Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241165EnglishN2024March18Healthcare
Effect of Exposure to Triclosan on Reproductive System of Female Rats at Different Developmental Phases
English0109Barnika BandyopadhyayEnglish Lakshmishri LahiryEnglish
Introduction: Triclosan (TCS), extensively used in different cleaning and personal care products due to its antimicrobial properties, is an endocrine disruptor that has raised health concerns.
Aim/Objective: To see the effects of exposure to sublethal dose of Triclosan on the development and function of reproductive system of female offspring rats in their early juvenile, pubertal and post pubertal stages of development.
Method: F1 generation of female rats (experimental animals), obtained from TCS treated mother rats, were exposed orally to sub-lethal doses of TCS, according to the concentration given to their respective mother, from PND 19. The body weights, reproductive organ weights, onset of puberty and estrous cycle, serum gonadotropin and ovarian hormones and histology of ovaries and uteri were studied.
Results: Pre-natal exposure to TCS through TCS-ingestion by mother rats did not affect the birth weights of the offspring. TCS treatment did not show change in the body weight gain at the end of one month when compared to untreated animals. Increased relative uterine and ovarian weights were observed upon TCS treatment. A dose dependent delay in the vaginal opening correlating with decreased serum level of FSH was observed indicating the disrupted hormonal balance that delayed the onset of puberty. TCS induced changes in number and growth of ovarian follicles and changes in thickness of uterine layers with increased width of uterine lumen was observed in all developmental phases. Prolonged TCS treatment till post pubertal stages of development induced decrease in FSH and Estradiol levels in the proliferative phases of estrous cycle and increased serum progesterone level sustained by increase in ovarian corpus luteum, thereby affecting the normal commencement of estrous cycle by increasing duration of metestrus-diestrus phases.
Conclusion: Chronic exposure of environmentally relevant concentration of TCS to female rats induced altered gonadostat resetting and delayed puberty and early onset of reproductive senescence during reproductive development indicating possibilities of infertility.
EnglishTriclosan, Puberty, Estrous cycle, Ovaries, Uteri, Gonadotropin hormoneshttp://ijcrr.com/abstract.php?article_id=4793http://ijcrr.com/article_html.php?did=4793
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Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241165EnglishN2024March18Healthcare
Post-Operative Outcomes of Valvular Cardiac Surgery and its Predisposing Factors
English1014Muhammad TariqEnglish Muhammad Ali GoharEnglish Attiya Hameed KhanEnglish Waqar Masud MalikEnglish Kifayat UllahEnglish Abdul NasirEnglish Syed Shahkar Ahmed ShahEnglish Mohammad WaleedEnglish
Introduction: Valvular heart disease remains common cardiovascular problem worldwide. The etiology of valvular heart disease differs as per the socio-economic factors. In industrialized countries, the most common etiology seems to be the degenerative valvular dysfunction. On the other hand, in third-world countries like Pakistan, rheumatic heart disease (RHD) is a common cause of valvular heart disease.
Aims/ Objective: To determine postoperative outcomes of valvular cardiac surgery and find any association of clinical predictors with the surgical outcome.
Methodology: This retrospective observational study was carried out at Peshawar institute of cardiology. We included all patients who underwent valvular surgeries from January 2022 to September 2022. Ethical approval was taken from hospital ethical review committee. Data was extracted from electronic medical record (EMR) and analyzed in SPSS version 22.0
Results: Mean age of patients for valvular surgery was (38.74±13.942), mean Body mass index (23.403±4.5330) and mean bypass time (155.80±53.626). 34% patients with mitral valve abnormalities and 24% aortic valve abnormalities.27% patients with the history of hypertension and 10.7% with Diabetic mellitus. Post-operative outcomes are significantly correlated with age, post-operative rhythm, heart rate and potassium level (r=-.170*,-.317**, .226** and .237** pEnglishDr. Mohammad Waleed, Associate Dean Research, Peshawar Institute of Cardiology, KPK, Pakistan.http://ijcrr.com/abstract.php?article_id=4794http://ijcrr.com/article_html.php?did=4794
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