Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411524EnglishN2023December30Healthcare Artificial Intelligence in Pharmacovigilance: A future to Manage Adverse Drug Reactions     English0103Pramod Kumar ManjhiEnglish Vikas MaharshiEnglishEnglishhttp://ijcrr.com/abstract.php?article_id=4780http://ijcrr.com/article_html.php?did=4780 1. Murali K, Kaur S, Prakash A, Medhi B. Artificial Intelligence in Pharmacovigilance: Practical utility. Indian J Pharmacol 2019;51:373-6. 2. P Wani et al. Role of artificial intelligence in pharmacovigilance: a concise review. Journal of Pharmaceutical Negative Results. 2022:13:6149-56. 3. Salvo F, Micallef J, Lahouegue A, Chouchana L, Létinier L, Faillie JL, Pariente A. Will the future of pharmacovigilance be more automated? Expert Opin Drug Saf. 2023 Jul-Dec;22(7):541-548. doi: 10.1080/14740338.2023.2227091. Epub 2023 Jul 12. PMID: 37435796. 4. Available at: https://who-umc.org/media/3086/vigi_tools_and_ methods.pdf Accessed on December, 1st 2023 5. Salas M, Petracek J, Yalamanchili P, Aimer O, Kasthuril D, Dhingra  S, Junaid T, Bostic T. The Use of Artificial Intelligence in Pharmacovigilance: A Systematic Review of the Literature. Pharmaceut Med. 2022 Oct;36(5):295-306. doi: 10.1007/ s40290-022-00441-z. Epub 2022 Jul 29. PMID: 35904529.

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411524EnglishN2023December30Healthcare Modern Trends in Complex Treatment of Patients with the Cervical Cancer     English0408O.V. BondarEnglish A.I. RybinEnglish K.M. DoikovaEnglish Introduction: Complex treatment of patients with the cervical cancer has been studied less. Aims: To assess the effectiveness of combined treatment (surgery + radiomodifier as chemotherapy and radiation therapy) in patients with cervical cancer. Methodology: Retrospective analysis of case histories of 661 patients with cervical cancer. Patients received treatment from 2015 to 2020. All women were divided into 2 subgroups: in the main (n = 336) surgery, radiomodifier and radiation therapy and the control group (n = 325), no radiomodifier was used. Results: An objective response after the first stage of treatment was achieved in 84.3% of patients in the main group and 59.4% of patients in the control group. Intra-systemic administration of cytostatics had a significant effect on the involution of infiltration in comparison with the effect of radiation only. In cases where neoplasm has not reduced, positive changes were observed: the exophytic part of the tumor, its bleeding and the volume of discharge decreased, superficial necrosis decreased or completely disappeared. Out of 336 patients from the main group IB2-III stage, 87% of patients are in remission for more than 3 years. Conclusion: The undeniable advantage combining radiation treatment with chemotherapy has been proven. Current standard may be considered as the weekly introduction of platinum preparations in the process of radiation treatment, as well as the use of fluoropyrimidine derivates as radio-modifying agents. Nature and extent of early complications did not differ reliably in comparison groups. EnglishCervical cancer, Gynecology, Chemoradiation therapy, Radiation therapy, X-ray, Radiomodifierhttp://ijcrr.com/abstract.php?article_id=4781http://ijcrr.com/article_html.php?did=4781 1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer 2015;136(5): 359-386. 2. American Cancer Society: Cancer Facts and Figures 2020. Atlanta, Ga: American Cancer Society, 2020,4, tab1. 3. Fedorenko Zoja P., Michailovich Youriy Yo., Goulak Lyudmyla O., Gorokh Yevgeniy L., Ryzhov Anton Yu., Soumkina Olena  V., et al. Bulletin of national cancer registry of Ukraine 2020; 21:6. 4. Fedorenko ZP., Michailovich Y Yo., Goulak LO., Gorokh YL., Ryzhov AYu., Soumkina OV., et al. Bulletin of nationl cancer registry of Ukraine 2020;21:10. 5. Myong ChL, Maria L, Seung HS. Practice guidelines for management of cervical cancer in Korea: a Korean Society of Gynecologic Oncology Consensus Statement. J Gynecol Oncol. 2017; 28(3):22. 6. Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R. Cancer of the cervix uteri. Int J Gynaecol Obstet 2018; 143(2):22. 7. Rose PG, Blessing JA, Mayer AR, Homesley HD. Prolonged oral etoposide as second-line therapy for platinum-resistant and platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group study. J Clin Oncol. 1998;16(2):405-410. 8. Chino J, Annunziata CM, Beriwal S. Radiation Therapy for Cervical Cancer: Executive Summary of an ASTRO Clinical Practice Guideline. Pract Radiat Oncol 2020; 10:220. 9. Vishnevskaya EE. Handbook of Oncology Gynecology. Minsk, Belarus. 2014. 10. Dexter LI., Maryanenko AI., Bohman YaV. Changes in clinical and immunological parameters in patients with cervical cancer under the influence of a polypeptide drug thymus (thymalin). Immunology of tumors. Riga: Zinatne, 2012. 150-152. 11. Bernardini M, Barrett J, Seaward G, Covens A. Pregnancy outcomes in patients after radical trachelectomy. Am J Obstet Gynecol. 2003; 189: 1378–1382. 12. Boss EA, van Golde RJ, Beerendonk CC, Massuger LF. Pregnancy after radical trachelectomy: a real option. Gynecol Oncol. 2005; 99: 152–156 13. American College of Obstetricians and Gynecologists ACOG practice bulletin. Diagnosis and treatment of cervical carcinomas. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet. 2002; 78: 79–91. 14. Weinberg M, Radiation therapy. Retrospection, looking to the future. J Med Radio 1994$ 39 (3): 68-71. 15. Keys HM, Bundy BN, Stehman FB, Muderspach LI, Chafe WE, Suggs CL 3rd, Walker JL, Gersell D. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med. 1999; 340(15):1154-1161. 16. Stolyarova KV., Vinokurov VL., Zharinov GM. Results of polyradiomodification in radiation therapy for cancer of the cervix and uterine body. Med Radiol. 2012; 3-4: 273-281. 17. Bohman YaV., Vishnevsky AS., Maksimov SYa. Petersburg scale of oncogynecology: some results and prospects. Vopr. onkol. 1997; 43(1):39-46. 18. Narimatsu A., Ito T. Neoadjuvent chemotherapy with continuos intraarterial infusion fCDDP, 5Fu in the treatment of advance cervical and endometrial adenocarcinoma. J. Jap. Soc. Cancer Then 2005; 30(2): 408. 19. Vishnevskaya EE., Kosenko IA. Long-term results of complex therapy of patients with cervical cancer with a palate prognosis. Vopr. onkol. 2009; 45(4): 420-423. 20. Alvarez SA., Harvilevsky LJ., Bae JV. Gyneacol. Oncol. 2007; 107(2). 21. Krikunova LI., Mkrtchan LS., Shentereva NI., Sychenkova NI. Cervical cancer. Therapeutic Radiology: A Guide for Physicians. LLC “MK”, Moscow 2010; 369-378. 22. Stolyarova KV., Vinokurov VL., Zharinov GM. Results of polyradiomodification  in radiation therapy for cancer of the cervix and uterine body. Med Radiol. 2012; 3-4: 281-292. 23. Greenlee R., Murray T., Bolden S. Cancer statistics. CA Cancer J. Clin. 2001; 36: 5115. 24. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Cervical cancer.

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411524EnglishN2023December30Healthcare Dental Materials: A Comprehensive Review of Evolution, Classification, Challenges and Future Prospects     English0916Sivamani S.English Anitha V.English Nishat FatimaEnglish Sudha RamaniEnglish The synthesis of historical insights, current applications, and future outlooks makes this review a valuable resource for researchers, practitioners, and educators in the field of dental science. The present comprehensive review explores the diverse applications of materials in dental science, emphasizing their pivotal role in restorative dentistry, prosthodontics, orthodontics, and periodontics. The historical evolution of dental materials sets the stage, highlighting the transition from traditional to advanced materials. Classification of dental materials encompasses restorative materials like dental amalgam, composites, and ceramics; impression materials such as alginate and elastomers; and biomaterials including dental implants, bone grafts, and membranes. Adhesive materials and their applications in bonding dental restorations are also discussed. The narrative extends to recent advance materials like amalgam and composites in dentistry. The review concludes with a discussion on challenges in dental materials and prospects for future developments. EnglishMaterials, Dental, History, Evolution, Classification, Propertieshttp://ijcrr.com/abstract.php?article_id=4782http://ijcrr.com/article_html.php?did=4782 1. Groover MP. Fundamentals of modern manufacturing: materials, processes, and systems. John Wiley & Sons. 2020 2. Lukkassen D, Meidell A. Advanced materials and structures and their fabrication processes. Narrik University College, Hin. 2003. 3. Blau PJ. On the nature of running-in. Tribol. Int.2005; 38(11-12):1007-1012. 4. Hirtz J, Stone RB, McAdams DA, Szykman S, Wood KL. A functional basis for engineering design: reconciling and evolving  previous efforts. Research in engineering Design. 2002;13:65- 82. 5. Akinribide OJ, Ogundare OD, Oluwafemi OM, Ebisike K, Nageri AK, Akinwamide S O Olubambi PA. A Review on Heat Treatment of Cast Iron: Phase Evolution and Mechanical Characterization. Mater.2022;15(20);7109. 6. Schedle A, Örtengren U, Eidler N, Gabauer M, Hensten A. Do adverse effects of dental materials exist? What are the consequences, and how can they be diagnosed and treated? Clin. Oral Implants Res.2007;18:232-256. 7. Moshaverinia A. Review of the modern dental ceramic restorative materials for esthetic dentistry in the minimally invasive age. Dent. Clin North Am.2020;64(4):621-631. 8. Mallineni SK, Nuvvula S, Matinlinna JP, Yiu CK, King NM. Biocompatibility of various dental materials in contemporary dentistry: a narrative insight. Journal of investigative and clinical dentistry (JICD).2013;4(1):9-19. 9. Blatz MB, Chiche G, Bahat O, Roblee R, Coachman C, Heymann HO. Evolution of aesthetic dentistry. J Dent Res.2019;98(12):1294-1304. 10. Elliott JA. Novel approaches to multiscale modelling in materials science. Int Mater Rev.2011;56(4):207-225. 11. Nelson RR, Winter SG. In search of useful theory of innovation. Res. Policy.1977;6(1):36-76. 12. Bunn HT. A taphonomic perspective on the archaeology of human origins. Annu. Rev Anthropol.1991;20(1):433-467. 13. Forbes RJ. Metallurgy in antiquity: a notebook for archaeologists and technologists. Brill Archive. 14. Richerson DW, Lee WE. Modern ceramic engineering: properties, processing, and use in design. CRC press. 2018 15. Rehren T. Glass production and consumption between Egypt, Mesopotamia and the Aegean. Contextualising grave inventories in the ancient near east. 2014;3:217-225. 16. Kumar N, Dixit A, Kumar N, Dixit A. Historical Perspective of Materials and Contemporary Warfare Technologies. Nanotechnol Sci Appl. 2019; :1-33. 17. Amis EJ, Xiang XD, Zhao JC. Combinatorial materials science: What’s new since Edison? MRS bulletin.2002;27(4):295-300. 18. Marsh P. The new industrial revolution: consumers, globalization and the end of mass production. Yale University Press. 2012. 19. Fitzgerald F. Bessemer: the technology and the times. Interdiscip. Sci Rev.1998; 23(4):362-371. 20. Suenaga K. The ‘Industrial Enlightenment’ and technological paradigms of the modern steel industry. Technol. Soc.2020;  63:101375. 21. Middlemiss R. Materials, processes and ink formulation towards viable, manufacturable passive-and active-printed electronics components. (Doctoral dissertation, Loughborough University). 2021 22. Kumar N, Kumbhat S. Essentials in nanoscience and nanotechnology. John Wiley & Sons. 2016. 23. Shrivastava S, Dash D. Applying nanotechnology to human health: revolution in biomedical sciences. J. Nanotechnol. 2009. 24. Larcher D, Tarascon JM. Towards greener and more sustainable  batteries for electrical energy storage. Nat. Chem. 2015;7(1):19-29. 25. Alivisatos P, Barbara PF, Castleman AW, Chang J, Dixon DA, Klein ML, et al. From molecules to materials: Current trends and future directions. Adv. Mater.1998; 10(16):1297-1336. 26. Hummel RE. Understanding materials science: history, properties, applications. New York: Springer. 1998:407 27. Zhou X, Huang X, Li M, Peng X, Wang S, Zhou X, et al. Development and status of resin composite as dental restorative materials. J Appl Polym Sci. 2019 136(44): 48180. 28. Singh H, Kaur M, Dhillon JS, Mann JS, Kumar A. Evolution of restorative dentistry from past to present. Indian J Dent Sci. 2017 9(1): 38-43. 29. Haque N, Yousaf S, Nejatian T, Youseffi M, Mozafari M, Sefat  F. Dental amalgam, In Advanced Dental Biomaterials. Woodhead Publ. 2019: 105-125.  30. Pini NP, Aguiar FHB, Lima DANL, Lovadino JR, Terada RSS, Pascotto RC. Advances in dental veneers: materials, applications, and techniques. Clin Cosmet Investig Dent. 2012: 9-16. 31. Bayne SC. Beginnings of the dental composite revolution. J Am DenT Assoc. 2013 144(8): 880-884. 32. Chan KH, Mai Y, Kim H, Tong KC, Ng D, Hsiao JC. Resin composite filling. Materials. 2010 3(2): 1228-1243. 33. Alqutaibi AY, Ghulam O, Krsoum M, Binmahmoud S, Taher H, Elmalky W, Zafar MS. Revolution of current dental zirconia: A comprehensive review. Molecules. 2022 27(5): 1699. 34. Höland W, Schweiger M, Watzke R, Peschke A, Kappert H. Ceramics as biomaterials for dental restoration. Expert Rev. Med Devices. 2008 5(6): 729-745. 35. Erickson RL, Barkmeier WW, Latta MA. The role of etching in bonding to enamel: a comparison of self-etching and etch-andrinse adhesive systems. Dent. Mater. 2009 25(11): 1459-1467. 36. Pereverzyev V. Digital Dentistry: A Review of Modern Innovations for CAD/CAM Generated Restoration, 2022. 37. Alghazzawi TF. Advancements in CAD/CAM technology: Options for practical implementation. J. Prosthodont Res. 2016 60(2): 72-84. 38. Sivaraman K, Chopra A, Narayan AI, Balakrishnan D. Is zirconia a viable alternative to titanium for oral implant? A critical review. J. Prosthodont Res. 2018 62(2): 121-133. 39. Alqahtani AM. Guided Tissue and Bone Regeneration Membranes: A Review of Biomaterials and Techniques for Periodontal  Treatments. Polymers. 2023 15(16): 3355. 40. Rodrigues L, Jamenis S, Kadam A, Shaikh A. Orthodontic wires and their recent advances-A compilation, IJSR, 2019 8(6): 969-973. 41. Jandt KD, Watts DC. Nanotechnology in dentistry: Present and future perspectives on dental nanomaterials. Dent Mater. 2020 36(11): 1365-1378. 42. Rekow ED. Digital dentistry: The new state of the art - Is it disruptive or destructive? Dent. Mater. 2020 36(1): 9-24. 43. Puckett AD, Fitchie JG, Kirk PC, Gamblin J. Direct composite restorative materials, Dent. Clin North Am. 2007 51(3): 659-675. 44. El-Mowafy O. The use of resin cements in restorative dentistry to overcome retention problems. Journal-Canadian Dental Association (JCDA). 2001 67(2): 97-102. 45. Roach M. Base metal alloys used for dental restorations and implants, Dent. Clin North Am. 2007 51(3): 603-627. 46. Jockusch J, Özcan M. Additive manufacturing of dental polymers: An overview on processes, materials and applications. Dent Mater J. 2020 39(3): 345-354. 47. Nicholson JW. Adhesive dental materials - A review. Int. J. Adhes Adhes. 1998 18(4): 229-236. 48. Al-Jabrah O, Al-Shumailan Y, Al-Rashdan M. Antimicrobial effect of 4 disinfectants on alginate, polyether, and polyvinyl siloxane impression materials. Int. J Prosthodont. 2007 20(3). 49. Vojdani MA, Torabi KA, Farjood EB, Khaledi AAR. Comparison the marginal and internal fit of metal copings cast from wax patterns fabricated by CAD/CAM and conventional wax up techniques. J. Dent. 2013 14(3): 118. 50. Eftekhar Ashtiani R, Alam M, Tavakolizadeh S, Abbasi K. The role of biomaterials and biocompatible materials in implant-supported dental prosthesis. Evidence-based Complementary and  Alternative Medicine (eCAM). 2021: 1-9. 51. Iftikhar S, Jahanzeb N, Saleem M, ur Rehman S, Matinlinna JP, Khan AS. The trends of dental biomaterials research and future directions: A mapping review. Saudi Dent J. 2021 33(5): 229- 238. 52. Hervás García A, Lozano M, Cabanes Vila J, Barjau Escribano A, Fos Galve P. Composite resins: a review of the materials and clinical indications, 2006. 53. Zhao R, Yang R, Cooper PR, Khurshid Z, Shavandi A, Ratnayake J. Bone grafts and substitutes in dentistry: A review of current trends and developments. Molecules. 2021 26(10): 3007. 54. Raghavendra SS, Jadhav GR, Gathani KM, Kotadia P. Bioceramics in endodontics–a review. Journal of Istanbul University Faculty of Dentistry (JIUFD). 2017 51(3 Suppl 1): 128 -137. 55. Kotha RS, Alla RK, Shammas M, Ravi RK. An overview of orthodontic wires. Trends Biomater Artif Organs. 2014; 28(1):32-36. 56. Zhou W, Liu S, Zhou X, Hannig M, Rupf S, Feng J, et al. Modifying adhesive materials to improve the longevity of resinous restorations, Int J. Mol Sci. 2019; 20(3):723. 57. Saeed F, Muhammad N, Khan AS, Sharif F, Rahim A, Ahmad P, et al. Prosthodontics dental materials, From conventional to unconventional. Mater Sci Eng. 2020; C(106):110167. 58. Alauddin MS, Abdul Hayei NA, Sabarudin MA, Mat Baharin NH. Barrier membrane in regenerative therapy: a narrative review. Membranes. 2022; 12(5):444. 59. Dossey CA, Abasolo ES, Starr IA. Bruxism Biofeedback Device. 2023. 60. Bharti R, Wadhwani KK, Tikku AP, Chandra A. Dental amalgam: An update, Journal of conservative dentistry (JCD). 2010;13(4):204. 61. Yadav RK, Verma UP, Tiwari R, Chaurasia A. Mercury or mercury free restorations in oral cavity. Int. J. Public Health Sci. 2018; 7:201-206. 62. Brownawell AM, Berent S, Brent RL, Bruckner JV, Doull J, Gershwin EM, et al. The potential adverse health effects of dental amalgam. Toxicol Rev. 2005; 24:1-10. 63. Boushell L, Wilder Jr. AD, Ahmed SN. Dental metallic, composed amalgam (silver amalgam or simply amalgam). Sturdevant’s Art & Science of Operative Dentistry-E-Book, 2017; 306. 64. Affairs Acos. Direct and indirect restorative materials. J. Am Dent Assoc. 2003; 134(4):463-472. 65. Habib E, Wang R, Wang Y, Zhu M, Zhu XX. Inorganic fillers for dental resin composites: present and future. ACS Biomater. Sci. Eng. 2016; 2(1): 1-11.