Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241158EnglishN2023April24Healthcare Evaluation of CDX2 Expression in Gastric Precancerous Lesions and Gastric Carcinoma     English0109Amina PervinEnglish Shahnaj BegumEnglish Khandaker Haris MohammedEnglish Sharmeen JahanEnglish Zubaida IslamEnglish Sifat ShamsEnglish Introduction: Gastric carcinoma is the fifth most common and fourth fatal cancer in the world. The current TNM staging system together with clinicopathological characteristics are not sufficient to detect prognosis. Expression of CDX2 in gastric mucosa is strongly associated with precancerous lesions and cancer. Aim/Objectives: The aim of the study was to evaluate CDX2 expression in different gastric premalignant lesions including intestinal metaplasia, chronic atrophic gastritis, adenoma / dysplasia and in gastric carcinoma and to evaluate the expression between histopathological types, grade and pTNM stages in gastric carcinoma. Methods: It was a cross sectional observational study conducted at Sir Salimullah Medical College & Mitford Hospital, Dhaka over a period of 2 years. CDX2 expression was examined by immunohistochemical method in 77 formalin fixed-paraffin-embedded surgical specimens of gastric precancerous lesions and gastric cancer. The association between CDX2 expression and gastric precancerous lesion was evaluated. The association between CDX2 expression and gastric cancer including histopathological types, grade and pT and pN stages were evaluated. Association between CDX2 expression and specimen type was also evaluated. Results: The mean age of the patient was 55.6+11.9 years ranging from 33 to 86 years and majority of the cases were male (n=53, 68.8%). Among total 77 cases, there were 60 malignant and 17 precancerous lesions. Majority of the cases were endoscopic biopsy specimens (n=42, 54.5%). CDX2 expression was significantly high in precancerous lesions (p=0.039). Among malignant tumors, significantly high expression was observed in well and moderately differentiated (p=0.001) and in low-grade malignant tumors (pEnglishEvaluation, Gastric Carcinoma, Precancerous Lesions, CDX2 Expression, pTNM stageshttp://ijcrr.com/abstract.php?article_id=4725http://ijcrr.com/article_html.php?did=4725

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241158EnglishN2023April24Life Sciences Characterization and Screening of Marine Pseudomonas stutzeri for Industrially Important Enzymes under Oligotrophic Condition         English1014Nambiar PrajithEnglish Malik NageshEnglishEnglishCell volume, FEG-SEM, Hydrolytic enzymes, Oligotroph, Pseudomonas stutzeri, Marine, Copiotrophhttp://ijcrr.com/abstract.php?article_id=4726http://ijcrr.com/article_html.php?did=4726

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241158EnglishN2023April24Healthcare Polycystic Ovary Syndrome and Its Impact on Women’s Quality of Life     English1521Deepthi Sowmya SEnglish Selvalakshmi AEnglish Hilda SolomonEnglish Jayanthi SwaminathanEnglish Anitha Rani AEnglish Introduction: Polycystic Ovary Syndrome (PCOS) is a major endocrine disorder in women affecting their Health-related Quality of Life (HRQOL) and their mental well-being as well. Aim & Objective: The current study aimed to access the Quality of life of women diagnosed with Polycystic Ovary Syndrome. Methodology: A prospective, cross sectional, questionnaire based HRQOL study was conducted among PCOS women aged between 18 - 45. Of 262 responses, 253 responses who were willing to participate in the study were included. The Polycystic Ovary Syndrome Questionnaire (PCOSQ) was used to assess the HRQOL among PCOS women. Results: Overall 57.71% of the participants were aged between 18 to 25 years of age. Among the five major domain, highest score was observed in Body hair (4.35±1.4) and the lowest score was observed in Body weight (3.43±1.21). The comparison of the mean score of PCOSQ among age groups, significant difference was observed among Body weight (p=0.01), Infertility (p=0.001) and body hair (0.04) in 18 – 25 years age group. There is a significant difference in HRQOL among marital status of women in terms of Infertility (p=0.002), Body weight (p=0.04) and Emotion (p=0.02). HRQOL among the socioeconomic status showed that there is a significant difference in Menstrual issues (p=0.04), infertility (p=0.047), emotional (0.04) PCOSQ domain. Conclusion: HRQOL is significantly reduced in PCOS women. Currents study data suggested that infertility, emotions, and body weight all had a significant impact on the HRQOL of women with PCOS. Overall, PCOS reduces the QOL, which needs to be assessed periodically. EnglishPCOS, Quality of life, Women, HRQOL, Body weight, Body hairhttp://ijcrr.com/abstract.php?article_id=4729http://ijcrr.com/article_html.php?did=4729