International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 6(1), January, 2014

Pages: 79-88

Print Article   Download XML  Download PDF

EFFICACY OF BARK OF ACACIA ARABICA IN MANAGEMENT OF BACTERIAL VAGINOSIS : A RANDOMIZED CONTROLLED TRIAL

Author: Rumaiza Jahufer, Wajeeha Begum

Category: Healthcare

Abstract:Back ground and Objective: Bacterial vaginosis (BV) is a polymicrobial syndrome having alteration of vaginal flora involving a decrease in Lactobacilli and predominance of anaerobic bacteria. Objective was to evaluate the efficacy of the Bark of Acacia arabica (chal babool) as an alternate therapy in the management of Bacterial Vaginosis. Methodology: This was a prospective, single blind, standard controlled randomized clinical trial on 45 patients (30 patients in test group and 15 in control group) who attended in and outpatient Department of OBG, National Institute of Unani Medicine hospital, Bangalore, India with complaint of abnormal vaginal discharge or vulvovaginal pruritus. Married patients aged 18- 45 years with regular cycles and diagnosed as having BV were included in this study. Patients were excluded if there was a blood stained discharge, any organic pelvic pathology, systemic illness, malignancy, AIDS, syphilis, gonorrhoea, pregnant and lactating women. Decoction of Chal babool was given orally (30gms twice daily) for one month and standard drug Tab. Metronidazole (400mg twice daily) for 7 days was given in test and control group respectively. For diagnosis and cure rate of bacterial vaginosis, Amsel's criteria were used. Results: There was a significant improvement in the subjective and objective parameters; test drug was found to have similar effective as in control drug in the management of Bacterial Vaginosis (P =1.000) statistically. Conclusion: Patients in both groups have shown improvement by treatment. This study confirms the efficacy of chal Babool as potent astringent and antimicrobial. Phase -3 clinical study shall be recommended with large sample size and prolonged duration.

Keywords: Bacterial vaginosis, Chal babool, Clue cells, Whiff test, Randomized controlled trial

Full Text:

INTRODUCTION

Bacterial vaginosis (BV) is a polymicrobial syndrome having alteration in vaginal flora involving a decrease in Lactobacilli and predominance of anaerobic bacteria including Gardnerella vaginalis, Mobiluncus species, Prevotella species, Mycoplasma hominis and Atopobium vaginae, is among the most common cause. Vaginal discharge is the most common complaint of women of childbearing age. At least 50% of patients have no symptoms [1,2,3]. The Centers for Disease Control and Prevention (CDC) has recently included bacterial vaginosis on their list of emerging infectious diseases [2]. The BV diagnosis was based on Amsel’s criteria [3,4]. The pH of normal vaginal fluid is usually in the range of 3.8 to 4.5. Low pH inhibits bacterial growth and decreases bacterial attachment. In BV the pH is usually above 4.7[5]. Overall there is a significant increase in the vaginal secretion to 109 –1011/gm instead of 105 –106 /gm, with increase of 100 fold to 1,000 fold bacteria[6].BV is more common in women with sexual transmitted infections (STIs), who have recently changed their sex partner, multiple sexual partner, cigarette smoking, stress, low Socioeconomic Status (SES), use of intra uterine contraceptive device (IUCD), frequent vaginal douches, early age at first intercourse and black ethnicity[1,5,7,8,9].The prevalence was 63% in women with multiple sexual partners, 34% in monogamous sexual relationship and 24-51% in lesbian women [10,11]..Women taking vitamin or nutritional supplements were less likely to have bacterial vaginosis[12], and recurrence is common[5,10,13]. BV has been associated with complications like a six fold increased rate of postpartum endometritis, a threefold of pelvic inflammatory, a three to fourfold of vaginal cuff cellulites, amniotic fluid infection and chorioamnionitis [14] and increases the risk of HIV transmission 2-4 fold [14, 15]. In Unani system of medicine white discharge per vaginum (sailanur rehm) is treated with many single drugs since ancient period. Therefore Bark of Acacia Arabica (Chal babool) was selected as research drug as it possess astringent (habis), styptic (qabiz)[16,17,18,19,20], desiccant (mujaffif), tonic(muqawi)[18], antibacterial, antimicrobial, antiseptic properties [20,21,22,23,24].Keeping the above mentioned properties in view an attempt has been made to evaluate the effect of bark of Acacia Arabica in the management of BV.

METHODOLOGY

Study design: A prospective, single blind, standard controlled randomized, pre and post evaluation clinical trial was conducted on 45 patients (30 patients in test group and 15 in control group) who attended in and outpatient department of OBG at National Institute of Unani Medicine hospital, Bangalore, India with complaint of abnormal vaginal discharge or vulvovaginal pruritus during November 2011 to April 2013.The study was performed in accordance with the Declaration of Helsinki and approved by institutional Ethical Committee, NIUM, Bangalore. Married patients aged 18- 45 years with regular cycles and diagnosed as having BV were included in this study after receiving informed consent. In both symptomatic and asymptomatic groups, the diagnosis of BV was based on the presence of at least 3 of the 4 clinical criteria proposed by Amsel and co-workers: adherent watery vaginal discharge, vaginal pH > 4.5, positive amine test, and presence of clue cells [25].Women were excluded if there was a blood stained discharge, any organic pelvic pathology, systemic illness, malignancy, AIDS, syphilis, gonorrhoea, pregnant and lactating women. A detailed history including demographic profile of patients was noted. Following complete evaluation of history and clinical examination, patients were subjected to baseline investigations of complete blood picture, complete urine analysis, random blood sugar, ESR, HIV, VDRL, pelvic ultrasound and Pap smear to exclude systemic illness and pelvic pathology. Safety of drug was assessed by SGOT, SGPT, alkaline phosphatase, blood urea and serum creatinine before and after the treatment. Diagnosis by Amsel’s criteria ie.Vaginal pH was measured by Ranbaxy pH indicator with a range of 4 to7. The pH strip used was a colour-fixed indicator stick. The amine test was considered positive when secretions emitted a fishy amine odor with the addition of 10% KOH[26]. Vaginal secretions were combined with 2 drops of normal saline on a slide and covered with a cover slip for the wet mount. Examination under high-powered microscopy identified the percentage of clue cells

Interventions

The patients were randomly allocated in to test (n=30) and control (n=15) groups by lottery method. Decoction of chal babool was given orally (30gms twice daily) before meal for one month and standard drug Tab. Metronidazole (400mg twice daily) for 7 days in test and control group respectively. Patients were called after two weeks during trial. At each visit vaginal pH, wet mount and amine test were performed. After the completion of the 4 weeks, pre and post treatment values of symptoms and signs were analyzed to evaluate the response or effect of the treatment. Follow up was scheduled to look for recurrence in two visits at 2 weeks and 4 weeks following completion of therapy in those patients who respond with treatment or who were clinically cured.

Assessment

Cure rate was assessed by Amsel’s criteria. Complete cure was considered when there was absence of signs of Amsel’s criteria and associated symptoms. Relief of disease was considered when significant changes in Amsel’s criteria with absence of associated symptoms. Partially relieved was considered when significant changes in Amsel’s criteria with presence of associated symptoms. No response for treatment was labelled when no change in pre-treatment subjective and objective parameters either during or after the treatment.

Statistical Analysis

The Statistical software SPSS 15.0 was used for the analysis of the data. Descriptive and inferential statistical analysis has been carried out in the present study. Results on continuous measurements were presented on Mean ? SD (Min-Max) and results on categorical measurements were presented in number (%).Significance was assessed at 5 % level of significance. Student’s t test (two tailed, independent) ,Chi-square/ Fisher Exact test has been used to find the significance of study parameters on categorical scale between two or more groups.

RESULTS

Patients’ recruitment is mentioned in Fig. 1. A significant improvement of white discharge was observed in test group 23(76.7%) compared to control group 11(73.3%) after intervention Table2. In present study associated symptoms like pruritus vulvae in 28(62.2%), low backache in 32(71.1%), burning micturition in 25(55.5%) and dyspareunia in 9(20%) were reported in test group. The symptoms were reduced with suggestive significance with P value 0.05< P< 0.10 after comparison of both groups after treatment. (Table2) DISCUSSION A detailed analysis revealed that the mean age of patients was 31.90±6.22 in the test group and 29.73±6.16 in the control group. According to SES majority of patients belongs to Upper Lower class (64.4%). Women educated in primary and secondary schools were the most commonly affected groups [13/45(28.9%) and 22/45(48.9%), respectively]. A majority of the patients were housewives (91.1%) as shown in Table 1. Present study showed that the test drug was significantly effective as metronidazole in BV. Table 1 shows majority of the patients were in the age group of 19 - 40 years. The mean ages of participants were 31.90±6.22 and 29.73±6.16 in test and control group respectively. This finding is correlated with the statement of Ayenalem S et al and Xueqiang et al. that disease is more commonly seen in childbearing age group [1, 27].In present study the incidence of bacterial vaginosis was observed more in low SES i.e 40 (88.8%) when compare to upper group, 5 (11.2%) (Table1). This finding is correlated with the statement of many studies conducted. [11, 28,29,30].Yang LR et al. reported that lower genital tract infections are found in low SES [31]. Table 1 shows the number of patients were maximum in the illiterate and secondary level education 40(88.9%) compared to intermediate and higher education 5(11.1%). This finding is in accordance with the statement of previous studies that the disease is more prevalent in illiterate people [28,29,32,33]. Our study showed that incidence of bacterial vaginosis is concerned with occupation of patients (Table 1) i.e., maximum in house wife group 41(91.1%) compare to working class 4(8.9%). Similar finding were reported by Holzman C et al [34]. A significant improvement of white discharge was observed in test group 23 (76.7%) compared to control group 11(73.3%) after intervention. This improvement may be due to antibacterial, antimicrobial, astringent properties of bark of Acacia arabica. [20,21,24]. In present study associated symptoms like low backache and dyspareunia were reported. The symptoms were reduced with suggestive significance. These findings are correlated with previous study conducted by Rajvaidhya et al states that the extract from bark of babool is highly astringent herb may block the body's pain triggers [35]. No adverse effect of test drug was observed during the trial and all the safety profile investigations were within normal limits, hence Acacia arabica was found as safe drug. The limitation of the study was small sample size causing statistical error. Therefore further trial can be carried out to confirm the efficacy and potency of drug on large number of patients.

CONCLUSION

It may be concluded that bark of Acacia Arabica was found to be beneficial in patients of bacterial vaginosis due to its antimicrobial, antibacterial, astringent, styptic, desiccant and tonic effects. It can serve as an alternate remedy for metronidazole, in which relapses are more. This study confirms the efficacy and safety of Acacia arabica as alternate therapy in the management of bacterial vaginosis. Phase three clinical trial can be carried out to confirm the efficacy and potency of research drug. Conflict of interest None

ACKNOWLEDGEMENT

The authors are grateful to the Department of Ayurveda, Yoga, Unani, Siddha and Homeopathy (AYUSH), Ministry of Health, India, Director IIM and commissioner, Colombo for providing all facilities to complete the research.

 

References:

REFERENCES

1. Ayenalem S, Yusuf L, Ashenafi M. Lactic Acid Bacterial Vaginosis among Outpatients in Addis Ababa. Ethiop J Health Dev. 2010; 24(3):198-204.

2. Misic M, Randelovic G, Kocic B, Antic S, Stojanovic M, Mladenovic V. Complications associated with Bacterial Vaginosis. A Review Article ACTA FAC MED NAISS 2005; 22 (4): 161-165.

3. Martinez RCR, Franceschini SA, Patta MC, Quintana SM, Gomes BC, Martinis ECPD et al. Improved cure of bacterial vaginosis with single dose of tinidazole (2g), Lactobacillusrhamnosus GR-1, and Lactobacillus reuteri RC- 14: a randomized, double-blind, placebo-controlled trial. Can J Microbiology 2009; 55: 133-138.

4. Larsson PG, Pedersen BS, Ryttig KR, Larsen S. Human lactobacilli as supplementation of clindamycin to patients with bacterial vaginosis reduce the recurrence rate; a 6- month, double-blind, randomized, placebocontrolled study. BMC Women's Health 2008; 8(3):1-8.

5. Eschenbach DA. Screening, Diagnosis and Management of Bacterial Vaginosis. Issues in Management of STDs in Family Planning Settings: 71-75. [cited on 06/03/12] Available at www.popline.org. 6. Robinson DT, Boustouller YL. Damage to oviduct organ cultures by Gardnerella vaginalis.Int J Exp Path 2011; 92: 260–265.

7. Turovskiy Y, Noll KS, Chikindas ML. The aetiology of bacterial vaginosis. Journal of Applied Microbiology 2011 May; 110(5):1105-28.

8. Hay P. Bacterial Vaginosis. Journal of Paediatrics, Obstetrics and Gynaecology 2002 ;Sep/Oct; 36-40

. 9. Gillet E, Meys JF, Verstraelen H, Bosire C, Sutter PD, Temmerman M et al. Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a metaanalysis. BMC Infectious Diseases 2011; 11(10): 1-9.

10. Verstraelen H, Verhelst R, Vaneechoutte M, Temmerman M. The epidemiology of bacterial vaginosis in relation to sexual behavior. BMC Infectious Diseases 2010; 10(81):1-11.

11. Anonymous Bacterial Vaginosis.Inverness Medical International (IMIL), Priory Business Park 2009 July; 3-16 [cited on 23/04/12] Available at www.balanceactiv.com.

12. Holzman C, Leventhal JM, Jones NM, Wang J. Factors Linked to Bacterial Vaginosis in Non pregnant Women. American Journal of Public Health 2001 Oct; 91(10):1664-1670.

13. Berek JS, Adashi EY, Hillared PA. Novak’s Gynaecology. 12th ed. London: Williams and Wilkins; 1996;430-431.

14. Zahra A, Fateme G, Reza AM. Comparison of the effectiveness of vitamin C vaginal tabletwith metronidazole vaginal gel in the treatment of bacterial vaginosis African Journalof Pharmacy and Pharmacology 2010 July; 4(7): 484-489.

15. Pirotta M, Fethers KA, Bradshaw CS. Bacterial vaginosis. Australian Family Physician 2009 Jun; 38 (6): 394-397.

16. Ghani N. Khazainul Advia. New Delhi: Idarae Kitabul Shifa; YNM: 339-340.

17. Ibn Sina. Al-Qanoon Fit-Tib (Urdu trans. by Kantoori GH). New Dehli: Idarae Kitabus Shifa; 2007:341.

18. Kabeeruddin M. MakhzanulMufradat. New Delhi: Ejaz Publication House; YNM; 118- 119.

19. Hakeem MAH. Bustan ul Mufradat. New Delhi: Idarae Kitabul Shifa; 2002: 120.

20. Zahoor N, Usmanghani K, Akram M, Asif HM , Saleem QE, Sami A et al. Pharmacological activities of Acacia arabica. Crown Journal of Medicine 2011 Nov; 1(2): 09-11.

21. Shazia M, Saadia MA, Jasmine F, Arif JM, Huma M. Anti-Microbial screening of some medicinal plants extracts. International Journal of Research in Ayurveda and Pharmacy 2011; 2 (4):1258-1264.

22. Malviya S, Rawat S, Kharia A, Verma M. Medicinal attributes of Acacia nilotica LinnA comprehensive review on ethno pharmacological claims. Int J of Pharm and Life Sci 2011 June; 2(6): 830- 837.

23. Yasir M, Shrivastava R, Jain P, Das D. Hypoglycaemic and Antihyperglycemic Effects of Different Extracts and Combinations of Withania coagulans Dual and Acacia arabica Lamkin Normal and Alloxan Induced Diabetic Rats. Pharmacognosy Communications 2012 AprJun; 2(2): 61-66.

24. Banso A. Phytochemical and antibacterial investigation of bark extracts of Acacia nilotica J Med Plant Res 2009 Feb; 3(2): 082- 085.

25. Amsel R, Totten PA, Spiegel CA, Chen KS, Eschenbach DA, Holmes KK. NSV Diagnosticcriteria and microbial and epidemiological association.Am J Med 1983; 74:14-22.

26. Egan ME, Lipsky MS. Diagnosis of vaginitis. Am Fam Physician. 2000; 62:1095-1104.

27. Xueqiang F, Yingzhi Z, Yanfang Y, Yutao D, Huiqing L. Prevalence and risk factors of Trichomoniasis, Bacterial vaginosis and candidiasis for married women of child bearing age in rural Shandong. Jpn J Infect Dis 2007; 60:257- 261.

28. Pawanarkar J and Chopra K. prevalence of lower reproductive tract infection in infertile women. Health and population 2004; 27(2):67-75. 

29. Jones FR, Miller G, Gadea N, Meza R, Leon S, Perez J et al. Prevalence of bacterial vaginosis among young women in low-income populations of coastal Peru. International Journal of STD and AIDS 2007; 18: 188–192.

30. Valiani M, Zolfaghari M,Nazemi M, Pirhadi M, Ebrahimian S. The relationship between family planning methods, individual hygiene, and fertility with vaginal infections among the women referring to selected health centers in Isfahan city. Iran J Nurs Midwifery Res. 2011 winter; 16(1):83–92.

31. Yang LR, Zhao H, Wang HP, Li Y, Niu JP, Su KJ et al. Improving ability of married women to prevent reproductive tract infections in rural western China. Environmental health and preventive medicine 2006 Sep; 11: 233-240.

32. Ashraf-Ganjoei T. Risk factor for bacterial vaginosis in women attending a hospital in Kerman, Islamic Republic of Iran. East Mediterr Health J 2005 May; 11(3):410-5.

33. Bhalla P, Chawala R, Garg S, Singh MM, Raina U, Bhalla R et al. Prevalence of bacterial vaginosis among women in Delhi, India. Indian J Med Res 2007 Feb; 125: 167- 172.

34. Holzman C, Leventhal JM, Jones NM, Wang J. Factors Linked to Bacterial Vaginosis in Nonpregnant Women. American Journal of Public Health 2001 Oct; 91(10):1664-1670.

35. Rajvaidhya S, Nagori BP, Singh GK, Dubey BK, Desai Pand, Jain S. A Review on Acacia Arabica- An Indian medicinal plant. IJPSR, 2012; 3 (7):1995-2005.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions