Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411622EnglishN2024November27Healthcare Effects of Active School Transportation on Physical Fitness of Congolese Intellectual Disabilities Adolescents       English0108Mabounda Kounga Paul RogerEnglish Boussana Alain MarcEnglish Agbodjogbe Wilfrid Kpedetin Dieu-DonneEnglish Introduction: Adolescents with intellectual disabilities (ID) tend to have poorer physical fitness than their typically developing peers. Active transport provides substantial health benefits from increased physical activity. But few is known on the Congolese normal-weight and overweight with intellectual disabilities. Aim/Objectives: This study aimed to evaluate the effect of active school-home transportation on the physical fitness of Congolese adolescents with intellectual disability disorder. Methods: A total of 28 adolescents with mild and moderate intellectual disability, were divided into normal-weight with intellectual disabilities (NWID, n = 18, age) and overweight with intellectual disabilities (OWID, n = 10, age). Their physical fitness parameters were assessed at three periods: on April-June 2023 (T0), October-November (T1) and December 2023 (T2). The active transportation (walking) and period of rest effects on adolescent’s physical fitness were assessed on T0/ T2 and T1 respectively. Physical fitness parameters were related to movement functionality (the test of balance) and health-related condition (waist circumference, 6-minute walk tests, push-up and sit-stand tests). Results: Waist circumference was significantly lowers (all p < 0.05) among NWID and OWID at T0 and T2 periods than on the T1 period. NWID scored significantly higher in flexibility, balance, push-up, 6MWT and VO2max (all p < 0.01) tests than OWID whereas OWID improve better the flexibility at the third period (p > 0.05). Compared to the second period, NWID scored significantly higher in the T0 period for balance, push-up and VO2max (all p < 0.05) and scored significantly higher in the T2 period for flexibility, balance, distance travel, push-up and VO2max (all p < 0.05). Conclusion: Active transportation widely improved functionality and health related parameters of normal weight Congolese intellectual disabilities adolescents. School time periods exerted more effects on balance, flexibility, distance traveled, and cardiorespiratory fitness than the holyday on both normal weight and overweight groups. EnglishPhysical fitness, Active school transportation, Intellectual disability, Congolese, Adolescents, Healthhttp://ijcrr.com/abstract.php?article_id=4828http://ijcrr.com/article_html.php?did=4828

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411622EnglishN2024November27Healthcare A Holistic Review on Applications of Different Grades of Polyethylene oxide in Pharmaceutical Formulation Development     English0917Dinesh Kumar DasEnglish Anjan KumarEnglish Ch Niranjan PatraEnglish Polyethylene oxide (PEO) is a multifaceted polymer with extensive applications in pharmaceutical product development. This review highlights its significant roles in various drug delivery systems. In hydrogels, PEO’s hydrophilicity and gel-forming capabilities enhance drug stability and controlled release. Osmotic pumps benefit from PEO’s ability to regulate osmotic pressure and drug solubility, ensuring precise and consistent drug delivery. PEO’s mucoadhesive properties improve drug retention and bioavailability in mucoadhesive drug delivery systems, providing sustained therapeutic effects. In gastro-retentive drug delivery systems, PEO prolongs gastric residence time, enhancing the bioavailability of drugs absorbed primarily in the stomach. Finally, PEO’s thermoplastic properties make it an essential component in hot melt extrusion processes, facilitating the formation of homogenous drug-polymer matrices and improving the solubility of poorly water-soluble drugs. Overall, PEO’s versatility and effectiveness across these applications underscore its critical role in advancing pharmaceutical formulations and optimizing therapeutic EnglishHydrogel, Osmotic DDS, Mucoadhesive DDS, Gastro-retentive DDS, Hot-melt extrusion process and polyoxhttp://ijcrr.com/abstract.php?article_id=4829http://ijcrr.com/article_html.php?did=4829 1. Hussain G, Al-Ghamdi K. PEO coating as lubrication means for SPIF of titanium sheet: characteristics and performance. Mater Res Innov 2014; 18 (2): 727-733. 2. Kim M, Vala M, Ertsgaard CT, Oh SH, Lodge TP, Bates J, et al. 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