Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareThe Five Ds for Rational Use of Antimicrobial Agents English0102Pramod Kumar ManjhiEnglishEnglishhttp://ijcrr.com/abstract.php?article_id=4385http://ijcrr.com/article_html.php?did=4385

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareClinical, Virological and Immunological Outcomes of Madhav Rasayan Tablet in COVID-19: Randomized Controlled Clinical Trial English0312Jamadagni SameerEnglish Pandkar PrasadEnglish Saundankar TusharEnglish Shirke GirishEnglish Malekar ShaileshEnglish Vaidya VidadharEnglishIntroduction: The world is facing health emergency of Covid-19. Ayurveda preparations are known for their immunomodulatory as well as antiviral efficacies. Integrated approach and holistic management of Covid 19 patients is need of hour. Aim: This research was conducted to clinically validate safety and efficacy of Madhav Rasayan tablet, an Ayurvedic formulation in the management of Covid 19. Materials and Methods: In present RCT, moderate COVID 19 patients (n=60) were randomized in two parallel groups (n=30/ group). The interventional group (Treatment) received Madhav Rasayan tablet 250 mg twice a day for 30 days along with standard care (SOC) as per ICMR, while the control group received SOC alone. The primary outcome of the study was to evaluate improvement of clinical symptoms, reduction in levels of inflammatory markers, negative RT-PCR for Covid 19 on day 5 and day 10 of intervention. The secondary outcomes were to reduce supplemental oxygen, hospital stay and ICU admission. Total Covid antibodies and Covid IgG antibodies were assessed on day 10 and day 30 of the intervention. Improvements in certain subjective aspects were assessed through questionnaires. Results: Madhav Rasayan significantly improved symptoms of COVID 19 like cough, breathlessness, fatigue and reduced inflammatory markers like CRP. The significant population (40%) turned RT-PCR negative on 5th day along with improved quality of life. The antibody status in the intervention group was shown to be better. There was reduced hospital stay, need of supplemental oxygen and in intervention group than control. Conclusion: Madhav Rasayan can be good option for integrating with standard care protocols. There was significant viral load reduction and more negative RT-PCR reports. There was better prognosis, speedy clinical recovery and reduction in inflammatory markers. It is a promising immunomodulator to offer long-term protection by helping production of neutralizing antibodies. This study will pave the path for integrating Ayurveda interventions in management of Covid 19. EnglishAyurveda, COVID 19, Madhav Rasayan, Immunomodulatory, Antiviral, Integrative medicinehttp://ijcrr.com/abstract.php?article_id=4386http://ijcrr.com/article_html.php?did=4386

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareFormulation & Optimization of Nilotinib Loaded Solid Lipid Nanoparticles Using Design of Experiment English1320K. SomeshwarEnglish B. RameshEnglishIntroduction: SLN is alternative to traditional colloidal carrier systems such as emulsion, liposome, and polymeric micro-and nanoparticles. They are highly biocompatible, have low cytotoxicity, target specific, scalability, prolonged drug release, and ease of production in industrial scale. Objective: Current study aims to formulate and characterize Nilotinib-loaded solid lipid nanoparticles (SLNs) carrier system. Methods: About 17 SLN formulations were fabricated employing hot emulsification/ ultrasonication technique. A full factorial design (33) was employed for formulation batches (i.e.,17 formulations) in which 3 factors namely lipid, surfactant and co-surfactant were tested at 3 levels of concentration. The effect of different levels of factors was evaluated at the particle size of resultant formulation, entrapment efficiency and % cumulative drug released. Kinetic model fitting for all nilotinib SLN formulations was done to interpret the release rate from the SLN. Optimized formulation was subjected for FTIR, SEM and stability studies. Results: The mean particle size, PDI, zeta potential, entrapment efficiency (EE), content uniformity and in-vitro drug release profile of optimized nilotinib-loaded SLNs (NF12) were found to be 132.11 ± 3.47nm, 0.128 ± 0.02, -18.02 ± 2.17mV, 84.12±2.66%, 98.96±1.23% and 98.86±2.12% respectively. The release kinetics suggest that drug release followed zero-order and release was anomalous non- fickian diffusion super case II transport. The FTIR studies revealed no incompatibilities between the drug and excipient, and SEM images showed that the nanoparticles appeared to be more porous and spherical in shape. The formulation was shown to be stable over a period of six months by stability studies. Conclusion: According to the results, the method of SLN preparation proposed in this study could be considered as the most suitable method for generating colloidal carriers loaded with nilotinib. English Nilotinib, Solid-lipid nanoparticle, Box-Behnken design, Independent variables, Release order kinetics, Solubilityhttp://ijcrr.com/abstract.php?article_id=4387http://ijcrr.com/article_html.php?did=4387

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareKnowledge, Attitude and Practice Regarding Physical Exercise Among Type II Diabetic Patients English2128Bute AarshaEnglish Chavan AmrutaEnglish T. Poovishnu DeviEnglishIntroduction: Diabetes mellitus is one of the most challenging public health problems in 21st century. Diabetes prevalence has been increasing more rapidly in developing countries. Physical activity is the cornerstone of lifestyle modification aimed at pre-venting and managing type II diabetes and its related comorbidities. Exercise has acute and chronic effects on glucose, lipid and protein metabolism. Our study focuses on awareness of regular exercise which helps in reduction of complications and control blood glucose levels as well as improve quality of life. Aims: To assess the awareness about physical exercise among type II diabetic patients. Methods: This was an observational study conducted among 61 type II diabetic patients between the age group of 35-65 years. The participants selection was done according to simple random sampling technique. The study was conducted on the rural population in Karad. Participants were selected according to inclusion and exclusion criteria. A structured questionnaire was distributed among the participants and completely filled questionnaires were taken. Result: The result of knowledge regarding physical exercise among type II diabetic patients showed that majority of participants 45.9% had good knowledge and 40.9% had average knowledge whereas 13.2% had poor knowledge. The attitude regarding physical exercise in our study was observed that 60.65% participants had positive attitude. The result of practice regarding physical exercise among type II diabetic patients showed that 42.62% participants had poor practice whereas 16.4% participants had good practice and 40.98% participants had average practice. Conclusion: The study concluded that most of type II diabetic patient had good knowledge and very few had poor knowledge regarding physical exercise. The attitude of patients regarding physical exercise was positive but the practice regarding physical exercise was poor. The study showed that most of the patients showed lack of interest towards exercise due to many reasons such as lack of time, lack of interest, busy in other work, doing other physical tasks and health conditions. EnglishAttitude, Knowledge, Practice, Regular physical exercise, Type II diabetes mellitus, Lifestyle modificationhttp://ijcrr.com/abstract.php?article_id=4388http://ijcrr.com/article_html.php?did=4388

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareDevelopment of Irinotecan Dissolution Rate by Snedds English2936Maddela Chandra ShekharEnglish Pamu SandhyaEnglishEnglish Irinotecan, S-SNEDDS, precipitation inhibitor, Solubility, Particle size, Zeta potentialhttp://ijcrr.com/abstract.php?article_id=4389http://ijcrr.com/article_html.php?did=4389

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareImpact of Covid-19 Outbreak on Hospital Based Cancer Registry in a Tertiary Care Hospital in South Tamilnadu English3742Shantaraman KEnglish Chandhru Mari REnglish Johnsy Merla JEnglishIntroduction: Covid 19 pandemic has affected the delivery of health care particularly cancer care services throughout the world. Excess health care services were used to manage this pandemic and its complications. So, the shift in health care caused gaps in cancer screening services and treatment which got reflected in the fall of cancer entries in hospital-based cancer registry(HBCR). Methods: Tirunelveli hospital-based cancer registry data were collected from the year 2016 to 2020. The entries made during the year 2016 -2019 were tabulated. For the pandemic year 2020, cancer case incidence at various sites for each month are collected and tabulated and the fall in total cancer cases were analysed Results: There is steady increase in total cancer cases entry in HBCR from 2016 – 2019. There is decreased total cancer case entries during the pandemic year 2020 compared to previous years from 2016-2019. In April – July 2020, during the peak of pandemic there is low cancer case entries in HBCR. This reflects there is shift in health care services delivery towards control and treatment of pandemic cases rather than to cancer care services. Conclusion: The impact of Covid 19 pandemic on cancer cases in the tertiary care hospital in south Tamilnadu has resulted in decrease and delay in identifying new cancer cases and treatment delivery. These problems if unsolved will result in increased cancer burden and mortality for the upcoming years. EnglishCancer screening, Covid 19 pandemic, Health care services, Hospital based cancer registry, Cancer Incidence, South Tamilnaduhttp://ijcrr.com/abstract.php?article_id=4390http://ijcrr.com/article_html.php?did=4390

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareFormulation and Characterization of Dasatinib Loaded Solid Lipid Nanoparticles by Design of Experiment English4350Baji Hussain KhanEnglish Sandhya PEnglishIntroduction: SLN is alternative to traditional colloidal carrier systems such as emulsion, liposome, and polymeric micro-and nanoparticles. They are highly biocompatibility, have low cytotoxicity, target-specific, scalability, prolonged drug release, and ease of production in industrial scale. Aims: The objective of the research is aimed at formulation of solid lipid nanoparticle (SLN) of dasatinib a tyrosine kinase inhibitor used in the treatment of chronic myelogenous leukemia. Methodology: By investigating the relationship between design factors and experimental data using response surface methodology. A 33 Box-Behnken design was chosen using amount of glycerol monosterate (X1) the amount of poloxamer 407 (X2) and amount of tyloxopol (X3) level as independent factors. SLN prepared by hot emulsification / ultra-sonication method technique using glyceryl monostearate as the solid lipid, and poloxamer 407as the surfactant. The dependent variables include particle size (Y1), entrapment efficiency(Y2) and drug release after 12 h(Y3). Properties of SLN such as the morphology, FT-IR, particle size, zeta potential, entrapment efficiency and drug release behavior were investigated. Results: From the results DF10 was found to be optimized formulation, which shown that the nanoparticle designed are spherical in shape with a mean particle size of 112 nm with PI of 0.40 and zeta potential of −25.6 mV. The in vitro release studies showed that more than 98.78% of drug was released from optimized SLN after 12 h, which is higher when compared with marketed formulation. The release kinetics of the optimized formulation followed zero Intriorder drug release and best fitted the Korsemeyer-peppas model. Conclusion: These results indicated that the dasatinib-loaded SLN formulation could potentially be exploited for the treatment of chronic myelogenous leukemia with controlled release manner. English Dasatinib, Solid lipid nanoparticle, Chronic myelogenous leukemia, Box-Behnken design, Particle size, SEMhttp://ijcrr.com/abstract.php?article_id=4391http://ijcrr.com/article_html.php?did=4391

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareDiode Laser 1470 nm versus Diode Laser 980 nm for Treatment of Primary Axillary Hyperhidrosis English5160Diaa Aldin Sayed IbrahimEnglish Mahmoud S. ElbasiounyEnglish Tarek F. ElwakilEnglish Nevien Ahmed SamyEnglish Maha Rafie AboEittaEnglishIntroduction: Primary axillary hyperhidrosis (PAH) is a distressing condition that can pose significant social embarrassment. Different treatments such as topical agents, systemic agentsand botulinum toxin are only temporarily effective. Thus, there is a need for evidence-based management. The following study describes a new technique for the management of (PAH). We study the efficacy and safety of the subdermal application of two different diode lasers, at 980 nm or 1470 nm, for ablation of the sweat glands versus intradermal Botulinum toxin A (BTA). Patients and Methods: This parallel-randomized controlled pilot study was conducted upon 90 PAH patients from December-2019 to July-2021 at the National Institute of Laser Enhanced Sciences (NILES), Egypt; the diode laser 980 nm group (30 cases), the diode laser 1470 nm group (30 cases) and the BTA group (30 cases). Results: The three groups were comparable regarding age, BMI, and gender. The laser groups had higher reductions of HDSS score than the BTA group at 1-month 1.37±0.49 and 1.20±0.41 versus 2.03±0.67 for the laser 980,1470 and the BTA groups, respectively (p values < 0.001) and at 6-months (1.37±0.48 and 1.20±0.41 versus 2.20±0.55; p-value < 0.001). At 1-month and 6-months, the laser groups had higher reduction of mean moisture percentages than the BTA group at 1-month with 49.34±5.88% and 48.93±6.62% versus 55.89±9.20%, respectively (p-values 0.003 & 0.001) and at 6-months 49.42±6.32% and 48.90±6.79% versus 56.21±7.98%, respectively (p-values 0.001 &< 0.001). At 1-month and month-6, there was a higher patient satisfaction in the laser groups than in the BTA group (p-values < 0.05). The laser groups demonstrated better GAIS score than the BTA group at both 1-month (p-values < 0.05) and 6-months visits (p-values< 0.001). Conclusion: The study showed that Diode laser 1470 nm is safer and more effective treatment for PAH than Diode laser 980 nm. EnglishBotulinum toxin A, Diode 980 nm laser, Diode 1470 nm laser, Primary axillary hyperhidrosis, Quality of life, Patients’ satisfactionhttp://ijcrr.com/abstract.php?article_id=4392http://ijcrr.com/article_html.php?did=4392

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareSecond Wave Covid-19: Survey on Attitudes and Acceptance of Vaccines and Psychological Impact of Second Wave English6170Vaishnavi PEnglish Shebin ShariefEnglish J. RamprasathEnglishIntroduction: The second wave of COVID-19 is distressing the majority of the planet. This raised questions about approximately a conceivable second wave of coronavirus infection in 2019. (COVID-19). Objective: The aim of this overview was to find out the level of vaccine information, demeanors, and acknowledgment, as well as to survey the mental status in connection to the second wave of COVID-19. Further, acceptance of COVID-19 vaccines is analyzed for Indian states by evaluating test inspiration and case death rates. At last, figures and noteworthy inputs are given based on scientific and epidemiological models. Methodology: Snowball sampling at procedures was utilized to perform the online overview. Results: The results are compared to the current COVID-19 wide scene; they choose up to urge to the mindfulness arrange, state of intellect against the antibodies, uneasiness, passionate trouble, as the affected individuals are seen as tall compared to the primary wave. Conclusion: It is especially critical to require care of the population’s mental well-being and valuable measures to moderate its badly arranged impacts within the middle of the COVID-19 second wave far-reaching, in spite of the truth that for the patients who are recovered from the COVID-19. EnglishCOVID-19, Second wave, Vaccines, Attitude, Behavior, Psychological impacthttp://ijcrr.com/abstract.php?article_id=4393http://ijcrr.com/article_html.php?did=4393

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareTotal Antioxidant Capacity and Total Phenolic Content of Traditionally Preparedyogurt Fortified with Some Dry Fruits and Fresh Fruits English7174Samidha M. PawaskarEnglish Saeema KhanEnglishEnglish Functional food, Yogurt, Total antioxidant capacity, Total phenolic content, Dry fruits, Fresh fruits http://ijcrr.com/abstract.php?article_id=4394http://ijcrr.com/article_html.php?did=4394

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareCarcinoembryonic Antigen-Related Cell Adhesion Molecule 5, a Potential Predictive Immunomarker in Invasive Ductal Breast Carcinoma English7580Henna NEnglish Iqbal SEnglish Iqbal FEnglish Sahrish FEnglish Anjum SEnglish Nagi AHEnglishIntroduction: Breast cancer is on rise in Asian population. Identification of more prognostic and predictive factor in breast invasive carcinoma is need of the time in order to provide best possible management to improve the outcome. Aim: the aim of the study is to observe Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) association with various clinicopathological parameters and molecular groups based on immunohistochemistry in invasive ductal breast carcinoma. Methodology: Eighty-three patients undergoing modified radical mastectomy with primary microscopically proven invasive ductal carcinoma were recruited from two tertiary care hospitals, Pakistan. Grossing & reporting including Biomarker was performed as per College of American Pathologists (CAP) protocol. Molecular groups were formed. Data was entered and analyzed using IBM SPSS version 27. Results: CEACAM5 was overexpressed in 78% of patients and negative in 22% of patient (pEnglishEstrogen Nuclear Receptor, Mammary Ductal Carcinoma, Invasive Ductal Carcinoma, Breast, Receptor, Progesterone, Triple Negative Breast Cancerhttp://ijcrr.com/abstract.php?article_id=4395http://ijcrr.com/article_html.php?did=4395

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareFear and Anxiety of COVID - 19 in a Disadvantaged Population in the San Juan De Lurigancho District of Lima English8188Rosa PSEnglish Hernan MSEnglish Eduardo MSEnglishBackground: The fear and anxiety of COVID-19 is one of the factors that alter the mental health of the population, forcing them not to develop the capacity to cope in situations that compromise the health of their family Objective: The objective is to determine the fear and anxiety to COVID - 19 in a disadvantaged population in the San Juan de Lurigancho district. It is a quantitative, correlational, non-experimental cross-sectional study, with a population of 617 participants, who answered a virtual questionnaire of sociodemographic data, the scale of fear of COVID - 19 and scale of anxiety due to COVID - 19. Results: In its results the relationship between anxiety and fear of COVID - 19, where 218 (48.8%) of the participants without dysfunctional anxiety presented a moderate effect on fear of COVID - 19 and in participants with dysfunctional anxiety 92 (54.1%) presented a high effect on fear of COVID - 19. Conclusions: It is concluded, strategies should be sought to address the consequences on the mental health of the population. EnglishPandemic, Coronavirus, Fear, Anxiety, Vulnerabilityhttp://ijcrr.com/abstract.php?article_id=4396http://ijcrr.com/article_html.php?did=4396

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareIn-vitro Estimation of Non-enzymatic Antioxidants from Ficusracemosa (Linn.) and Caesalpiniabonducella (Linn.) English8992Samidha M. PawaskarEnglish Heena ShahEnglishEnglishFicusracemosa (Linn.), Caesalpiniabonducella (Linn.), Non-enzymatic antioxidants, Plant parts - leaves, Bark, Seeds and kernelshttp://ijcrr.com/abstract.php?article_id=4397http://ijcrr.com/article_html.php?did=4397

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareEffect of Aerobic Exercises on Fatigue Among Breast Cancer Patients Receiving Chemotherapy in Selected Hospitals English9399Payal RathodEnglish Sadhana AdhyapakEnglish Rupali SalviEnglish Nisha NaikEnglishIntroduction: Physical exercise has been identified as a potential intervention to improve quality of life in women with breast cancer receiving chemotherapy. Fatigue is the most common side effect of breast cancer treatment with chemotherapy, selected biologic response modifiers. Aim: To assess the effect of aerobic exercises on fatigue among breast cancer patients receiving chemotherapy in selected hospitals. Method: Quasi–experimental with pre-test post-test control group design was adapted. The study was conducted among breast cancer patients receiving chemotherapy.60 samples were selected using non-probability purposive sampling and data collection was done using demographic variables, Clinical Profile, and Modified Fatigue Assessment Scale. The interventional group received an aerobic exercise programme with low to moderate intensity, two times a day, lasting for 20 minutes for 2 weeks. Results: Aerobic exercises were significantly effective in reducing the level of fatigue among experimental breast cancer patients receiving chemotherapy. Conclusion: This study concludes that an aerobic exercise program of precisely defined intensity, duration, and frequency can be prescribed as therapy for primary fatigue in breast cancer patients. English Assess, Aerobic exercises, Breast cancer, Chemotherapy, Effect, Fatiguehttp://ijcrr.com/abstract.php?article_id=4398http://ijcrr.com/article_html.php?did=4398

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareFear of the Pandemic of the New Variant of Covid - 19 in the Population of the Puente Piedra District in North Lima English100105Rosa PSEnglish Hernan MSEnglish Eduardo MSEnglish Anika RAEnglishBackground: Fear is one of the perceptions that respond to how vulnerable a person is to a situation of risk of contagion by COVID-19 and compromises their well-being Objective: The objective is to determine the fear of pandemic due to the new variant of COVID - 19 in the population of the Puente Piedra district in North Lima. It is a quantitative, non-experimental, descriptive, cross-sectional study, with a total population of 577 participants, who answered a virtual survey with sociodemographic data and the COVID-19 fear scale. Results: In its results, we observe that in the population of the district of Puente Piedra, 82 (14.2%) presents a low effect on fear of COVID - 19, 260 (45.1%) a moderate effect on fear of COVID - 19 and 235 (40.7%) a high effect on fear of COVID - 19. Conclusions: It is concluded that the negative emotional charge due to the fear of COVID - 19 considerably affects the mental health of the population. EnglishFear, Coronavirus, Covid – 19, Pandemic, Effect of fearhttp://ijcrr.com/abstract.php?article_id=4399http://ijcrr.com/article_html.php?did=4399

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareA Hospital-based Investigation of Patterns of Acetabular Fractures English106109Madan LalEnglish Zahoor Illahi SoomroEnglish Nisar Ahmed SoomroEnglish Masood Ahmed QureshiEnglish Abdul Rehman KhanEnglish Niaz Hussain KeerioEnglish Yed Shahid NoorEnglishIntroduction: The greatest alternative for a satisfying functional outcome is a firm anatomical reduction, particularly of the weight-bearing dome. The fracture management outcome analysis contains the majority of information on the epidemiological characteristics of acetabular fractures. Aim: This study aimed to assess the acetabular fractures and their injury patterns. Methodology: Patients with acetabular injuries (n=70) were hospitalized and collected prospectively. The collected information was based on patients’ ages, gender, fracture site and surgical patterns with its complications. A cross-sectional study. This study was conducted at Sheikh Khalifa Medical City Ajman, United Arab Emirates from April 2020 to April 2021. Results: A total of seventy people were examined for this study. The left-side acetabulum was fractured in 40 individuals (57.14 %), while the right-side acetabulum was fractured in 30 patients (42.85 %). Car accidents accounted for n=39 (55.71 %), with motorcycle accidents accounting for n=22 (31.42 %) and falls accounting for n=9 (12.85 %). According to the Letournel classification, the utmost communal fracture pattern was an anterior column with posterior Hemi transverse n=25 (35.71%), charted by posterior wall fractures n=16 (22.85%), and transverse type n=14 (20 %). The most prevalent fracture was the distal end, which accounted for n=8 (11.42 %), followed by pelvic injuries, which accounted for n=6 (8.5 %) Conclusion: This study concluded that the left side of the body was shown to be more affected. The posterior Hemi transverse was the most prevalent injury pattern. The most pervasive surgical consequences were injuries to the sciatic nerve. The fracture of the distal end of the radius was the most pervasive related injury. EnglishAcetabular Fracture, Fracture Pattern, Epidemiology, Complications, Injuries, Affected.http://ijcrr.com/abstract.php?article_id=4437http://ijcrr.com/article_html.php?did=4437

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcarePattern and Prevalence of Unintentional Childhood Injuries in Pakistan: A Cross-Sectional Study English110113Mushtaque AhmedEnglish Khuda BuxEnglish Nazia HussainEnglish Mansoor ul HaqueEnglish Khushboo ChandioEnglish Asif Ali TheboEnglishIntroduction: Injuries during childhood are considered a non-communicable epidemic across the globe, and in Asia, an emerging trend is being observed in childhood morbidity and mortality due to injuries. Aim: To identify the pattern and prevalence of childhood injuries in individuals who are between the age group of 0-14 years. Methodology: The study included 780 children who were between the age group of 0-14 years of age. The data regarding their injuries was collected by conducting an interview with the mothers of children who had injuries and the results were statistically analyzed using SPSS version 23. A cross-sectional study. This study was conducted at, Global Institute of Medical and Health Sciences in Hyderabad Pakistan from March 2020 to March 2021. Results: Out of all the children, 220 injury events were reported with an overall injury prevalence of 21.2%. Most of the injuries were superficial in nature mostly due to falling from an elevated surface and most of the children had injured their extremities. Conclusion: Injuries during childhood are quite prevalent and such studies must be conducted to design public health education, seminars for the awareness of parents regarding unintentional injuries of their children. EnglishChildhood injuries, Prevalence, Risk factors, Awareness, Infectious diseases, Public health educationhttp://ijcrr.com/abstract.php?article_id=4438http://ijcrr.com/article_html.php?did=4438

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241145EnglishN2022March1HealthcareFunctional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study English114118Zahoor Illahi SoomroEnglish Farukh HussainEnglish Khurram Shahzad ShahwaniEnglish Hassan Amir Us SaqlainEnglish Abdul Rehman KhanEnglish Niaz Hussain KeerioEnglish Syed Shahid NoorEnglishIntroduction: In adults, many types of injuries take place, but distal radius fractures frequently occur with a 15 to 19% of ratio. There are many techniques to treat these fractures such as fixation and percutaneous Kirschner wire and ORIF with dorsal or volar plates. Aim: To assess the functional outcomes following fixation of a marginal distal radius fracture with two commonly used volar locking plates Methodology: The study was conducted which is retrospective in nature. Patients were divided into two groups each with one of the two designs of VLP. The initial results reported by patients were pain scores and range of movements. The final results were based on the satisfaction of patients while performing physical activities. A retrospective comparative study. This study was conducted at Peoples University of Medical & Health Sciences Nawabshah, Pakistan from February 2019 to March 2020. Results: A total of 41 patients were included in the study. Twenty-two patients were in the Synthes LCP group and 19 in the Acumed Acu-Loc group. By observing the patients, it was concluded that Acumed Acu-Loc group patients gave better results. Conclusions: Despite various surgical techniques, tendon rupture and complexities is still an issue unresolved. This study shows that the Acumed Acu-Loc system gives better results than Synthes LCP when placed accordingly to the watershed line. EnglishAcumed Acu-Loc system, Than Synthes LCP, Marginal distal radius fracture, Surgical techniques, Injuries, Patientshttp://ijcrr.com/abstract.php?article_id=4439http://ijcrr.com/article_html.php?did=4439