Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareEffectiveness of Turmeric (Curcuma longa Linn) Extract Gel (EG) on Wound Healing in Female Rats (Rattus Novergicus) English0206Arfiani BusmanEnglish Andi Nilawati UsmanEnglish Risfah YuliantyEnglish Mardiana AhmadEnglish PrihantonoEnglish Latifah RahmanEnglish Andi SumidartiEnglishObjective: The purpose of this study was to identify differences in wound healing and wound healing time at each concentration of turmeric extract gel (Curcuma longa Linn) and base gel on days 3, 7 and 14, and identify the most effective turmeric extract gel for wound healing in cuts female rats (Rattus Novergicus). Method: This study was an experimental laboratory using a post-test only with a control group. This study used 16 female rats, 3 treatment groups, and 1 control group (each group consisted of 4 mice). Female rats were injured in the back section by slashing along 1.5 cm with a depth of 0.2 cm. The treatment group was given turmeric extract gel with a concentration of 5%, 10%, 15%, and the control group was only given a gel base. This research was conducted for 14 days of topical turmeric extract gel by giving 2 times a day. The normality test uses the Shapiro Wilk test, then the Kruskal Wallis test, and continued with the PostHoc Mann-Whitney. Results: The mean on the 3rd day of the EG group was 5% (0.95cm), the EG group was 10% (0.98 cm), the group was 15% (1.23 cm), and the control group (1.25 cm). On the 7th day EG 5% (0.58 cm), EG 10% (0.65 cm), EG 15% (0.73 cm) and the control group (1 cm). On day 14 showed wound healing in the treatment group, but the control group showed mean wound length on day 14 (0.15 cm). Test results on day 3 obtained p = 0.007, on day 7 obtained p= 0.010 and on day 14 obtained p-value = 0.017. P values on days 3, 7, and 14 showed significant differences with pEnglish Turmeric extract, Gel, Female rat, Woundhttp://ijcrr.com/abstract.php?article_id=3192http://ijcrr.com/article_html.php?did=3192

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareRole of Botox Therapy in Dentistry, Beauty with Fillers - A Review English0711Aditi Vinay ChandakEnglish Surekha Godbole DubeyEnglish Seema SatheEnglish Tanvi Rajesh BalwaniEnglishIntroduction: In recent years the use of the minimally invasive technique of treatment is giving quite promising results not only in cosmetics but also in dentistry. Botulinum toxin is injected in the affected muscles which in turns inhibits the acetylcholine and results in the reduction of the tone of muscles. The commonly used name for Botulinum toxin is BOTOX. There are seven serotypes of botulinum toxin. Mainly two types are used. Patients who are contraindicated for conventional therapies can easily undergo BOTOX therapy as it is a preventive treatment at low cost. Aim and Objective: This review article explains about the various applications of botulinum toxin for painful conditions in dentistry and also for aesthetics. EnglishBotulinum toxin, Aesthetics, Masticatorymuscles, Minimal invasive treatmenthttp://ijcrr.com/abstract.php?article_id=3193http://ijcrr.com/article_html.php?did=3193

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareCytomorphological Profile and Patterns of Lymphadenopathy English1215Anil MeenaEnglish Gajendra Pal Singh UikeEnglish Jagannath JatavEnglishBackground: Enlargement of lymph nodes or lymphadenopathy is one of the ubiquitous clinical presentations of patients attending the outpatient department (OPD). Fine-needle aspiration cytology (FNAC), as the initial investigation, has assumed importance in diagnosing various diseases. It is a cost-effective, reliable, immediate, preliminary, relatively little traumatic procedure compared to open biopsy. However, there is not always a specific diagnosis, thus providing ample information for further management and reducing the amount of open biopsy. Objectives: In the present study, we identified the pattern of diseases in the different anatomical locations of lymph nodes and the role of FNAC in the diagnosis of diseases. Materials and Methods: A two-year study of 920 cases of lymphadenopathy presenting to the Department from January 2016 to December 2017 taken up for our study. FNAC performed using a 23/24 gauge needle and a 20 ml syringe. Four of the prepared smears, two were fixed in alcohol and stained with hematoxylin and eosin and Papanicolaou stain. Two smears air-dried, one stained with Leishman stain, and the other by May-Grunwald-Giemsa (MGG) stain. Special stains like periodic acid–Schiff for mucin (PAS) and Ziehl–Neelsen stain (ZN) stain for acid-fast bacilli (AFB) performed for the diagnosis of peculiar lesions. Results: Most common lesion observed in our study was reactive lymphadenitis (33.26%), followed by granulomatous lymphadenitis (28.15%), tubercular lymphadenitis (17.39%) and metastatic lesions (14.23%). Cervical lymphadenopathy found to be the most common site in our study. Conclusion: Our study highlighted the various morphological patterns and incidence of lymphadenopathy concerning various regions and sex. FNAC as a straightforward, cost-effective, relatively painless, quick, repeatable, and reliable method of investigation for lymphadenopathy and also very useful in developing countries like India where costly investigations are not easily affordable. English Fine Needle Aspiration Cytology (FNAC), Granulomatous Lymphadenitis, May-Grunwald-Giemsa (MGG) stain, Metastatic Lesionshttp://ijcrr.com/abstract.php?article_id=3194http://ijcrr.com/article_html.php?did=3194

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareComparative In vitro Anthelmintic Activity of Aqueous and Organic Extract of Root and Bark of Punica Granatum Linn English1618Atul A BaravkarEnglish Madhukar V ShendeEnglish Nilesh A NalawadeEnglish Nitin B. AherEnglishIntroduction: Punica granatum (Punicaceae) has a wide variety of medicinal application owing to its different parts such as leaves, the rind of the fruits, seeds, roots, stems, bark. Up till now very less or no research has been done on the comparative evaluation of the anthelmintic activity of the bark and roots of Punica granatum. Aim: This research study aimed to evaluate aqueous and organic extracts of bark and root of Punica granatum for their anthelmintic activity using Indian adult earthworm called Pheretima Posthuma and to perform comparative evaluation between aqueous and organic extract. Methods: Different concentrations of aqueous and organic extract ranging from 10 to 100 mg/ml were made and tested on a said earthworm. These extracts were tested for bioassays which includes time for paralysis and time for the death of the worms. Results: Aqueous as well as organic extract of bark exhibited strong anthelmintic activity at a concentration of 100 mg/ml as compared to the root. Lower concentrations did not produce significant anthelmintic activity. The standard reference drug which is used for comparing the anthelmintic activity of these extracts was piperazine citrate at a concentration of 10 mg/ml. Conclusion: Both aqueous and organic extracts of bark and root of Punica granatum are evaluated for and showed potential anthelmintic activity. EnglishPunica granatum, Extraction, Worms, Anthelmintic activity, Piperazine citrate, Helminthiasis, Pheretima Posthumahttp://ijcrr.com/abstract.php?article_id=3195http://ijcrr.com/article_html.php?did=3195

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareStudy on Etiology and Immediate Outcome of Adult Comatose Patients in Medical Ward English1922Pijush Kanti BiswasEnglish Arijit SinhaEnglishIntroduction: Adult comatose patients are challenging in General Medicine ward. Proper and prompt handling of such patients is important to get the best results. To reach etiological diagnosis early is important for the outcome. Methods: It is an observational, analytical, prospective study among 300 adult non-traumatic comatose patients (GCS ≤ 10) admitted in the Medical ward. Cases were evaluated with details history, clinical examinations, investigations. The etiological and immediate outcome was assessed. Results: In our study, most common causes were stroke (48.99%) followed by metabolic derangement (28.98%), infection (14.3%), poisoning (5.66%) and malignancy (2%). Among death patients, stroke is in the top (71.1%) then metabolic causes (13.32%), infection (7.4%), poisoning (5.92%), malignancy (2.22%). Among 300 patients 32% had one or more co-morbid illness. Conclusion: Stroke is the most common cause of non-traumatic coma but metabolic and infective causes are equally important in a tertiary care hospital. English GCS (Glasgow Coma Scale), NTC (Non-Traumatic Coma), Adult comatose patientshttp://ijcrr.com/abstract.php?article_id=3196http://ijcrr.com/article_html.php?did=3196

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareForensic Diatomological Mapping: A Data Base for Diatom Profiling to Solve Drowning Cases English2331Ekta SainiEnglish Pooja RohillaEnglishDrowning data from past years shown a large number of people pass away accidentally in rivers, ponds, lakes and oceans. A Forensic expert can locate the probable or putative site of drowning by considering the diatom test. The present review focused on the investigation of drowning death is an essential aspect for the law enforcement agencies. However, a limited or little knowledge of forensic experts in the field of diatomology can hamper diatom related analytical strategies. Review implicate the progress and generation of Diatomological mapping of water bodies to make more conversant the scientists, researchers and other academician dealing with the investigation of drowning cases. EnglishDrowning, Diatom test, Diatomological mappinghttp://ijcrr.com/abstract.php?article_id=3197http://ijcrr.com/article_html.php?did=3197

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareBaseline Assessment of Oral Health Status of Ashram Schools in Wardha District English3237Anuja IkharEnglish Manoj ChandakEnglish Nidhi MotwaniEnglish Akshay ThoteEnglish Supriya SawantEnglishIntroduction: Oral health is an essential and vital component of overall health and is associated with much more than just healthy teeth. Ashram schools are one of the initiatives of the government of India for providing education to the children of tribal communities. Aim: To evaluate the effectiveness of oral health care initiatives in reducing oral morbidities by improving oral health care behaviour amongst ashram school students. Method: 8 ashram schools were selected for the study. Teachers from 8 Ashram schools attended the one-day Orientation Workshop. A qualitative (semi-structured interview of teachers) and quantitative (survey) method was undertaken for baseline assessment in both the groups. The baseline assessment targeted on detection of dental caries, gingival and periodontal health dietary habits and tobacco chewing habit. Results: The major weaknesses of Ashram schools were poor training of teachers in detecting health problem and lack of timely treatment of illnesses. Students are from poor and low socio-economic strata of disadvantaged sections of the society. In baseline assessment in the control group, 32% of students had Caries. In the control group, 57.42% of students had the presence of the periodontal problem which increases to 63.58 %, in the control group, 28.85% of students had the presence of fluorosis which increases to 33.64%. Discussion: The oral morbidities during baseline assessment in all the ashram schools was examined. 33.28 % of students have tooth decay, whereas 67% of students detected with bleeding gums. The fluorosis was found to be in 38.28% of students and teeth which undergone minor trauma (enamel fracture, dentinal fractures) were seen with 9.14 % students. Conclusion: This study initiates the thought-provoking response for the dental educators who carry out camps in different setups and indifferent population. The oral morbidities during baseline assessment in all the ashram schools was examined. 33.28 % of students have tooth decay, whereas 67% of students detected with bleeding gums. The fluorosis was found to be in 38.28% of students and teeth which undergone minor trauma (enamel fracture, dentinal fractures) were seen with 9.14 % students. Conclusion: This study initiates the thought-provoking response for the dental educators who carry out camps in different setups and indifferent population. EnglishAshram School, Oral health, Tribal community, Fluorosis, Tobacco addiction, Dental carieshttp://ijcrr.com/abstract.php?article_id=3198http://ijcrr.com/article_html.php?did=3198

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareRational Development of Carbamazepine Osmotic-Controlled Release Oral Delivery System for Multiple Therapeutic Advantages English4348Shrinivas GatlewarEnglish Rutuja MeshramEnglish Purushottam S. GanganeEnglish Debarshi Kar MahapatraEnglish Nilesh M. MahajanEnglishBackground: Carbamazepine is used in the management of seizures by decreasing the central nervous system disorganized electrical activity and also has analgesic properties. It exerts serious side effects in normal administration owing to the extrapyramidal effect which signifies the importance of its incorporation into the extended-release system to reduce the possible side-effects associated with the drug. Objective: In the present study, multiple extended-release systems of Carbamazepine was formulated using various polymers. The effect of viscosity modifying polymers of different grades and its contribution to the release behaviour was examined. Different formulations were prepared and studied for their drug release potentials. Among them, selected formulations were further evaluated for dimensions of the portal. Methodology: Trial batches were designed with osmogen and cellulose polymers along with solubility enhancer as the model drug used to have low solubility. The optimization of the formulation was done by wavering concentration of cellulose polymers and the dimensions of the release portal were determined. Result: A new strategy for extended delivery has been accomplished by extended-release solid oral tablet formed by the combination of solubility enhancers and cellulose polymers. The arrangement of a hydrophilic polymer with a surfactant as solubility promoter and the use of cellulose polymer represents an innovative and effective approach for the delivery of poorly water-soluble. The study further can be used to deliver a cost-effective and robust system for water-insoluble drugs in a zero-order manner. Conclusion: The rapid development of these investigational therapeutic formulations will put forward new avenues for future commercialization of drug after completion of required clinical studies. EnglishCarbamazepine, Osmotic, Controlled Release, Oral Delivery System, Drug release, Solubilityhttp://ijcrr.com/abstract.php?article_id=3199http://ijcrr.com/article_html.php?did=3199

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareIleocecal Valve Lipomatosis: Evaluation by Computed Tomography English4952Manisha Narayanbhai SolankiEnglish Vasant Kumar Jethabhai RathodEnglish Ashish AravindEnglish Harshil K AgheraEnglishIntroduction: IC (ileocecal) valve lipomatosis is characterized by the deposition of fat in the submucosal layer of the IC valve. CT (computed tomography) scan is highly sensitive & specific for it. Objectives: (1) To know how common/uncommon it is to encounter IC valve lipomatosis in day-to-day routine radiology practice (2) To know is there any age or gender predisposition for the development of IC valve lipomatosis (3) To know is there any association of obesity or idiopathic inflammatory bowel disease with IC valve lipomatosis. Methods: This prospective study included all cases of CT abdomen (plain as well as contrast-enhanced ) performed for any indication from 1st November 2019 to 15th July 2020. Repeat/follow up cases were excluded from our study. Total of 800 cases was evaluated to see the presence/absence of IC valve lipomatosis. Cases of IC valve lipomatosis were evaluated in detail for age, gender, obesity & other bowel abnormalities. Results: Out of 800 cases of CT abdomen, 78 cases showed the presence of IC valve lipomatosis. Out of 78 cases of IC valve lipomatosis, 41 were male & 37 were female. The mean age for the IC valve lipomatosis in our study was 46.7 years. All cases of IC valve lipomatosis showed no evidence of idiopathic inflammatory bowel disease on CT scan. Conclusion: It is not uncommon to encounter IC valve lipomatosis in day-to-day routine radiology practice even in patients below 40 years of age. We haven’t found female predominance or association of idiopathic inflammatory bowel disease with IC valve lipomatosis in our study. Results of our study support the association of obesity with IC valve lipomatosis. EnglishIC valve, Lipomatosis, CT scan, Intestine, Bowel, Crohn’s diseasehttp://ijcrr.com/abstract.php?article_id=3200http://ijcrr.com/article_html.php?did=3200

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareDiabetes Diagnosis in Population by Intelligible Machine Learning English3842VidushiEnglish Akash RajakEnglish Ajay Kumar ShrivastavaEnglishIntroduction: At this junction, machine learning demand is enhancing in almost every critical area to catch interesting and decision-making patterns. This inductive research objective is investigating sophisticated different techniques of machine learning to effectively analyze health data. Naturally, the present health-related dataset is most sensitive, crucial, and needs accurate analysis, hence result generated by different learning algorithms have paramount importance. This sensitivity enhances and promoted data analytics, interest, and role through machine learning in the health sector. Objectives: This research aims to analyze and predict diabetes by applying elegant learning algorithms on the diabetes dataset. The article also shows a comparative study analysis of algorithms. Methods: This research uses the median method to preprocess the dataset. After preprocessing, ten different machine learning algorithms are applied to the diabetes dataset in this paper. Results: This document uses a diabetes dataset that has eight different symptoms or features to predict disease. To get a better classification technique, various ML mechanisms results are compared and analyzed. This study outcome can be further utilized in incoming research based on diabetic health problems. Conclusion: A linear support vector machine shows better detection results compared to others. EnglishMachine Learning, Predictive Analysis, Gaussian Process, Diabetes Prediction, SVM, Decision Tree, Nearest Neighborhttp://ijcrr.com/abstract.php?article_id=3201http://ijcrr.com/article_html.php?did=3201

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareInterleukin-6 (IL-6) Levels of Preeclampsia Pregnant Women in Ethnic Bugis, Makassar, Mandar, and Toraja English5357Eka Fitri AmirEnglish Muh Nasrum MassiEnglish Sitti WahyuniEnglish Yuyun WidaningsihEnglish Sharvianty ArifuddinEnglishIntroduction: The imbalance between proinflammatory cytokines impairs the permeability in blood vessels resulting in increased blood pressure. In preeclampsia, patients found an increase in IL-6 levels compared to normotensive mothers. Objective: To determine differences in levels of cytokines IL-6 in pregnant women with preeclampsia and normotension in the Bugis, Makassar, Mandar and Toraja tribes so that it can be used as a marker for the prevention of the continuation of advanced preeclampsia and is used as one of the determinants of early detection. Methods: This research is a cross-sectional study with a case-control study where respondents were 44 pregnant women with a gestational age over 20 weeks with a diagnosis of preeclampsia and 44 pregnant women over 20 weeks with normotension. The criteria for respondents in this study were not suffering from systemic diseases and were domiciled in the study area which was the Makassar, Bugis, Mandar, and Toraja tribes. Data collected included age, body mass index (BMI), parity, history of preeclampsia, and Tribal Status. Serum Interleukin levels were determined using the Human Interleukin 6 ELISA Kit. Results: Differences in mean IL-6 levels in the preeclampsia group in four ethnic groups namely Makassar, Bugis, Mandar and Toraja with a significant value of p-value 0.032 (pEnglishInterleukin-6, Preeclampsia, Ethnicity, Pregnancyhttp://ijcrr.com/abstract.php?article_id=3202http://ijcrr.com/article_html.php?did=3202

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareEffects of Vitamin D3 Deficiency on Performance in Football Players English5863Khadijeh J. MenaiEnglish Ali IraniEnglish Roli DaveEnglishIntroduction: Football is a sport where speed and kicking performance are of utmost importance for most of the actions during the sport. Such intense actions require vitamin D at optimal levels. There is a global prevalence of vitamin D deficiency even in countries with ample sunlight, India being an example.70%–100% of the general population in India is considered to have low vitamin D levels. Very few studies have aimed at finding out the vitamin D status in sportsmen while maximum studies have addressed the community in general. Objective: The study aims at finding out the prevalence of vitamin D3 deficiency along with the effects of its deficiency on the kicking performance in football players. Methods: This experimental study was carried out on 150 elite level football players from local clubs and academies across Mumbai city. All the subjects went through a screening blood test to determine vitamin D3 levels. Performance parameters were analyzed by assessing side kick distance, instep kick distance and kick velocity both at the beginning and end of 4 weeks supplementation. Results: Paired T-test was used to analyze the data which showed statically significant improvement in sidekick distance, instep kick distance and kick velocity post 4 weeks of vitamin D3 supplementation. About 87% players recorded vitamin D3 levels < 30 ng/ml (nanograms/milliliter) and 99% players recorded vitamin D3 < 40 ng/ml (nanograms/milliliter). Conclusion: We concluded that the vitamin D3 level in professional football players in Mumbai city is far below optimal. Supplementation may improve their performance and speed in terms of kick distance and kick velocity. EnglishSidekick distance, Instepkick distance, Kick velocity, Vitamin D deficiencyhttp://ijcrr.com/abstract.php?article_id=3203http://ijcrr.com/article_html.php?did=3203

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareEvaluation of the Efficacy of Tranexamic Acid in the Management of Menorrhagia English6469P. Yamini Shoba VaniEnglish K. NirmalaEnglish Parlapally Shashi jyothsnaEnglishBackground: Abnormal uterine bleeding(AUB) negatively affects physical, emotional, sexual and professional aspects of the life of women, worsening their quality of life. Objectives: Study is to know the efficacy of tranexamic acid in Abnormal uterine bleeding in our hospital. Methods: The present study was conducted in 50 patients with complaints of regular excessive menstrual flow were included. The study included measurement of menstrual blood loss, duration of bleeding, number of sanitary pads used for two menstrual cycles in women who complained of regular excessive menstrual bleeding using pictogram and PBAC Scoring (Pictorial blood loss assessment charts ). The oral drug, tranexamic acid 500 mg thrice daily was given to these women after obtaining who had mean menstrual blood loss of more than 80ml, according to PBAC scoring more than 100, based on the assessment in the previous two menstrual cycles. Results: Significant decrease in the amount of menstrual bleeding was noticed in 39 out of 50 women. Mean menstrual blood loss during one pre-treatment cycle was dropped to 60 ml from 120 ml. The mean decrease was 54.7 ml in one cycle. The decrease in the amount of blood loss was about 45% to 50%, which was indicating that the drug was very effective in decreasing blood loss. Increase in haemoglobin concentration is also noticed. But there was not much difference in the duration of menstrual bleeding. 74% of them had haemoglobin less than 10 gm%, after treatment with tranexamic acid and oral iron therapy, this percentage was decreased to 42%. Conclusions: Treatment with tranexamic acid increases the quality of life of women by reducing the impairment of social activities and impairment at work and there is substantial improvement in overall well being. EnglishTranexamic acid, PBAC Scoring (Pictorial blood loss assessment charts), Blood losshttp://ijcrr.com/abstract.php?article_id=3204http://ijcrr.com/article_html.php?did=3204

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareExpression of Programmed Death Ligand (PD-L1) in Ovarian Surface Epithelial Tumours English7074S. Shanmuga PriyaEnglish Susruthan MuralitharanEnglish Lawrence D'CruzeEnglish Padmapriya BEnglish Barathi GEnglishIntroduction: Malignant surface epithelial ovarian carcinomas usually present at an advanced stage of the disease and also one of the leading causes of cancer-related deaths in women despite multimodality treatment. Programmed death-ligand -1 (PDL-1) is a co-regulatory molecule expressed on the surface of ovarian tumour cells as well as immune cells, binds to its receptor programmed death receptor (PD-1) and suppresses the local tumour immunity thereby helping the tumour cells to spread and metastasize. Objective: To determine the immunohistochemical expression of PD L-1 in tumour cells and immune cells in malignant surface epithelial tumours of the ovary. To correlate the level of PDL-1 expression with histopathological parameters of surface epithelial tumours of the ovary. Methods: Immunohistochemical expression of PDL-1 in 100 cases of surface epithelial tumours of ovary were studied. Clinicopathological parameters, history of presurgical treatment, response to treatment, presence of tumour implants and presence of metastasis etc were obtained from the hospital medical records. The intensity and extent of membranous staining by anti-PD L-1 were scored for the tumoural cells and the tumour infiltrating immune cells separately. Statistical analysis was done on the data collected using the “SPSS Version 11” statistical program. Pearson Chi-square test was used to determine significant clinicopathological differences between PD-L1 expression in positive and negative tumours. Results: PDL-1 expression in tumour cells was high in 6(6%) cases and 22(22%) cases showed expression in immune cells in tumour micro-environment. A significant statistical correlation between PDL-1 expression and grade and histological type of tumour was noted. Conclusion: High expression of PD-LI was noted in tumour infiltrating immune cells in more number of cases than that of the expression in tumour cells. The present study indicates that expression of PD-L1 is related to histologic type, the grade of the tumour and ovarian surface involvement by tumour cells with statistical significance. EnglishPDL-1, Immunohistochemistry, Ovarian surface epithelial tumour, Immune cells, Immunotherapy, Ovarian cancerS. Shanmuga Priya, Susruthan Muralitharan, Lawrence D'Cruze, Padmapriya B, Barathi G Englishhttp://ijcrr.com/abstract.php?article_id=3205http://ijcrr.com/article_html.php?did=3205

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcarePhysical Anthropometry in Estimation of Stature: A Systematic Review English7579Pinki RaiEnglish Ashima DasEnglish Ajay Kumar AgrawalEnglish Diksha AroraEnglishThe spectrum of medical science is very broad and it seems to embrace almost every field of scientific study. The tools and techniques vary from as basic anthropometric measurement to as advanced as studying genes depending upon the field of medical science. Anthropometry is mainly covered under the departments of Anatomy and forensic and/or criminology units. Stature has been estimated by various researchers using arm span, hand length, length of the foot, length of fingers, demi-span, sitting height and many more. This review was aimed to study various parameters used for stature estimation and finding out the most supported one. This systematic review has included studies which have primarily focused on measurement of height with any other correlate to getting a brief account of anthropometric data on stature. The articles were sorted out using various databases which include Google Scholar, Scopus, Research Gate, PubMed and MEDLINE. All the articles were reviewed twice and most relevant articles were included and analyzed. Out of different parameters used for predicting the stature of an individual, the arm-span is the most efficient and accurate. Arm span can be used for prediction of the stature of the particular population. EnglishArm span, Demi span, Sitting height, Stature estimation, Hand and foot lengthhttp://ijcrr.com/abstract.php?article_id=3206http://ijcrr.com/article_html.php?did=3206

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareA Clinical Study of Epidemiology of Anterior Uveitis in a Tertiary Care Teaching Hospital English8084Dawson Vinay KumarEnglish Dawson Elizabeth ManasviEnglishIntroduction: Uveitis, is a complex intraocular inflammatory disease with multifactorial etiology. The cause of inflammation might be an infectious agent or trauma, but in some cases, the underlying mechanism appears to be autoimmune. Aim: The present study aimed to evaluate the etiological pattern, treatment, and outcome and complications of anterior uveitis. Methods: A prospective clinical study was done in the Department of Ophthalmology. All patients aged between 21-70 yrs with clinical signs and symptoms of anterior uveitis were included. All the patients underwent complete clinical evaluation and investigation were performed to determine etiology. Patients were put on specific and non-specific treatment and were followed up for 6 months. Complications were noted. Results: Patients n=44(88%) of the total n=50(100%) patients were having acute anterior uveitis and n=6(12%) were having a chronic type of anterior uveitis shown in table 3. In the present study, most of the cases n=45(90%) were suffering from non-granulomatous infection and n=5(10%) were having granulomatous inflammation. Cataract was the common compilation of anterior uveitis out of the n=7 cases in this study n=6 cases reached the maximum post-operative vision of 6/12 and one was able to reach n=6/9 with refraction and they were prescribed glasses. Conclusion: The primary etiology of anterior uveitis remained obscure in several cases. Every case should be subjected to complete clinical examination and investigations to determine the final diagnosis. Early diagnosis and treatment will ensure a good clinical outcome. However, ocular morbidity remains a problem in chronic and recurrent cases. EnglishClinical Study, Etiological pattern, Anterior Uveitis, Visual impairment, Ocular inflammationhttp://ijcrr.com/abstract.php?article_id=3207http://ijcrr.com/article_html.php?did=3207

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareNon-Ischemic Central Retinal Vein Occlusion (CRVO) and its Management using Ayurvedic Therapies: A Case Series English8595Sreekala Nelliakkattu ParameswaranEnglish Manjusree Radhakrishnan ParappurathuEnglish Aravind KumarEnglish Krishnendu SukumaranEnglishIntroduction: Central retinal vein occlusion (CRVO) may result in either blurring of vision in the non-ischemic variety or vision loss in the ischemic variety. The two varieties of CRVO are identifiable by distinctive fundus findings. Observation is the first line of management in non-ischemic CRVO, but this does not always produce desired results. Hence, options in complementary and alternative medicine, including Ayurveda, may be sought. Case Series: Data about three patients of non-ischemic CRVO who underwent conventional management but got marginal relief of their symptoms are presented here. The patients were managed using specially-tailored Ayurvedic treatments such as oral medicines, purification procedures, and local therapies for both the eyes and head. Results: Satisfactory results in visual acuity, posterior segment examination, and optical coherence tomography (OCT) were noted. Conclusion: The main aim and challenge in management were to improve visual acuity while bringing back normal findings and maintaining the integrity of the retina by both fundus examination and OCT. The results obtained in this series indicate the potential of Ayurvedic treatments to manage non-ischemic CRVO. EnglishCase report, Kriyakalpa, Panchakarma Therapy, Timirahttp://ijcrr.com/abstract.php?article_id=3208http://ijcrr.com/article_html.php?did=3208

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareEffect of Sap Palm (Borassus flabellifer) on Blood Glucose Level in Pre-Diabetic Patients English96100Ida Leida MEnglish Ridwan M. ThahaEnglish Andi Selvi YusnitasariEnglish AfsahyanaEnglishIntroduction: Herbal medicines are good alternative treatment for management of blood glucose level. One of the herbal medicines that have potential as anti-diabetic is palm juice (Borassus flabellifer). Objective: This study was aimed to determine the effect of sap palm (Borassus flabellifer) on the decrease of blood glucose levels in patients with pre-diabetic. Methods: Design of quasi-experimental with a randomized pre-test post-test control group design. The total sample was 50 people, divided into two groups: the sap palm intervention group and education of 25 people and the control group with the education of 25 people. Result: There was a decrease in blood glucose levels in the group that received sap palm interventions, and a significant difference between the groups that received sap palm interventions with the control group. Based on the results of the follow-up, there was a decrease in blood glucose levels every week between the intervention group and the control group. However, the reduction was greater in the group with sap palm intervention. Provision of sap palm for three weeks at a dose of 200 ml 2 times a day, such as a morning and evening after eating, proved effective in reducing blood glucose levels in patients with pre-diabetic. Conclusions: Sap palm can be used as an alternative herbal medicine for pharmacological therapy in pre-diabetic. EnglishSap palm, Pre-diabetic, Education, Blood glucosehttp://ijcrr.com/abstract.php?article_id=3209http://ijcrr.com/article_html.php?did=3209

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareEnhanced Safe and Secure Distributed Healthcare System Through Efficient Duplication Detection Approach English101105J. PrassannaEnglish Jani L. AnbarasiEnglish R. PrabhakaranEnglish Kanchana Devi VEnglish Rajiv VincentEnglish R. ManikandanEnglish Ambeshwar KumarEnglishIntroduction: Currently the Manual Health Care System works on a Referral basis where a Village Patient is referred to District Level Hospital for further treatment and then to State/National Level Hospitals if not cured. The patient needs to carry all the medical prescription records manually for each level and there is no data security. Missing of any data will lead to undergo a tedious process. Objectives: This study aims to analyse the drawbacks in the existing healthcare system in the rural areas and proposed an effective secured assistive health care system for rural areas. Methods: Local village structure and the patient information were studied and an application is developed to store the patient’s information in a secured way. The secured data is distributed to the state and national level hospitals during treatment. This allows the early diagnosis and treatment of a person in villages. Results: The system helps to monitor and update the entire patient record securely using encryption. Avoids duplicated file processing and stores the data in Distributed Servers by enabling high maintenance and security thereby maintaining better health care system. Conclusion: The proposed distributed system will reduce the manual work and help to maintain the patient record in sync at the village-district-state-national level. This distributed system is a procedural healthcare system. It satisfies the patient requirements and it stores the prescription data and information about patients in a distributed system for easy maintenance of data. This system has enabled the security system with auditing files, which are stored in distributed servers. Englishe-Health Care Management, Distributed Storage, Patient Information, Progressive Sorted Neighbourhood Methodhttp://ijcrr.com/abstract.php?article_id=3210http://ijcrr.com/article_html.php?did=3210

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcarePeritoneal Fluid Culture and Sensitivity in Case of Perforation Peritonitis: A Cross-Sectional Study English106110Ohang ChaudhariEnglish Pranjal ShindeEnglish Honeypalsinh H. MaharaulEnglishIntroduction: Peritonitis is a frequently encountered pathology by a general surgeon. The development of antimicrobial agents and the advancement of surgical techniques in the past decade have decreased morbidity and mortality. The complications range from minor wound infection to life-threatening septic shock and Systemic Inflammatory Response Syndrome (SIRS). Usage of appropriate antimicrobial agents that covers gram-positive, gram-negative, and anaerobic organisms provides good recovery in the patients. But inappropriate usage of antibiotics without following guidelines leads to the development of antibiotic resistance and treatment failure. Objectives: To study the microbiological pattern of the peritoneal fluid in culture and sensitivity and to identify the pattern of antibiotic sensitivity for routinely used organisms. Methods: This is cross-sectional study conducted in 50 patients with peritonitis and perforation confirmed on chest x-ray. Peritoneal fluid is isolated and nature of microorganism are characterized along with antibiotic sensitivity. Results: In this study, the most common site of perforation leading to peritonitis is Duodenum followed by the stomach. Mostly secondary to peptic ulcer disease. The most common organism isolated was Klebsiella followed by E.coli, mixed cultures, Proteus, and pseudomonas. Most of the organisms isolated from the peritoneal fluid on culture were sensitive to the Cephalosporin group followed by Fluoroquinolones and macrolides. Conclusion: Appropriate antibiotic use based on the sensitivity pattern is essential to improve the morbidity and mortality in patients who suffered from perforation secondary to peritonitis and to prevent antimicrobial resistance. EnglishPerforation, Peritonitis, Antimicrobials, Peritoneal fluid, Microorganism, Culturehttp://ijcrr.com/abstract.php?article_id=3211http://ijcrr.com/article_html.php?did=3211

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareComparison between Ropivacaine 0.25% and Bupivacaine 0.25% in Paediatric Caudal Anaesthesia in Infra Umbilical Surgeries (A Study of 60 Cases) English111114Tejash H. SharmaEnglish Kaushik SharmaEnglish Dinesh ChauhanEnglish Jatin PatelEnglishNilam ShahEnglishBackground: Caudal epidural is the most common regional anaesthesia technique for treating post-operative pain in pediatric patients. It is commonly used for procedures like urogenital, rectal, inguinal and lower extremity surgery. Objective: To compare the anaesthetic potential of bupivacaine 0.25% and ropivacaine 0.25% for infra-umbilical surgical procedures. Methods: This study included 60 children of ASA (American society of anesthesiologists) I & II grade of either gender, scheduled for various elective infra-umbilical surgical procedures. Patients were randomized to receive bupivacaine 0.25% or ropivacaine 0.25% each total dose of 1 ml kg-1. The randomization sequence was computer-generated and prepared in a double-blind manner. Post-operative motor block was assessed with Bromage motor scale and postoperative analgesia was observed with an observer pain scale. Statistical data were analyzed by using student’s unpaired t-test. Results: The mean duration of analgesia in group B was 266.0±1.89 minutes and group R was 251±2.68 minutes. The difference was statistically highly significant (pEnglishCaudal block, Bupivacaine 0.25%, Ropivacaine 0.25%, Paediatric, Infra umbilical surgeries, Age 4-6 years.http://ijcrr.com/abstract.php?article_id=3212http://ijcrr.com/article_html.php?did=3212

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareFunctional Results of Use of Mesh in Orthopaedic Oncology Surgery (Long Term Follow Up) English115119Manish R ShahEnglish Manisha M ShahEnglish Yaswanth Teja VattikutiEnglish Sarvang M DesaiEnglish Paresh P GolwalaEnglishBackground: Diagnosis of a malignant bone tumour has been confusing to a general orthopaedic surgeon. Advancement in radio and chemotherapy fields and better diagnostic modalities helped a lot in the improvement of results of limb salvage surgery. In limb salvage surgeries after tumour resection, replacement with mega-prosthesis is one of the standard methods. To improve functional outcomes, we have used mesh in our study. Objectives: To evaluate the results of the use of mesh in limb salvage surgeries done for malignant bone tumours by comparing the range of movements with a group of patients in which mesh was not used. The objective is to assess the clinical and functional outcomes of the patients. Methods: A retrospective study of 19 patients was carried out. We included patients with a minimum follow up of 6 months. The study includes all common regions of the body affected by the malignant bone tumour (lower end femur, upper-end tibia, upper-end femur and upper-end humerus) operated by limb salvage surgery and mega-prosthesis replacement. Two study groups, one without mesh and one with the use of mesh were compared. We have used mesh in primary reconstruction surgery. Results: Results were evaluated by the Musculo Skeletal Tumour Society (MSTS) scoring system showed a good range of movements in terms of Shoulder abduction (for Proximal humerus replacement) [Figure 1,2&3] and knee extension. Conclusion: Use of mesh induces fibrosis and provides anchorage to soft tissues and muscles in limb salvage surgery. Thus achieves a good range of active movements and can lessen the time for immobilization. Thus it helps psychosocial rehabilitation of the family and society5,6. EnglishOrthopaedic oncology surgery, Limb salvage surgery, Mega-prosthesis, Bone cancer surgery, Mesh in Orthopaedic Oncology, Psychosocial rehabilitation in bone cancerhttp://ijcrr.com/abstract.php?article_id=3213http://ijcrr.com/article_html.php?did=3213

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareMedical and Organizational Measures to Improve the Provision of Medical Care in the Dermatovenerology Profile English120122Rizaev JAEnglish Ashirov ZFEnglish Toshev SUEnglish Islamov NHEnglish Salamova LAEnglish Baratova MREnglishIntroduction: Most Dermatovenerological diseases belong to the category of socially significant diseases. Objective: To improve the organization of medical care for Dermatovenerological patients and improving their health. Methods: The present study was carried out within 2 years from 2018-2019 at the DS of the Samarkand region. Legislative and regulatory acts of the Federal and regional levels, local self-government bodies; literature data on the experience of creating management systems were evaluated. Results: In this regard, changes in the country’s socio-economic development affect the epidemiological situation and the quality of medical care. Historical experience shows that any socio-economic changes in society entail the need to modernize the existing system. Conclusion: In the third millennium, the state of the epidemiological situation and socio-economic development of society indicates the need to manage the quality of medical care, improve the organizational basis for the prevention of Dermatovenereological care to the population. EnglishDermatovenerological service, Quality medical care, Work motivation of Dermatovenerologistshttp://ijcrr.com/abstract.php?article_id=3214http://ijcrr.com/article_html.php?did=3214

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareCharacteristics of the Vegetative Status and Autonomic Regulation in Children with Different Severity of Bronchial Asthma English123129Khurmatkhon KhankeldievaEnglishBackground: Disorders of vegetative regulation in asthma relates to both adrenergic and cholinergic link. Maintenance of the vegetative balance in the development of the pathological process allows maintaining the achieved level of compensation to ensure adequate peripheral blood flow and normal bronchial tone. Objective: To assess the hyper sympathicotonic reaction in chindren with bronchial asthma. Methods: Characteristics of vegetative status in adolescents with asthma is evaluated. Further, the structure of the heart rhythm in patients with bronchial asthma depending on the initial vegetative tonus in children is characterized. Results: Patients in this group increased somewhat the share of hyper sympathetic reactive children (30,8% vs 23,1% before treatment; PEnglishBronchial asthma, Autonomic regulation, Hyper-sympathicotonia, Helio-geomagnetic, Cephalgia, Cardialgiahttp://ijcrr.com/abstract.php?article_id=3215http://ijcrr.com/article_html.php?did=3215

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareEfficacy of Fumigation in Management of Rodents in Rice Shellers in District Kaithal, India English130134Priyanka ChaudharyEnglishIntroduction: Rodents are the most destructive among all the vertebrate pests. Rodents cause heavy losses to crops as well as to stored food grains. Rodents contaminate food with their urine, hair and droppings causing large scale infestation. Also, rodents are carriers and reservoirs of many diseases. Chemical control of rodents is the most practical, popular, effective and economic method. Objective: This study was conducted in randomly selected different sized rice shellers in district Kaithal to devise an effective management strategy of rodents using chemical method. Methods: In the present study, fumigation treatment was done through celphos (aluminium phosphide) tablets for the management of rodents in randomly selected different sized rice shellers in dist. Kaithal. Results: A significant reduction in rodent populations by analysing through tracking markers census and bait intake census before and after fumigation. Significant control success was achieved resulting in 80.75%, 76.6% and 63.9% reduction in tracking marker census and 81.45 (g), 72.97 (g) and 60.42 (g) reduction in bait intake (g)/ bait box/ day in small, medium and small-sized rice shellers respectively. Conclusion: Phosphine fumigation and venting can be achieved to disinfest grains stored in silo bags and the fumigant can be applied using widely available aluminium phosphide tablets in a method that must not contaminate the grain with residues. EnglishStored food losses, Rodents, Management, Fumigationhttp://ijcrr.com/abstract.php?article_id=3216http://ijcrr.com/article_html.php?did=3216

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareProtein Metabolism Disorders in Patients with Purulent Wounds with Thyrotoxicosis Against Diabetes Mellitus English135139O.M. KurbanovEnglish M.S. SharapovaEnglish A.N. ZulfikorovEnglish I.Sh. Muhammad ievEnglishIntroduction: The course of purulent wounds against the background of diabetes and the accompanying thyrotoxicosis is one of the urgent tasks of modern purulent surgery Objective: Improving the results of treatment of purulent wounds in patients with a combined pathology of thyrotoxicosis with diabetes mellitus, by studying disorders of protein metabolism. Methods: A retrospective analysis of the clinical course of purulent surgical diseases associated with thyrotoxicosis in patients with diabetes mellitus (DM) and an assessment of protein metabolism disorders in this category of patients was performed. Thyrotoxicosis in combination with diabetes was diagnosed in 104 (16.8%) of 619 patients treated in the clinical base of BSMI Results: In patients with purulent surgical diseases associated with thyrotoxicosis on the background of diabetes, there is a pronounced violation of protein metabolism, which negatively affects the course of the wound process. Conclusion: Timely correction of hormonal disorders in thyrotoxicosis and hyperglycemia leads to better treatment results. Such patients must be treated by an endocrinologist. EnglishPurulent surgical diseases, Endocrine system, Phlegmon, Hydradenitis, Purulent lymphadenitis, Panaritiumhttp://ijcrr.com/abstract.php?article_id=3217http://ijcrr.com/article_html.php?did=3217

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareThe Distal Row Carpal Bones - A Morphometric Treatise English140145Ripujit RandhawaEnglish Ravikant SharmaEnglish JS KullarEnglish Gaurav AgnihotriEnglishIntroduction: A comprehension of customized geometry of carpals is essential for preoperative planning and creation of implants and fixators. The present morphometric treatise on distal carpal bones has an anatomical, anthropological and clinical significance. Objective: To assess the gross morphological features with special emphasis on the dimensions and configurations of the articular facets. Methods: The study was done on 480 distal carpal bones.120 bones (60 right and 60 left) of each type (hamate, capitate, trapezoid and trapezium) were selected from the bone museum at Government Medical College, Amritsar. The morphometry and morphology of each distal carpal bone were studied. Results: The mean values as measured for right and left-sided bones when compared were found to be statistically insignificant (‘p’ value >0.01) for most parameters. A statistical significance was observed for the width of capitate at its base (‘p’ value EnglishDistal carpals, Morphometry, Morphologyhttp://ijcrr.com/abstract.php?article_id=3218http://ijcrr.com/article_html.php?did=3218

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcarePeculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome English146150Badritdinova MNEnglish Razhabova GKhEnglish Akhmedova ShMEnglish Akhmedova GIEnglishBackground: Diabetes mellitus and impaired glucose tolerance, in general, are more associated with the duration of painful episodes than normal glucose tolerance. However, in the presence of ischemic heart disease cardiac ischemia, the duration of painful episodes among patients with diabetes mellitus and impaired glucose tolerance is lower than among those without cardiac ischemia. Objective: To study the specifics of the duration of a painful attack in patients with coronary artery disease in the presence of the main components of the metabolic syndrome. Methods: Patienst with complaining of pain in the chest and his left hand were evaluated. In all patients parameters as blood pressure, body weight (Quetelet index), cholesterol, triglycerides, and glycemia were studied. Results: The study of the relationship between the duration of painful attacks and the presence of hypertension showed that the presence of hypertension significantly increases both the risk of coronary artery disease as a whole and the appearance of ischemic changes on the electrocardiography. The study of the duration of painful attack depending on body weight showed that the duration of painful attack among cardiac ischemia patients is lower than among those without this disease. Conclusion: The study suggests a link between the duration of painful attacks and the presence of the main components of metabolic syndrome. The data obtained to give a certain idea of the relationship between the duration of painful attacks in the chest and the presence of certain components of the metabolic syndrome. EnglishHypertension, Hyperlipidemia, Diabetes, Abdominal obesity, Metabolic syndrome, Painful attack, Coronary heart diseasehttp://ijcrr.com/abstract.php?article_id=3219http://ijcrr.com/article_html.php?did=3219

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareTo Assess the Effectiveness of Planned Teaching on the Knowledge Regarding Epilepsy in Children Among the Anganwadi Workers English151154Vaishali TaksandeEnglish Nilesh BurbareEnglish Karishma ChaureEnglish Nitisha DeogadeEnglish Shubham DeshmukhEnglish Jayshree DholeEnglishIntroduction: Epilepsy is the most common clinical entity in neurology clinics with prevalence of 18.5 (0.8–49.0) per thousand with major causes perinatal injuries. There are very few epidemiological studies looking at the incidence of epilepsy from India. As per a recent study, 70 million people have epilepsy worldwide and nearly 90% of them are found in developing regions. The study also estimated a median prevalence of 1.54% (0.48-4.96%) for rural and 1.03% (0.28-3.8%) for urban studies in developing countries. Objective: To assess the effectiveness of planned teaching on knowledge regarding epilepsy in children’s among the Anganwadi female workers in selected Anganwadi. Methods: The Descriptive evaluator approach was used in this study and the sampling technique was non-probability convenient sampling was used. Data was collected using a self-structured knowledge questionnaire and sample size was110 Anganwadi female workers. Result: Study shows that pretest knowledge of Anganwadi female worker 3(2.73%) had a poor level of knowledge score, 58(52.73%) had an average level of knowledge, 45(40.9%) had good knowledge and no one was in excellent knowledge score, whereas in post-test 65(59.09% had very good knowledge score and 23(20.91%) had excellent knowledge score. Conclusion: Neurologists, public health professionals, psychiatrists, psychiatric social worker, psychiatric nurse, and program managers need to join hands for prevention, improved care, and rehabilitation of persons with epilepsy in India. EnglishPlanned teaching, Epilepsy, female workers, Anganwadi and knowledgehttp://ijcrr.com/abstract.php?article_id=3220http://ijcrr.com/article_html.php?did=3220

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareInvitro Study to Analyse and Evaluate the Antimicrobial Activity of Coelomic Fluid of Earthworm Octochaetona suriensis (Michaelsen, 1910) English155160Rathod GeetaEnglish Hatti S.S.English Naresh RathodEnglishIntroduction: Earthworms are true coelomates, metamerically segmented annelids. The coelomic fluid of Earthworms is said to have demonstrated antimicrobial activity. Objectives: To study the antimicrobial activity of different concentrations (5 μl, 10 μl, 15 μl, 20 μl/ disc) of coelomic fluid of Earthworm O. suriensis (Octochaetona suriensis) against standard ATCC (American type culture cells /colonies) strains of microbes likeS. aureus (Staphylococcus aureus), E. faecalis (Enterococcus faecalis), E. coli (Escherichia Coli), P. aeruginosa (Pseudomonas aeruginosa) and C. Albicans (Candida albicans). Methods: A standard antibiotic disc of AMP (Ampicillin) 10 μg /disc was used as a positive control for bacteria and KT(Ketoconazole) 10μg/disc for fungi. A plane 6mm Whatman’s filter paper disc was used as a negative control on a Petri plate, that was incubated overnight at 37°C for bacteria and 25°C for fungi and results were tabulated. Results: The coelomic fluid of O. Suriensis has exhibited excellent antimicrobial activity against all ATCC strains of microbes even at minimum concentrations. In P. aeruginosa it has shown 20mm zone of inhibition at 5μl and at 37 mm zone of inhibition 20 μl, while standard antibiotic Ampicillin did not exhibit any zone of inhibition. In C. albicans it has shown 11mm zone of inhibition at 20μl which is very near to inhibition shown by positive control (ketoconazole 10μg/disc) 12mm. Conclusion: We conclude that coelomic fluid of earthworm O. suriensis is a potent antimicrobial substance. The molecular study should be carried out that may help us to discover new antimicrobial agents. EnglishEarthworms, Antimicrobial activity, Coelomic fluid, Octochaetona suriensis, Antimicrobial substances, Antimicrobial resistancehttp://ijcrr.com/abstract.php?article_id=3221http://ijcrr.com/article_html.php?did=3221

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareSocio-demographic Predictors of Cancer Patients Caregiver Burden: A descriptive Cross-sectional Study of Central India English161165Deepak MittalEnglish Shashi Prabha TomarEnglish Rajesh TiwariEnglishIntroduction: In India, around 2.0–2.5 million people are living with one or another kind of cancer menace and above 7–8 lakhs new cases added every year to the existing burden. Availability of data in this regard is mostly from developed countries where the social-demographic scenarios are quite different from developing countries on comparing data from developed countries. Although fewer studies had been carried out in India in this regard seems to be non-sufficient for addressing the problem. Objective: To explore social-demographic predictors of Caregiver burden among caregivers of cancer patients attending cancer hospital Jabalpur. Methods: This is a descriptive cross-sectional, hospital-based study conducted in cancer hospital Jabalpur in 340 caregivers. Chi-square test was applied to determine the association of study variables with caregiver burden. Results: Mean scores as assessed by ZBI was found to be 38± 11 (median = 36). 197 (57.9 %) caregivers were male, 143 (42.1%) were female. 81 % of males feel cared for giving burden, while among females only 55 (41.4%) feel it. Despite contributing only 40.6% study population, urban caregivers experienced significantly high (82%) caregiver burden. the maximum caregiving burden observed in middle class 86.4%, which constitutes only 25% of the study population and the caregiver burden was found statistically significant. Conclusion: These finding suggested coping with the problem of care-giving burden more policies and programmes in this direction should have been planned with special attention particularly to reduce burden amongst those having more suffering. EnglishZarit burden Interview, Institutional ethics committee, Caregiver burdenhttp://ijcrr.com/abstract.php?article_id=3222http://ijcrr.com/article_html.php?did=3222

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareSerum Magnesium, Manganese and Selenium in Diabetes Mellitus Patients and Their Association with Glyoxalase-1 English166172Shaik Fayazul HaqEnglish Kamla Pati MishraEnglish Busi KarunanandEnglish Dinesh Kumar SharmaEnglish Ajit SinghEnglishIntroduction: Glyoxalase-1, an erythrocyte enzyme of the glyoxalase system catabolizes the methylglyoxal is the main precursor of advanced glycation end products (AGEs). Elevated methylglyoxal and AGEs are strongly associated with the development of diabetic complications. The association between trace elements and glyoxalase-1 in diabetic patients is not well established. Objective: To assess the concentration of serum Mg, Se, and Mn in diabetic patients and compare these in different groups defined in terms of duration of the DM. Methods: The present study compares the concentration of micronutrients (magnesium, selenium, and manganese) in non-complicated (group A ≤4 years) and complicated (group B >4years) diabetes mellitus type-2 patients. Sixty-four (50.8%) patients were in group A, and 62 (49.2%) patients in group B. This cross-sectional study also correlates the concentrations with glyoxalase-1 levels. Results: Glyoxalase-1 has shown higher concentration in group B than A (50.65±5.32 vs. 41.29±3.58 ng/mL; p-value EnglishMethylglyoxal, Advanced glycation end products, Micronutrients, Diabetic complications, Nephropathy, Retinopathy, Neuropathyhttp://ijcrr.com/abstract.php?article_id=3223http://ijcrr.com/article_html.php?did=3223

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcarePrimer Screening and Genetic Diversity Analysis of Jabon putih (Anthocephalus cadamba (Roxb) Miq.) based on Random Amplified Polymorphic DNA (RAPD) Markers English173178Siti Halimah LarekengEnglish Rathna PaelonganEnglish Yuni Fitri CahyaningsihEnglish NurhidayatullahEnglish Muh. RestuEnglishIntroduction: Jabon putih population has currently decreased because of intensive exploitation and land use conversion. Genetic diversity is an essential factor in maintaining the existence of a species. Objective: The objective of this study was to determine the genetic relationship in Jabon putih from the genetic resource area of the second region of Seed/Seedling Forest Office in Bellabori, Parangloe, Gowa, based on RAPD markers. Methods: The analysis was carried out using 145 DNA samples from seven populations. Primer screening using randomly selected twelve DNA observed three polymorphic primers out of 21 screened RAPD primers. Result: The polymorphic primers were OPP-08, OPY-09, and OPD-20. The mean of heterozygosity was 0.46, and that of the highest was detected in Luwu Population and Wajo Population (0.48, respectively). Conclusion: The individuals tended to randomly group (did not group according to their provenances), and consequently, the genetic diversity among populations is high. EnglishGenetic diversity, Jabon putih, RAPD, Primer Screeninghttp://ijcrr.com/abstract.php?article_id=3224http://ijcrr.com/article_html.php?did=3224

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareNewborn Screening for Congenital Hypothyroidism in Institutional Set Up in an Urban Area in Odisha English179182Prasanna Kumar SahooEnglish Arakhita SwainEnglish Gangadhar SahooEnglish Smaraki MohantyEnglish Kulani BarikEnglishBackground: Congenital hypothyroidism (CH) is the most common preventable cause of mental retardation. Clinical manifestations of CH are not usually manifested at birth and remain undetected. The undetected CH infants show signs and symptoms of mental retardation at later age. Newborn screening for CH is a cheap and affordable tool to detect CH at birth to prevent mental retardation. There is the paucity of studies for detection of CH in this region of Odisha, hence this study. Objective: To ascertain the incidence of CH in newborn babies and the effect of different variables on the level of TSH at birth. Methods: This is retrospective observational study in babies born in selected centre of Odisha and newborns attending for a normal health check-up within 3-5 days. Estimation of TSH level from venous blood samples collected from 1530 neonates, included in this study, at 72-120 hours after birth and from 163 newborns, recalled for reestimation, at 21-30 days. Results: Out of 1530 neonates, no case of CH was found. Incidence of CH was zero. However, different variants influenced the level of TSH. Level of TSH decreased with the advancement of age. Neonates with male sex, low birth weight and those born by vaginal delivery had a significantly higher TSH. Gestational age and parity did not affect TSH level.163 neonates probably had Transitional Hypothyroidism. Conclusion: CH can be detected at an affordable cost which outweighs the cost of investigation and treatment of CH and mental retardation in later life. EnglishThyroid Stimulating Hormone (TSH), Newborn Screening (NBS), Congenital Hypothyroidism (CH).http://ijcrr.com/abstract.php?article_id=3225http://ijcrr.com/article_html.php?did=3225

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcarePossible Management Options for Manoswasthya in Ayurveda English183186Sunita GuptaEnglish Jancy JoshephEnglish Vinayak ShegaonkarEnglishAyurveda explains Manoswasthya in-depth & in a broad manner with the help of Yoga, Aahar & Sadvrittas. All these concepts of Manoswasthya play an important role to keep & maintain strong mental health. Mental Health is also an important subject like physical health. The clutches of numberless psychosomatic diseases due to stress. Ayurveda describes in a wide-ranging manner for keeping healthy manna that has been described in two ways – i) by explaining manovighat in diseases & ii) by explaining the maintenance of manoswathya in daily routine. Prasanna Means because of happiness of manna our soul gets strength & a person with prasannamanna can do every work with concentration, full efficiency & by using abilities. By doing such work, a person can solve many problems by giving suggestions to himself as well as others. Ayurveda explains Manoswasthya in-depth & in a broad manner with the help of Yoga, Aahar and Sadvrittas. Englishhttp://ijcrr.com/abstract.php?article_id=3226http://ijcrr.com/article_html.php?did=3226

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareThe Role of Emotional Intelligence on Health Care Professionals Occupational Stress and Burnout English187196Swarnima TiwariEnglish Deepak BhagatEnglishIntroduction: Though relevance and importance of emotional intelligence have been documented in various fields, yet, the emotional intelligence dimension of health care professionals has not been given adequate attention and very little empirical research has examined the role of EI on occupational stress. Objective: To systematically explore and describe the relationship between EI and the dimensions of occupational stress. Methods: To this aim, a sample of 257 nurses and 131 doctors working in hospitals, PHC’s, CHC’s, & sub-centres were selected from all the hospitals, CHC’s, and PHC’s. The study included 4 questionnaires: Emotional Quotient Test, Occupational Stress Index (OSI), Oldenburg Burnout Inventory (OLBI), and Perceived stress scale (PSS). Data obtained were analyzed using ANOVA, Pearson correlation, and multiple regression. Results: The results highlighted an inverse significant relationship between the dimensions of occupational stress and emotional intelligence. Additionally, a positive relationship was also found between age, working experience, and stress, with younger healthcare professionals and those with a shorter length of service experiencing more stress. However, EI and health are not related to age or length of service. Conclusion: The study concluded that emotional intelligence can help in reducing occupational stress among health care not only by decreasing or controlling the stressors present in the workplace but also by increasing the potential of employees to effectively deal with those stressors. EnglishEmotional Intelligence, Occupational Stress, Burnout, Perceived Stress, Healthcare, Doctors, Nurseshttp://ijcrr.com/abstract.php?article_id=3227http://ijcrr.com/article_html.php?did=3227

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareRhino-orbital Mucormycosis - A Dreaded Clinical Entity English197203Santosh Kumar SwainEnglish Smarita LenkaEnglish Saurjya Ranjan DasEnglishOrbital mucormycosis is a filamentous fungal infection which is found to be inflaming the orbit along with the cerebrum, initiating from paranasal sinus, is scrutinized in the department of Otorhinolaryngology. Mucorales remains common and frequently isolated microorganisms, causing mucormycosis but Mucor spp. and Rhizomucor spp., are responsible for 70% of total cases. Inflammation is initiated at paranasal sinus and is disseminated to orbit. The whole inflammatory process goes through four stages of pathogenesis. Germination is supported by high glucose, low oxygen concentration, high iron levels and acidic medium and then germinates into hyphae. This analytical review has tried to drag attention upon complete systematic steps of orbital mucormycotic infection including physical, clinical as well as the pathological presentation of orbital mucormycosis. Rhino-orbital mucormycosis is a dreaded clinical entity. It invades and occludes vascular lumina, forms a characteristic black eschar on paranasal sinus. The disease, through the ethmoid and maxillary sinuses, spreads to the paranasal sinuses into the orbit and then to the cranial cavity by way of the orbital apex, cribriform plate, orbital nerves or orbital vessels. It could be diagnosed by histopathologically, magnetic resonance imaging (MRI) and computed tomography (CT) scan. Epithelial cells and phagocytic cells help in host defence mechanism but Mucorales spores trap the nasal epithelial cells coming to contact with GRP78 through fungal spore coat protein CotH3 and harm the primary cell lining. By utilizing iron chelators, hyperbaric oxygen and immunity-boosting of individuals can be proved as a complementary process to the management of orbital mucormycosis. EnglishMucormycosis,rhino-orbital mucormycosis, Amphotericin B. paranasal sinushttp://ijcrr.com/abstract.php?article_id=3228http://ijcrr.com/article_html.php?did=3228

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareSynthesis and X-Ray Crystallographic Study of N,N’-bis(2-, 3-, and 4-methoxybenzamidothiocarbonyl) Hydrazines English204210Syadza FirdausiahEnglish Siti Aishah HasbullahEnglish Bohari M. YaminEnglishIntroduction: Most of carbonyl thioureas have been synthesized from the reaction of carbonyl isothiocyanate with amine compound in acetone. Only a few of them have been synthesized from diamine compound to produced bis-carbonyl thioureas. Objective: To investigate the one-pot reaction of 2, 3, and 4-methoxybenzoyl chloride with ammonium thiocyanate and hydrazine in acetone by reflux condition. Methods: Each of the crystal compounds was analysed by X-ray crystallography. Result: Three compound of bis-thiorea derivatives, namely N, N’- bis (2-methoxy-benzamidothiocarbonyl) hydrazine (1), N, N’- bis (3-methoxybenzamidothiocarbonyl) - hydrazine (2), and N, N’ - bis (4-methoxybenzamidothiocarbonyl) hydrazine (3) were successfully synthesised by the reaction of each 2, 3, and 4-methoxybenzoyl chloride with ammonium thiocyanate and hydrazine in acetone. The structure of these compounds was studied by chemical crystallography. Conclusion: Compound 1 and 3 were crystallized in the triclinic crystal system while compound 2 was crystallized in the monoclinic crystal system. The thiourea moiety in all compounds have trans geometry and each of the hydrogens of the amide group is trans to the carbonyl group. EnglishBis-carbonyl thiourea; bis-thiourea; carbonyl thiourea; N, N’-bis(benzamidothiocarbonyl) hydrazine derivatives; X-ray Crystallographyhttp://ijcrr.com/abstract.php?article_id=3229http://ijcrr.com/article_html.php?did=3229

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareKnowledge and Attitude Towards Covid 19 Among Indian Residents: A Cross-Sectional Study English211216Manisha PraharajEnglish Kshirabdhi TanayaEnglish Saurjya Ranjan DasEnglishBackground: The 2019 coronavirus outbreak has caused a global health epidemic which changed the way we view our environment and our daily lives. The rate of transmission challenged our sense of identity and for safety and to prevent the spread of infection also need social distancing. Objectives: The survey aimed to assess the knowledge & attitude on coronavirus infection among the general population. Methods: A total of 620 participants from Odisha urban community agreed to participate in the survey regarding COVID-19. A self-structured questionnaire was used to collect data. Participants were selected by convenient sampling method. The demographic characteristics were represented by frequencies and percentage. Descriptive statistics used to calculate mean, SD and P-value. Results: Among the participants (n=620), most of the participants 75.9% were females, more than half 59.4% of participants were between 31 to 40 years, majority 75.1% were living in the nuclear family, the majority 76.4% participants were married and a majority 75.9% were completed graduation. 80.28% of participants have good knowledge, 58.03% of participant’s attitude was positive. Most of 72.6 % participants believe India can win the battle against COVID 19, 85.1% reported that their daily routine changed due to the pandemic. Conclusion: The emerging coronavirus disease outbreak demands all people should maintain a minimum of 1-meter distance from each other and different various methods to ensure the safety of general people. There is a need for active public awareness, clear information, and strict guidelines to improve the knowledge and attitude of the general population. EnglishCovid-19, Knowledge, Attitude, Cross-sectional Studyhttp://ijcrr.com/abstract.php?article_id=3230http://ijcrr.com/article_html.php?did=3230

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareIndependent Prognostic Factors of Burns Injury and Evaluation of RPR as an Important Risk Factor English217228Kirti PanwarEnglish Amit YadavEnglish Sheetal AroraEnglish Meenakshi ShankarEnglishBackground: Injuries from burn remain the second largest group of injuries after road traffic accidents. Approximately 1-1. 5 lakh people die from burns and around 2.8lakh people require multiple surgeries and prolonged rehabilitation. Objectives: To evaluate independent prognostic factors of burns injury and evaluation of RPR as an important risk factor. Methods: The present retrospective study patients of all age groups admitted to burns department from 1st March 2018 to 31st May 2018 with variable %TBSA burned were included. For 100 patients noted the clinical details like age, gender, burn index, inhalation injury if present, complete blood count, blood urea and serum creatinine levels. Medical notes were used to retrospectively record the patients. Their blood samples were routinely collected between 5 am and 7 am during 5th, 7th, 10th and 20th-day post-burn. The medical records were used to document the time from injury to adverse events. Results: The age, % of burns, RDW, RPR, MPV, WBC, urea and creatinine values were considerably high in patients with mortality in the day 5, day 7, day 10 and day 20 datasets, whereas the haemoglobin, platelet values were low. Conclusion: In this study, results indicated that parameters like haemoglobin, RDW, blood urea and serum creatinine and % of burns are statistically significant independent mortality predictors in burn patients. Whereas, RPR did not prove to be a statistically significant independent mortality predictor. EnglishBurn Injuries, independent Prognostic factors, RDW to platelet ratio, Burn injuries, Multiple surgerieshttp://ijcrr.com/abstract.php?article_id=3231http://ijcrr.com/article_html.php?did=3231

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14HealthcareDevelopment in Drug Discovery English0101Dr. Little MahendraEnglishEnglishhttp://ijcrr.com/abstract.php?article_id=3232http://ijcrr.com/article_html.php?did=3232

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411224EnglishN2020December14Healthcare Menstrual Irregularities in Adolescent Girls and Correlation with the Extent of Exposure to Plastics: A Case-Control Study English229235Suman YadavEnglish Irsad AhamadEnglish Smita BhatiaEnglish M. Gouri DeviEnglish Rita SinghEnglish Introduction: Menstrual irregularities in adolescent girls are rapidly increasing worldwide. Exposure to endocrine-disrupting chemicals such as plastics including Bisphenol A (BPA), Phthalates and Polyvinyl chloride (PVC) are potential environmental toxins contributing to hormonal imbalance and irregular menstrual cycles. Aim/Objectives: We examined the association between plastic usage and menstrual cycle characteristics among Adolescent girls aged 15–19 years who were participating in a questionnaire-based cohort study under the program on reproductive health awareness in adolescent girls. Materials and Methods: A case-control study of 360 girls was conducted in 2016 and 2019 in a school in Rajasthan, India. We used self-reported information through a questionnaire to assess the association of irregular menstrual cycles (≤25 days and ≥35 days) with extent of plastic usage categorized here as medium and high. Results: The study cohort had a high prevalence of irregular menstrual cycles (40.8%). Heavy plastic exposures increased the chances of getting irregular periods significantly. Girls with irregular menstrual cycles had more prevalence of hair fall, acne, acanthosis nigricans, and abnormal hair growth/hirsutism. Girls with family history of diabetes and CVD were more susceptible to develop irregular menstrual after heavy usage of plastics. Both medium and high exposures to plastics were associated with abnormal hair growth/hirsutism (p EnglishPlastics, BPA, Phthalates, PVC, Irregular, Menstrual cyclehttp://ijcrr.com/abstract.php?article_id=4706http://ijcrr.com/article_html.php?did=4706 1. De Sanctis V, Rigon F, Bernasconi S, Bianchin L, Bona G, Bozzola M, et al. Age at Menarche and Menstrual Abnormalities in Adolescence: Does it Matter? The Evidence from a Large Survey among Italian Secondary School girls. Indian J Pediatr. 2019 Jan;86(Suppl 1):34-41 2. Patel S, Zhou C, Rattan S, Flaws JA. Effects of Endocrine Disrupting Chemicals on the Ovary. Biol. Reprod. 2015 Jul; 93(1):20. 3. Glueck CJ, Woo JG, Khoury PR, Morrison JA, Daniels SR, Wang P. Adolescent oligomenorrhea (age 14-19) tracks into the third decade of life (age 20-28) and predicts increased cardiovascular risk factors and metabolic syndrome. Metabolism. 2015 Apr;64(4):539-53. 4. Thein-Nissenbaum JM, Rauh MJ, Carr KE, Loud KJ, McGuine TA. 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Endocrinol. 2019 Dec; 35(12):1084–1087. 29. Xin F, Susiarjo M, Bartolomei MS. Multigenerational and transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation? Semin. Cell Dev. Biol. 2015 Jul; 43:66–75.