Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareCOVID-19 Risks to Malaysian Food Security Assurance English0101Mohamad N. AzraEnglishEnglish Aquaculture; Fisheries; Movement Control Order; SARS-CoV-2; Shellfish http://ijcrr.com/abstract.php?article_id=2846http://ijcrr.com/article_html.php?did=2846

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcarePrevalence of Metabolic Syndrome in Hypothyroidism Patients English0206Gajanan V. WasalwarEnglish D. S. WasnikEnglishIntroduction: Hypothyroidism and Metabolic Syndrome (MetS) is well-established predecessor of atherogenic cardiovascular disease. MetS includes a group of risk factors characterized by hypertension, hyperglycemia, dyslipidemia, prothrombotic, and proinflammatory conditions, which speed up the body's atherogenic process. Hypothyroidism causes hyperlipidemia, diastolic hypertension, endothelial dysfunction, and cardiovascular disease. Hypothyroidism is also associated with increased cardiovascular morbidity for which various theories have been proposed. One of the hypotheses suggested is causal interaction with the metabolic Syndrome (MetS). The Adult Treatment Panel III report (ATP III) of the National Cholesterol Education Program has identified the MetS as a Multiplex risk factor for cardiovascular disease that deserved more clinical attention. The prevalence rates vary greatly depending upon MetS, population, age, ethnicity etc. in India a rapid increase in its prevalence has been noted due to socioeconomic transitions to increasing mechanization, affluence, urbanization and urban migration. Useful changes within the thyroid organ might have an affiliation with MetS and its related components counting weight, affront resistance (AR), lipid and glucose digestion system anomalies, raised blood weight, and cardiovascular brokenness. MetS and Thyroid dysfunction (TD) are both characterized by a cluster of common variations from the norm such as stomach weight, hyperglycemia, and hypertension, decreased high-density lipoprotein cholesterol (HDL-C), and raised triglycerides (TG). Additionally, IR, distinguished as a fundamental component for MetS, too plays a part in hypothyroidism. Worldwide the most prevalent endocrine disorders are among thyroid diseases. Various studies in India showed that about 42 million people suffer from thyroid diseases. Aim: The main aim of this study is to find Prevalence of metabolic syndrome in hypothyroidism patients. Material and Methods: In this study, 100 patients known to have hypothyroidism with different age groups from 20 years to 60 were included. It was reported from all the patients who visited the hospital as detailed history of Outdoor patients and Indore patients, and laboratory analysis was also done. History regarding hypothyroidism symptoms was recorded as well as laboratory examination results like thyroid profile tests and Glucose and lipid analysis were also recorded. Result: In this study out of total 100 patients, 32 were males and 68 were females. The ratio of female to male was 2.125:1. The mean age was 42.7 years old. The mean TC, TG, LDL-C, and HDL-C levels in males were 179mg/dL, 142 mg/dL, 92 mg/ dL, 34.5 mg/dL and females were 166 mg/dL, 140 mg/dL, 85 mg/dL, and 43 mg/dL respectively. The mean WC in male and female was 110.5 and 105.2, respectively. Elevated TG (>150 mg/dL) was found in 17(53.1%) males and 60 (88.2%) females. Low HDL?C (≤40 mg/dL in men and ≤50 mg/dL in female) was found in 14 (43.8%) male and 62 (91.2%) female. Increased WC was found in 19 (59.4%) male and 66 (97.1%) female. Hypertension was found in 6 (18.8%) male and 30 (44.1%) female with an overall prevalence of 36%. MetS with three or more component was found in 19(59.4%) male and 65 (95.6%) females with overall prevalence of 84%. Conclusion: This study showed significant association between subclinical hypothyroidism and MetS. The overall prevalence rate of the MetS in this study was little bit higher than the rates reported in the general population in various studies and comparable to studies of hypothyroid patients. In Indian MetS patients’ hypothyroidism was the most common TD. English Prevalence, Metabolic syndrome, Hypothyroidism, TD, MetShttp://ijcrr.com/abstract.php?article_id=2847http://ijcrr.com/article_html.php?did=2847

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareEffectiveness of Intravenous Ketamine on Postoperative Pain Relief in Laparoscopic Appendicectomy Under Spinal Anaesthesia: A Comparative Study English0709Dahale SurajEnglish Sireesh IEnglishIntroduction: Aim of our study is to assess the efficacy of intravenous ketamine to control the postoperative pain in patients who have undergone appendicectomy. Methods: A total of 50 adult patients who were undergoing surgical intervention for acute appendicitis were examined and evaluated. They were randomly divided into two groups. In 25 cases (test group) after spinal anaesthesia and level of anaesthesia fixed at T4, 0.5 mg/kg of ketamine was given along with butorphanol, midazolam and glycopyrrolate, 10 mins before surgical incision. While in rest of 25 cases (control group), the same anaesthesia technique was used but intravenous ketamine was not given before pneumoperitoneum. The severity of pain was evaluated at 0 hrs (just after arousal), 4 hrs, 12 hrs and 24 hrs after surgery using 10 points visual analogue scale (VAS). Results: The VAS score was remarkably lower in the study group as compared to the test group for all the time durations postoperatively. Also, there was no drug interaction or side effect observed in test subjects. Conclusion: Preemptive administration of low dose ketamine has a phenomenal effect on the reduction of postoperative pain after appendicectomy. English Appendicectomy, Low dose ketamine, Pre-emptive analgesiahttp://ijcrr.com/abstract.php?article_id=2848http://ijcrr.com/article_html.php?did=2848

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareManagement of Proliferative Diabetic Retinopathy and its Associated Conditions using Ayurvedic Therapies: A Case Series English1022Narayanan Namboothiri NarayananEnglish Sreekala Nelliakkattu ParameswaranEnglish Sreekanth Parameswaran NamboothiriEnglish Anjaly Naduvathu VasudevanEnglish Aravind KumarEnglish Krishnendu SukumaranEnglishIntroduction: Proliferative diabetic retinopathy (PDR), characterized by neovascularization either at the optic disc (NVD) or elsewhere (NVE), may be associated with clinically significant macular oedema (CSME) or cystoid macular oedema (CME). Tractional retinal detachment in PDR is the result of neovascularization. As conventional management of PDR may not always prove effective, alternative options, including Ayurvedic treatment protocols, may be sought. Case Series: 3 diagnosed cases of PDR with associated conditions were managed using specially tailored Ayurvedic oral medicines, external therapies for both the eyes and head and a dietary protocol at Sreedhareeyam Ayurvedic Eye Hospital and Research Center, India. Both ocular and systemic parameters showed improvement at discharge. Discussion: The patients’ symptoms were compared to Timira or blurring of vision. Diagnostic parameters in Ayurveda were explored along the lines of pathological activity of Tridoshas (three somatic senses of humour - Vata, Pitta, and Kapha) and Rakta (blood tissue). Treatments were aimed not only at PDR and its complications, but also to normalize digestion and metabolism, thus revitalizing normal physiology. This holistic approach can make Ayurvedic management of PDR an option to consider.. EnglishAyurveda, Holistic approach, Case series, Herbal medicines, Macular oedema, Tractional retinal detachmenthttp://ijcrr.com/abstract.php?article_id=2849http://ijcrr.com/article_html.php?did=2849

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareCOVID-19 and Indian Commerce: An Analysis of Fast Moving Consumer Goods (FMCG), and Retail Industries of Tomorrow English2331Gaurav ShettyEnglish Shrey NougarahiyaEnglish Dheeraj MandloiEnglish Tapesh SarsodiaEnglish Sapna Jain DabadeEnglishIntroduction: This paper examines the effect of COVID-19 on Fast Moving Consumer Goods (FMCG) and Retail industries of India and examines emerging trends in these markets. Background: COVID-19 has impacted our lives from all the fronts. Businesses and Global Commerce will never be the same once the world restarts post COVID-19. Multiple new trends like Direct to Consumer model(D2C), Omnichannel fulfilment, etc. would emerge in the industries of tomorrow. Macroeconomic Dynamics, consumer behaviour and supply-side disruptions form a complex network that drives these trends in the economy. This network has to be studied to proactively identify the emerging trends in the industry. Methods: Existing literature on COVID-19 and its effect on business and commerce in India were retrieved through secondary research. The retrieved literature was analyzed to identify emerging trends. Conclusion: Emerging trends in FMCG and Retail industry suggest that the previously existing layers of wholesalers, distributors, etc. between the producer and the end consumer is being eliminated. Companies are leveraging technology to achieve direct distribution and thus, are getting closer to the customer. EnglishCOVID-19, Fast-moving consumer goods (FMCG), Retail, Post COVID FMCG, COVID-19 and Commerce, COVID -19 and Businesshttp://ijcrr.com/abstract.php?article_id=2850http://ijcrr.com/article_html.php?did=2850

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareSecure MedRecord – Your Medical Record, in Your Pocket English3244Choi KelvinEnglish Julia Binti JuremiEnglish Maen Tayseer Ekrayem AlrashdEnglishBackground: This research outlines the problems faced by users of the availability of medical documents which may vary in terms of having no softcopy, loss of hardcopy due to inefficient storage by the medical practitioners or failure to prepare a copy of their medical documents beforehand. Medical documents may also present an inconvenience to users whereby certain procedures will require a certain amount of time to prepare with a minimal amount of fees taken for medical practitioners to prepare the medical documents for their patients when requested. Purpose: Hence, this study serves as documentation for a solution to increasing the availability of medical documents through Secure MedRecord. It is a system designed to allow patients to carry a softcopy of their medical documents with them at all times. This is done by allowing patients to access their medical documents via a web application containing the softcopy version of the medical documents. Results: The web application serves as a platform which allows medical practitioners to manage their patients’ medical documents to allow for the patient to obtain a copy of the document for viewing purposes. This improves medical document availability together with providing efficient medical document processing and storage for disaster recovery purposes. EnglishElectronic Health Records, Privacy, Security, Healthcare, Medical Recordshttp://ijcrr.com/abstract.php?article_id=2851http://ijcrr.com/article_html.php?did=2851

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareA Study on Covid-19 Situation in Andhra Pradesh: Current Scenario and Projections English4550D. Srinivasa RaoEnglish Ch. RajasekharEnglish K. Santa RaoEnglishAim: Andhra Pradesh (AP) has seen a 20 times rise in COVID-19 cases soon after unlock and now stood in top five worst-hit states in India. The state which had 3,042 cases at the end of May, now has 69816 cases. Nearly, 65,000 cases were registered in just one and half month. The purpose of this study is to assess the current status of COVID-19 in Andhra Pradesh and to forecast the condition of future, which will help to strengthen management. Methodology: AP daily health bulletin and Health, Medical and Family Welfare (HMFW) data are used for the estimation of the forecast from 25 March to 23 July 2020. The forecast data charts in Microsoft Excel are used to estimate the potential COVID-19 cases for the Andhra Pradesh State. Results: Based on projected results, AP will cross 476534 cases by mid-September 2020. The proportion of positive cases out of tested samples in the state may go up to 30%. The COVID-19 death toll in the state may cross the 5000 value. In summary, the projection says that the increasing trend in COVID cases may continue a few months, while the death toll may be kept low with proper medical planning. Conclusion: The current situation in AP has put officials in alert to bring down the growth of COVID cases. Although several control measures are being taken by the government, still it needs to adapt intelligent strategies to better handle the pandemic. EnglishAndhra Pradesh, COVID-19, Disease, Scenario, Projectionhttp://ijcrr.com/abstract.php?article_id=2852http://ijcrr.com/article_html.php?did=2852

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareThe Immediate Effects of Breathing Exercises with Acapella and Incentive Spirometer on Preventing Early Pulmonary Complications Following Cabg. - A Comparitive Study English5158Sachin ChaudharyEnglish Neha Ingale ChaudharyEnglish Babaji GhewadeEnglish Gaurav MahajanEnglishBackground: The incidence of postoperative pulmonary complications (PPCs) following coronary artery bypass grafting (CABG) is between 30% and 60% and are the most significant contributor to morbidity, mortality, and expenses associated with the hospitalization. Chest physiotherapy is the fundamental component in post-operative physiotherapy. This study will specify the preferable technique for early prevention of postoperative pulmonary complications. Objective: The study aims at comparing the immediate effects of deep breathing with acapella and incentive spirometer in preventing early postoperative pulmonary complications followed by CABG. Method: In this study, 30 subjects fulfilling criteria divided into group A and group B randomly. Group A received breathing exercises with acapella and group B with the incentive spirometer. The outcome was evaluated through SPO2 levels, peak expiratory flow rate (PEFR), and numerical rating scale scores for dyspnea (NRS). The data was analysed and the inference was drawn through paired and unpaired t-tests. Results: The study obtained very discrete findings. Out of 4 days recordings of the outcome, the SPO2 levels were significantly improved in group B than group A on the first day of treatment, while after 4days of treatment there was no significant difference between group A and group B. The PEFR score was significantly higher in group A than group B after four days. There was no significant difference in the lowering of NRS score for perceived shortness of breath among both groups. Conclusion: In this study it is concluded that the breathing exercises through Acapella and Incentive Spirometer are effective in preventing early PPCs followed by CABG by improving PEFR(mostly through acapella), SPO2 levels and reduction of shortness of breath, thus improving quality outcome. EnglishAcapella, Incentive Spirometer, PPCs, SPO2, PEFR, NRS, Prevention, CABGhttp://ijcrr.com/abstract.php?article_id=2853http://ijcrr.com/article_html.php?did=2853

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareAn Unusual Case of Simultaneous Bilateral Elbow Dislocation and Associated Injury: A Case Report English5961Avinash KumarEnglish Binod Chandra RauloEnglish Anand Kumar SinghEnglishSimultaneous bilateral elbow dislocation with distal radius and radial head fracture is an unusual case. Only one case of bilateral elbow dislocation with distal radius fracture has been reported yet. A 58-year old male farmer with a history of fall from a tree presented with bilateral elbow dislocation with a wound over the right elbow, with distal radius fracture along with a radial head fracture. Left side close reduction and right side elbow dislocation reduced followed by external fixator applied. Distal radius fracture is managed by multiple k-wires. The aim of this study is to know the mechanism of such injury and its appropriate management. EnglishBilateral, Elbow dislocation, Wound, Distal radius, External fixator, Medial collateral ligamenthttp://ijcrr.com/abstract.php?article_id=2854http://ijcrr.com/article_html.php?did=2854

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareData Management for Healthcare with a Focus on Privacy and Security for Cancer Patients English6270Hardeep Singh SandhuEnglish Daniel Mago VistroEnglishBackground: Despite the technological advancements in the medical field and patient care, a key area that is lacking for the healthcare sector is on patient privacy and security of the infrastructure enabling and managing patient data in digital format. Numerous security incidents such as ransomware and gross violations of patient security were observed in the healthcare sector, patient privacy must receive more attention from the medical sector. Furthermore, as the severity of the illness increases, it becomes paramount for the patient’s privacy to be protected as there are socio-economic impacts on a patient’s lifestyle. One such disease that is receiving greater attention and funding is cancer. With cancer-killing, some 8 million patients on an annual basis further research and diagnostics measures can leverage on various data management techniques to improve results accuracy and gain critical insights into the disease. Methods: As such the cervical cancer dataset from “Hospital Universitario de Caracas” in Caracas, Venezuela is used to explore various data cleaning techniques for filling missing values such as global constants, proportion-based filling of missing values and using central tendency measures. Furthermore, as most data in this form of research tends to be skewed, data transformation techniques are also discussed to normalise the data. Another transformation which is applied extensively in this study is the discretisation methods that is used to bin continuous variables to qualitative groupings that are then used for machine learning techniques. Results: As medical data can be extremely large, the Apache Hadoop framework is used to upload the dataset and Optimised Row-Column (ORC) is the most optimal way to store and read data is also demonstrated. Several hypotheses were developed and tested to gain some preliminary insights into cervical cancer. English Data management, Privacy, Security, Healthcare, Hadoop, Optimized row-column (orc), Cervical cancerhttp://ijcrr.com/abstract.php?article_id=2855http://ijcrr.com/article_html.php?did=2855

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareStudy of Lipid Profile, Estradiol for Evaluation of Cardiovascular Risk in Pre- and Post-Menopausal Women English7175Prajakta WarjukarEnglish Rakesh Kumar JhaEnglish Prakash KuteEnglishIntroduction: Following menopause, decreased oestrogen production from ovaries leads to lipoprotein profile derangement, drastic alterations in the metabolism of glucose and insulin, distribution of body fat, coagulation and fibrinolysis and vascular endothelium dysfunction. Oestrogens include many cardioprotective mechanisms that alter the vascular tone by enhancing the levels of nitrous oxide. Endothelial cells are stabilized by oestrogens, they augment antioxidant potential and alter fibrinolytic proteins. These are all cardioprotective mechanisms that are reduced with the beginning of menopause. Objectives: To evaluate the relation of oestradiol hormonal variation with plasma lipid concentrations in pre- and postmenopausal women. Material and mMethods: 50 premenopausal women and 50 postmenopausal female were selected as subjects. Data were obtained via clinical assessment from laboratory investigations and questionnaires. Results: Serum levels of Total Cholesterol (TC), Triglycerides (TG), LDL-cholesterol, and VLDL-cholesterol in postmenopausal women were significantly elevated when matched with premenopausal women. For postmenopausal women, the level of HDLcholesterol declined substantially. The concentration of estradiol in post-menopause women was significantly lower (pEnglishMenopause, Oestrogen, Cardiovascular disease, Plasma lipids, Coronary heart diseasehttp://ijcrr.com/abstract.php?article_id=2856http://ijcrr.com/article_html.php?did=2856

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcarePrevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension English7683Jabbar DesaiEnglish Amit R. PorwalEnglish U. T. ManeEnglish R. S. ThoratEnglish R. A. ManeEnglishIntroduction: This is a case-control study comparing various lung function indices suggestive of OAD amongst the patients with ischemic heart disease and /or hypertension and healthy control population without ischemic heart disease and/or hypertension. Methods: In present study total of 100 subjects are cases, which include subjects with hypertension and / or ischemic heart disease. Results: Out of total 100 cases, 34 are IHD 37 are with essential hypertension and 29 are with IHD and Hypertension. In case population total 59 subjects are male (IHD,HTN: 18; IHD:23 ; HTN: 18) and 41 subjects are female (IHD,HTN: 12; IHD:11; HTN: 18). In control group total 74 are male and 26 are female Descriptive Statistical analysis for case group in following table number 3 shows mean values of age: 53.24, SBP: 157, DBP: 90.74, FEV1:1.531, FVC: 1.897, FEV1/FVC ratio %: 80.95, FEF 25-75:1.684, PEFR: 3.6, BMI: 22.71 Kg/m2. Out of a total of 37 hypertensive patients, 8 are having (21.62 % (OR=23.31) 95% confidence interval) OAD. Out of a total 34 IHD patients, 6 are having (17.34 % (OR=21.21) 95% confidence interval) OAD. Out of total 29 IHD with hypertensive patients, 4 are having (13.79 % (OR=15.84) 95% confidence interval) OAD. The mean FEV1/ FVC (%) in the male population is significantly low (58.396) compared to the female population (64.670) amongst the case group (p< 0.001). The mean SBP and DBP is significantly high in female population (163.333; 100.667) compared to male population (152.667; 89.600) with p < 0.05. Conclusion: The use of FEV1 and FEV1/FVC % as the part cost-effective investigation of any health assessment of middleaged patients should be considered. Patients with IHD and hypertension should routinely undergo inexpensive investigation like spirometry to detect the presence of underlying asymptomatic or subclinical OAD. English Airway Disease, IHD, Hypertension, FEV, FVChttp://ijcrr.com/abstract.php?article_id=2857http://ijcrr.com/article_html.php?did=2857

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareHaematological Malignancies – A Clinico Haematologial Profile English8492S. V. JagtapEnglish Jyoti S. TeleEnglish Sujata R. KanetkarEnglish Nanda PatilEnglish ChetanEnglishIntroduction: Disease can emerge from any tissue in the body. Tissues with quickly duplicating cells are at more danger of having the disease. The haemopoietic framework is one of them. Aim: The present study aims at knowing the break up of haematological malignancies, they are the clinico-haematological correlation; classify them by adapting the FAB classification and providing study based suggestions for better diagnosis and treatment of haematological malignancies Methods-In the present study, a total of ninety-eight cases of haematological malignancies were studied to evaluate the clinico-haematological spectrum of different types of haematological malignancies. Patients belonged to all age groups, the youngest being 1 year old and the eldest 86 years. Results: Majority of cases were seen in 5th-7th decades. Majority of cases of ALL were below 20 years of age while AML was seen in all age groups. CML was commonly found in middle age whereas CLL was seen in the elderly. The male: female ratio was 2.92: 1. Common clinical signs included pallor, splenomegaly and/or hepatomegaly. In CML, weakness, abdominal fullness and pain, and fever were the common presenting feature whereas; splenomegaly was present in the majority of the cases. In laboratory investigations, the majority of cases of AML and ALL had severe anaemia (Hb English Haematology, Malignancies, Myelodysplastic syndrome, Acute Lymphomas, Chronic Lymphomashttp://ijcrr.com/abstract.php?article_id=2858http://ijcrr.com/article_html.php?did=2858

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareIoMT: A Review of Open APS System Security for Type 1 Diabetes Mellitus English93100Jasvindir SinghEnglish Nor Azlina Abd RahmanEnglishBackground: To improve the health of patients, the Internet of Medical Things designates the interconnection of communication-enabled medical grade devices and their incorporation into broader health network. However, the Internet of Medical Things still faces significant challenges because of the critical nature of health-related systems, particularly in terms of reliability, safety and security. Purpose: This research paper will present a brief overview of type 1 diabetes mellitus, as well as its current treatment modalities. Results: In this regard, solutions in the view of problems patients face with current generations of insulin pumps are being discussed. Open APS (Artificial Pancreas System) attempts to reduce the burden of patients with type 1 diabetes by making a relatively safe and effective basic artificial pancreas system widely available. Besides that, this research paper will also discuss potential vulnerabilities that are faced by this system, as well as methods to overcome these issues. EnglishIoMT, Type 1 diabetes mellitus, Open APS, vulnerability, Attacks, Countermeasureshttp://ijcrr.com/abstract.php?article_id=2859http://ijcrr.com/article_html.php?did=2859

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareEvaluating the Role of Celosia argentea Powder and Fenugreek Seed Mucilage as Natural Super-Disintegrating Agents in Gliclazide Fast Disintegrating Tablets English101108Purushottam S. GanganeEnglish Savita H. GhughuskarEnglish Debarshi Kar MahapatraEnglish Nilesh M. MahajanEnglishObjective: The objective was to formulate gliclazide (GLZ) fast disintegrating tablets (FDTs) by using fenugreek seed mucilage and Celosia argentea powder as natural disintegrating agents as well as sodium starch glycolate as a synthetic disintegrating agent. Experimental: An attempt was made to extract the fenugreek seed mucilage and prepare the C. argentea powder and evaluated both for various physicochemical characterizations. FDTs of GLZ were formulated by direct compression method using different concentrations (3-7% w/w) of fenugreek seed mucilage and C. argentea powder and compared with synthetic disintegrating agent sodium starch glycolate. The formulated tablets were evaluated for various physical tests like weight variation, friability, hardness, etc. and the complied results fall with the limits. Results: Among all the formulations, F9 containing 7% C. argentea powder produced the least disintegrating time of 19 sec resulting in a higher drug release rate of 98.13% at the end of 60 min. C. argentea powder as a natural disintegrant showed better disintegrating property than the most widely used synthetic disintegrant sodium starch glycolate in the formulations of FDTs. Conclusion: The study concluded that C. argentea powder will act as a good disintegrating agent and it may be believed to exhibit promising additive anti-diabetic activity with GLZ. EnglishGliclazide, Tablet, Celosia argentea, Fenugreek seed mucilage, Natural, Super-disintegranthttp://ijcrr.com/abstract.php?article_id=2860http://ijcrr.com/article_html.php?did=2860

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareAn insight on Wabai Amrad (Epidemic diseases) and COVID-19 like conditions – Unani Perspective English109119Athar Parvez AnsariEnglish N. Zaheer AhmedEnglish K Kabiruddin AhmedEnglish Asim Ali KhanEnglishBackground and Objective: The World Health Organization has declared the COVID-19 as global pandemic on March 11, 2020. Hippocrates the father of medicine was supposedly the first ancient Unani physician to document the infectious diseases with their conspicuous clinical features which are today named as malaria, tuberculosis, influenza, mumps and diphtheria etc. In Unani medicine, the epidemic diseases are referred to as Amr?d-i-Wab?i. The present review has been embarked on to explore the Unani perspective into the scientific insight on epidemic diseases with the focus to unearth tangible information and solution to control the COVID-19 pandemic. Methodology: A total of 89 citations comprising classical Unani texts and published papers in various reputed indexed journals from 2005 to 2020 were reviewed about prevention and management of epidemic/ pandemic diseases; antiviral, antipyretic, antitussive, immunomodulators activities of Unani drugs etc. Results: Various measures such as isolation, social distancing; spray and fumigation treatment with Unani drugs for sanitization of the environment; modified diets such as barley water, murabba-i-turanj, sikanjbeen, vinegar etc to augment the immune system of the body; and pharmacotherapy such as Tiryaq-i-Afayee, QursKafoor, Sharbat-i-Khaksi, Khameera Marwareed, Cydonia oblonga, Zizyphus jujube etc have been mentioned by Unani physicians for prevention and management of epidemic diseases and COVID like conditions. Discussion: Certain scientific studies have reported that the individual ingredients of Tiryaq-i-Afayee(a pharmacopoeial preparation) such as Aloe vera and Crocus sativus possess significant antiviral effect, and the whole preparation exhibited an immunomodulatory effect. Sharbat-i-Khaksi and Khameera Marwareed (pharmacopoeial preparations) revealed potent antipyretic and immune system potentiating effects, respectively. Cydonia oblonga and Zizyphusjujuba possesses antiviral, antiinfluenza, antitussive, antipyretic and immunomodulator activities. Conclusion: The aforesaid Unani classical and contemporary material surveyed has yielded substantial key information and practical solutions in the prevention and control of epidemic diseases and COVID like conditions. EnglishAmr?d-i-Wab?i, COVID-19, Epidemic diseases, Tiryaq-i-Afayee, Unani medicinehttp://ijcrr.com/abstract.php?article_id=2861http://ijcrr.com/article_html.php?did=2861

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareLow Dose Magnesium Sulphate Regime for Eclampsia and Imminent Eclampsia English120123Manisha M. LaddadEnglish Anjali PatilEnglish P. A. HavaleEnglish S.S. VhawalEnglish Bahulekar AshitoshEnglishIntroduction: In India especially in rural areas, the majority of eclampsia cases report to hospital in an emergency. They are unregistered with inadequate antenatal care and travel a long distance before reaching the hospital as the rural health centres are not sufficiently equipped to manage this condition. Aim: To determine the efficacy of low dose magnesium sulphate in eclampsia and imminent eclampsia. To measure serum levels of magnesium with this regime. To correlate serum magnesium levels and efficacy. To identify complications of magnesium sulphate therapy in the mother and the baby. Methods: 120 cases of preeclampsia and eclampsia were allotted by simple random sampling technique to two groups i.e. low dose regime group and Pritchard regime group. It was observed that the majority of the cases were unbooked (90%) and were in the age group of 21-25 years (76.6%). Results: Study observed that eclampsia was primarily a disease of primigravida (61%). Most women in the study group had a bodyweight of fewer than 50 kgs (74%). The average total dose of magnesium sulphate required was 20 grams i.e. 54.5% less than that required in standard Pritchard regime. Majority of the cases (90%) responded to the low dose regime with the recurrence rate being (10%) as compared to Pritchard regime group being (91.6%) and recurrence being 8.33%. The success rate for seizure prophylaxis in imminent eclampsia being 100% in both the groups. The average serum magnesium levels low dose regime in sample 1 was 3.36±0.76 and 3.30±0.69 for sample 2. The therapeutic serum magnesium levels for the present low dose regime being 2.61 to 4.05 mg/dl. The cost of therapy while doing so was reduced to less than half with low dose regime than that of Pritchard regime. The perinatal mortality was 30% with low dose regime. Conclusion: Low dose magnesium sulphate regime was effective in seizure prophylaxis in imminent eclampsia patients and as effective as Pritchard regime in eclampsia patients. The dose required for control of convulsions was less than half used in Pritchard regime and even cost of therapy was half than Pritchard regime.. EnglishLow Dose, Magnesium Sulphate, Eclampsia, Imminent Eclampsia, Seizure prophylaxishttp://ijcrr.com/abstract.php?article_id=2862http://ijcrr.com/article_html.php?did=2862

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareNon Cryopreserved Autologous Peripheral Blood Stem Cell Transplantation in Multiple MyelomaSeries of Cases in a Teaching Hospital in Eastern India English124127Girija Nandini KanungoEnglish Priyanka NagrathEnglish Jasmine SultanaEnglish Rachita BeheraEnglish Priyanka SamalEnglishBackground: An autologous stem cell transplant is an established treatment option for patients with Multiple Myeloma. Many centers treat these patients and have transplantation capabilities but due to the high cost and lack of technical expertise lack of cryopreservation facilities for processing and preserving cells. Methods: This retrospective study was conducted in IMS & SUM Hospital, Bhubaneswar, Odisha from August 2019 to January 2020 in which all the five cases of multiple myeloma which were eligible for stem cell transplant were included. Three stem cell transplants were performed in the COBE spectra auto PBSC system (Terumo BCT, Lakewood, CO) and rest two were performed in the Spectra Optia Apheresis system. Analysis of various characteristics like gender, age, weight, disease status, regimen used, pre-procedure total leukocyte count, pre-procedure CD34 positive cells count, pre-procedure absolute CD34+ cell count, mobilization regimen, time of harvest, and processed apheresis volume was done. All patients were followed until their engraftment and discharge. Results: The number of days of stem cell harvest was 5th and 6th day. The median CD34 cell dose was 47.2/cells/µl. In all cases CD34 count in bag > 5 x 106/ kg .The median time to neutrophil engraftment was 10th day and platelet engraftment was 11th day in all cases. There were no adverse reactions during HPC transfusion. All patients were doing well till date. Conclusion: Autologous Hematopoietic Stem Cell Transplant without cryopreservation resulted in adequate engraftment. Proper planning and coordination between clinicians and Transfusion Medicine specialist are a basic fundamental for efficient transplant and the best possible outcome. English Multiple myeloma, Cryopreservation, Autologous Transplantation, Hematopoietic stem cell transplant, Engraftmenthttp://ijcrr.com/abstract.php?article_id=2863http://ijcrr.com/article_html.php?did=2863

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareBrain Natriuretic Peptide in The Diagnosis of Heart Failure English128131V. Balaji Tulse DassEnglish R. BalamuruganEnglishIntroduction: Heart failure (HF) is a global problem, with more than 20 million people affected. The overall prevalence of heart failure in developed countries is around 2%. The significance of natriuretic peptides (NPs) is well established in the diagnosis of heart failure (HF). Materials and Methods: In this cross-sectional study, 100 consecutive patients who presented with acute dyspnea to the Emergency department of a tertiary medical centre in Palakkad were included from December 2019-April 2020. The initial diagnosis for dyspnea was assigned to the emergency department. Later the patient was evaluated in the cardiology department and a final diagnosis was made. A rapid microparticle enzyme immunoassay (AXSYM SYSTEMS ABOTT) was used for the quantitative determination of BNP measurement. EDTA plasma of the patients was subjected to the estimation of BNP according to the manufacturer’s instructions. Results: Out of 100 patients, 79 % had abnormal BNP levels (>100pg/ml); Out of these,6 In this study, among patients with elevated BNP levels 55 % had abnormal ECG changes and 45 % had normal ECG 1% (n=47) were diagnosed to have CCF(pEnglish BNP, Dyspnea, Heart failure, ECG, Axsym Systems Abotthttp://ijcrr.com/abstract.php?article_id=2864http://ijcrr.com/article_html.php?did=2864

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareYogic Eye Exercises Followed by the Ergonomic Advice on Eye Fatigue in Children Attending Online Classes in COVID-19 English132136Mujahid K SheikhEnglish Rutuja MalavdeEnglish Sachin DaigavaneEnglishBackground: Computer use by children especially school-aged children is growing rapidly. In these decades, due to the rising use of IT, they are using computers or laptops not only for education purpose but also, for playing online games for a prolonged period. Therefore, extensive viewing of the computer screen can lead to eye discomfort, fatigue, blurred vision and headaches, dry eyes and other symptoms of eyestrain. But nowadays, in this hazardous situation, it has been compulsive and essential for the children to get an education by attending online lectures at home environment. Methodology: 44 school-aged children attending online classes in the age group 6 to 15 years were included. Eye fatigue was assessed through the 7-point Likert Scale before the exercise session. The participants were instructed to follow the eye exercises and ergonomic advice for 6 days per week (twice a day) as a 4 weeks protocol. After the exercise session, again eye fatigue was assessed through the 7-point Likert Scale. Later data were collected and analysis was done. Results: A significant reduction was seen in eye fatigue with self- relaxing yogic eye exercises followed by the ergonomic advice in school-aged children attending online classes in COVID-19. Conclusion: Eye fatigue was significantly reduced in the post-exercise session followed by the ergonomic advice as compared to the pre-exercise session in school-aged children attending online classes.. EnglishEye fatigue, Computer use, Children, Eye exercises, Ergonomic advicehttp://ijcrr.com/abstract.php?article_id=2865http://ijcrr.com/article_html.php?did=2865

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareIntensive Care Needs of Chronic Pulmonary Disorders in ICU- Rate of Mortality and Health Care Quality of Life English137143Kedarnath DewanganEnglish Mohd Raheem HussainEnglish Priyadershini RangarEnglishBackground: Chronic obstructive pulmonary disease (COPD) is characterized by expiratory airflow limitation that is not fully reversible. Acute respiratory failure, altered mental status, and hemodynamic instability associated with acute exacerbations of COPD are commonly encountered and require careful management in the intensive care unit (ICU). Noninvasive and invasive ventilator support in conjunction with pharmacotherapy can be lifesaving, although mortality remains high. Aim: To investigate the mortality rate, characteristics and health-related quality of life of COPD patients admitted to Sri Shankaracharya Institute of medical sciences ICU and how the decision is made whether to use invasive or non-invasive intensive treatment of the newly admitted COPD patient in need of ventilator support. Material and Methods: 70 patients admitted to ICU, Sri Shankaracharya Institute of medical sciences were included in the study and their detailed data, including Health-Related Quality of Life (HRQL) was assessed at the time of discharge, 3 months and 6 months post-discharge. A questionnaire was distributed to concerned ICUs personnel to define decisive factors in making the choice between invasive and non-invasive ventilation. The collected data and answers were analysed. Results: 1.5-2% of all ICU admitted patients needed ventilation. The mean age of patients was 68 years and all were severely ill on admission, with high respiratory rates. There were more men than women. The short- and long term mortality was high despite intensive care treatment. The majority of patients were treated with Non-Invasive Ventilation (NIV) with a short hospital stay. NIV seems to be preferable to invasive ventilation at admission for short and long term benefits. The health-related quality of life of COPD patients after treatment in ICUs is lower than in the general population. However, it does not decline between 3 and 6 months after ICU discharge. At the end of 6 months, the HRQL is quite similar to that of COPD patients not treated on the ICU. Conclusions: Patients admitted to ICU for COPD are severely ill and have long term mortality despite ventilation and intensive care. NIV should be the first treatment modality after ICU admission and has short and long term benefits. Also, NIV doesn’t increase mortality if failed. Health-related quality of life post-treatment is lower in such patients than the general population but similar to COPD patients not treated in ICU at 6 months post-discharge. English COPD, HRQL, ICU, Mortality, Ventilationhttp://ijcrr.com/abstract.php?article_id=2866http://ijcrr.com/article_html.php?did=2866

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareQuality of Life and Their Effects on Employment of Rural Diabetic Foot Ulcer Patients in Central India English144151Swagata BrahmachariEnglish SK Khairul EnamEnglish Kshitij GuptaEnglish Vaishali BhagatEnglishBackground: Evidence on HRQL, employment-related factors and expenditure related factor is extremely rare in central India particularly among rural diabetic population. Objectives: This study was performed to measure the effects and health-related quality of life among patients suffering from healed and unhealed diabetic foot ulcer in the central Indian rural population. Method: This was an observational and cross-sectional survey among 118 diabetic foot ulcer patients of either sex were selected randomly from the patients visiting the routine Surgery OPD of tertiary care centres. A pre-tested structured interview proforma was used to collect demographic, social, familial, treatment-related factors, employment and expenditure details. The 29 types of question item DFS- SF was used to evaluate the health-related quality of life among the same diabetic patients in rural population. For the economic loss, this was calculated by the total value of man-days lost in case of the employed population. Results: The mean ± SD of total HRQL score for the healed group was 74.86 ± 12.11, and the unhealed group was 59.92 ± 15.41. The difference between the mean scores for ulcer duration and sex was 16.75 (95% CI = [-22.66, -10.81]). The median value for the total economic loss was 26000 INR (range of 450 to 42000 INR). Conclusion: The mean HRQL score was statistically significant when compared between healed and unhealed groups. There is a gross economic burden imposed on the family by diabetic foot ulcer which needs greater attention. A multidisciplinary approach is needed to reduce the social and economic consequences of diabetic Mellitus causing severe foot ulcers. English Diabetic foot ulcer, HRQL score, Ruralhttp://ijcrr.com/abstract.php?article_id=2867http://ijcrr.com/article_html.php?did=2867

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareThe Clinical Picture of Acute Obstructive Bronchitis in Children and the Rationale for Immunomodulatory Therapy English152155Ibatova Sh. M.English Mamatkulova F. KhEnglish Ruzikulov N.Y.EnglishIntroduction: Acute obstructive bronchitis is a widespread disease among children, leading to frequent relapses and complications. This pathology occupies one of the leading places in the structure of childhood morbidity and mortality. Analysis of risk factors in predicting the likelihood of acute obstructive bronchitis in children is essential for modern pulmonology. Acute pneumonia in patients with acute obstructive bronchitis occurs 4 times more often and almost always has a complicated course. When exposed to an infectious factor and other agents, various immunological changes are observed in children and the body's ability to develop a full-fledged post-infectious immunity is sharply reduced. Result: We examined 65 children with acute obstructive bronchitis and 35 children with acute simple bronchitis without obstruction at the age of 3 months. up to 3 years. Children with acute obstructive bronchitis were at the age of 6 months. up to 3 years old, of which 39 (60%) were boys, 26 (40%) were girls. Immunological research was carried out in the clinical laboratory of the clinic of the Samarkand Medical Institute. The number of T-lymphocytes, T-helpers, T-suppressors, as well as B-lymphocytes, was determined by a modified method. The concentration of serum immunoglobulins A, M, G in peripheral blood was determined by the method of Mancini et al. Phagocytic activity of neutrophils was studied using latex particles. The first group of patients was on traditional treatment with the inclusion of T-activin, and the second group of children was only on traditional treatment. Conclusion: Dynamic immunological study revealed a decrease in factors of phagocytic activity of neutrophils, cellular immunity and developing transient insufficiency of humoral immunity with an increase in the duration of the disease. EnglishAcute obstructive bronchitis, Thymus gland, lymphocytes, T-activin, Children, Clinical and diagnostic observation.http://ijcrr.com/abstract.php?article_id=2868http://ijcrr.com/article_html.php?did=2868

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareComplementary and Alternative Medicine in Association with Type 2 Diabetes Mellitus English156162Pranati ChavanEnglish Pushpa KaraleEnglish Pratibha ThawareEnglish Pranaya MisarEnglishBackground: Type 2 Diabetes Mellitus is a clinical condition that is associated with energy metabolism, particularly carbohydrate and fat management in the organism. An increase in the prevalence of diabetic population and the association of decreasing patient compliance and medication adherence leads to prefer a new concept for the management of disease complications. The use of complementary and alternative medicine (CAM) has proved to be effective for controlling diabetes. Objectives: The purpose of this review is to perform an overview of CAM use, to emphasize its importance for managing diabetic complications and to get outfits of CAM. Discussion: A literature survey was done by using various articles related to CAM and Diabetes mellitus. The focus was kept on the frequency of CAM use, the methods they use, the factors related to the use of CAM, the sources of information about CAM treatment, and the effect of the method used for disease management. Conclusion: This review concluded that CAM therapy found to have adept at reducing blood glucose, maintaining a healthy body, and relieving symptoms of DM. From the study, the relevance of CAM for managing Diabetic complications was verified and the future need to perform scientific researches on CAM use was analyzed. EnglishComplementary And Alternative Medicine, Type 2 Diabetes Mellitus, Neutraceuticals, Mind-body interventions, Healthhttp://ijcrr.com/abstract.php?article_id=2869http://ijcrr.com/article_html.php?did=2869

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareBlood Donor Notification and Counselling: Experience from a Teaching Hospital in Eastern India English163166Santosh MishraEnglish Girijanandini KanungoEnglish Priyanka NagrathEnglish Milind AgrawalEnglishAims: To evaluate the response rate of transfusion transmissible infections (TTI) reactive donors after notifying their abnormal test results at a teaching hospital in eastern India from March 2019 to January 2020. Materials and Methods: This study is a retrospective analysis performed at our department for a period of 11 months. We evaluated the response rate of the sero-reactive donors towards notification of their abnormal test results as a part of post-donation counselling as per the existing strategy of our institute (one telephonic call followed by two reminder calls within one week) in the mobile number provided by the donor. Results: During the period of study among 9922 blood donors 201(2.02%) were sero reactive. Among these the sero-reactive pattern of HIV, HBV, HCV, Syphilis, Malaria were 0.06%, 0.65%, 0.60%, 0.69%, and 0.01%, respectively. After notifying them telephonically about 63.1 %( n=127) could be contacted, advised, and termed Responders. About 36.8% (n=74) could not be contacted and termed Non-Responders due to various reasons analyzed. 25.2 % (n=32) reported at our institute for face to face counselling. Conclusion: Donor notification is an effective method of curtailing TTI but undermined by communication failure with donors, resulting in a persistent load of blood transmissible infectious risk. We need a better structure of pre-donation counselling with the latest and more developed means of communication with our valuable blood donors. EnglishSero-reactive donors, Donor Notification, Responders, Transfusion transmissible infections, Donor Counsellinghttp://ijcrr.com/abstract.php?article_id=2870http://ijcrr.com/article_html.php?did=2870

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareA Clinical Study of Hypernatremic Dehydration in Neonates at a Tertiary Care Hospital English167171S. SandeepEnglishBackground: Hypernatremic dehydration is a serious condition occurring exclusively in neonates. The management is challenging because rapid correction can lead to serious complications. Certain factors like the average environmental temperature play an important role in the frequency of cases detected. Aim: We in the present study tied to evaluate the frequency of hypernatremic dehydration in neonates presenting to our tertiary care hospital. Methods: This Prospective case-control study was conducted in the Department of Neonatology, Aditya Hospital, Hyderabad, from January 2017 to December 2017. A total of n=115 cases>36wks 6 days of gestation age and or 2.499Kg of birth weight, discharged by 36 hours in case of normal vaginal delivery and 72 hrs to 96 hours in lower section cesarean section. With features quite like that of sepsis, neonatal hyperbilirubinemia, but on investigations finally diagnosed and managed as hypernatremic dehydration without sepsis. A total of n=31 cases of hypernatremic dehydration were found out of total n=115 cases in the study. Results: Out of n=31 cases of hypernatremic dehydration, 61.29% were male and 38.7% were females. The average sodium levels throughout the year were estimated in cases with suspicion of dehydration. The sodium levels in the summer months were minimum 159.2 mEq/L and maximum values were 168.1 mEq/L and the average values were 160 mEq/L. Conclusion: The frequency of hypernatremic dehydration is very high in summer seasons in neonates. The typical features of presentation were weight loss, lethargy, hunger, and dehydration. The weight loss was significantly greater in the summer months. Management was done by slow rehydration as per protocol (IV Fluids). Early recognition and prompt treatment will prove beneficial in reducing morbidity and mortality. English Hypernatremic Dehydration, Neonates, Diagnosis, Managementhttp://ijcrr.com/abstract.php?article_id=2871http://ijcrr.com/article_html.php?did=2871

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareCoronavirus Disease (COVID) 2019 in Children – a Short Review English172177Sham Balkisanji LohiyaEnglish Sachin DamkeEnglish Richa ChaudharyEnglishSince December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a series of Cases of severe pneumonia worldwide. It originated in Wuhan in Hubei province, China. SARS-CoV-2 causes infection by ACE receptors, similar to SARS. It causes potential damage to vital organs, mainly the lungs. COVID- 19 mainly affects respiratory tract with symptoms ranging from upper respiratory tract infection like symptoms to full-blown ARDS. Although the pediatric age group is shown to be less susceptible to severe infection, they can very well act as an intermediate in the transmitter of the virus. Treatment is symptomatic for mild diseases, but severe disease and ARDS require ICU management and specific treatment. EnglishCOVID 19, Neonate, Pediatrics, Suspetible, Treatmenthttp://ijcrr.com/abstract.php?article_id=2872http://ijcrr.com/article_html.php?did=2872

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareCorrelation between ARM Span and Height in Age Group of 21-23 Years English178181Vaishali S. MandhanaEnglish G.A. ShroffEnglish Manjiri V. GanjewarEnglish Anagha NavalEnglishObjectives: The height of an individual is an important parameter in a person’s identity. However, in some situations like lower limb deformities, amputations, or in accidents or mass disasters, where mutilated parts of the body are available, measurement of height in the upright position is not possible and here the anthropometry becomes an important aid. Method: In the present study, we included 200 young, healthy medical students of 21-23 years. Out of these 100 were male and 100 were female students. Their height and arm span were calculated in cms using standard procedures. Observation: The data were subjected to statistical analysis. The mean, standard deviation, and standard error of the mean were calculated and the regression equation was derived for the height of males and females separately as Male: Ht=78.233+(0.534) As; R-value=0.702Female; Ht=18.802+(0.861)As; R-value=0.878 Conclusion: Thus It can be concluded that there is a correlation between height and arm span of an individual. And the arm span becomes one of the important and most accurate measures to find the height of a person. English Height, Arm span, Correlation, Regression Equation, Mutilated Body partshttp://ijcrr.com/abstract.php?article_id=2873http://ijcrr.com/article_html.php?did=2873

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareEffect of COVID 19 Affecting Geriatric Patients English182187Vishwa S. PadoleEnglish Ravi P. KalsaitEnglish Ranjit AmbadEnglish Prakash KuteEnglishIntroduction: In December 2019, an upheaval of serious intense respiratory condition coronavirus 2 (SARS-CoV-2) diseases happens in Wuhan, Hubei Province, China spread across the country and glob. On February 12, 2020, WHO authoritatively name the illness brought about by the novel coronavirus as Coronavirus Disease 2019 (COVID-19). Discussion: Geriatric are at high danger of COVID-19 contamination due to lessening invulnerability and a few partners with comorbidities like diabetes, hypertension incessant kidney ailment, ceaseless obstructive aspiratory malady. The mortality in geriatric patients with COVID – 19 is at raised hazard. Conclusion: This survey means to sum up early discoveries on the study of disease transmission, clinical highlights, conclusion, the executives, and anticipation of COVID-19 in geriatric public. English COVID-19, Geriatric, SARS-CoV-2, WHO, Viralhttp://ijcrr.com/abstract.php?article_id=2874http://ijcrr.com/article_html.php?did=2874

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareChallenges and Edge of Tuberculosis Diagnostic Techniques English188192Jyotsana BhattEnglish Nidhi DobhalEnglish Akbar NawazEnglishAim: Tuberculosis remains the most deadly infectious killer affecting about one-quarter of the world population. Early diagnosis and correct detection of TB has always been a challenge since its discovery in 1882. The economic burden in low- and middleincome countries is estimated to be US$ 10.1 billion in 2019. It is necessary to analyze the current tuberculosis diagnostic techniques and understands their advantages and limitations for future advancement. Observation: The current status of tuberculosis necessitates advancement in diagnostic techniques. In recent years with the initiatives taken by WHO, various new diagnosis techniques have been introduced to the world. Techniques such as Fluorescent microscopy and bleach microscopy with their improved sensitivity are proposed to give a new face to the microscopy. Whereas molecular techniques such as Cartridge based NAAT and line probe assay are also proving their potential. Culture techniques such as MB/BacT, Versa TREK/ESP, and Thin layer agar cannot be replaced for their sensitivity and specificity, but they are required to be used alongside new techniques. Novel techniques such as biosensors with the aid of their higher sensitivity, low detection cost, and simple methodology are paving a better future for the world. Conclusion: Despite the long list of conventional diagnostic techniques, early and precise diagnosis of tuberculosis is still a challenge in developing countries. For the complete eradication of tuberculosis from world, we need to focus on developing new diagnostic techniques and also increase awareness about the existing techniques. English Tuberculosis, Microscopy, Nucleic acid amplification test, Biosensors, Transducer, Multi drug-resistanthttp://ijcrr.com/abstract.php?article_id=2875http://ijcrr.com/article_html.php?did=2875

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52411217EnglishN2020September8HealthcareIn-Silico Analysis of Interaction of Human Tetherin Protein with SARS-COV-2ORF7A Proteins and its Mutants English193199Kaveri BishtEnglish Kumud PantEnglish Navin KumarEnglish Akshara PandeEnglish Bhasker PantEnglish Devvret VermaEnglishObjective: One of the best ways to counter any pathogen including SARS-CoV-2 is through enhancement of self-immune response. Tetherin or BST2 is one such interferon-induced antiviral protein or immune regulatory protein of the human host that can restrict the release of virions of SARS-CoV-2. The ORF7a encoded protein of SARS-CoV-2 in-turn has been found to act as an antagonist to the human tetherin protein by interacting with key amino acid residues, thereby weakening the immune response. Methods: In this research after consensus analysis of results from various servers mutations have been induced in selected residues of ORF7a coronavirus protein. Most conserved residues have been obtained through Consurf server, ligand binding pockets, and active sites have been identified after combining results from multiple servers like CastP and 3DLigand Site. Results: The most deleterious mutation has been identified through DUET and DynaMut servers and mutations induced thereafter have been tested for a decrease in binding affinity through the HawkDock server. The protein-protein interaction studies have been performed before and after the induction of mutation through the HawkDock server. Conclusions: The decrease in binding affinity between human tetherin and ORF7a protein is supportive of the need to study the induction of mutation and its detrimental effect on viruses, so that effective combat study can be designed with the interplay of our native immune system and drugs from external sources. Moreover, other deterrents like anti-viral peptides can be designed against selected amino acids. EnglishORF7a, Tetherin protein, Immunomodulation, In-silico, COVID-19, Coronavirus, SARS-COV-2http://ijcrr.com/abstract.php?article_id=2876http://ijcrr.com/article_html.php?did=2876