Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411424EnglishN2022December31Healthcare The Application of an Enamel Matrix Protein Derivative (Emdogain) in Furcations: A Review of Literature     English0105Rawia KaramehEnglish Mahmoud Abu-Ta’aEnglish Periodontal disease results in the loss of the attachment apparatus. The search for techniques and products to encourage the regeneration of this tissue has received more attention over the past three decades. The results from basic research have shown that although there are not many studies on the use of EMD in the treatment of furcations, it is an essential option in the difficult management of furcations, and more research in periodontal regeneration is required. This paper aims to evaluate the effect of enamel matrix derivative (EMD) in the treatment of furcations. EnglishEnamel matrix protein derivative, Emdogain, Furcations, Regenerative periodontal therapy, Class I furcations, Class II furcations, Mandibular furcations, Maxillary furcatiohttp://ijcrr.com/abstract.php?article_id=4668http://ijcrr.com/article_html.php?did=4668

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411424EnglishN2022December31Healthcare Material Transfer Agreement (MTA) in the Context of Scientific Research from the Point of View of German Law     English0611Christoph GerstEnglish Paula HasselmannEnglish Raees AhmedEnglish The exchange of information and materials within the framework of research projects can be managed in different ways. In most cases a so-called “Material Transfer Agreement” (MTA) is necessary. What looks like a simple ascertainment of rights and duties of the contracting parties, is clearly more fraught with risks than it looks at first sight. An individual arrangement and initial negotiation are necessary to prevent legal risks and not to burden the cooperation between the contracting parties and scientists with legal conflicts and uncertainties. Of course, confidential clauses shouldn’t be missing. While the precise regulations of the scope of work serves the concretion of the subject matter of the contract, clauses for the protection of property and IP rights regulate the handling with the research and possible publications regarding the use of the provided materials and their specific ownerships. The following will deal with the areas of application, the requirements and the regulatory content of this important type of contract. EnglishMTA, Agreement, Intellectual Property, Publication, German Law, Germanyhttp://ijcrr.com/abstract.php?article_id=4669http://ijcrr.com/article_html.php?did=4669 1. Emmerich V. BGB §320 Rn.30. In: Krüger W. Münchener Kommentar zum BGB, Schuldrecht - Allgemeiner Teil II. Vol 3. 8th ed. München: C.H.BECK; 2019. 2. Armbrüster C. BGB Vor §116 Rn.6 f. In: Schubert C. Münchener Kommentar zum Bürgerlichen Gesetzbuch. Vol 1 Allgemeiner Teil. 17th ed. München: C.H.BECK; 2018. 3. Mansel H-P. BGB Vor. §116 Rn.7ff. In: Stürmer R. Jauernig Bügerliches Gesetzbuch, Kommentar. 17th ed. München: C.H.BECK; 2018. 4. Bubela T, Guebert J, Mishra A. Use and misuse of material transfer agreements: lessons in proportionality from research, repositories, and litigation. PLoS Biol.2015;13(2):e1002060. 5. Kahl L, Molloy J, Patron N, Matthewman C, Haseloff J, Grewal D, et al. Opening options for material transfer. Nat Biotechnol.2018;36(10):923-927. 6. Schubert C. BGB §164 Rn.11ff. In: Schubert C. Münchener Kommentar zum Bürgerlichen Gesetzbuch. Vol 1 Allgemeiner Teil. 17th ed. München: C.H.BECK; 2018. 7. Mansel H-P. BGB §164 Rn.6. In: Stürmer R. Jauernig Bügerliches Gesetzbuch, Kommentar. 17th ed. München: C.H.BECK; 2018. 8. Schubert C. BGB §164 Rn.182. In: Schubert C. Münchener Kommentar zum Bürgerlichen Gesetzbuch. Vol 1 Allgemeiner Teil. 17th ed. München: C.H.BECK; 2018. 9. Bayreuther F. BGB §184 Rn.3 f. In: Schubert C. Münchener Kommentar zum Bürgerlichen Gesetzbuch. Vol 1 Allgemeiner Teil. 17th ed. München: C.H.BECK; 2018. 10. Mansel H-P. BGB Vor. §184 Rn.2. In: Stürmer R. Jauernig Bügerliches Gesetzbuch, Kommentar. 17th ed. München: C.H.BECK; 2018. 11. Merz J. Kompliziert, sicher, unverschämt? Labor Journal.2019(3):12-15. 12. Nielsen J, Bubela T, Chalmers DRC, Amber J, Linda K, KamensJ, et al. Provenance and risk in transfer of biological materials. PLoS Biol.2018;16(8):e2006031. 13. Sassenberg T. §3 Rn.20 ff. In: Sassenberg T, Faber T. Rechtshandbuch Industrie 4.0 und Internet of Things. 2nd ed. München: C.H.BECK; 2020. 14. Bachmann G. BGB §241 Rn.17. In: Krüger W. Münchener Kommentar zum BGB, Schuldrecht - Allgemeiner Teil I. Vol 2. 8th ed. München: C.H.BECK; 2019. 15. Schmidt A. In: Weber K. Rechtswörterbuch. 28th ed. München: C.H.BECK; 2022. 16. Berger C. BGB §434 Rn.8. In: Stürmer R. Jauernig Bügerliches Gesetzbuch, Kommentar. 17th ed. München: C.H.BECK; 2018. 17. Preis U, Seiwerth S. Geheimnisschutz im Arbeitsrecht nach dem Geschäftsgeheimnisgesetz. Recht der Arbeit.2019(6):351-360.

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411424EnglishN2022December31Healthcare Dengue Status in a Tertiary Care Rural Hospital     English1217Vijayshri KhairkarEnglish Deepashri MaraskolheEnglish Ruchita AttalEnglish Hindol MaityEnglish Introduction: Dengue is one the most common arthropod-borne virus-transmitted disease of the tropics. Though many remains asymptomatic, a huge population gets infected with some persons leading to a serious form of the disease. As rapid urbanization allows to thrive the Aedes albopictus mosquito which is mainly involved for the transmission of the disease, seasonal outbreaks are becoming a common fact to deal Acute Febrile Illnesses year after year. Aims/Objectives: To study the epidemiology of dengue through the serological, demographic profile, regional distribution, vectors and circulating serotypes. Materials and Methods: Demographic data and presenting symptoms of fever 10476 cases reported to the clinic were recorded. Suspected patients were tested for dengue, chikungunya, scrub typhus and malaria. Dengue-specific NS1 and IgM ELISAs were performed, followed by RNA extraction, PCR and sequencing to detect circulating DENV serotypes. Results: Of the 10476 fever patients tested from July to September 2021, 2767 cases were Dengue NS1 positive, while 2624 were Dengue IgM positive. Of the 200 samples analyzed, 19.1% had concurrent infection with multiple dengue serotypes DEN 1,2 & 3; 63.8% was DEN 1, and 18.2% was DEN 2. Conclusion: Wardha is endemic to Dengue, and concurrent infections with multiple DENV serotypes have become a frequent finding in this region. The most prevalent febrile illness nowadays is Scrub typhus or Dengue Fever in the rural part of central India, which has predominantly replaced typhoid fever and malaria. They may be asymptomatic or give rise to undifferentiated fever, Dengue Fever (DF), Dengue Haemorrhagic Fever (DHF), or Dengue Shock Syndrome (DSS). Annually, 100 million cases of dengue fever and half a million cases of DHF occur worldwide. It is essential to know the prevalent serotype and disease pattern for better recovery of the patients. Though much research is ongoing for a new vaccine against Dengue, reaching rural India will take time and effort. Early recognition and prompt initiation of appropriate treatment are vital if disease-related morbidity and mortality are to be limited. EnglishAcute Febrile Illness, Central India, Dengue serotyping, Epidemiology, Seasonality, WGShttp://ijcrr.com/abstract.php?article_id=4670http://ijcrr.com/article_html.php?did=4670 1. Pathak VK, Mohan M.A notorious vector-borne disease: Dengue fever, its evolution as public health threat. J Fam Med Prim Care. 2019, 8(10):3125-9. 10.4103/jfmpc.jfmpc_716_19 2. Oza JR, Patel UV, Gajera KD. Clinico-epidemiological profile of dengue fever cases admitte at tertiary care hospital, Rajkot, Gujarat, India. Int J Community Med Public Health. 2016, 3:2667-71. 10.18203/2394-6040.ijcmph20163093 3. Dengue and severe dengue. Accessed: November 19, 2022: https://www.who.int/news-room/fact-sheets/detail/dengue-and severe-dengue. 4. Afreen N, Deeba F, Naqvi I, Shareef M, Ahmed A, Broor S, et al. Molecular Investigation of 2013 Dengue Fever Outbreak from Delhi, India. PLoS Curr. 2014, 6:0411252-8. 10.1371/currents. outbreaks.0411252a8b82aa933f6540abb54a855f 5. Tazeen A, Afreen N, Abdullah M, Deeba F, Haider SH, Kazim SN, et al. Occurrence of co-infection with dengue viruses during 2014 in New Delhi, India. Epidemiol Infect. 2017, 145(1):67- 77. 10.1017/S0950268816001990 6. Bharaj P, Chahar HS, Pandey A, Diddi K, Dar L, Guleria R et al. Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India. Virol J. 2008, 5:1. 10.1186/1743-422X-5-1 7. Dhanoa A, Hassan SS, Ngim CF, Lau CF, Chan TS, Adnan NAA et al. Impact of dengue virus (DENV) co-infection on clinical manifestations, disease severity and laboratory parameters. BMC Infect Dis. 2016, 16:406. 10.1186/s12879-016-1731-8 8. Kumaria R: Correlation of disease spectrum among four Dengue serotypes: five years hospital-based study from India. Braz J Infect Dis. 2010, 14:141-6. 10.1016/S1413-8670(10)70027-1 9. Kalayanarooj S, Nimmannitya S: Clinical and laboratory presentations of dengue patients with different serotypes. Dengue Bulletin, WHO Regional Office for South-East Asia. 2000, 24:53-59. 10. Pandey N, Nagar R, Gupta S, Omprakash, Khan D, Singh DD, et al. Trend of dengue virus infection at Lucknow, north India (2008- 2010): A hospital-based study. Indian J Med Res. 2012, 136:862-7. 11. Damodar T, Dias M, Mani R, Shilpa KA, Anand AM, Ravi V, et al. Clinical and laboratory profile of dengue viral infections in and around Mangalore, India. Indian J Med Microbiol. 2017, 35:256-61. 10.4103/ijmm.IJMM_15_423 12. Chandralekha, Gupta P, Trikha A. The north Indian dengue outbreak 2006: a retrospective analysis of intensive care unit admissions in a tertiary care hospital. Trans R Soc Trop Med Hyg. 2008, 102:143-7. 10.1016/j.trstmh.2007.11.002 13. Saini S, Kinikar AG, Deorukhkar S, Bhalerao D, Roushani SB. Epidemiology and seropositivity of dengue fever cases in a rural tertiary care hospital of western Maharashtra, India. Int J Biomed Adv Res. 2013, 4:473-7. 10.7439/ijbar.v4i7.406 14. Kumar A, Rao CR, Pandit V, Shetty S, Bammigatti C, Samarasinghe CM. Clinical Manifestations and Trend of Dengue Cases Admitted in a Tertiary Care Hospital, Udupi District, Karnataka. Indian J Community Med. 2010, 35(3):386-90. 10.4103/0970- 0218.69253 15. Patil PS, Chandi DH, Damke S, Mahajan S, Ashok R, Basak S. A Retrospective Study of Clinical and Laboratory Profile of Dengue Fever in Tertiary Care Hospital, Wardha, Maharashtra, India. J. Pure Appl. Microbiol. 2020, 10.22207/JPAM.14.3.32 16. Dussart P, Labeau B, Lagathu G, Louis P, Nunes MR, Rodrigues SG, et al. Evaluation of an enzyme immunoassay for detection of dengue virus NS1 antigen in human serum. Clin Vaccine ImImmunol. 2006, 13:1185-9. 10.1128/CVI.00229-06 17. Datta S, Wattal C. Dengue NS1 antigen detection. a useful tool in early diagnosis of dengue virus infection. Indian J Med Microbiol. 2010, 28:107-10. 10.4103/0255-0857.62484 18. Libraty DH, Young PR, Pickering D, Endy TP, Kalayanarooj S, Green S et al. High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. J Infect Dis. 2002, 186:1165-8. 10.1086/343813 19. Thavara U, Siriyasatien P, Tawatsin A, Asavadachanukorn P, Anantapreecha S, Wongwanich R, et al. Double infection of heteroserotypes of dengue viruses in field populations of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) and serological features of dengue viruses found in patients in southern Thailand. Southeast Asian J Trop Med Public Health. 2006, 37:468- 76. 20. Phillips ML. Dengue Reborn: Widespread Resurgence of a Resilient Vector. Environ Health Perspect. 2008, 116(9): A382-8. 10.1289/ehp.116-a382