International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 6(5), March, 2014

Pages: 01-08

Print Article   Download XML  Download PDF

TOPICAL VERSUS CONTINUOUS BETAMETHASONE DIPROBIONATE PHONOPHORESIS IN THE TREATMENT OF ATOPIC DERMATITIC PATIENTS

Author: Intsar S. Waked, Abdel Hamid N. Deghidi

Category: Healthcare

Abstract:Purpose: The purpose of this study was to compare Topical versus Continuous Betamethasone Diprobionate Phonophoresis in the Treatment of Atopic Dermatitic Patients Methods: Forty six patients atopic dermatitis were participated in this study and were randomly assigned to one of two groups. Phonophoresis group received continuous 0.05% betamethasone dipropionate phonophoresis, three sessions per week for 4 weeks, and control group received topical betamethasone dipropionate cream daily. Measurements were carried out by ultrasonography and SCORAD score. Results: results revealed that there was a significant difference between both groups as regard to primary outcomes ( SCORAD score) as well as secondary outcomes ( skin thickness measurements). Conclusion: it was concluded that continuous betamethasone diprobionate phonophoresis is a safe and effective modality more than topical cream for the treatment of atopic dermatitis.

Keywords: Phonophoresis, betamethasone dipropionate phonophoresis, SCORAD score, ultrasonography, Atopic dermatitis.

Full Text:

INTRODUCTION

Atopic Dermatitis (AD) is a chronic (long-lasting) disease that affects the skin. The word “Dermatitis” means inflammation of the skin. “Atopic” refers to a group of diseases that are hereditary (that is, run in families) and often occur together, including asthma, allergies such as hay fever. In atopic dermatitis, the skin becomes extremely itchy and inflamed, causing redness, swelling, cracking, weeping, crusting, and scaling1. Any chronic illness can have major impact on the sufferer's life. Atopic disease have become a major health problem. Its chronic course with extreme pruritus and loss of sleep affects the whole family. AD may have profound effects on the quality of life, social relationships and development. It also interferes with school and physical activities. Treatment may be demanding with frequent hospital attendances2 . Topical corticosteroid such as betamethasone phonophoresis is effective in patients with AD. Although topical corticosteroids have been the mainstay of treatment for the past 40 years, they have local and systemic side effects. Local effects include skin atrophy, telangiectasias, hypopigmentation, rosacea, perioral dermatitis and acne. Systemic side effects include adrenal suppression, cataracts, glaucoma and growth retardation in children. These effects cause anxiety for both patients and clinicians and this is the main reason for patients' poor compliance with treatment3 . The major barrier to the delivery of transcutaneous drugs is the skin. Pharmaceutical companies are continually involved in research to try to find new

ways to enhance the delivery of topical drugs. Although complex chemical enhancers have been integrated into some transdermal delivery systems, physical agents such as electricity and ultrasound (US) are becoming increasingly popular as enhancers. The use of electricity as an enhancer is referred to as iontophoresis, and the use of US as an enhancer is referred to as phonophoresis or sonophoresis4 . Phonophoresis (PH), has been claimed to enhance the percutaneous absorption of certain pharmacological agents such as anti-inflammatory, steroids and local anesthetics from intact skin into the underlying subcutaneous structures by ultrasound, therefore improving their effectiveness. PH offers the potential advantage of delivering a pharmacologic agent in a relatively safe, painless, and easy manner to structures that lie somewhat deep within the body 5 . Phonophoresis (PH) has been studied in vivo with several anti-inflammatory drugs, including hydrocortisone 6 , benzydamine 7 , dexamethasone 8 , and salicylates 9 and with anesthetics, such as lidocaine 10 , with variable results. However, no study in literature review conducted to study the efficacy and safety of betamethasone dipropionate phonophoresis in patients with AD. Therefore, we used 0.05% betamethasone dipropionate cream on daily bases as the reference for comparing and evaluating the efficacy and safety of phonophoresis 0.05% betamethasone dipropionate applied every other day in young adult with AD.

PATIENTS AND METHODS

Subjects This study was carried out on 46 patients with mild to moderate atopic dermatitis. Signed informed consent was obtained from each participant before enrollment in the study. History and clinical examination were done for all subjects and diagnosis of AD was made according to criteria proposed by Hanifin and Rajka, modified diagnostic criteria11 . Reasons for exclusion were patients had severe AD, known sensitivity to the study treatments or eczema confined to the face or nappy area. Patients were excluded if they had received any therapy for AD other than emollients or antihistamines within four weeks before the start of the study. Treatment was stopped when the SCORAD system 12 was below 9 (clinically healed) or ultimately after 4 weeks. All subjects were participated in single blind, randomized, controlled trial. To detect a 50% reduction in SCORAD index scores at the 5% significance level with 80% power, 23 patients per group are required. We recruited a larger number to allow for an estimated 10% withdrawal rate. A computerized random number list was generated and the subject allocation sequence was created from the list. The patients met with the blinded investigators who conducted the assessments. Following their assessments, the patients were assigned into 2 groups of equal number. PH - group received 0.05 % Betamethasone Dipropionate phonophoresis (BDP). Control group received 0.05 % Topical Betamethasone Dipropionate (TBD).

Measurements

All measurements have been recorded by blinded investigators who did not know the assignment groups. Primary outcome measurement included assessment of AD severity using SCORAD. The SCORAD have been collected at baseline (Pre) after 2 and 4 weeks. 2-week follow-up period with basic skin care only served to evaluate the AD and whether a rebound occurred. Secondary outcome included assessment of the thickness using ultrasonography, and safety analysis via measuring cortisol exertion in urine.

Severity of AD using SCORAD

The clinical severity of AD was evaluated by using the SCORAD index that developed by the European Task Force on atopic dermatitis (1993) 13. It defines a score of three parameters: extent, intensity and subjective symptoms. Extent is calculated with the rule of nines. Intensity items are erythema, edema/papulation, oozing/crust, excoriation, lichenification and dryness of non involved skin (0 to 3 points for each item). Subjective symptoms are pruritus and sleep loss for the last 3 days or nights (0 to 10 points for each item). The final score is then calculated according to the following equation: A/5 + 7B + C, where, A represents extent, B represents intensity and C represents subjective symptoms. The SCORAD is considered mild AD is less than 25, moderate lies 25-50 and severe AD is above 50. 

Ultrasonography Measurements \

Throughout this study the depth of the lesions was evaluated using a high-resolution ultrasound system dedicated to skin applications 14. A Derma Scan C Ver. 3 (Cortex Technology ApS, Hadsund, Denmark) was used. The system frequency was at 20 MHz and with 10 mm penetration. The size of the probe was 19X33 mm and the scan length 12.1 mm. The principle of ultrasound imaging is based on the ultrasonic wave being partly reflected at the boundary of adjacent structures when traveling through tissue. The strength of this reflection depends on differences in the density of such structures, which leads to an amplitude variation of the reflected signal. Finally, processing of the signal received from multiple ultrasound pulses over an area of the skin forms a two-dimensional image; a so-called B-scan Safety Analysis Three 24-hour urine sample were collected for urinary-free cortisol/creatinine analysis at the beginning (baseline), the last day of the treatment period and at follow up. The 24-hour urine collections were mixed and stored frozen at-200C until they were analyzed in the clinical laboratory department 15 .

Treatment Procedures

Continuous Betamethasone Dipropionate phonphoresis has been conducted through Ultrasound device (Nonius, Sonopuls 434, SN 03- 202 type 1463.900, Enraf, Holland) , three sessions per week for 4 weeks. The patients assumed a comfortable position, then therapist clean and hydrate the body part under treatment. Adjust the US frequency to 1MHz, with intensity 1.5 W/cm2 and the time of treatment was 5 min 16 . For control group: The patients were instructed to apply the ointment to the selected area once daily

Statistical Analysis

Data were expressed as mean ± standard deviation (SD). Student t test was used to assess the difference between the studied parameters in two groups. Paired t test was used to analyze the thickness of the skin within the group. We analyzed severity scores by using a repeated measure analysis of variance. Cortisol excretion between the two groups was compared using the Mann-Whitney U test, and compared in time within each of the two treatment groups using the Wilcoxon test. Analysis was performed using SPSS/PC software (SPSS Inc., Chicago, IL, USA). All p values less than 0.05 were considered to be statistically significant.

RESULTS

Baseline Characteristics of the Patients Fifty-five patients enrolled in the study. Of these, 46 completed the study and nine dropout (3 patients in the PH -group and 6 in the control group). At baseline, the demographic characteristics, disease severity thickness of lesion and cortisol level were similar in both treatment groups. Table 1 lists the baseline characteristics.\

Results of the Primary Outcome SCOARD

No differences were observed in the SCORAD at the beginning of the study between the groups. Analysis of variance demonstrated significant difference in the mean downward linear trend of SCORAD within each group at 4 weeks compared to baseline and 2 weeks respectively. After 2 week of the treatment, the SCORAD (mean ± SD) significantly decreased in both treatment groups (PH: 17.04 ± 9.72, control: 19.56 ± 5.62). In spite of the marked improvement after 2 week, only 9 patients in the PH -group was scored as clinically healed (SCORAD < 9), and 3 patients was scored as clinically healed in the control group. At the 4 weeks of the treatment, the improvement of AD was more pronounced in the US-group. The mean SCORAD had dropped significantly to 8.08 ± 2.72 for US group compared with 14.26± 6.52 for the control group. There were 27 subjects with a SCORAD of 9 or less (17 in the PH -group and 10 in the control group). Two weeks after discontinuation of active treatment, the mean SCORAD had increased to 13 ± 9 (PH group) and 21 ± 7 (control group

 after 4 weeks of treatment for PH and control group was 9.13±1.09 and 12.12±1.38 respectively. These results confirm the effectiveness of ultrasound in enhancing transfer of betamethasone diprobionate so enhancing healing and treatment of atopic dermatitis patients. Numerous studies16-18have since demonstrated that US is generally safe, with no negative long- or short-term side effects, but the mechanisms by which US works as an enhancer are less clearly understood. The simplest explanation for the effectiveness of US as an enhancer of drug delivery is based on its heating effects. Heat increases the kinetic energy of the drug molecules and the proteins, lipids, and carbohydrates in the cell membrane. Temperature changes of approximately 5°C are necessary to cause measurable changes in cell membrane permeability. This level of increase in heating only predictably occurs when the US intensity is 1.5 W/cm 2 or higher 19. Overall, the reviews of the research on the efficacy of phonophoresis are promising. Some of the studies, however, suffered methodological constraints that limit generalizability (eg, no control group, the experimenters were not blinded, the US delivery system was not calibrated, methods of documenting effectiveness were not objective, a small number of subjects were studied, or the topical drug used was not checked to ensure that it transmitted US (transmissivity). All these constraints were avoided in our study. And the transmissivity of betamethasone diprobionate was tested by Cameron MH and Monroe LG 20. Bommannon and colleagues17 concluded that highfrequency US was effective as an enhancer of transcutaneous drugs and could be used safely for short periods of time. When 16-MHz US is used for more extensive periods of time, it is possible that the bubbles of the micronuclei begin to grow, then collapse and self-destruct (cavitation), secondarily enhancing drug penetration. Tyle and Agrawala 21 reviewed the effects of drug delivery by phonophoresis in 1990 and concluded that US effectively enhanced localized and systemic drug delivery. Friberg24 reported that some of the studies that showed increases in drug diffusion with US were correlated with damage to the stratum corneum. This damage was either part of the pathology designated for treatment (eg, psoriasis, dermatitis, and ulcer) or it was an outcome of the US treatment itself or the use of a stationary sound head. Draper and Prentice 22 reported that the thermal effects of ultrasound increase tissue permeability, and the acoustic pressure created by the ultrasound beam drives the medication into the tissue. Naik et al.,23 reported that both the thermal and nonthermal effects of US increase cell permeability. Also Abd El Baky and Waked24 concluded in their study that phonophoresis is an effective method to enhance the delivery of ibuprofen and so enhance the improvement of grip strength. Barbara.,25 documented that both the thermal and nonthermal characteristics of high-frequency sound waves can enhance the diffusion of topically applied drugs. Heating from US increases the kinetic energy of the molecules in the drug and in the cell membrane, dilates points of entry such as the hair follicles and the sweat glands. And increases the circulation to the area sonicated. These physiological changes enhance the opportunity for drug molecules to diffuse through the stratum corneum and be collected by the capillary network in the dermis. In order to assess the safety of the study, Comparing the 24-hour urinary cortisol excretion at the beginning with the excretion at the end of treatment for both groups and the results revealed that there was no significant difference between the beginning and the end of treatment in both groups.

CONCLUSION

Finally, according to the results of our study and reports of other investigators in similar studies, It can be concluded that, betamethasone diprobionate phonophoresis is a safe and effective modality more than topical cream for the treatment of atopic dermatitis.

References:

REFERENCES

1. Eldy DJ. What’s new in atopic dermatitis? Br. J. Dermatol.2001;(145): 380-384.

2. Staab D, von Rüden U, Kehrt R, Wahn U. The Impact of Childhood Atopic Dermatitis on Quality of Life of the Family. Dermatology and Psychosomatics 2000;1;(4):173-178.

3. Charman, C.R.: Outcome Measures of Disease Severity in Atopic Eczema. Arch. Dermatol. 2000; (136): 763-769,.

4. Kost J, Levy D, Langer R. Ultrasound as a transdermal enhancer. In: Osborne DW, Amann AH, eds. Topical Drug Delivery Formulations: Volume 42. New York, NY: Marcel Dekker inc; 1990: chap 34(603-632).

5. Srbely,S.: Ultrasound in the management of osteoarthritis: part I: a review of the current literature, JCCA J Can Chiropr Assoc. 2008;; 52(1): 30–37.

6. Kuntz AR, Griffiths CM, Rankin JM, Armstrong CW, McLoughlin TL. Cortisol concentrations in human skeletal muscle tissue after phonophoresis with 10% hydrocortisone gel. J Athl Train. 2006;41:321–324.

7. Benson HA, McElnay JC, Harland R. Use of ultrasound to enhance percutaneous absorption of benzydamine. Phys Ther. 1989;69:113–118.

8. Darrow H, Schulthies S, Draper D, Ricard M, Measom GJ. Serum dexamethasone levels after Decadron phonophoresis. J Athl Train. 1999;34: 338–341.

9. Ciccone CD, Leggin BG, Callamaro JJ. Effects of ultrasound and trolamine salicylate phonophoresis on delayed-onset muscle soreness. Phys Ther. 1991;71:666–678.

10. Benson HAE, McElnay JC, Harland R. Phonophoresis of lignocaine and prilocaine from EMLA cream. Int J Pharm. 1988;44:65– 69.

11. Williams HC, Burney PG, Hay RJ, Archer CB, Shipley MJ,Hunter JJ, et al. The UK working party's diagnostic criteria for atopic dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis. Br J Dermatol 1994;131:383-396.

12. Kunz B, Oranje AP, Labreze L, Stalder JF, Ring J, Taieb A. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology 1997;195:10-19.

13. European Task Force on Atopic Dermatitis. Severity scoring of atopic dermatitis: the SCORAD index. Dermatology 1993;186:23- 31.

14. Serup J, Keiding J, Fullerton A, Gniadecka M, Gniadecka R. High-frequency ultrasound examination of skin: introduction and guide. In: Serup J, Jemec BE, eds. Handbook of noninvasive methods and the skin. USA: CRC Press, 1995; 239 - 256.

15. Wolkerstorfer A, Strobos MA, Glazenburg EJ, Mulder PG, Oranje AP. Fluticasone propionate 0.05% cream once daily versus clobetasone butyrate 0.05% cream twice daily in children with atopic dermatitis. J Am Acad Dermatol 1998;39:226-31

16. Byl NN, McKenzie AL, Halliday B, Wong T, O’Connell J. The effects of phonophoresis with corticosteroids: a controlled pilot study. J Orthop Sports Phys Ther. 1993;18:590–600.

17. Bommannan D, Okuyama H, Stauffer P, Guy RH. Sonophoresis, I: the use of highfrequency ultrasound to enhance transdermal drug delivery. Pharmceutical Research. 1992; 9:559-564.

18. Bommannan D, Menon GK, Okuyama H, et al. Sonophoresis, II: examination of the mechanisms(s) of ultrasound-enhanced transdermal drug delivery. Pharmaceutical Research. 1992;9:1043-1047.

19. Nyborg WL. Mechanisms. In: Nyborg WL, Ziskin MC, eds. Biological Effects of Ultrasound. New York, NY: Churchill Livingstone Inc; 1985:23-33.

20. -Cameron MH, Monroe LG. Relative transmission of ultrasound by media customarily used for phonophoresis. Phys Ther.1992 ;72:142–148

21. Tyle P, Agrawala P. Drug delivery by phonophoresis. Pharmaceutical Research. 1989;6: 355-361.

22. -Draper, O.O. and Prentice W.E.: Therapeutic ultrasound. In: Draper, O.O. and Prentice, W.E. (ed): Therapeutic modalities for allied health professional. New York, McGraw- Hill, 1st ed. 263-309, 1998.

23. -Naik, A., Kalia, Y.N, and Guy, R.H.: Transdermal drug delivery: overcoming the skin’s barrier function.PSTT:3(9): 318- 326,2000.

24. Abd El Baky A.M and Waked I.S; Nonsteroidal anti-inflammatory phonophoresis versus topical application in improvement of hand grip strength in psoriatic arthritic patients; Journal of American Science, 2011;7(6); 110-114.

25. Barbara, C.: Phonophoresis versus topical application of ketoprofen: comparison between tissue and plasma level. Phys. Ther. August: 349-356, 2003 .

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions