Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareAn Overview of Malignant Ovarian Tumors at a Tertiary Care Institute of Eastern India English0107Mishra SPEnglish Dalal CEnglish Voola SEnglish Pendyala SEnglishEnglishMalignant Ovarian Tumours, Papillary, Serous, Adenocarcinoma, Chemotherapy, Adnexahttp://ijcrr.com/abstract.php?article_id=3982http://ijcrr.com/article_html.php?did=3982

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcarePolycystic Ovarian Syndrome Among the Medical Students of Tertiary Care Hospital of Eastern India - A Cross-sectional Study English0812Sujata PEnglish Dash MMEnglish Mishra SPEnglish Bodla HEnglish Sahoo GEnglishObjective: To evaluate the prevalence of Polycystic ovarian syndrome (PCOS) and the risk factor profile among medical students. Methods: This was a cross-sectional study carried out among the 117 MBBS students of IMS & SUM Hospital, Bhubaneswar staying at the institutional hostel. Pre-existing hypothyroid was present in 8 students and were excluded from the study. They belonged to the age group of 17 to 25. Data was collected regarding risk factors of PCOS from 109 students by adopting a self-designed questionnaire method. PCOS was diagnosed in the study population as per AE-PCOS (2006) society. Results: In our study prevalence of PCOS was 9.17%. The mean age of the population was 20.68±2.06. The average age of menarche was 12.86±1.58. The mean BMI of the population was 21.89±4.54. On chi-square analysis of different risk factors of PCOS, overweight and obesity, W/H ratio had a significant association with PCOS with p values of 0.00 and 0.00 respectively. Conclusions: A simple questionnaire-based study can be used as an efficient and cost-effective tool for the screening of PCOS and identification of risk factors present in a target population. EnglishPCOS, Hyperandrogenism, Ovulatory Dysfunction, Obesity. Lifestyle, Basal Metabolic Indexhttp://ijcrr.com/abstract.php?article_id=3983http://ijcrr.com/article_html.php?did=3983

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareClinico-pathological Outcomes of Hirschsprung Disease in Pediatric Population: A Retrospective Cohort Study and Brief Review of Literature English1318Pradhan AntaryamiEnglish Mallick BhabagrahiEnglish Nanda DebasishEnglishEnglishHirschsprung disease, Intestinal Obstruction, Chronic Constipation, Bowel Perforation, Laparotomy, Duhamel procedurehttp://ijcrr.com/abstract.php?article_id=3984http://ijcrr.com/article_html.php?did=3984

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareAn Unusual Long Standing Foreign Body in the Left Bronchus of 6 Year Old Boy - A Case Report English1922Swain SKEnglish Swain SEnglish Acharya SEnglishIntroduction: Inhalation of foreign body (FB) into the airway is considered a serious problem in a pediatric patient. Children of less attention by parents at an early age are more vulnerable to inhalation of FB. A long-standing undiagnosed FB such as whistle in bronchus is very rare and lethal. Case Report: A 6-year-old boy was presenting with a mild dry cough for 2 months. He had no evidence of breathing difficulty. He developed occasional whistling sounds during sleep for 5 days. Result: The FB was confirmed by computed tomography (CT) scan of the thorax and was removed successfully by rigid bronchoscopy under general anaesthesia without any complications. Conclusion: The diagnosis of FB in the bronchus is often difficult because of lack of parental ignorance and the absence of clear history. FB inhalation is often associated with significant morbidity. EnglishForeign body, Inhalation, Bronchus, Long-standing, Whistle, Rigid Bronchoscopyhttp://ijcrr.com/abstract.php?article_id=3985http://ijcrr.com/article_html.php?did=3985

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareErythroleukoplakia: A High Risk Red-White Premalignant Lesion of the Oral Cavity English2325Swain SKEnglish Bhuyan REnglish Kar DEnglishAim: The leukoplakia, erythro-leukoplakia and oral verrucous hyperplasia are premalignant lesions found in the oral cavity. Erythroleukoplakia is an uncommon painless precancerous lesion found in the oral cavity. The erythro-leukoplakia is often seen in the oral mucosa, vermillion and gums. The aetiology of erythro-leukoplakia is often variable and usually associated with cigarette smoking, alcoholism, infections and other agents. Case Report: A 35-year-old man presented with complaints of burning sensation in the mouth for two months. Oral cavity examinations revealed a reddish-whitish lesion on the right side buccal mucosa. The patient underwent complete surgical excision of the erythro-leukoplakia from the oral cavity. Results: Biopsy from the lesion is mandatory to rule out malignant transformation and the histopathological examination, in this case, showed dysplastic changes. Conclusion: The diagnosis of erythro-leukoplakia is based on the clinical presentations and histopathological reports. Clinicians should perform the oral cavity examination properly and alert for the patient’s addiction to smoking and alcohol consumption. The treatment of choice is surgery and it should be initiated early for preventing malignant transformation. EnglishErythro-leukoplakia, Leukoplakia, Erythroplakia, Premalignant lesionhttp://ijcrr.com/abstract.php?article_id=3986http://ijcrr.com/article_html.php?did=3986

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareHead and Neck Mucormycosis Infections - Our Experiences English2630Swain SKEnglish Jena PPEnglish Bhuyan REnglishIntroduction: An uncommon therapeutic entity is mucormycosis and immunocompromised patients are often affected by this infection. This fungus is under the order of the Mucorales. The Rhizopus genus is the most common causative organism related to mucormycosis. It is an acute disorder and there is a poor prognosis. Objective: To study the experiences of mucormycosis treatment at our tertiary care teaching hospital over the last three years in the head and neck area. Materials and Methods: A retrospective research involved 8 patients diagnosed with mucormycosis of the head and neck over 3 years between January 2019 and February 2021. Results: There are 5male and 3 female patients, aged between 29 to 65 years. Out of 8 patients, 4 were diabetic and the rests were with haematological disorders. There were 5 sinonasal mucormycosis and 3 non-sinonasal involvement. Diagnoses were established by histopathological study. In this study, two patients faced cerebral involvement. Conclusion: The early diagnosis and recovery from this infection are enhanced by early diagnosis with a tissue biopsy, local management of the disease by urgent surgical debridement and adequate systemic antifungal treatment. Mucormycosis therapy includes antifungal agents such as Amphotericin B and broad surgical debridement. Early diagnosis and care are also required for patients to survive. Englishhttp://ijcrr.com/abstract.php?article_id=3987http://ijcrr.com/article_html.php?did=3987

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareAssessment of Airway Among South Indian Population - A Cephalometric Study English3135Dhayananth XEnglish Clement EEnglish Faizee SHEnglish Hema MaliniEnglish Iswarya AEnglish Christy ASEnglishIntroduction: Normal airway is one of the important factors for the normal growth of the craniofacial structure. The form and function of the pharynx have been an interest to orthodontic research. Cephalometry enables analysis of dental, skeletal and soft tissue anomalies; it also helps to assess the airway morphology. Method: This retrospective study includes lateral cephalogram of 300 healthy individuals in which 150 males and 150 females with class I malocclusion from South India and patients above the age of 20 years were taken for the study. Results: The mean upper and lower airway values for male patients were 13.61mm and 11.31mm and for female patients, it was 13.5 mm and 11.50 mm. Conclusion: The study concludes that there is a difference between upper and lower airway width among Caucasians and South Indian populations with Class I skeletal patterns. The study also suggests that there is no difference between upper and lower airway width among male and female South Indian populations. EnglishCephalometrics, Cephalogram, Lower airway, McNamara analysis, South Indians, Upper airwayhttp://ijcrr.com/abstract.php?article_id=3988http://ijcrr.com/article_html.php?did=3988

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareFacial Nerve Paralysis and its Social and Psychological Impact - A Review English3641Swain SKEnglish Panda SEnglish Das SEnglishEnglishFacial nerve paralysis, Social impact, Psychological impact, Bell’s palsy, Depression, Quality of lifehttp://ijcrr.com/abstract.php?article_id=3989http://ijcrr.com/article_html.php?did=3989

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareEfficacy of Herbal Antimicrobial Mouthrinse in Comparison with Chlorhexidine and Essential Oil for Orthodontic Patients English4246Faizee Shahul HameedEnglish Piradhiba REnglish Clement EvanEnglish Archana S.English Anitha DEnglish Ambika SEnglishIntroduction: The purpose of the study was to determine the efficacy of herbal antimicrobial mouth rinse compared to chlorhexidine, essential oil against streptococci genus in orthodontic patients. Method: The samples were tested on 80 patients undergoing fixed orthodontic treatment with a mean age of 24.5 years. Patients were divided into 4 groups: Group A- placebo mouth rinse, Group B- Herbal mouth rinse, Group C-Essential oil and Group D-Chlorhexidine. Participants were asked to rinse twice a day in the morning and evening after brushing for 2 weeks. Swabs were collected on the first day, seventh day and fourteenth day from the labial surface of the maxillary lateral incisors. The collected samples were cultured through Mitissalivarius agar medium, the results were expressed in CFU and the collected data were subjected to statistical analysis. Results: All three mouth rinses used in the study were effective against the streptococci genus in which Herbal mouth rinse showed the highest efficiency. Conclusion: The efficacy of Herbal mouthwash was most consistent when compared with other groups. EnglishChlorhexidine rinse, Colony-forming unit, Essential oil, Herbal mouth rinse, Mitissalivarius agar, Streptococci genushttp://ijcrr.com/abstract.php?article_id=3990http://ijcrr.com/article_html.php?did=3990

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcarePremalignant Lesions of the Oral Cavity: Our Experiences at a Tertiary Care Teaching Hospital of Eastern India English4752Swain SKEnglish Agrawala REnglish Samal SEnglish Kar DEnglishBackground: Premalignant oral cavity lesions are potentially malignant diseases that include oral leukoplakia, erythroleuko place, oral submucous fibrosis (OSMF), and lichen planus. There are various etiological factors associated with premalignant lesions of the oral cavity. The most frequent etiological factors are tobacco use, consumption of alcohol, chewing of betel quid containing areca nut and solar rays. Objective: To study details of the premalignant lesions, including their incidence, etiological factors and management at a tertiary care teaching hospital. Materials and Methods: This is a retrospective observational study conducted between December 2018 to January 2021. There were 652 patients with oral cavity premalignant lesions enrolled in this study Result: There were 383 male and 275 females patients with a male to female ratio of 1.39:1. The majority of the patients with oral cavity premalignant lesions are in the age group 50 to 60 years. Out of 658 patients, 262 had oral leukoplakia, 149 had OSMF, 48 erythroplakia,52 oral candidiasis and 25 had oral erythroleukoplakia. Conclusion: Early diagnosis and prompt treatment are important steps for managing the premalignant lesions of the oral cavity as late stags may progress into severe dysplasia and even carcinoma in situ and/or squamous cell carcinoma in the oral cavity. English Premalignant lesions, Oral cavity, Leukoplakia, Erythroleukoplakia, Oral submucosal fibrosis, Oral cancerhttp://ijcrr.com/abstract.php?article_id=3991http://ijcrr.com/article_html.php?did=3991

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareIntestinal Parasitic Infection: Prevalence in Recent Years in a Tertiary Care Hospital English5356Jain SwatiEnglish Kabi SunitaEnglish Bhoi PriyadarshiniEnglish Panigrahy RajashreeEnglish Sahu Kundan KumarEnglishIntroduction: Intestinal parasitic infection is a major global health problem, more so in poor and socio-economically deprived communities in the tropics and subtropics. These are among the 10 most common infestations of the world. Intestinal protozoa and helminths flourish in settings characterized by poor sanitation, dirty water, substandard and crowded housing. To determine the prevalence of intestinal parasitic infection in patients, a prospective laboratory analysis of stool samples for intestinal parasites was carried out in a tertiary care hospital. Aim: To determine the prevalence of intestinal parasitic infection in patients, prospective laboratory analysis of stool samples to study the intestinal parasites. Methodology: A total of 2700 symptomatic patients were investigated for intestinal parasites in their stool samples. All stool samples were subjected to direct wet mount, concentration techniques and modified acid-fast staining and looked for the presence of ova and cysts. Results: The prevalence of intestinal parasitosis was 7.2% (195/2700). There was a high prevalence of protozoan parasites (75.4%) than helminthic parasites (24.6%). A total of 8 different parasites were found. E. histolytica (39.3%) was the most common parasite found, followed by G. lamblia (35.7%) and A. duodenale (8.7%). Conclusion: As these parasitic infections are acquired because of poor personal and environmental hygiene, it is necessary to develop effective prevention and control strategies, the most important being health education. The expansion of health services for an improvement in community health must be enforced. EnglishAncylostoma duodenale, Entamoeba histolytica, Giardia lamblia, Enterobius vermicularis, Necator americanus, Soil-transmitted helminthshttp://ijcrr.com/abstract.php?article_id=3992http://ijcrr.com/article_html.php?did=3992

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareBrihatpanchmoola: An Overview of Morphological, Phytochemical and Biological Profiles English5766Pasrija AnubhutiEnglish Popli HarvinderEnglish Mitra RanjanEnglish ChitralekhaEnglish Singla ChhaviEnglish Dhiman AnjuEnglish Jain KajalEnglishIntroduction: Brihatpanchmoola is an integral part of Dashmoola herb which is a combination of ten ayurvedic herbs which are Aegle marmelos (l) Correa, Clerodendrum phlomidis l.f., Oroxylum Indicum (L) Benth. Ex. Kurz, Stereospermum. suaveolens (Rox.) DC, Gmelina Arborea Roxb., Solanum Indicum auct. Non-L, Solanum xanthocarpum Schrad & H., Desmodium gangeticum (L) DC., Uraria picta (Jacq) DC and Tribulus Terrestris. The above-mentioned first five herbs of Dashmoola are collectively called Brihatpanchmoola and it is used traditionally in various ayurvedic formulations like Dashmolarishta, Dashmool ghritam, Chywanprash, Mahanarayan Tail etc. Aim: The present review aims to put together various published reports on Brihatpanchmoolaand analyse them critically. Methodology: Various published literature and researches on individual plants of Brihatpanchmoola species are studied deeply in detail covering their morphological parameters, geographical distribution, chemical constituents and Pharmacological activities. This is perhaps the first such compilation of all the species of Brihatpanchmoola in a single article. Result and Conclusion: The enormous medical significance of Brihatpanchmoola species has resulted in huge demand which has increased the pressure on the natural/wild resources. There is an immediate need to reexamine this species using appropriate scientific procedures. EnglishBrihatpanchmoola, Chywanprash, Dashmoola, Herb, Rutaceae, Bignoniaceaehttp://ijcrr.com/abstract.php?article_id=3993http://ijcrr.com/article_html.php?did=3993

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021August26HealthcareAn Unusual Cause of Unilateral Profound Hearing Loss and Disabling Tinnitus - A Case Report English6769Swain SKEnglish Kar DEnglish Bhuyan REnglishEnglishVascular loop, Anterior inferior cerebellar artery, Internal auditory canal, Tinnitus, Cerebellopontine angle, MRIhttp://ijcrr.com/abstract.php?article_id=3994http://ijcrr.com/article_html.php?did=3994

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareAssociation of Sleep Disorder on Motor Function of Pre-School and School-aged Cerebral Palsy Children in a Tertiary Rehabilitation Centre of Eastern Zone, India English7378Mohakud KEnglish Sahoo SEnglish Mishra DPEnglish Das SPEnglish Sahu RKEnglishEnglishSleep Problem, Cerebral Palsy, Motor Function, School Children, Association, Gross Motorhttp://ijcrr.com/abstract.php?article_id=3996http://ijcrr.com/article_html.php?did=3996

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareBell’s Palsy and Its Social Impact: Our Experiences at a Tertiary Care Teaching Hospital of Eastern India English7984Swain SKEnglish Agrawala REnglish Pani SREnglishBackground: Bell’s palsy is a common clinical entity found in routine practice. Although Bell’s palsy is not a life-threatening disease, it is associated with higher rates of morbidity along with social stigma if stays for a longer period. Although there are several studies for etiologies, clinical presentations and, management for Bell’s palsy, but the majority do not provide any insight into the social impact of Bell’s palsy. Materials and methods: This is a retrospective and observational study. There were 52 patients of Bell’s palsy enrolled in this study. This study was conducted at the Department of Otorhinolaryngology between December 2018 to January 2021. The enrolled patients were diagnosed with Bell’s palsy with fulfilling the selection criteria. Results: Out of 52 patients with Bell’s palsy, 28 were male (53.84%) and 24 were female (46.15%) with a male to female ratio of 1.16:1.There were right side facial palsy in 59.61% of cases, left side in 38.46% of cases and, both sides in1.92% of cases. There were 21.15% of patients presented with a defect in communications, anxiety in 19.23% cases, depression in 15.38% cases and, social isolation in 5.76% of cases. Conclusion: Bell’s palsy has several ranges of effects on the quality of life. It can affect in a variety of ways such as difficulty in facial expression, speech, vision, drinking and, eating. It can also result in physical discomfort and psychosocial manifestations. Management of the social stigma related to Bell’s palsy is more challenging and can be resolved with proper counselling with patients and their family members. English Bell’s palsy, Facial nerve paralysis, Facial nerve, Social impact, Depression, Social isolation.http://ijcrr.com/abstract.php?article_id=3997http://ijcrr.com/article_html.php?did=3997

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareComputational Genomic Analysis of Oral Squamous Cell Carcinoma - A New Diagnostic Approach English8590Rath SEnglish Das MEnglish Kar DEnglish Bhuyan REnglishBackground: Betel quid chewing, smoking and, alcohol consumption being the primary cause of oral cancer in India, has been driving its death rate rapidly over the years. The low five-year survival rate has been seen since oral malignant growth is commonly distinguished in advanced stages. With the advancement of medication and innovation in the clinical sciences still, the cause of OSCC is unknown at the molecular level. Aim: There is a vital need for computational biology to reconsider the helpful methodologies of oral squamous cell carcinoma (OSCC) detection to recognize the malignancy in its beginning phases and analysis at the genomic level to find the target region, furthermore to distinguish the molecular sub-classes so as a propose to personalize the treatment with an early diagnosis. Objective: This review paper principally reports on a few techniques and tools that have been applied to analyze OSCC at a molecular, structural, and functional level so that the quality of gene expression dataset of oral squamous cell carcinoma to distinguish the differentially expressed genes. Further, a few other clustering techniques that are utilized for protein-protein interaction and pathway study have been discussed. Conclusion: A series of literature has been reviewed to locate the techniques used nowadays for the computational genomic analysis to distinguish the expected cancer diagnosis, prognosis, or medication reaction at an early stage as to help oral cancer mitigation through the recognizable proof of target gene and the stage-explicit genes of OSCC with the support of bioinformatics and computational biology for an early diagnosis. EnglishEpithelial carcinoma, Diagnostic approach, Genomic analysis, Computational biology, Bioinformatics, Gene Ontologyhttp://ijcrr.com/abstract.php?article_id=3998http://ijcrr.com/article_html.php?did=3998

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareOral Health Conditions and Challenges to Dental Treatment in Patients with Cerebral Palsy in Odisha, India English9197Bhuyan RuchiEnglish Das Sakti PrasadEnglish Bhuyan SidhantEnglish Kar DattatreyaEnglish Kuanar AnanyaEnglish Nayak GaytreeEnglish Sahu AkankhsyaEnglish Bhuyan Sanat KumarEnglishBackground: The prevalence of dental disease, the types and quality of dental care, and the provision of services were assessed for 100 cerebral palsy children in a special hospital for cp patients. Aim: To access the challenges during dental procedures and awareness and knowledge of parents towards dental treatment. Objective: To perform a descriptive cross-sectional study with a sample determined by spontaneous demand for treatment consisting of 100 patients with CP aged 6-12 years. Results: 75% of children suffered from type I-III level of CP and 25% from type IV-V level in our study. The oral health index (OHI) of CP children was poor (65 %), only 7 % had good OHI while 28% had moderate OHI. 57% of CP children had grade II gingival hyperplasia,25% had grade III and a minimum of 18% had grade I gingival hyperplasia.81% of children had malocclusion while tongue thrusting was experienced by 79% of children.69% of children crowding was observed.61% and 39% had an open bite and deep bite. The mean number of Dental treatments performed on CP children was 14.2 teeth which include extraction of permanent teeth (11.1%), extraction of primary teeth (37%), filling (35%), fluoridation (6%), a pulpotomy (4%), sealants of primary teeth (6%) and space maintainers (1%). Conclusion: CP child requires special attention and care during dental treatment and knowledge, awareness and perception of parents also should be good towards dental treatment. It is a challenge to dental practitioners also for the management of these children. EnglishCerebral Palsy Child, Oral health, Treatment challenge, DMF Index, DFT, OH Indexhttp://ijcrr.com/abstract.php?article_id=3999http://ijcrr.com/article_html.php?did=3999

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareRelation of Concha Bullosa and Chronic Sinusitis: Our Experiences at a Tertiary Care Teaching of Eastern India English98103Swain SKEnglish Acharya SEnglish Panda SEnglish Bhuyan REnglishBackground: Chronic sinusitis is an important health issue often seen in daily clinical practice. Concha bullosa is an anatomical variation found in patients which leads to chronic sinusitis. Concha bullosa is hypertrophied pneumatized middle turbinate which obstructs the drainage of the anterior group of paranasal sinuses into the stomatal complex and nasal cavity. Objective: To study the role of concha bullosa in patients with chronic sinusitis. Materials and Methods: This is a prospective cross-sectional study. This study was done between December 2019 to February 2021 at a tertiary care teaching hospital in eastern India. Result: There were 118 patients with middle turbinate concha bullosa were detected. The mean age of the patients in this study was 32 years with an age range from 1 to 70 years. There were 67 males and 51 females with a male to female ratio of 1.3:1. Out of 118 concha bullosa, 54 (45.76%) were found on the right side, 41(34.74%) on the left side, and 23 on both sides (19.49%). Out of the 118 cases of concha bullosa, lamellar type was found in 36 cases (30.50%), bulbous type in 44 cases (37.28%) and extensive in 38 cases (32.20%). Conclusion: The middle turbinate is considered a possible causative factor for chronic sinusitis. English Chronic sinusitis, middle turbinate concha bullosa, osteomeatal complex, deviated nasal septum, paranasal sinus, computed tomography.http://ijcrr.com/abstract.php?article_id=4000http://ijcrr.com/article_html.php?did=4000

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareManagement of a Pregnant Patient with Platelet Type Von Willebrand Disorder: Case Report and Review of Literature English104107Merin DanaEnglish Sidharthan NeerajEnglish K VKarthikaEnglish Unni ManojEnglish G RemaEnglish K N AnilaEnglishIntroduction: Platelet type Von Willebrand disorder(PT - VWD) is an autosomal bleeding syndrome induced by an irregular glycoprotein Ib protein function that results in platelets that are hyperresponsive. While this condition seems to be well described due to this single molecular defect, diagnosis and management can be difficult. It usually has an autosomal dominant pattern of inheritance. PT-VWD is the least popular among all other VWDs, and only fewer than 50 patients have been reported in the literature. Objective: To investigate the impact of platelet transfusion and also to assess the bleeding risk in the management of platelet type vWD patients, especially pregnant women, and therefore, a lack of data on the most competent method for assessing bleeding risk and supervising hemostasis in these patients. Methods: The participant was a 27-year-old female with platelet type vWD along with hypothyroid, who came with 6 weeks of gestation for expectant management of her pregnancy. Results: Since there were no bleeding risks, the platelet (SDP) was transfused before delivery. A healthy female baby was delivered with no further complications and the patient was comfortable with stable vitals. Conclusion: This case report highlights the significance of multiple lab investigations in the diagnosis of the different forms of vWD, complications in management decisions, avoiding bleeding in such patients. This case study also evokes interest in the utility of platelet transfusions in PT -vWD. Our patient had an uneventful pregnancy with no bleeding complications and delivered a healthy female child. EnglishPT-vWD, Von Willebrand Factor, GP1bA, Factor VIII, Type 2B vWD, Bleeding disorder.http://ijcrr.com/abstract.php?article_id=4001http://ijcrr.com/article_html.php?did=4001

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareComparision of Iron Status Among Childrens with Simple Febrile Seizure and Control - A Hospital Based Observational Study in Eastern India English108112Giri SEnglish Behera BKEnglish Dash DKEnglish Mohanty MDEnglish Sahoo SEnglish Das RKEnglishIntroduction: Correlation between simple febrile seizures (FS) and iron deficiency anaemia (IDA) is not conclusive due to diversified results reported in numerous previous studies. Low serum ferritin levels have been shown to reduce the seizure threshold. Simple FS and IDA are particularly common in children aged 6 to 60 months. In India, around 60% of children’s have nutritional anaemia predominantly due to iron. Objectives: To find out any correlation between Febrile Seizure and Iron Deficiency Anemia. Method: In this hospital-based observational study, we evaluated 90 children aged 6 to 60 months in two equal groups taking fever with seizures as cases and fever without seizures as controls. The study was conducted in the Department of Pediatrics’, IMS & SUM Hospital Bhubaneswar from January to June 2019. Detection of IDA was based on complete blood count, serum iron, total iron-binding capacity and serum transferrin level, which were done in all participants as a part of the routine test for the evaluation of microcytic hypochromic anaemia. Results: IDA was found in 64.4% among fever with the seizure group as compared to 28.8% in the group having a fever without a seizure. Boys outnumbered girls in the febrile seizure group. Upper respiratory tract infection mostly of viral aetiology was the most common cause of fever in both cases (51.1%) and controls (46.5%). We found 64.4% of children in the cases group had IDA as compared to 35.6% in the control group and this was statistically significant (adjusted odds ratio 4.4615, 95% CI 1.8363-10.8402, p=0.001). The Chi-Square test indicated a significant association between IDA and FS (p =0.0007). p EnglishSeizure, Anaemia, Iron deficiency, Fever, IDA, Hypoglycaemiahttp://ijcrr.com/abstract.php?article_id=4002http://ijcrr.com/article_html.php?did=4002

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareA Time-Motion Study in the Immunization Clinic of a Tertiary Care Hospital in Odisha English113117Maharana SabitaEnglish Kanyari S SuneetiEnglish Mishra AparajitaEnglishIntroduction: A time-motion study helps us to determine the amount of time necessary to perform a specific movement or task. Aims: To determine the activity time at different service delivery points. Methods: The present observational cross-sectional study was done in the immunization clinic of Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, Odisha, over 2 months from 01/08/2020 to 30/09/2020. The sample size was 327. The study population included the mothers/caregivers attending the immunization clinic with their children. Predesigned and pretested schedules were used to record time and other information, while pre-synchronised stopwatches were used to record the total activity time at various stations of the immunization clinic. Results: The mean total time taken (from entry to exit) for each participant to complete the immunization process was 36.6±15.7 minutes. The mean total time was maximum during registration and checking of immunization status, 14.3± 6.2 minutes. This was followed by the mean time for vaccination proper which was 10.8±4.5 minutes. The highest number of beneficiaries visiting the immunization clinic was on Wednesday and the mean total time at all service delivery points was maximum on Wednesday (42.5±19.8 minutes) between 10 am - 12 pm. Conclusion: Time management at all levels of the health care system is the need of the hour which has to be addressed. Efficient functioning of the immunization clinic is therefore required to achieve the goal of universal immunization. Conclusions: In this study, there was a statistically significant correlation between IDA and simple FS. EnglishTime motion study, Immunization, Vaccine, Tertiary care hospital, Odisha, Eastern Indiahttp://ijcrr.com/abstract.php?article_id=4003http://ijcrr.com/article_html.php?did=4003

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareStrategic Analysis of Warning Letters Issued by United State Food and Drug Administration to Pharmaceutical Companies Globally English118123Tiwaskar G. H.English Pise A. G.English Pise S. A.English Bhardwaj PEnglishIn pharmaceutical companies, the term “Quality” has special importance. It deals with the patient’s healthcare as well as their safety. To maintain this “Quality” there are various regulatory authorities around the world and these are according to the different countries such as the United States Food & Drug Administration (USFDA) for the US, Medicine & Healthcare Products Regulatory Agency (MHRA) for the UK, Therapeutic Good Administration (TGA) for Australia, etc. These regulatory authorities conduct an audit to identify the common issues that arise in pharmaceutical companies in a variety of sectors such as manufacturing quality, prescription drug promotion, immediate office, etc. and the authorities are responsible for giving a detailed report of violations of regulations in the form of CODE OF FEDERAL REGULATIONS (CFR) in the form of Warning letters. In this paper, we will mainly focus on the manufacturing quality and the common issues that arise in FDA483 for the U.S.A. EnglishAudit, FDA483, Quality, Regulatory affairs, Warning letters, Guidelineshttp://ijcrr.com/abstract.php?article_id=4004http://ijcrr.com/article_html.php?did=4004

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareInfluence of Emotional Intelligence on Scholastic Achievement of Children with Visual Impairment English124128G. MadhukarEnglishVisual impairment referred to an eye disorder at the tissue level, but subsequently, visual impairments took on a broader meaning to include the consequence of a functional loss of vision caused by several eye disorders. Emotional Intelligence (EI) has been defined as the ability to empathize, persevere, control impulses, communicate, make thoughtful decisions, solve problems, and work with others in a way that earns friends and success. These abilities allow an individual to recognize and regulate emotion, develop self-control, set goals, develop empathy, resolve conflicts and develop skills needed for leadership and effective group participation. The present study was aimed to investigate the influence of Emotional Intelligence on the scholastic achievement of children with visual impairment. The information was collected from the sample i.e. students of class 8th& 9th on location, class, age, gender, category, type of school management, medium of instruction, father qualification, mother qualification, father occupation, mother occupation and parental income. EnglishEmotional Intelligence, Achievement, Children with Visual Impairmenthttp://ijcrr.com/abstract.php?article_id=4005http://ijcrr.com/article_html.php?did=4005

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26Healthcare Comparative and Mechanistic Study on the Anti-Cancer Potentiality of Lycopersicon Esculentum Fruits and Cassia Fistula Pods in Breast Cancer English129139Ajmire PrashantEnglish Patel RakeshEnglish Kayande NanduEnglish Bakal RavindraEnglishEnglishLycopersicon esculentum fruits, Cassia fistula pods, Breast cancer, Angiogenesis, Apoptosis, MCF-10Ahttp://ijcrr.com/abstract.php?article_id=4006http://ijcrr.com/article_html.php?did=4006

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareCeftazidime-Avibactam: A Salvage Therapy in the Treatment of Drug-Resistant Gram-Negative Bacterial Infections English140149Kripa LEnglish Anjana SEnglish Jeni REnglish AnandchandranEnglish Meenu VEnglishDrug-resistant Gram-negative bacterial infections are increasing at an alarming rate and treatment options for these types of infections are still a challenge in the modern world. Complicated urinary tract infections, complicated intra-abdominal infections, hospital-acquired pneumonia (including ventilator-acquired pneumonia), sepsis, and skin and soft tissue infections are the most commonly encountered gram-negative infections. Over the last decade, an increase in carbapenem-resistant isolates has resulted in the widespread use of colistin as a ‘last resort’ of antimicrobial agents. However, an increase in colistin resistance is a major concern that leads to the spectre of untreatable Gram-negative infections with difficult antibiotic therapy. To overcome the resistance against gram-negative bacterial infections, an agent called ceftazidime-avibactam was introduced. The drug is mainly active against multi-resistant gram-negative organisms such as Enterobacteriaceae (E.coli, Klebsiella pneumonia ) and Pseudomonas aeruginosa, including those expressing certain types of Class A, Class C, and Class D enzymes. Dosage regimen for ceftazidime-avibactam can be expressed as total grams of combination product and its typical dosing is 2.5g administered every 8 hours by intravenous infusion over 2 hours in adults. It is a well-tolerated drug with no nephrotoxicity compared to colistin. Dose adjustment is needed according to the variation in creatinine clearance of the patient. English Ceftazidime-avibactam, Enterobacteriaceae, Gram-negative, Klebsiella Pneumonia, Nephrotoxicity, Pseudomonas aeruginosahttp://ijcrr.com/abstract.php?article_id=4007http://ijcrr.com/article_html.php?did=4007

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareEthnopharmacological Relevance of Medicinal Plants from Karimnagar District, Telangana English150153SM ShaheedhaEnglish Sandeep Reddy CherukuEnglishIntroduction: Natural medication (HM) is the support of correlative and elective medication, which lately is progressively acquiring boundless ubiquity everywhere in the world and slowly gushing toward coordination into the standard medical care frameworks. Aim: This investigation was performed in Karimnagar district, Telangana state to report the ethnopharmacological information of two traditional herbs namely Mucuna pruriens Linn. Family: Fabaceae and Triumfetta pilosa Roth. Family: Malvaceae. Methodology: Opinions from several traditional herb experts in the Karimnagar fields have been taken about the medicinal properties of these two herbs. Mucuna pruriens and Triumfetta pilosa have been reported to be used in several ailments. Results: Mucuna pruriensis viewed as a nerve tonic, utilized in powdered form in leucorrhoea, spermatorrhoea, and so forth and as a sexual enhancer. pods are coved with solid hairs, which produce exceptional irritation of the skin. They are utilized as anthelmintic. Hairs mixed with honey have been used as a vermifuge. Triumfetta pilosa is an enduring spice or bush growing up to 3 meters tall. The plant is regularly frail stemmed and straying or climbing. The plant has a scope of neighbourhood utilizes, being reaped from the wild particularly for its fibre and restorative applications. An infusion of the Triumfetta pilosa leaf is drunk to treat colic and diarrhoea, though in East Africa a concentrate of the leaf is recorded to be drunk as a laxative. Leaf maceration is utilized as an eye shower for the treatment of eye problems. The squashed leaf and twig are applied as glue on sores. The bark and new leaves are astringent. They are utilized in the treatment of diarrhoea. The leaves and blossoms are utilized for the treatment of leprosy. Conclusion: This Knowledge of the medicinal properties of Mucuna pruriens and Triumfetta pilosa could be helpful in novel drug discovery and to approve the ethnomedicinal information. EnglishMucuna pruriens, Triumfetta pilosa, Karimnagar district, Ethnopharmacological, Medicinal properties, Drug discoveryhttp://ijcrr.com/abstract.php?article_id=4008http://ijcrr.com/article_html.php?did=4008

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareIncidence, Risk Factors and Etiology of Surgical Site Infections in a Tertiary Care Hospital English154159Das SKEnglish Das SKEnglish Panigrahy REnglish Jain SEnglish Baral PEnglishEnglish?-lactamase, Emergency surgeries, MRSA, SSI, S. aureushttp://ijcrr.com/abstract.php?article_id=4009http://ijcrr.com/article_html.php?did=4009

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareRecent Trends in Sensitivity Pattern of Staphylococcus species English160165Otta SaritaEnglish Bhoi PriyadarshiniEnglish Sahu Kundan KumarEnglish Swain BichitranandaEnglishIntroduction: Staphylococcus particularly MRSA (Methicilin resistant Staphylococcus aureus) and MR CoNS (Methicilin resistant Coagulase Negative Staphylococcus) are important cause of hospital and community acquired infections. But there are reports of resistance to anti-MRSA drugs particularly vancomycin, teicoplanin, linezolid, tigecyclin which is a cause forconcern. Aim: The present study was conducted to determine the susceptibility of Staphylococci and note the pattern of minimum inhibitory concentration (MIC) of the second line anti staphylococcal drugs in common clinical use. Method: Various culture samples submitted to Department of Microbiology from Sept 2019 to May 2020 and yielding growth of Staphylococcus were included in the present study. Sensitivity pattern was determined by Vitek 2, Biomerioux and MIC of drugs were interpreted as per recent guidelines. Result: 264 Staphylococcus were included in the study of which 39 were Staphylococcus aureus, 72 were S. epidermidis and 67 were S. haemolyticus.Besides these, 46, 14 and 11 strains of S.hominis, S cohinii and S. capitis respectively were isolated. With cefoxitin screen method, 23 (58.9%) isolates were MRSA where asonly 16 (41.03%) were MSSA. Of the S.epidermidis and S.haemolyticus isolated 98.59% and 95.01% were methicillin resistant and all other isolated CONS were methicillin resistant. MRSA isolates had higher degree of resistance in comparison to MSSA to all the antibiotics tested except quinolones and erythromycin.All the S.aureus isolates were 100% sensitive to linezolid, vancomycin, daptomycin, teicoplanin, rifampicin and nitrofurantoin. None of the Staphylococcus showed any creeping of the minimum inhibitory concentration (MIC)of vancomycin. CONS particularly S.epidermidis and S. haemolyticus had a greater degree of resistance to linezolid , daptomycin and teicoplanin than S.aureus.Tigecyclin a reserve drug was the most sensitive antibiotic in all the species. Conclusion: The study highlights high degree of resistance in CONS isolates to all drugs. Linezolid a useful oral drug also showed high resistance to many CONS and few S.aureus strains. Rifampicin and tigecyclin are other useful drugs for Staphylococcus in the present study. EnglishStaphylococcus spp, Vitek 2, Linezolid resistance, Tigecycline, Vancomycin, MIC creep.http://ijcrr.com/abstract.php?article_id=4010http://ijcrr.com/article_html.php?did=4010

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareComparative Evaluation of the Tensile Bond Strength of Heat-Cured Soft Liners with Nanoparticles Reinforced Polymethylmethacrylate (PMMA) Resins in Polymerized and Unpolymerized Forms: An in Vitro Study English166173Parikh KEnglish Mahajan NEnglish Bhatt NEnglish Sharma DEnglishIntroduction: The bonding of existing heat-cured soft liners with nanoparticles reinforced denture base resins remain unclear. Therefore, this study was undertaken to evaluate and compare the tensile bond strength of heat-cured acrylic and silicone-based soft liners with conventional, 5% TiO2 and 7% ZrO2 nanoparticles reinforced PMMA resins in polymerized and unpolymerized forms. Materials & Methods: One hundred and twenty samples were fabricated with dimensions of 10×10×3 mm and divided into Polymerized and Unpolymerized groups. It further consisted of twelve subgroups in which heat-cured acrylic-based (Super-Soft) and heat-cured silicone-based soft liner (Molloplast-B) were bonded with conventional, 5% TiO2 and 7% ZrO2 reinforced PMMA resins in polymerized and unpolymerized forms. All the samples were thermocycling for 5000 cycles between the baths of 50 and 550 for 30 seconds dwell time. Tensile bond strength was determined with Autograph Universal Testing Machine, at a crosshead speed of 5 mm/min. Results: The mean and the standard deviation (SD) were calculated for each group. An unpaired t-test was used for statistical analysis. P-value was kept < 0.05. The tensile bond strength of Group A1 (3.36 kg/cm2 ) and Group B1 (3.97 kg/cm2 ) was not within the clinically acceptable range when compared to (4.5 kg/cm2 ). All other groups showed acceptable bond strength. Conclusion: Super soft liner bonded significantly with conventional, 5% TiO2 and 7% ZrO2 nanoparticles reinforced denture base resins in unpolymerized form. Molloplast-B bonded significantly with conventional and 7%ZrO2 nanoparticles reinforced denture base resin in both polymerized and unpolymerized form. Bonding of 5%TiO2 nanoparticle reinforced denture base resin with Molloplast-B was significantly better in unpolymerized form than the polymerized one. English Denture bases, Polymethylmethacrylate, Titanium dioxide, Tensile strength, Nanoparticles, Zirconiumhttp://ijcrr.com/abstract.php?article_id=4011http://ijcrr.com/article_html.php?did=4011

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareRole of Early Tracheostomy for Preventing Ventilator-Associated Pneumonia at the Intensive Care Unit-Our Experiences at a Tertiary Care Teaching Hospital of Eastern India English174178Swain SKEnglish Behera ICEnglish Jena PPEnglishEnglish Tracheostomy, Nosocomial infection, Ventilator-associated pneumonia, Intubation, Mechanical ventilation, Intensive care unithttp://ijcrr.com/abstract.php?article_id=4012http://ijcrr.com/article_html.php?did=4012

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareA New RP-HPLC Assay Method Development and Validation for Simultaneous Quantitation of Bilastine and Montelukast in Bulk and Tablet Dosage Form English179188Chandra UmeshEnglish Kumar ManishEnglish Sharma ShresthaEnglish Gupta PankajEnglishIntroduction: Estimation of individual drug components from the multidrug combination tablet is considered a quite tedious task. Moreover, the combination of Bilastine and Montelukast in the oral tablet dosage form is recently launched in the market for the treatment of allergic rhinitis associated with asthma in adults. Further, no reliable method with precise and accurate quantification is available for simultaneous estimation of both drugs. Aim: Development and validation of a rapid, simple, precise yet reliable method for simultaneous estimation of Bilastine and Montelukast from the bulk mixture and a tablet formulation. Methodology: The analysis was performed on a high-performance liquid chromatographic system using Hypersil BDS C-18 column as a stationary phase and triethylamine buffer: Acetonitrile as a mobile phase operated in a gradient mode. The flow rate of the mobile phase was 1.0 ml/min with 40°C column oven temperature and 10°C autosampler temperature. Injection volume for all samples was fixed at 10 µl and the spectrum was recorded at 220nm. Result: The retention time of Bilastine and Montelukast was 1.67 and 7.43 min respectively and the run time for 1 sample analysis was 13 min. The calibration standards show a good linear relationship with R2value of0.99966for Bilastine and 0.99929 for Montelukast. Conclusion: The observations recorded proved that the proposed analytical method is reliable for accurate, precise and rapid quantification of both drugs from the bulk drug as well as pharmaceutical dosage forms. English Bilastine, Force degradation, ICH Guidelines, Montelukast, RP-HPLC, Validationhttp://ijcrr.com/abstract.php?article_id=4094http://ijcrr.com/article_html.php?did=4094

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26HealthcareMolecular Docking and In Vivo Screening of Some Bioactive Phenoxyacetanilide Derivatives as Potent Non-Steroidal Anti-Inflammatory Drugs English189196Rajib Kumar SinghEnglish Arun Kumar MishraEnglish Pranesh KumarEnglish Debarshi Kar MahapatraEnglishIntroduction: Cyclooxygenases (COXs) are the enzymes that specifically influence the production (minute quantities) of prostaglandins and their derivatives, which are responsible for discomfort, inflammation, and other symptoms. The study aimed to develop certain new phenoxyacetanilide derivatives in multi-step synthesis and to screen their anti-inflammatory and analgesic perspectives along with docking studies against main inflammatory target COX-2 enzyme as well as enzyme-linked immunosorbent assay (ELISA) analysis against two prominent inflammatory mediators; Interleukin-6 (IL-6) and COX-2 enzyme. Methods: The newly synthesized substances were developed through multi-step schemes and were analyzed thoroughly employing advanced analytical techniques such as Fourier-Transformed Infrared Spectroscopy (FT-IR), Proton-Nuclear Magnetic Resonance Spectroscopy (1 H-NMR), Mass spectroscopy, and Elemental Analysis. The possibility of a binding site and binding strength of new acetanilide derivatives were discovered using a molecular docking study against COX-2 enzyme using AutoDock Vina software. All of the synthesized derivatives were tested for analgesic activity (using Eddy’s hot plate method) and anti-inflammatory effects (employing the carrageenan-induced paw edema method). Results: As compared to the standard drug diclofenac sodium, (2-[2-methoxy-4-(prop-2-en-1-yl)phenoxy]-N-(2-methylphenyl) acetamide) (RKS-1) expressed both strong analgesic as well as anti-inflammatory activity along with demonstrating the lowest docking score (-8.9 Kcal/mol) against COX-2 enzyme. Conclusion: RKS-1 was found to be the most potent lead. The in vivo results were found to be successfully correlated with the obtained in silico data. The current study will draw the attention of global chemists towards the rational development of newer synthetic phenoxyacetanilide derivatives with pronounced non-steroidal anti-inflammatory drugs (NSAID) activity. EnglishPhenoxyacetanilide Derivatives, Anti-inflammatory, Analgesic, NSAID, Molecular Docking, Inhibitorshttp://ijcrr.com/abstract.php?article_id=4124http://ijcrr.com/article_html.php?did=4124

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26Healthcare Aesthetic Rehabilitation of Abrasive Wounds Using Platelet-Rich Fibrin to Correct Soft Tissue Defects of Face-Case Report English197200Ekta KeswaniEnglish Yogesh KiniEnglish Vidisha NagdevEnglish Varun IraniEnglish Swarup Sanjay PatilEnglish Introduction: Abrasive soft tissue wounds are a common occurrence in Oral and Maxillofacial Surgery. The aetiology is commonly due to road traffic accidents, cases of slip and fall, assault or interpersonal violence. Platelet-rich fibrin contains a concentrate number of WBCs along with macrophages, which prevents infection of wound, promotes platelet aggregation and fibrin formation which assists the granulation process, while allowing to correct the volume defect caused by abrasive wounds of the epidermis and dermis layer of skin. Case Report: This paper aims to present a case of an acute abrasive soft tissue wound on the face of a 17-year-old male patient who presented to D.Y Patil Hospital casualty with an alleged history of facial trauma due to slip and fall from his two-wheeler. The patient was treated with platelet-rich fibrin to promote tissue regeneration, prevent infection and provide aesthetic soft tissue healing. Conclusion: Use of autologous platelet-rich fibrin allows for accelerated healing, and restores volume in tissue injuries with volume loss to provide aesthetic soft tissue recovery. Platelet-rich fibrin can be used to treat volume defects in acute soft tissue injuries with volume loss. EnglishPlatelet-Rich Fibrin, Acute Soft Tissue Wounds, Aesthetic Rehabilitation, Tissue Regeneration, Aesthetic Soft Tissue Healing, WBCshttp://ijcrr.com/abstract.php?article_id=4694http://ijcrr.com/article_html.php?did=4694 1. Miron RJ, Fujioka-Kobayashi M, Bishara M, Zhang Y, Hernandez M, Choukroun J. Platelet-rich fibrin and soft tissue wound healing: A systematic review. Tissue Eng Part B Rev. 2017 Feb;23(1):83-99. doi: 10.1089/ten.TEB.2016.0233. Epub 2016 Oct 10. PMID: 27672729. 2. Cieslik-Bielecka A, Choukroun J, Odin G, M Dohan Ehrenfest D. L-PRP/L-PRF in esthetic plastic surgery, regenerative medicine of the skin and chronic wounds. Curr Pharm Biotechnol. 2012 Jun; 13(7): 1266–1277. 3. Rozman P, Bolta Z. Use of platelet growth factors in treating wounds and soft-tissue injuries. Acta Dermatovenerol Alp Pannonica Adriat. 2007 Dec;16(4):156-65. PMID: 18204746. 4. De Pascale MR, Sommese L, Casamassimi A, Napoli C. Platelet derivatives in regenerative medicine: an update. Transfus Med Rev. 2015 Jan;29(1):52-61. doi: 10.1016/j.tmrv.2014.11.001. Epub 2014 Nov 18. PMID: 25544600.

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26Healthcare Pleomorphic Adenoma: A Case Report English201203Ketaki BhorEnglish Avinash TamgadgeEnglish Treville PereiraEnglish Suraj ManishankarEnglish Atharva Anil KatheEnglish Mahek SuryanarayanEnglish Introduction: Pleomorphic adenoma is a benign salivary gland tumour that most commonly originates in the parotid gland, mainly involving the superficial lobe. Pleomorphic adenoma is a painless growth that grows in size over time if left untreated. It is more common in women and occurs between the ages of 30 and 60. Surgical excision exposes the facial nerve to injury as it penetrates the substance of the parotid gland and separates into terminal branches. Case Report: We discuss a case of a pleomorphic adenoma of the right parotid gland presented by a 35-year-old lady and handled by surgical excision, as well as details of the critical structures encountered. Conclusion: Despite being a benign tumor of the salivary gland, pleomorphic adenoma should be detected early, and complete local surgical excision with negative microscopic margins is advised. Whenever possible, care should be taken to protect the facial nerve when dealing with the parotid gland. For preventing recurrence and malignant transformation, care must be made to completely eradicate the lesion. EnglishPleomorphic Adenoma, Salivary Gland Tumor, Parotid Gland, Facial Nerve, Benign Tumorhttp://ijcrr.com/abstract.php?article_id=4695http://ijcrr.com/article_html.php?did=4695 1. Jain S, Hasan S, Vyas N, Shah N, Dalal S. Pleomorphic Adenoma of the Parotid Gland: Report of a Case with Review of Literature. Ethiop JHealth Sci. 2015; 25(2): 189–194. https://doi. org/10.4314/ejhs.v25i2.13 2. Dalati T, Hussein MR. Juvenile pleomorphic adenoma of the cheek: A case report and review of literature. Diagn Pathol.2009; 4: 32-8 3. Khanal P. Pleomorphic Adenoma of the Submandibular Gland: A Case Report. JNMA; journal of the Nepal Medical Association. 2019 Jan-Feb; 57(215): 53–55. https://doi.org/10.31729/ jnma.4001 4. Phillips DE, Jones AS. Reliability of clinical examination in the diagnosis of parotid tumors. JR Coll SurgEdinb. 1994; 39(2):100-2. 5. Aggarwal A, Singh R, Sheikh S, Pallagatti S, Singla I. Pleomorphic adenoma of minor salivary gland: A case report. RSBO Revista Sul-Brasileira de Odontologia. 2012; 9:97-10

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical AspectsEnglishN2021May26Healthcare Verruciform Xanthoma: A Case Report English204206Abhishek JadhavEnglish Pooja KamathEnglish Vishal PunjabiEnglish Priyadharshini T KEnglish Sahil SEnglish Sourabh SavaleEnglish Introduction: Shafer first described the entity Verruciform Xanthoma (VX) in the year 1971 as an uncommon lesion of the mucosa of the oral cavity with unknown etiopathology. It is a papillary, polypoid or sessile growth that is usually non-symptomatic in nature. There is no gender predilection. It is reddish in color but sometimes may appear pale or hyperkeratotic with a cauliflower-like growth. The size of the lesion ranges from 2mm to 2cm or more. The hallmark and distinguishing feature of VX is the presence of lipid-laden foamy histiocytes usually present in the papillary region of the connective tissue. Case Report: Here we present a case of a 63-year-old male patient with a chief complaint of a whitish growth on the lower anterior gingiva which was firm in consistency measuring about 2 x 1 cm. A biopsy was taken and it was sent for histopathological diagnosis of the same. Conclusion: Verruciform xanthoma is a rare benign proliferative lesion of the oral cavity, characterized by the presence of foam cells within the connective tissue papillae. It is important to make the correct diagnosis for verruciform xanthoma by histopathology because of its resemblance to papilloma and other verrucous lesions. EnglishVerruciform Xanthoma (VX), Xanthoma Cells, Papilloma, Histopathological Diagnosis, Lower Anterior Gingiva, Papillary Regionhttp://ijcrr.com/abstract.php?article_id=4696http://ijcrr.com/article_html.php?did=4696 1. Akshay S, Kourosh N, Yogesh L, Maryam M, Iman M. “Oral Verruciform Xanthoma: A Case Report and Literature Review.” Case Reports in Dentistry. 2013 Jan (6); 528967: https://doi. org/10.1155/2013/528967 2. Hegde U, Doddawad VG, Sreeshyla H, Patil R. Verruciform xanthoma: A view on the concepts of its etiopathogenesis. J Oral Maxillofac Pathol. 2013;17(3):392–6. 3. Rajendran R. Shafer’s Textbook of Oral Pathology (6Th Edition). Elsevier India; 2009. 4. Sah K, Kale A, Hallikerimath S. Verruciform xanthoma: Report of two cases and review on pathogenesis. J. Oral Maxillofac. Pathol.2008;12(1):41. Available from: http://dx.doi. org/10.4103/0973-029x.42198 5. Mohsin SK, Lee MW, Amin MB, Stoler MH, Eyzaguirre E, Ma CK, et al. Cutaneous Verruciform Xanthoma. Am J Surg Pathol. 1998;22(4):479–87. Available from: http://dx.doi. org/10.1097/00000478-199804000-00014 6. Reich O, Regauer S. Recurrent Verruciform Xanthoma of the Vulva. Int J Gynecol Pathol. 2004;23(1):75–7. Available from: http://dx.doi.org/10.1097/01.pgp.0000101143.79462.f7 7. Connolly SB, Lewis EJ, Lindholm JS, Zelickson BD, Zachary CB, Tope WD. Management of cutaneous verruciform xanthoma. J Am Acad Dermatol. 2000;42(2 Pt 2):343–7