post-surgical man agement of Colles fracture; randomized clinical trial. Indian J Physiother Occup Ther. 2007;1(4):14-19. 7. Donelson R. Evidence-informed management of chronic low back pain with the McKenzie method. Spine J. 2008;8:134-141. 8. Agency for Health Care Policy and Research (AHCPR). Acute low back pain problems in adults. Bigos S, Bowyer O, Braen GR, et al., editors. Rockville (MD): U.S. Department of Health and Human Services; 1994 9. Deyo RA, Rainville J, Kent DL. What can the history and physi cal examination tell us about low back pain? JAMA. 1992; 268(6):760-765. 10. Bratton RL. Assessment and management of acute low back pain. Am Fam Physician. 1999;60(8):2299-2308. 11. Ahmed R, Shakil-ur-Rehman S, Sibtain F. Comparison between specific lumbar mobilization and core stability exercise with core stability exercise. Pak J Med Sci. 2014;30(1):157-160. 12. Dutta A. A comparative study to find out the effectiveness be tween core stabilization exercises versus McKenzie exercise. Indian J Physiother. 2015;2(5):791-797.