Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareLactate Dehydrogenase as Predictor for Severity in Sickle Cell Disease English0305M. A. EhteshamEnglish Bhavana LakhkarEnglish Rakesh AdkaneEnglishIntroduction: Pyruvate to lactate in a glycolytic pathway is caused by enzyme lactate dehydrogenase (LDH) with the conversion of NADH TO NAD+. Lactate dehydrogenase can be found in different body tissues. For hemolysis marker lactate dehydrogenase levels can be used. In sickle cell anaemia patient those who are in the steady-state (SS) there will be an increase in the level of lactate dehydrogenase(LDH). In sickle cell disease, the life of the patient is hampered due to crisis and it is very difficult to predict the crisis. Hence in our study, we used a marker lactate dehydrogenase (LDH ) to predict the severity of the crisis. Objectives: To study the ability of serum LDH levels in predicting the severity of disease in sickle cell anaemia. Methodology: To achieve the objective we assess serum LDH levels during steady-state and crisis and to correlate above with chronic complications (PH, Microalbuminuria, Liver functions) and severity of the crisis.Patients fulfilling selection criteria will be recruited after obtaining written consent. Detailed history including the age of onset, frequency and severity of the crisis, frequency of admissions and transfusions, quality of follow up, quality of treatment received will be taken. Detailed examination including anthropometry will be recorded. The severity of the acute crisis will be decided based on the duration of pain more than 2 days, need for admission & stay more than 3 days, death, need for surgery, need for support and need for other procedure. Expected Results: We expect the LDH level to be significantly higher during the crisis. If steady-state patients are considered LDH level will be high in patients with moderate and severe disease (frequency more than 3/ year). EnglishLactate Dehydrogenase, Sickle Cell Disease, Predictionhttp://ijcrr.com/abstract.php?article_id=3111http://ijcrr.com/article_html.php?did=3111

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareClinical Profile of Children with Cerebral Palsy English0609Pooja KumariEnglish Jayant VaghaEnglish Prachi PalsodkarEnglishBackground: Cerebral palsy is a broad range of static, non-progressive motor disabilities that present from birth or early childhood as a result of injury to neuromotor components of the central nervous system. Etiologies are numerous and can occur during prenatal perinatal and postnatal periods. Methods: The study was conducted throughout 1year in the department of Paediatrics JNMC, Sawangi. The study population included children diagnosed with CP. Exclusion criteria were non-consenting patients with non-central causes of motor deficit. The cases were studied for presentation and sent for appropriate referrals during study and analysis was done by the use of appropriate statistical methods. The patient is diagnosed with help of history and clinical finding which are correlated together to make a diagnosis of cerebral palsy. Special focus is given on the central nervous system examination. Total of 113 patients is included in the study up to the age of 16 years. Expected Results: During the study period 113 patients up to the age of 16 years are expected to show functional disability and developmental delay with an overall male: female ratio of 1.3:1 and more commonly in male patients. English Clinical profile, Cerebral palsy, Developmental delay, Children, Perinatal insulthttp://ijcrr.com/abstract.php?article_id=3112http://ijcrr.com/article_html.php?did=3112

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareBirthing Simulator (SIMMOM) as a Learning Tool for Skills Development in Management of Normal Labour English1012Sandhya S PajaiEnglish Neema AcharyaEnglish Nicole DoundEnglish Arvind PatilEnglishBackground: We aim to compare the effectiveness of traditional video demonstration vs. simulation-based training on SimMomin terms of competencies in interns regarding the management of normal labour and to study their perception of both the methods. Methods: This study will be conducted over 1 year in the department of obstetrics and gynaecology in association with a virtual school of learning at DMIMSDU after acquiring ethical committee clearance.100interns of the department of obstetrics and gynaecology will be divided into two groups of 50 each. Group 1 will be provided video lecture-based training on normal labour, Group 2 will be provided birthing simulator(SimMom) used as a learning tool. Results: There will be a significant improvement in skill-based competencies of trainees who undergo simulation-based learning compared through those who undergo video-based learning for management of normal labour. Conclusion: Hence simulation-based learning should be part of routine intern training in the curriculum in management of normal labour apart from didactic video sessions for better acquisition of skill-based competencies. English SimMom, Normal labour, Skills developmenthttp://ijcrr.com/abstract.php?article_id=3113http://ijcrr.com/article_html.php?did=3113

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareThe Effect of Antenatal and Postnatal Pelvic Floor Muscle Training on the Risk of Developing Pelvic Floor Dysfunction - A Cohort Study English1315Neema AcharyaEnglish Manjusha AgrawalEnglish Priyanka SinghEnglish Tejaswini FatingEnglishIntroduction: Pelvic floor dysfunction is a common gynaecological problem affecting women’s health apart from their quality of life. It manifests as Urinary and faecal incontinence and pelvic organ prolapse. The present evidence is not conclusive about the need and long term benefits of pelvic floor muscle rehabilitation. Objectives: The present study is aimed to study the effect of antenatal and postnatal rehabilitation of the pelvic floor by pelvic floor muscle training. Methods: The occurrence of pelvic floor muscle. The dysfunction will be assessed periodically in a cohort of women who receive pelvic floor muscle training antenatally and postnatally and compared with that in a comparable cohort of women who didn’t receive. Results: The anticipated results are that the pelvic floor muscle dysfunction will be significantly more in women who did not receive muscle training. Conclusion: The occurrence of pelvic floor muscle dysfunction will be significantly more in a cohort of women who receive pelvic floor muscle training antenatally and postnatally and compared with that in a comparable cohort of women who didn’t receive. English Stress, Urinary incontinence, Pelvic floor muscle, Pelvic organ prolapsehttp://ijcrr.com/abstract.php?article_id=3114http://ijcrr.com/article_html.php?did=3114

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcarePolycystic Ovarian Syndrome (PCOS) in Obese Metabolic Phenotypes English1618Neema AcharyaEnglish Sourya AcharyaEnglish Samarth ShuklaEnglish Ketav JoshiEnglish Uplabdh GopalEnglishIntroduction: Obesity can be divided into metabolic syndrome (MetS) or metabolically unhealthy obesity (MUO) and metabolically healthy obesity (MHO). In the current scenario, with researches nearing a definition for MHO, it becomes crucial to establish the risks of associated comorbidities of obesity in its subtypes, namely MHO and MetS. With PCOS being generally associated with obesity and an increased risk of cardiovascular diseases, research must be done to determine its relation with MHO and MetS. Objectives: Therefore, the purpose of this study is to investigate and compare the key anthropometric and metabolic frameworks of women having PCOS in obese phenotypes, namely, MHO and MetS/MUO in the reproductive age group. Results: The clinical attributes and metabolic aspects in women having polycystic ovarian syndrome with MHO will be significantly different than those found in PCOS with MetS/MUO in the reproductive age group. Conclusion: The clinical and metabolic aspects of women with MHO as study group will be different in PCO women with or without MetS/MUO and may have more risk of development of the cardiovascular disease. English Obsesity, Metabolic syndrome, Polycystic ovarian syndrome, Metabolically healthy obesityhttp://ijcrr.com/abstract.php?article_id=3115http://ijcrr.com/article_html.php?did=3115

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcarePrediction of Pre-Eclampsia by Urinary Calcium and Creatinine Ratio English1922Smriti KhandelwalEnglish Surekha TayadeEnglish Chetan GodeEnglishBackground: Prediction of preeclampsia and instituting preventive measures in high-risk individuals will favourably affect pregnancy outcomes. Urinary calcium/creatinine ratio is a low-cost biochemical test for prediction of preeclampsia which has not been studied extensively especially in a rural setup. This study aims to evaluate its efficacy. Objectives: To study urinary calcium/creatinine ratio in pregnant women of rural setup and determine its association with preeclampsia to assess it as a screening stool for its prediction. Methods: This is a prospective observational study wherein 500 pregnant women will be recruited after informed consent before 20 weeks of gestation and urinary calcium creatinine ratio will be calculated from a spot sample. The study participants will then be followed up until their delivery to note the development of preeclampsia. A low ratio will be considered as a good predictor. Results: The researcher will note hypertensive disorders in study subjects and classify them according to severity. Mean urinary calcium creatinine ratio will be determined and the role of its spot value for predicting preeclampsia will be evaluated. A low value is expected in women with pre-eclampsia as compared to normotensive women. Conclusion: Depending on the study outcome, we would like to comment on the frequency of preeclampsia and the effectiveness of urinary calcium creatinine ratio in predicting it in a low resource setting. EnglishPre-eclampsia, Urinary calcium, Urin creatinine, Ratiohttp://ijcrr.com/abstract.php?article_id=3116http://ijcrr.com/article_html.php?did=3116

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareCorrelation of Intraoperative Findings & Foetal Outcome in Patients with Caesarean Section for Non-Reassuring Foetal Status on Cardiotocography English2326Nicole DoundEnglish Sandhya PajaiEnglish Amoli BelsareEnglishIntroduction: Instances of foetal distress if not detected at the earliest can lead to adverse foetal outcomes, so proper surveillance in terms of cardiotocographic abnormal findings, intraoperative findings have to be monitored as its early recognition can avoid unfavourable circumstances because of the foetal outcome by shortening the decision to delivery time(caesarean section in this case). Aim: To study the correlation of Intraoperative findings (like meconium-stained liquor, cord around the neck of the foetus) and foetal outcome (like Apgar score at birth and 5 mins, NICU admission) in patients undergoing C-section for foetal status which is non-reassuring on Cardiotocography. Study Population: Methods: This is prospective observational study In labouring patients with non-reassuring foetal status will be conducted from September 2019 to September 2021. The study will be done on patients who are labouring. Pregnant women who underwent caesarean section for non-reassuring foetal status as detected by cardiotocographic changes and fulfilled the inclusion criteria will be enrolled in the study after due written consent. Patients history in detail, G.A, P/A, P/V & P/S examination, including Cardiotocography, will be recorded in a proforma. Results: The abnormal cardiotocographic changes seen on CTG may be related to intraoperative findings and adverse foetal outcome, justifying the need for a caesarean section., or they may not be related causing a rise of unnecessary caesarean sections. Conclusion: Considering the rise of unnecessary caesarean sections a proper interpretation of CTG tracings and precisely picking up cases of foetal distress is important and likely to improve foetal outcome. EnglishFoetal distress, Cardiotocography, Intraoperative findings, Pregnancyhttp://ijcrr.com/abstract.php?article_id=3117http://ijcrr.com/article_html.php?did=3117

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareLabour Outcome in “Programmed Labour” and “Expectant Management of Labour”: A Comparative Study English2730Saunitra InamdarEnglish Himanshi AgarwalEnglish Shikha ToshniwalEnglish Aarti MishraEnglish Rakhi WaigiEnglishBackground: Programmed labour targets at curtailing the duration of labour, pain during labour and frequency of cesarean section and ameliorate the maternal and neonatal outcome. Till now, the approach to pain during labour has been passively managed, but with the help of programmed labour protocol, obstetricians try to alleviate the misery and the complications of obstructed labour, sepsis, prolonged labour along with dehydration, acidosis, exhaustion and post-partum haemorrhage have been reduced. Objectives: This study focuses on, to conduct the active management of all stages of labour and analgesia or pain relief during labour. The present study is a prospective case-control study, conducted in our hospital in 2 years. Methods: The sample size includes 1000 women and of them, the women who are low-risk primigravida in the active phase of labour and keen to participate are included in the study group and those who are not ready to participate are included in the control group. Result: The study group is subjected to the programmed labour protocol, in form of Active management of the first stage of labour, analgesics, smooth muscle relaxants, sedatives with photographic monitoring of labour. Conclusion: All the patients who are included in both, the study group and the control group are evaluated based on the duration of labour, pain relief, mode of delivery, APGAR score at birth, maternal and foetal outcome. English Programmed Labour, Expectant Labour, Induction of Labour, Analgesics, Antispasmodicshttp://ijcrr.com/abstract.php?article_id=3118http://ijcrr.com/article_html.php?did=3118

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareTherapeutic Hypothermia in Moderate and Severe Hypoxic-Ischemic Encephalopathy: Use of LowCost vs High Technology Cooling Technique English3134Bhavana B. LakhkarEnglish Sachin DamakeEnglish Revat MeshramEnglish Shyam LohiaEnglish Sagar KarotkarEnglishIntroduction: Birth asphyxia is a leading cause of death and neurodevelopmental problems in children. Perinatal insult is the common cause for brain injury and therapeutic hypothermia is said to be beneficial. State of the art equipment for hypothermia is costly and may not be available in institutions where birth asphyxia is common. Aims and Objectives: To compare the effect of low-cost cooling techniques with high-cost cooling techniques in terms of morbidity and mortality and neurodevelopmental outcome at 12 months age. Methods: All the term babies who present within 6-12 hours of birth and have moderate to severe encephalopathy will be recruited. Babies will be randomised for Low cost or high-cost cooling technique. Babies will be started on therapeutic hypothermia and will be monitored as per protocol. This will continue till 72 hours and then slow re-warming will be achieved. Any complications will be treated as per NICU protocol. Baby will be discharged when feeding is achieved and is vitally stable. Baby will be followed up until one year of age. Outcome Measures: Death, duration of stay, neurological status at discharge and neurodevelopmental outcome at one year will be the outcome measures. English Therapeutic hypothermia, Birth asphyxia, Neurodevelopmentalhttp://ijcrr.com/abstract.php?article_id=3119http://ijcrr.com/article_html.php?did=3119

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareEvaluation of the Correlation between Spot Urinary Protein/Creatinine Ratio and Serum Uric Acid and its Association with Feto-maternal Outcome in Hypertensive Pregnancy English3537Arzoo ChadhaEnglish Mehul SalveEnglish A.V. BapatEnglishBackground: Hypertension complicating pregnancy affects almost 7- 15% of all gestations and accounts for approximately one-fourth of all antenatal admissions. Serum uric acid is a predictor of oxidative stress, tissue injury and renal impairment, and thus may be useful in detecting preeclampsia complications. The Spot Urinary Protein / Creatinine Ratio (P/C) predicts with high accuracy the amount of urinary protein excretion 24 hours a day. Objective: To study the Spot Urinary P/C Ratio and Serum Uric Acid levels as prognostic indicators and their effect on feto-maternal outcome in females with singleton pregnancy suffering from pre-eclampsia. Methodology: A basic head to toe examination followed by a systemic examination of CVS and RS system would be done. BP values would be recorded for all cases and controls at 4 hourly intervals. A complete obstetric examination will be conducted to clinically assess various maternal and fetal parameters. Investigations will include complete blood count (CBC), liver function test, kidney function tests, Urine test, and level of uric acid and lactate dehydrogenase (LDH). Clinical follow up till of all cases till delivery to look for progression of preeclampsia/eclampsia. Involvement of other organ systems will be noted if any. Results: There exists a positive correlation between Spot Urinary P/C Ratio and Serum Uric Acid and adverse feto-maternal outcome. Conclusion: Urine collection is easy and hassles free in addition to being non-invasive and cost-effective. It requires simple instruction for collection. Hence, Spot Urinary P/C Ratio and Serum Uric Acid is a useful approach for monitoring women with pre-eclampsia at community and hospital setting. Key Words: Urinary protein, Urinary creatinine, S English Urinary protein, Urinary creatinine, Serum uric acidhttp://ijcrr.com/abstract.php?article_id=3120http://ijcrr.com/article_html.php?did=3120

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareEvaluation of Postoperative Analgesia Using Clonidine as an Adjuvant with Caudal Bupivacaine in Paediatric Patients Posted for Infraumbilical Surgery English3842Sinjini AgarwalEnglish Neeta Chaudhary (Verma)English Amol SingamEnglish Kavita SinghEnglishIntroduction: Caudal block epidurally is a highly popular means of administering pain relief to children undergoing infra-umbilical surgeries. Addition of clonidine, a centrally acting alpha 2 agonist as an adjuvant to caudal Bupicaine has added advantages of providing prolonged postoperative analgesia and also, thus reducing the no. of doses of postoperative rescue pain relief agents. Objective: To compare the efficacy and safety of caudally administered clonidine as an adjuvant to bupivacaine. Methods: The study will be carried out with 40 patients in each group randomly allocated using computer-generated software, posted for infraumbilical surgeries between the age group 2 years to 7 years, ASA grade I and II. Children less than 2 yrs or more than 7 yrs, ASA grade III-IV, in case of any allergy to drugs involved in this study, serious cardiac or respiratory disease, history of developmental delay or mental retardation, caudal block site infection if present, then it will be excluded from the study. Group B (control group) Caudal epidural with 0.25% bupivacaine 1 ml/kg +1 ml Normal saline (NS) Group C (study group) Caudal epidural with 0.25% bupivacaine 1ml/kg with clonidine 1 ug/kg+1ml Results: It is expected that the duration and quality of postoperative analgesia in group C will be prolonged as compared to that in group B. Haemodynamic changes with no significant difference between the 2 groups are expected. Also minimal or no adverse effects are anticipated. Conclusion: We expect to conclude that caudally administered clonidine, in a dose of one microgram /kg as an adjuvant to 0.25% bupivacaine 1 ml/kg, will prove to be efficacious in providing prolonged analgesia both intraoperatively and postoperatively. Also, we hope that this addition reduces the requirement of postoperative rescue analgesia and its associated side effects. English Caudal block, Neuraxial block, Caudal epiduralhttp://ijcrr.com/abstract.php?article_id=3122http://ijcrr.com/article_html.php?did=3122

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareThe Study Protocol of Comparative Study on Efficacy of Marma Chikitsa, Agnikarma and Physiotherapy in Avabahuka (Frozen shoulder) English4347Amol DeshpandeEnglish Priti DesaiEnglish Mayuri DeshpandeEnglish Sonali ChoudharyEnglish A. R. NarkhedeEnglishBackground: Frozen shoulder or adhesive capsulitis is a disease that usually occurs between the age group of 40-70 years; the females and diabetic patients more prone to the disease. Physiotherapy and Agnikarama are the commonest modalities used for the treatment of this disease in contemporary science and Ayurveda respectively. The traditional Vaidyas, Nadi Vaidya and bonesetters are commonly practising another modality called Marma Chikitsa, however, the literature regarding this is very sparse. Objective: To compare the efficacy of Marma Chikitsa, Agnikarma and physiotherapy in Avabahuka. Methods: 150 patients of Avabahuka (frozen shoulder) will be randomly allotted to three groups having 50 patients in each. Group A will be treated with the Marma Chikitsa for the alternate day. Group B will be treated with the Agnikarma, which will be repeated after 7 days, such three settings will be done. Group C will be treated with the physiotherapy for 15 continues days which shall include Ultrasound, TENS and Exercise for a range of motion (ROM). Statistical Analysis will be done after the last visit of the patient for the anticipative outcome by using Paired t-test, Unpaired t-test and one way ANOVA tests. Results: We anticipate that Marma Chikitsa may have a better outcome as compared to Agnikarma and Physiotherapy. Conclusion: Marma Chikitsa will be the new inclusion in the therapeutic model of Avabahuka and also can be studied in different musculoskeletal disorders EnglishAgnikarma, Avabahuka, frozen shoulder, Marma Chikitsa, Physiotherapyhttp://ijcrr.com/abstract.php?article_id=3123http://ijcrr.com/article_html.php?did=3123

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareEvaluation of Recurrence rate of Bhagandar (Fistula in ano) managed by Udumbar (Ficusglomarata) KsheerSutra - Protocol English4851Pooja ShrivastavEnglish Kiran KhandareEnglish Manoj PatilEnglish Kavita SinghEnglishBackground: Bhagandar (Fistula in ano) is one among the Ashtamahagad (8 dreadful disorders). Most fistulas are thought to arise as a result of cryptoglandular infection with resultant perianal abscess. It has been a surgical problem because of the high number of postoperative complications such as incontinence of gases and faeces and recurrent course of the disease. Aim: Evaluation of recurrence rate of Bhagandar (Fistula in ano) managed by Udumbar (Ficusglomarata) KsheerSutra. Methods: Participants fulfilling the inclusion criterion will be selected.After the complete healing of the surgical wound and the external opening without any sign of recurrence the observation will start. The postoperative site will be assessed at 30th, 90th, 180th, 365th day (1, 3, 6 and 12 months) after the healing of the fistula. Failure was defined as a clinical diagnosis of fistula recurrence at any time in the postoperative follow-up defined by clinical interview and physical examination for perianal abscess or boil, pus discharge, tenderness and in durations. Faecal continence and patient satisfaction will be recorded at each follow-up visit and adverse events will be monitored. Results: Results will be drawn from the observations of objective parameters. Conclusion: This will be drawn based on statistical analysis of the collected data. EnglishAshtamahagad, Bhagandar, Fistula in ano, Apamarga KsharSutra, Udumbar KsheerSutrahttp://ijcrr.com/abstract.php?article_id=3124http://ijcrr.com/article_html.php?did=3124

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareStudy of Erectile Dysfunction in Prediabetes English5254Gaurav JagtapEnglish T K KambleEnglish Sunil KumarEnglish Y.U. ChitrivEnglishBackground: Diabetes is a setup chance factor for sexual dysfunction in men; a triple expanded danger of erectile dysfunction (ED) was archived in diabetic contrasted with nondiabetic men. Risk of ED had not been studied in Pre-Diabetics. This study had been planned to see Erectile Dysfunction prevalence in patients diagnosed with Prediabetes. Objectives: To correlate erectile dysfunction with cardiovascular risk factors in patients of prediabetes. Methods: This cross-sectional research study will be directed in the department of general medicine between august 2019 to September 2021. Cases will be selected by set questionnaires amongst prediabetes patients and controls will be selected as age and sex-matched normoglycemic patients. Expected Results: Prediabetes may be associated with the risk of erectile dysfunction. English Prediabetes, Erectile dysfunction, Testosteronehttp://ijcrr.com/abstract.php?article_id=3125http://ijcrr.com/article_html.php?did=3125

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareEffect of Platelet Rich Plasma Versus Steroid Infiltration on Planter Fasciitis English5558Priyanshu PandeyEnglish Nitin SamalEnglish S. S. KhedkarEnglishBackground: Plantar fasciitis (PF) is an overuse injury that seriously affects the patient’s daily activities and quality of life. Plantar fasciitis is often unclear and may be multifactorial because of high incidence in runners it is best populated to be caused by repetitive microtrauma. Risk factors include obesity, an occupation requiring prolonged standing and weight-bearing. Primarily it is a clinical diagnosis and a self-limited condition in the majority of patients. It takes months and years to resolve; thus poses challenges to treating clinicians. Methods: The study was conducted over 1 year in the department of orthopaedics JNMC Sawangi. The study population included patient diagnosed with plantar fasciitis clinically and radiologically. Total 30 patients were included in this study which was divided into 2 groups randomly group A and group B for PRP and local corticosteroid injection. Expected Results: Result will be summarized as-Number of cases included for analysis, sex distribution of study participant, sex ratio, prevalence among male and female, the age distribution of participants, socioeconomic status. English PRP, Corticosteroid, Plantar fasciahttp://ijcrr.com/abstract.php?article_id=3126http://ijcrr.com/article_html.php?did=3126

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareStudy of Facial Dermatoses in Adult Patients in Tertiary Care Hospital English5961Palak KediaEnglish Sugat JawadeEnglish Kavita SinghEnglishBackground: Face is the most prominent part of the body. Every person is concerned about their physical appearance. Even a single lesion on the face can cause anxiety and can lead to poor self-image. As there is the paucity of comprehensive data on facial skin disorders, this study has been taken up to determine the frequency and clinical characteristics of the skin disorders predominantly affecting face. Objectives: To study the prevalence & clinical pattern of facial dermatoses in adult patients. Methods: The study will be done in the Department of Dermatology, JNMC and AVBRH, Sawangi, Wardha. 1045 patients of age 18 years and above will be included after taking informed consent. After considering the inclusion & exclusion criteria, a record of patients with facial dermatoses will be maintained. Results: The result would be undertaken by SPSS. Conclusion: Conclusion will be based on the findings of the study. English Facial dermatoses, Acne, Pigmentation, Melasma, Facehttp://ijcrr.com/abstract.php?article_id=3127http://ijcrr.com/article_html.php?did=3127

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareCarotid Artery Evaluation and its Correlation with White Matter Hyperintensities: A Study Protocol English6264Kaustubh Anil MadurwarEnglish Suresh Vasant PhatakEnglish Chetan GodeEnglishBackground: White matter hyperintensity is an independent and one of the important risk factors than can foresee future stroke and is a very common MRI brain finding. It is one of the most accessible markers to access the effect of vascular hemodynamics on the brain. Carotid Doppler indices have a strong correlation with WMH mainly due to atherosclerotic plaques. Thus these indices we can predict the white matter Hyperintensity burden Objectives: Study cerebral white matter hyperintensities association with structural and hemodynamic parameters of the carotid artery. To calculate composite intima-media thickness. Evaluate white matter Hyperintensity into low and high burden plaques. Methodology: 76 patients with white matter hyperintensities will be included in the study subsequent Carotid artery Doppler will be performed to determine various indices which will be later be correlated to MRI findings Results: Statistical parameters like specificity, sensitivity, accuracy, negative predictive value and positive predictive value of each carotid Doppler value will be correlated to white matter score. ROC curve will be plotted to prove its diagnostic accuracy Conclusion: Using carotid artery doppler, we can predict the burden of T2/FLAIR white matter ischemic changes in the brain and thus can be used as a predictor of stroke. English Carotid Artery, White matter hyperintensities, Composite intima-media thicknesshttp://ijcrr.com/abstract.php?article_id=3128http://ijcrr.com/article_html.php?did=3128

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareComparative Study of Visual Acuity and Astigmatism Determination Between Small Incision Cataract Surgery and Phacoemulsification by Corneal Topography English6568Neha BajpayeeEnglish Pravin K. TidakeEnglish Prasanna M. PalsodkarEnglishBackground: Among adults as cataract being the most common cause of the correctable diminution of vision. There is 12.5 million blind, in India and blindness due to cataract is estimated to be 50% to 80%. Due to cataract, an additional 3.8 million become blind each year in addition to backlog against which cataract surgeries are done every year are 2.7 million. Two main approaches are there for cataract extraction 1)manual small incision cataract extraction. 2)phacoemulsification. Corneal astigmatism is a type of refractive error where point focus is not formed leading to unequal refraction. This plays an important role in compliance with post-cataract extraction surgery. Since the cornea is responsible for 70% of eyes refractive power, its examination by corneal topography is of clinical importance in determining the quality of vision. Objectives: 1) To study visual acuity changes between sics and phacoemulsification, 2) To study mean astigmatism between phacoemulsification and SICS.3)To estimate the net induced astigmatism and its association with refraction between SICS and phacoemulsification. Methods: A observational interventional study with 120 patients will be conducted in a hospital based setting utilizing the data of patients eye. Preoperative visual acuity, astigmatism and postoperative visual acuity and corneal astigmatism are compared in two groups. Expected Results: As compared to other studies present we expect to find to have a better visual outcome, the reduction is astigmatism by 6 weeks and less surgically induced astigmatism in the phacoemulsification group than Sics. EnglishSmall Incision Cataract Surgery, Phacoemulsification, Surgically Induced Astigmatism, Visual Acuity, Corneal topographyhttp://ijcrr.com/abstract.php?article_id=3129http://ijcrr.com/article_html.php?did=3129

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareEvaluation of Transdermal Fentanyl Patch as Preemptive Analgesia for Improvement of Postoperative Pain Relief in Patients Undergoing Major Abdominal Surgeries Under General Anaesthesia English6971Saranya REnglish Vivek ChakoleEnglish P. S. PatilEnglishBackground: In the postoperative period, pain is a major factor which increases morbidity. Major abdominal surgeries lead to debilitating pain after the surgery. Hence we are using transdermal fentanyl patch, applied during the pre-operative period, for effective pain control in the postoperative period. Methodology: 60 patients will be randomly selected belonging to ASA physical status I/II aged 20 years to 50 years, divided into two groups of 30 each. Group A will receive transdermal fentanyl patch 6 hours before surgery whereas Group B will receive a placebo transdermal patch. Both the groups will be compared based on the duration of postoperative analgesia, number of doses of rescue analgesia required and side effects ( if any ) Expected Result: It is expected that the group receiving fentanyl transdermal patch will have superior post-operative analgesia with the requirement of a lesser number of doses of rescue analgesia. English Transdermal, Fentanyl, Patch, Postoperative analgesia, Abdominal surgerieshttp://ijcrr.com/abstract.php?article_id=3130http://ijcrr.com/article_html.php?did=3130

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareCorrelation of Diet Regimen in Manifestation of Skin Diseases - A Survey Based on Ayurved Perspective English7274Shivani KapurkarEnglish Sonali ChalakhEnglish Pooja GhumdeEnglish Manoj PatilEnglish Y.U. ChitrivEnglishBackground: Ayurveda has described dietary regimen as the main cause for every disease. Nutritional, biochemical and metabolic aspects of diet play a major role in maintaining normal integrity of the skin. It also promotes the immunological role of skin. Adopting a strict lifestyle and diet regime may help in preventing not only skin diseases but also many lifestyle-induced serious systemic diseases. Observation of specific diet or activity as triggering factors of skin diseases, by avoiding such can prevent exacerbations and relapses of the diseases. Ahara forms the chief foundation upon which life of an individual is founded. In kushta nidana plays an important role in the manifestation of the disease, therefore steps have to be taken to avoid nidana i.e., viruddha ahara one among the nidan of kushta So to assess the type of diet and the dietary regime in the patient of skin diseases this study has been evaluated. Aim: Assessment of correlation between dietary regimes in the manifestation of skin diseases. Methods: Patients visiting OPD of Kayachikitsa in Mahatma Gandhi Ayurved College, Hospital & Research Centre, Salod (H), Wardha Result: The result will be based on observation and analyzed data. Conclusion: If it is found that pathya and apathy ahara leads to kushta then proper guidelines will be provided to the patients. EnglishAhara, Ayurveda, Dietary regimen, Kushta, Skin diseaseshttp://ijcrr.com/abstract.php?article_id=3131http://ijcrr.com/article_html.php?did=3131

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareComparative Study of Manjishtadi Oil and Ashwagandha Oil Matrabasti on Vishwachi (Cervical Radiculopathy) English7578Shweta ParweEnglish Vaishali KuchewarEnglish Milind NisargandhaEnglish Manoj PatilEnglish S.S. ChoudhariEnglishBackground: Ayurveda suggested many treatments for Vata vyadhi. Cervical problems mimic Vata disorders. Thus the Vata managements of medicated oils through rectal is better management for the identified clinical condition Vishwachi (Cervical Radiculopathy) in the present study. Among such disorders, Ayurvedic classics have described a disease in the name of Vishwachi. The signs and symptoms of Cervical Spondylosis with radiculopathy, such as neck pain radiating to upper limbs, restricted neck movements have been explained in Harrisons Principles of Internal medicine, Davidsons’s principles of Internal medicine and Golwalla medicine for students. Because of present-day lifestyles, food, habits, excessive stress-strain and anxiety more people are getting these problems and the incidence of the disease Viswachi is drastically increased day by day. Aim and Objectives: To study the effect of Manjishtadi oil Matrabasti in Vishwachi (Cervical Radiculopathy). And to compare the effects of Manjishtadi oil and Ashwagandhadi oil Matrabsti on Pain, Tingling sensation and Nerve Conduction Study. Methodology: Procedure In this examination, 30 patients will be separated haphazardly into 2 groups (15 in each ). In Group A (Control) – Ashwagandhai oil Matrabasti 30 ml will be managed a day after food for 21 days and Group B (Experimental) – Manjishtadi oil Matrabasti 30 ml will be controlled a day after food for 21days. The evaluation will be recorded on 0 and 21st day. Results: Changes will be observed in objective outcomes. Conclusion: Manjishtadi oil will be effective in Nerve conduction parameters. English Matrabasti, Vishwachi, Nerve Conduction Study, Cervical radiculopathyhttp://ijcrr.com/abstract.php?article_id=3132http://ijcrr.com/article_html.php?did=3132

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareCorrelation of p53 Status with Histopathological Grading of Glial Tumors English7981Tabish HassanEnglish Sunita VaghaEnglish Samarth ShuklaEnglish Amoli BelsareEnglishIntroduction: Glial tumours account for 70% of all brain tumours with astrocytoma (38.7%) being the most frequent tumour. The prognosis of high-grade gliomas is very poor and have a limited overall survival rate. Aim: To establish the role of p53(immunohistochemical) with histopathological grades of various glial tumours such as astrocytoma, oligodendroglioma and ependymoma. Methods: This will be a Prospective analytical Study. The study will be carried out from 1st August 2018 to 31st July 2020 in the Histopathology division and Immunohistochemistry section in the Department of Pathology, Jawaharlal Nehru Medical College (J.N.M.C) in co-ordination with Department of Neuro-Surgery. A total of 50 resected specimens of radiologically suspected cases of Glial tumours operated in the Department of Neurosurgery will be considered for the study. The resected specimens will be grossed, processed and evaluated for histopathology and p53 expression. Results: A direct correlation between the histopathological grade and the p53 expression will be observed. Conclusion: High-grade gliomas exhibit high p53 expression. Thus, p53 as an adjunct to histological grade can provide a supportive clue to the clinicians to predict the biological behaviour of gliomas. English Glial tumour, p53, Immunophenotypinghttp://ijcrr.com/abstract.php?article_id=3133http://ijcrr.com/article_html.php?did=3133

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareEffect of Introduction of ‘Research Orientation Module’ in Ayurveda Undergraduates English8285Vaishali KuchewarEnglish Priti DesaiEnglish Gaurav SawarkarEnglish Roshan UmateEnglish S.S. ChoudhariEnglishBackground: Research is important to the scientific progress and crucial in health sciences to understand the problems which affect the health of individuals, communities, and health systems. The study by YD Shilpashree observed the reasons for noninvolvement of undergraduates in research are lack of motivation and proper knowledge about the research. The Central Council of Indian Medicine (CCIM) in 2016 introduced a subject of Research Methods and Biostatistics in undergraduates of Ayurveda curriculum.11 but, the applied aspect is lacking as students are reading it only for examination purpose. Objective: This study is designed to introduce the ‘Research orientation module’ to undergraduate students through the workshop and to assess their perception and improvement in proposal writing. Methodology: The study will be conducted in two phases. In the first phase, Ayurveda undergraduates will be exposed to the questionnaire to explore their research attitude. In the second phase, 60 students (20 students from each year) will be selected by homogenous sampling method. Consecutive three days (two hours/day) training workshop on Research Methodology will be conducted. Before the workshop, students will be directed to design a short research proposal. Pre-test and post-test will be administered before and after the workshop. On completion of the workshop, the student will be given a month to rewrite the previous proposal. The proposals will be evaluated by a committee of 5 faculties (expert in research) using a performance-checklist. Conclusion: This study will help to explore basic knowledge of undergraduates about research. It will also assess the improvement in proposal writing skills on their orientation of Research. EnglishResearch attitude, Research orientation module, Ayurveda undergraduateshttp://ijcrr.com/abstract.php?article_id=3134http://ijcrr.com/article_html.php?did=3134

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareA Survey Study on Etiological factors of Mutrashmari (Urolithiasis) in Perspective of Ayurved and Contemporary Era English8688Krushna Chaitanya PatnaikEnglish Seema H. ThakareEnglish Prashil P. JumadeEnglish Shilpa GaidhaneEnglish Rakesh AdakaneEnglishBackground: Mutrashmari is one of the most common conditions in which stone formed in the urinary tract. The word Ashmari in Sanskrit denotes the stone or calculi and Mutra means urine which is carried by Mutravaha Srotas. According to Acharya Sushruta Mutrashmari is one among the Ashta Mahagada. Mutrashmari is dreadful and has the potential to disturb the anatomy and physiology of the urinary system. Once it formed in the body it tends recurrence thus get difficult to cure & hence Acharyas called it as Mahagada. In modern medical science, it can be correlated with Urinary Calculi or Urolithiasis based on their signs and symptoms. Factors like diet, water, climate, geographical conditions are responsible for the formation of calculi. Objectives: To compare etiological factors of Mutrashmari mentioned in Ayurveda and contemporary era. To put forth the recommendations based on study results. Methodology: This is a descriptive cross-sectional study conducted at AVBRH, Sawangi (Meghe) Wardha. Total of 60 diagnosed patients selected by simple random sampling method was enrolled in the study. Patients were contacted and interviewed at urology OPD of AVBRH Sawangi (Meghe) twice a week with a semi structured questionnaire. The study will be conducted in 3 months during which data will be collected as per the questionnaire. Discussion: This cross-sectional study helps to provide data regarding etiological factors for Mutrashmari (Urolithiasis) from both Ayurveda and Contemporary view. English Ayurveda, Etiological factors, Mahagada, Mutrashmari, Urolithiasishttp://ijcrr.com/abstract.php?article_id=3135http://ijcrr.com/article_html.php?did=3135

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareA Study of Clinical Profile in Patients with Vestibular and Non-Vestibular Vertigo English8992Aditya RanjanEnglish Shraddha JainEnglish S.S. ChaudhariEnglishBackground: Dizziness is the 3rd commonest cause for presentation to a general practitioner and its causes are mainly otological followed by central, sensory and visual. Diagnosis of dizziness is majorly clinical. However, there is a lack of quality studies evaluating the clinical profile in vertigo and dizziness of different origin(vestibular and non-vestibular) and different age groups. Moreover, we have seen that a significant bulk of the patient present with “cervicogenic giddiness” but at present, there are no standard guidelines for diagnostic criteria for cervicogenic giddiness which may occur alone or associated with other types of giddiness and that treating such patients with physiotherapy can relieve and even reverse the condition. Objectives: To study the clinical profile in patients with vestibular and non-vestibular vertigo. To study any association between cervicogenic vertigo and labyrinthine vertigo, like Benign Paroxysmal Positional Vertigo and Meniere’s Disease. To study clinical features in patients with dizziness and vertigo, when multiple conditions co-exist. Methods: In all the 96 patients of dizziness or vertigo, a pre-designed proforma will be filled, followed by a general and systemic examination with special emphasis on cardiovascular and a detailed neurological assessment. Special Clinical Tests for vertigo like Dix-Hall pike Manoeuvre, Tandem walking, Dysdiadokokinesis, tests for postural hypotension, Vertebrobasilar insufficiency, cervicogenic dizziness will be carried out. Results: The collected data will be tabulated and statistical analysis will be done by estimating means and standard deviations for various measurements related to radiologic and other measurements. Conclusion: This study will help the clinicians for better understanding of giddiness and differentiate between different types of giddiness in different age groups and their association with changes in the cervical spine and association with cervicogenic giddiness. Englishhttp://ijcrr.com/abstract.php?article_id=3136http://ijcrr.com/article_html.php?did=3136

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareClinical Effect of Siravedha at Dakshin Kurpar Sandhi in the Management of Non-Alcoholic Fatty Liver Diseases - A Randomised Controlled Trial Protocol English9396Gaurav SawarkarEnglish Priti DesaiEnglish Punam SawarkarEnglish Shilpa GaidhaneEnglish Amoli BelsareEnglishBackground: Sushruta explained the Sira Vedha at Dakshin Kurpara Sandhi (Right Elbow Joint) as a remedy for YakritVikara (Liver Diseases), the same treatment was explained by modern science, but the exact site was not mentioned. Similarly, the amount to be withdrawn and interval also not revealed by previous researches. Although, in ancient science, the same was explained in the context, lack clinical evidence it was missing in the main stream. So, it is the need of time to study the principal of Sushruta regarding the treatment of liver diseases. Objective: To study the effect of Sira Vedha at Dakshin Kurpara Sandhi (Right Elbow Joint) in the management of Non-Alcoholic Fatty Liver Diseases (NAFLD) as an adjuvant therapy Material and Method: 120 patients will be randomly allotted to Group A and Group B having 60 patients in each group. Group A will be treated with only lifestyle modification and diet regime and Group B, Sira Vedha with lifestyle modification and diet regime. Sira Vedha will be done at three times by the interval of fifteen daysandLFT, lipid profile and CBC investigations will be carried out concerning regular visit. The analysis will be done after the last visit of the patient for the anticipative outcome of the Sira Vedha in the present scenario. Expected Results: The Sira Vedha with the minimum amount of bloodletting have better outcomes compared to only lifestyle management and diet regimen. EnglishSira Vedha, Phlebotomy, NAFLDhttp://ijcrr.com/abstract.php?article_id=3137http://ijcrr.com/article_html.php?did=3137

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareStandardization of Udumbar KsheerSutra and its Clinical Efficacy in Comparison with Apamarga KsharSutra in the Management of Bhagandar (Fistula in ano) – Protocol English97101Pooja ShrivastavEnglish Kiran KhandareEnglish Obaid NomanEnglish Prasanna Mukund PalsodkarEnglishBackground: Acharya Sushrut, the ancient surgeon has included Bhagandar among the Ashtamahagad (8 dreadful diseases). The one which causes Bhag (vulva), Guda (anal region) and Basti Pradesh (urogenital area) Daran (cutting) are known as Bhagandar. As defined in modern science, this can be associated with Fistula in ano. Fistula in ano is an abnormal track in the perianal region with an external opening that interacts with the rectum or anal canal through a specific internal opening. Various modern surgical and medical treatments are trendy to manage Fistula in ano but there are certain limitations to all treatments. Aim and Objectives: ToStandardize Udumbar KsheerSutra and evaluates its clinical efficacy in comparison with Apamarga KsharSutra in the managing Bhagandar (Fistula in ano). Methodology: Standardization will be done by organoleptic and physicochemical testing of UdumbarKsheer and Udumbar KsheerSutra and then the standards of KsheerSutra will be determined. Total of 130 participants will be equally distributed in two groups with a minimum of 65 participants in each. In a group, A UdumbarKsheerSutraand in group B Apamarga KsharSutra will be changed after 7 days till the cure of fistula. Assessment of the patienswill be done on days 0, 15, 30, 45 and 60 and after the intervention, follow up will be taken on days 90 and 120. Results: Results will be drawn from the observations of objective parameters. Conclusion: Conclusion of the study will be drawn based on statistical data calculated from the collected data. EnglishAshtamahagad, Bhagandar, Fistula in ano, Apamarga KsharSutra, Udumbar Ksheer Sutrahttp://ijcrr.com/abstract.php?article_id=3138http://ijcrr.com/article_html.php?did=3138

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareFunctional and Radiological Evaluation of the Management of Tibial Plateau Fractures English102104Priyank BhattEnglish Sunil NikoseEnglish A.V. BapatEnglishBackground: The proximal tibia is very important stress-bearing area; fractures proximal tibia affecting joint alignment, stability and movement. Prompt diagnosis and treatment of these fractures are required for decreasing patient morbidity leading to reduction of complications of the risks, particularly post-traumatic arthritis. Proximal tibia fractures are responsible for 1% of fractures and occur due to high-velocity mechanisms. Open reduction and internal fixation is currently the standard of care for proximal tibia fractures with step-off at the articular surface, widening of the condyles, instability due to ligament pathology. Methodology: All the admitted patients in the Department of Orthopaedics, at AVBRH, Sawangi, Wardha during this period from May 2018 to April 2020. The total physical examination of a tibial fracture would include an assessment of the entire knee, comparing with the other (presumably uninjured) knee, with particular detail to Hemarthrosis, Neurovascular examination and compartment evaluation of leg. Radiological and functional evaluation was done. Expected Results: The results will be based on assessment through Rassmussen clinical and radiological score and functional assessment through Mcmaster knee score. We will be including displacement, comminution and complications to assess the outcome of the individual case. We expect good to fair results postoperatively and at 6 months follow up. Conclusion: Will be drawn on completion of the study. English Proximal tibia fractures, Plate osteosynthesishttp://ijcrr.com/abstract.php?article_id=3139http://ijcrr.com/article_html.php?did=3139

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareOutcome Analysis of High Tibial Osteotomy in Osteoarthritis of Knee: A Study Protocol English105107Shivshankar JadhavEnglish Ulhas DudhekarEnglish Kiran SaojiEnglish S.S. ChaudhariEnglishBackground: Osteoarthritis knee is an important cause of disability in women and 8th in men. Uni-compartmental involvement of knee joint is more common in osteoarthritis leading to various deformity and pain in the knee. Objective: To analyse the outcome based on the functional and radiological evaluation. Methods: The study is an observational study with a prospective study design at Acharya Vinoba Bhave Rural Hospital (AVBRH) in the Orthopaedic department. Patients who are diagnosed with osteoarthritis of the knee based on X-rays will be analysed on their clinical, functional and radiological outcomes based on Oxford Knee Score and Tegner Lysholm Knee Score. The patient will be chosen based on age above 50 years and the ones who agree to participate in the study. Patients with varus deformity of more than 10 degrees and the ones with knee instability will be excluded from the study. Assessment of patient will be done based on Oxford knee scoring and Tegner Lysholm knee score The patients will be scored pre-operatively and post-operatively to evaluate the relief from pain or the symptoms before the surgery and after the surgery and scoring will be done and will be compared. Expected Results: High tibial osteotomy is expected to help reduce the pain in osteoarthritic patients, which hampered their daily activities. This surgery will help assess the pre-operative and post-operative scores which will be assessed based on Oxford knee score and Tegmen Lysholm score. English Osteoarthritis, High tibial osteotomy, Open wedge osteotomy, closed wedge osteotomy, varus deformity, biomechanics of the kneehttp://ijcrr.com/abstract.php?article_id=3140http://ijcrr.com/article_html.php?did=3140

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareEvaluation of the Effect of Ashwagandhadi Ksheerbasti on Peri-menopausal Psychological and Vasomotor Conditions Through Serum Estradiol Estimations English108111Pratiksha RathodEnglish Shweta ParweEnglish K.S.R. PrasadEnglish Roshan UmateEnglish P.S. PatilEnglishIntroduction: Perimenopause is the time between the onset of waning ovarian function associated with menstrual irregularity and vasomotor symptoms and the year after the last menses. This period is characterized by irregularities of menses; lengthy and heavy menses with episodes of amenorrhea, sub-fertility, hot flushes which falls under vasomotor symptoms, a psychological symptom like insomnia. Objectives: To evaluate the effect of Ashwagandhadi ksheerbasti on psychological symptoms, vasomotor symptoms and serum estradiol fluctuations in perimenopause with the administration of Ashwagandhadi kheer Basti along with counselling in one group and only with counselling in other groups. Methods: In age group ranging of 41-50 years, women suffering from perimenopausal psychological and vasomotor symptoms meeting the criteria mentioned in standard score scale included in the study. Expected Results: Recent studies show bone marrow transplantation restores follicular maturation and steroid production in mouse models for primary ovarian failure. Follicular recruitment occurs in the bone marrow before ovaries. We postulate a theory based on Ayurveda principle stating, the base of the reproductive system is in the bone marrow. The female reproductive component is generated and derived from the bone marrow and its treatment leads to improve folliculogenesis, estradiol levels and symptoms like hot flush, depression, insomnia and panic disorder. Conclusion: It will be drawn after obtaining the results of the study. English Ashwagandhadi ksheerbasti, Perimenopausal, Estradiolhttp://ijcrr.com/abstract.php?article_id=3141http://ijcrr.com/article_html.php?did=3141

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareEvaluation and Comparison of Madanaphala, Jeemutaka and Ikshwaku Vamana in Tamakshwasa - A Study Protocol English112116Sahebrao K. KadamEnglish Shweta ParweEnglish Manoj PatilEnglish Milind NisargandhaEnglish Amoli BelsareEnglishBackground: Tamakashwasa (bronchial asthma) is a disease of Pranavaha Srotasa (Respiratory system) in which Kapha and Vata Doshas are having supremacy. It is a chronic inflammatory airway disease characterized by dyspnoea, cough, expectoration, wheezing, coryza, dyspnoea, hoarseness of voice. It affects the quality of life and takes economical implication over the patient as well as society. Vamana (therapeutic emesis) is an internal purificatory practice which is the best among all the Panchakarmas for the elimination of morbid Kapha Dosha. It is mainly indicated in Tamakshwasa having Bahudoshavastha. Objectives: To study the effect and safety of Jeemutaka and Ikshwaku Vamana and to compare with Madanaphala Vamana in Tamakshwasa. Methods: In the present comparative clinical trial, 90 patients of Tamakshwasa will be divided into 3 groups (30 patients in each group). Group A: Madanaphaala Vamana, will compare with Group B: Jeemutaka Vamana and Group C: Ikshwaku Vamana in Tamakshwasa. Patients with symptoms of Tamakshwasa will be assigned randomly into three groups and Vamana will be given after 1 day Snehapana and on the second day, Vamana will be performed after Bahyasnehana and Swedana at 7 a.m. Samsarjana Krama will be given for 3 days and assessment will be recorded on 0th, 5th day. Expected Results: The Result will be evaluated based on subjective and objective parameters. Conclusion: Madanpahala, Jeemutaka and Ikshwaku Vamana will be effective and safe in Tamakshwasa to the improvement of Peak expiratory flow rate (PEFR). EnglishTamakshwasa, Sadyovamana, Bronchial Asthama, Vamana therapeutic emesishttp://ijcrr.com/abstract.php?article_id=3142http://ijcrr.com/article_html.php?did=3142

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareEffect of Occupational Environment on Male Infertility English117121Akshay Vinod TayawadeEnglish Aakash MoreEnglish Mehul SalveEnglish Deepti ShrivastavaEnglishBackground: The impact of the environment on Male Infertility has shown the effect on, mood disorders, cancers at the genital region, declination in sperm concentration and multiple alterations in sexual behaviour. In the case of male infertility in the Indian population, some studies have also concluded that a specific mutation on MTHFR (Methylen etetrahydrofolate_Reductase) at C677T site is quite briefly associated with the male infertility problem. Similarly, in males; increased susceptibility to various complex disorders have been reported for the same type of mutation. Objectives: To correlate MTHFR gene polymorphism and occupational environmental factors with defects in morphology, count and motility of sperm by normal sperm. Methodology: Details of the occupational environment of the individual patient before Semen analysis. The semen analysis will be performed according to the WHO Guidelines 2010. Blood samples will be collected from patients matching the inclusion criteria, then Cryopreserving of sediments of blood samples will be done if required. Extraction of genomic DNA from blood Genotyping of MTFR gene PCR-RFLP method Identification of genotype by Electrophoresis and then Statistical analysis will be done for checking occ. Environmental factor effect with MTHFR gene polymorphism Comparison of epigenome between defected sperm and healthy sperm. Expected Results: Three variable groups (Heat; Telecommunication radiation and chemical) will be formed concerning the exposure of environmental occupation on fertility perspective. Eventually, the severity of epigenetic cause for male infertility is expected to see in participants with ±15 years the exposure of any one or a combination of the variables of occupational environment. EnglishMale infertility, Occupational Environmental, Epigenetichttp://ijcrr.com/abstract.php?article_id=3143http://ijcrr.com/article_html.php?did=3143

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareAwareness and Psychosocial Effects of COVID-19 Pandemic on Health Care Professionals and Medical Students Across the State of Maharashtra English122125Sanket BakshiEnglish Vaishnavi ToshniwalEnglish Aman AgrawalEnglish Sourya AcharyaEnglish Samarth ShuklaEnglishBackground: COVID 19 -The pandemic which has advanced globally in mere time, is a disease resulting from an infection by a newly discovered strain of coronavirus- ‘ SARS-coV-2’. The healthcare professionals, are working tirelessly, and are honouring their services towards the general population, despite the threat of getting infected. Therefore in such circumstances, it has become essential to assess the knowledge and attitude of the medical professionals towards this pandemic, and also to discuss the effects this crisis is causing on their psychosocial stability. Objective: 1. To assess the knowledge regarding COVID-19 mode of transmission, clinical effects, its protective and preventive measures from our health care professionals and medical students. 2. To assess psychological behavioural pattern in the form of fear, anxiety, sleep patter, depression from analyzing solutions from these questionnaires. Methodology: A validated questionnaire was distributed amongst the doctors, private practitioners, Postgraduate residents, interns, medical students and the nursing staff in various government and private institutions. The results were then analysed statistically and the answers were recorded, tabulated and represented in pie charts. Results: The study would play a key role in assessing the level of knowledge, attitude and practices of healthcare professionals and medical students have in context to COVID 19. Conclusion: COVID-19 pandemic has affected psychologically as well as psychosocially on medical professionals which could be analysed from our study English Covid19, Psychological effects, Pandemic, Healthcare professionals and medical studentshttp://ijcrr.com/abstract.php?article_id=3144http://ijcrr.com/article_html.php?did=3144

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareComparative Study between Various Reagents of Plastination in Making Museum Specimen English126128Darshana ToteEnglish Sachin ToteEnglishBackground: Plastination uses polymer as an agent which preserves the specimen in a near-natural state. This technique has advantages over the traditional method of body part preservation and handling of the specimen. But the main drawback remains its cost and availability of the reagents. Till date, this technique of specimen preservation has not been used by any surgeon. Hence we plan to use this technique of plastination for the preservation of museum specimen. We also plan to compare various reagents used for the same as commercially available resins and touchwood primer paint. Objectives: Primary objective: to study the efficiency of various reagents of plastination for the preservation of the surgical specimen. Methods: This is a prospective interventional randomized study over 1 year period. Study population: 5 specimens in each group of reagent. All the specimens in both groups will be subjected to the same process of Plastination, specimen selection, dehydration and defatting, vacuum impregnation, positioning, curing, specimen analysis over 6 months. Results: The Plastination specimen of Touchwood reagent will be compared with the standard Plastination reagent specimen in terms of durability, handling, clarity of specimen and cost-effectivity. Conclusions: The specimen should be comparable to the specimen of epoxy resin reagent in terms of durability, clarity and ease of handling. English Plastination, Surgery museum specimen, Resin, Touchwood painthttp://ijcrr.com/abstract.php?article_id=3145http://ijcrr.com/article_html.php?did=3145

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareComparative Study on Haematological Parameters in Leech Application for Acute Inflammation English129132Rucha Narendra SelkarEnglish Kiran KhandareEnglish Manoj PatilEnglish Chetan GodeEnglishBackground: Ayurveda believes Raktamokshan to be an idiosyncratic minor operative procedure useful in treatment for letting blood in conditions where blood is vitiatedancient sages of Ayurved like Acharya Sushruta, who is considered as the father of ancient Indian surgery narrates about normal and disturbed functioning bit part of Rudhira and its major role in various operative methods. More than a bloodletting therapy, an amazing cocktail of medicinal substances is present in the salivary secretions of the leech. This has led to its therapeutic utilization in countless medical and surgical ambiences. About the environment and normal body conditions, parameters related to blood are essential. The foreign bodies present in blood can be disclosed from the evaluation of haematological and differential parameters. The estimation of this criterion: Erythrocytes, leukocytes and thrombocytes give the approach to evaluate the presence of assorted module in the blood of animals which is been instrumental in pathological, physiological, and nutritional status of animals. Objectives: To Evaluate of Haematological Parameters of Leech Application in Acute Inflammation by assessing the changes in the haematological parameters (CBC with ESR) before and after 24 hrs of leech application in acute inflammation. Methodology: 20 Patients of age group between 20 to 50 years of either sex with acute inflammation indicated for leech therapy will be selected, Nirvisha leech used for medicinal purpose Hirudo medicinalis will be applied and haematological changes will be compared before and after leech application. Results: After data analysis results will be noted. Conclusion: Few changes will be seen in haematological parameters. EnglishRaktamokshan, Haematological, Leech, Acute inflammationhttp://ijcrr.com/abstract.php?article_id=3146http://ijcrr.com/article_html.php?did=3146

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareRehydration of Air-dried Smears for Papanicolaou Staining in Cytopathological Section of Department of Pathology English133136Shweta BahadureEnglish Pragati M. ShahareEnglish Sunita VaghaEnglishBackground: Wet fixed smears are commonly used for routine investigation in determining many precancerous and cancerous lesions. Wet fixed smears are associated with few side effects which leads to diagnostic difficulties. Therefore the present study is used to determine the effects of rehydration on air-dried smears by comparing cellular preservation and staining quality in rehydration smears and wet fixed smears. Objectives: 1) To compare the cytomorphological features in conventional Pap smears and rehydration air-dried Pap smear. 2) To compare the staining quality in rehydration smears and wet fixed smears. 3) To identify if rehydration techniques can be used as an alternative method particularly in rural setup or in resource-limited settings. Methods: Our study is a prospective analytical study to be conducted in Cytopathology section of the Department of Pathology. 100 fluid sample were examined during the study period. Wet fixed smears are processed routinely. Air-dried smears are rehydrated with normal saline for thirty seconds and immediately added to the jar containing fixative 95% ethanol for thirty minutes. Both the smears were then processed and stained by the Papanicolaou technique. Both the smears will be screened, assessed and graded for various cytomorphological parameters. The cervical smears will be reported as per the 2014 Bethesda system. Expected Results: Statistically significant similarities can be observed in between two groups one with wet fixed smears and other with rehydrated air-dried smears when compared for various cellular features. On comparing two groups for its cytological diagnosis, results can be found out in the agreement. The rehydrated air-dried technique can be used effectively for FNACs, Effusion fluids, Exfoliated cells. Interpretation of rehydrated air-dried smears and staining quality is far better when compared to conventional wet smears. Conclusion: The conclusion will be based on the results of the study English: Cervical cytology, Pap smears, Rehydration smears, Wet fixed smearshttp://ijcrr.com/abstract.php?article_id=3147http://ijcrr.com/article_html.php?did=3147

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareTo Study the Outcome/Analysis of Fracture Distal End Radius Managed with Antegrade K/L-Wire Fixation English137139Abhiram AwasthiEnglish Kiran SaojiEnglish Prachi PalsodkarEnglishIntroduction: The treatment options for fracture lower end radius range from closed reduction and cast application to interlock nailing to the application of external fixators. Despite the advancements in treatment, close reduction and immobilization in the cast still prevail the standard reliable method for the management of minimally displaced intra-articular and extra-articular distal end radius fractures. The gold standard for the treatment of distal end radius fractures remains to be Volar Locking Plate Osteosynthesis. In this study focused on the alternative modality for the treatment of fracture distal end radius managed with antegrade k-wire fixation. Mathods: This will be a prospective interventional study conducted on 30 patients between the age group of 18 to 60 years. In this modality, the distal end radius fracture is fixed with 2-3 k/l wires in the antegrade direction. Detailed clinical, radiological and functional assessment was done and after fulfilling the inclusion and exclusion criteria patients were selected. Data was spread on the master chart and analyzed Expected Results: Results will be assessed after the study has been completed. Treatment with Intramedullary L-wire fixation is a cost-effective alternative which can also be performed in rural health setups. they are less invasive and overall provide better compliance for the patient. The results will be calculated with the help of SPSS software version 26. Conclusion: Treatment with Intramedullary L-wire fixation is a cost-effective alternative which can also be performed in rural health setups. they are less invasive and overall provide better compliance for the patient. English Fracture, Radius, K-Wire, Fixationhttp://ijcrr.com/abstract.php?article_id=3148http://ijcrr.com/article_html.php?did=3148

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcarePharmaceutico-Analytical Standardization and In Vivo Evaluation of Acute Toxicity, Genotoxicity, Anti-Genotoxic Effect and Spermatogenic Action of Musalyadi Churna English140145Mujahid B. KhanEnglish Bharat RathiEnglish Shital TelrandheEnglish Amoli BelsareEnglishIntroduction: Infertility is a major reproductive health problem today in which Male infertility may be contributory to 30 to 40 % of infertile couples. Musalyadi Churna is most commonly utilized classical Ayurvedic formulation in the management of impotency and infertility which are a major increasingly worldwide concern. It is a combination of herbal drugs like Musali (Chloro-phytum borivilianum), Vidarikanda (Pueraria tuberosa DC), Guduchi Tinospora cordifolia (Willd Miers ex Hook. f. and Thoms.), Kapikacchu (Mucunna prurita Hook.), Gokshura (Tribulus Terrestris Linn.), Shalmali (Bambax malabaricum DC) and Amalaki(Phyllanthus Emblica Linn.). Methods: Musalyadi Churna will be prepared as per the reference of classical text Sharangdhar Samhita for pharmaceutical study and then its analytical study will be done. In experimental studies To assess the toxicity of Musalaydi churna, its acute oral toxicity on Wistar/SD rats will be performed using OECD 423 guidelines; Genotoxicity and Antigenotoxicity will be performed using Chromosomal aberration assay on 36 Swiss albino mice and Spermatogenesis study will be conducted on 60 Wistar/SD male rats as per OECD guidelines and scientific research articles. Expected Results: Observations of pharmaceutical and experimental studies will be noted and presented in the form of tables, chart, photographs etc. Conclusion: As the ingredients of Musalyadi churna are easily available and the method of preparation does not require much time and manpower, therefore if this formulation showed significant efficacy then this will open a new gateway for the management of infertility. EnglishMusalyadi churna, Genotoxicity, Spermatogenesis, Infertilityhttp://ijcrr.com/abstract.php?article_id=3149http://ijcrr.com/article_html.php?did=3149

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcarePharmaceutical-Analytical Standardization of Palasha Kshara Prepared by Two Different Combinations and Evaluation of Their Diuretic Action in Wister Rats English146149Meenakshi JaiswalEnglish Anita WanjariEnglish Obaid NomanEnglishBackground: Rasashastra and Bhaishjya Kalpana, the pharmaceutical and therapeutic branch of Ayurveda consists of various varieties of dosage forms of medicine and Kshara Kalpana is one of the medicaments among them. Kshara is an alkaline substance prepared from the ashes of plants, animals or minerals. In compendia, Palash (Butea monosperma Lam)is referred to as “Kshara- Shretha”. Objectives: To standardize the method of preparation of Palasha Kshara by preparing it with two combinations i.e. one with Palasha Panchanga and the another is with roots, stem, and leaves of Palasha Plant and to evaluate their diuretic action in Wister rats. Methods: The procurement and authentication of parts of Palasha plant will be done according to the Dravya Guna Department, MGACH & RC, Wardha. Both combinations of Palasha Kshara will be prepared by using the reference of the text Rasa Tarangini. Expected Results: The pharmaceutical- analytical study may reveal that which combination has more efficacies for the diuretic action. The data will be assessed for its pharmaceutical, analytical and experimental results by using Unpaired ‘t’ test and One way ANOVA test. Conclusion: The method of preparation explained in compendia i.e. using Palasha Panchanga has same analytical results and diuretic action as that of the altered one i.e. using the parts of Palasha plants which are available all the year along. Key Words: Palasha Kshara, Ayurveda, Alkali Preparation, Two combinations, Diuretic action, Pharmaceutics, Analytics, Standardization, Experimental Study EnglishPalasha Kshara, Ayurveda, Alkali Preparation, Two combinations, Diuretic action, Pharmaceutics, Analytics, Standardization, Experimental Studyhttp://ijcrr.com/abstract.php?article_id=3150http://ijcrr.com/article_html.php?did=3150

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareTo Study the Correlation of Embryo and Oocyte Quality with Clinical Pregnancy Rate English150153Revati Sunil ThoratEnglish Aakash MoreEnglish Mehul SalveEnglish Deepti ShrivastavaEnglishBackground: Embryo and oocyte grading or scoring is the selection and classification of embryo and oocyte according to its quality. Embryo quality is an important factor for successful delivery. It is a non-invasive method of embryo evaluation. It is an easy assessment of embryo without any harm which includes morphological observation. A well morphologically graded oocyte improves the quality of the embryo. Objectives: This study aims to use a standard grading system for better morphological assessment of oocytes and embryos. Eventually, the correlation of oocyte and embryo quality with pregnancy outcome will be determined. Methodology: This non-invasive methodology includes the recording of treatment history and the indications. Counselling of the participants for research will be done. The further protocol includes the morphological assessment of oocyte as well as an embryo by grading system (Gardner) and β hCG level will be evaluated. Expected Results: 50 women will be included. Embryo and oocyte grading system by Gardner will be used for morphological analysis of embryos at cleavage as well as at blastocyst stage according to the day of transfer. Gardner oocyte grading/scoring system may predict the selection of best oocyte for IVF/ICSI. Further Gardner embryo grading system may predict the best morphological evaluation of embryo and eventually selection of best quality embryo for transfer. Thus by using the above grading method for selection of embryo for transfer, implantation and clinical pregnancy rate may increase. English Oocyte, Embryo grading system, Non-invasive methodology, Embryo quality, Morphology, Pregnancy Ratehttp://ijcrr.com/abstract.php?article_id=3151http://ijcrr.com/article_html.php?did=3151

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241ClinicalinEnglishN2020November30HealthcareIs your work making you ill? English0102Debasish Kar MahapatraEnglishEnglishhttp://ijcrr.com/abstract.php?article_id=3152http://ijcrr.com/article_html.php?did=3152