International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 06 Issue 06, March, 2014

Pages: 93-99

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TUBERCULAR CERVICAL LYMPHADENITIS : EXPERIENCE OVER A FOUR YEAR PERIOD

Author: Vineet Chaudhary, M. Abbas Ali, Ravi Mathur

Category: Healthcare

Abstract:Objective: This Study was done with the Aim to investigate various Clinico-pathological aspects of Tubercular cervical lymphadenitis. Material and Methods: Four hundred patients with cervical lymphadenopathy of all age group, out of which 220 males and 180 females who attended OPD of NIMS Medical college, Jaipur between March 2009 and Feb 2013 were included in study.FNAC of Cervical lymph nodes was done. The lymph node biopsy was done in selected patients. Mycobacterial culture was also done in selected patients. Total 218 cases of tubercular cervical lymphadenitis (proved by FNAC/Biopsy) were included in this study. Results: Most common cause of cervical lymphadenopathy was found to be tubercular in 218 patients (54.5%). Female/Male Ratio was 1:84. Younger Age Group (15-30 years) was most commonly affected, seen in 77 patients (35.32%). Diagnostic accuracy of FNAC in tubercular lymphadenitis was 95.41% .Concurrent pulmonary tuberculosis was seen in 33 patients (15%).Constitutional symptoms were present in 32 patients(14.67%).Montoux Test was positive in 100 patients(45.87%). Posterior Triangle of neck was most commonly involved.Commonest presentation of tubercular lymph nodes was multiple matted lymph nodes, seen in 110 patients (50.45%).In our study 150 patients (68.80%) presented as 2-4cms size lymph nodes. Conclusion: This study also emphasizes that complications can be minimized by regular anti tubercular treatment, good patient compliance and regular follow up especially for development of fresh complications.

Keywords: Tubercular cervical lymphadenitis, FNAC, ATT, Defaulters, Excisional biopsy, mycobacterium culture.

Full Text:

INTRODUCTION
Cervical lymphadenopathy is one of the commonest clinical presentation of the patients attending hospital outdoor.Grossly cervical lymph node enlargement can be classified as Acute and chronic cervical lymphadenitis. Chronic cervical lymphadenitis usually presents as chronic painless enlargement of cervical lymph nodes. Etiology of chronic cervical lymphadenitis is either tubercular or due to secondary malignant deposits or lymphomas. Tubercular lymphadenitis (historically referred to as scorfula) is the commonest form of extrapulmonary tuberculosis reported in children from TB endemic areas ,present in 8-10% of children diagnosed with TB in India and South Africa (1,2). Lymph nodes become infected with mycobacterium tuberculosis following lymphatic drainage from local disease site or after haemetogenousdisiminetion .The aim of this study was to investigate various clinicopathological aspects of tubercular cervical lymphdenitis among patients presenting to Four hundred patients with cervical lymphadenopathy of age group,new born to s

our institute over a four year period.

MATERIALS AND METHODS

eventy five years,out of which 220 males and 180 females who attended OPD of NIMS Medical college, Jaipur between March 2009 and Feb 2013 were included in study .Written Informed consent was obtained from all study subjects. All patients were clinically assessed and a detalied history was taken regarding age , sex ,mode of onset ,duration, distribution, family history, presence or absence of pain, fever, weakness, loss of weight, night sweats, anemia, cough, progress of disease. All clinical records were maintained. After taking patient’s history, full clinical examination was done. Special emphasis was made to site/size/clinical stage of cervical lymph node. All patients were subjected to routine investigations CBC, ESR,MT, X-Ray chest PA view. FNAC of Cervical lymph nodes was done with help of 10cc disposable syringe and needle (22gauge). Half smears were dried in air and half were fixed by immersing in absolute alcohol for one hour .The lymph node biopsy was done in selected patients. Mycobacterial culture was also done in selected patients.Total 218 cases of tubercular cervical lymphadenitis (proved by FNAC/Biopsy) were included in this study.

OBSERVATIONS

Out of total 400 patients, 220 (55%) were males and rest 180(45%) were females. Tubercular lymphedentis was the most common FNAC finding in 208 patients (52%) followed by Reactive hyperplasia in 100 patients (25%).

DISCUSSION

Lymphadenitis is the most frequently occurring form of pulmonary TB, with cervical Nodes being most commonly involved in adults. Although inguinal, mesenteric and mediastinal Nodes may be involved (1, 2.) It has been found that by FNAC alone, 208 patients (52%) were found to have tubercular cervical lymphadenitis followed next by Reactive Hyperplasia in 100 patients (25%). These 100 patients with Reactive Hyperplasia group were also subjected to Excisional Biopsy. It has been found in our study that 10 patients of Reactive Hyperplasia group proved to be Tubercular by Excisional Biopsy. So overall by Excicional Biopsy overall 218 (54.5%) patients proved to be tubercular in our study. This study emphasises that Tubercular cervical lymphadenitis is one of the most common clinical presentation of Extra pulmonary tuberculosis. In our study, FNAC of cervical lymph Node Biopsy was positive for Tubercular lesion in 208 patients, out of 218 patients. So, Diagnostic accuracy of FNAC in Tubercular Cervical lymphadenitis was 95.41% in our study. This study emphasises importance of FNAC in diagnosis of Tubercular Cervical Lymphadenopathy. Fine Needle aspiration is suggested as an initial investigation if lymph node Tuberculosis is suspected. (3) FNAC constituted main diagnostic tool, with positive yield in 90% on Patients, TB cervical lymphadenitis can be readily diagnosed by FNAC as a simple and cost-effective test. (4) Fine needle aspiration is simple, cheap and may be of value in the diagnosis of Tuberculosis, especially in developing countries with limited diagnostic and therapeutic resources.(5) In our study, 77 patients(15.32%) were found to have Tubercular Cervical Lymphadenitis in 15-30 year age group, followed by 67 patients (30.73%) patients in children age group (0-15 yr); 42 patients (19.20%) in 30-45 years age group and 32 patients (14.60%) in >45 age group. Our study shows maximum incidence of Tubercular Cervical Lymphadenitis in younger and children age group.Tuberculosis was found to be common in young patients who are in accordance with local data as well as international data. (6)In another study, Tuberculosis found to be commomest in young adult females (15-24yrs) age group and rare above age of 45yrs. (7) It has peak incidence in 20-40 age groups. (8) In our study. Tubercular Lymphadenitis was found in 118 (54.12%) female patients as compared to 100 (45.87%) male patients. So in our study, M: F was 0.84:1. TB lymphadenitis is showing some atypical characteristics for its distribution according to age and sex as it is more common in females and in younger age groups, in compare to pulmonary TB which is more commonly affects males and older age group.(9) Family History of any form of Tuberculosis in our study was found in 55 patients (25%). Concurrent Pulmonary tuberculosis was found in 33(15%) patients in our series. Constitutional symptoms were found in 32 (14.67%) patients. Fatigue, Bodyache was commonest symptom in 10 patients (4.58%) followed by loss of weight, failure to thrive (children) in 7 patients (3.21%), cough in 6 patients (2.75%), fever in 5 patients (2.29%), Night sweats in 4 patients (1.83%).Most physicians agree that Tubercular Cervical Lymphadenitis is a local manifestation of systemic infection but a striking feature of many reports in infrequent occurrence of systemIc features and specifically of pulmonary involvement. (10) Constitutional symptoms were not present in most patients in few series. In several series, in approximately 80% (11) patients, the chest films were normal so there is continuous debate whether Tubercular Cervical Lymphadenitis is a localized disease or a part of systemic disease. (12) Post Traingle of Neck was found to be most common involved in 98 patients (44.95% ) followed by upper deep cervical lymph nodes in 66 patients(30.27%) , submandibular lymph node in 20(9.17%) patients ,supraclavicular in 18(8.25%),preauricular lymph node in 16 patients(7.33%). In a study by Pameraetal (15) regarding distribution of enlarged lymph nodes, the upper jugular, submandibular and supraclavicular groups were found involved more often and occipital group less often. Montoux Test was positive in Tubercular Cervical Lymphadenitis in 100 patients (45.87%). Among 100 Tubercular cases (M.T. positive), 48 patients were below 15 years age. Hence Montoux Test was positive in 48 patients, out of 67 patients (71.64%) in 2cm, upto 4 cm) was found in 150 patients (68.80%), followed by LN size (>4cm) in 41 patients (18.80%), LN (<2cm) in 27 patients (12.38%). Pus/discharge sent frorMycobacterial culture in 40 patients presenting as soft fluctuant swelling(Abscess) and remaining 16 patients presenting as Sinus/Ulcer Pus culture for mycobacterial infection was found to be positive in 38patients (67.85%) In another study (16), 52 patients out of 80 (65%) showed positive culture for Mycobacterium Tuberculosis of human type in Lowenstein Jensen medium.Comparison was made between two groups. First group included 152 patients (70.18%) who were regularly taking ATT and second group included 65 patients (29.81%) with poor compliance/defaulters. It was found that in Defaulter group, appearance of fresh nodes was seen in 7 patients,increase in size of nodes in 6 patients, fresh abscess development in 6 patients and sinus formation in 7 patients, as compared to 1st group( Patients on regular ATT andgood compliance)these figures were 3 patients,3 patients, 4patients ,4 patients respectively. Over complication rate during course of ATT was seen in 26 patients (40%) in defaulter group campared to 14 patients (9.15%) in 1st group. This emphasises importance of Regular course of ATT in management of tubercular lymphadenitis. 14(9.15%) patients inspite of regular ATT developed various complications like Abscess/Sinus formation. Fresh untreated cases of tubercular cervical lymphadenitis were managed by 2 months Isonex, Rifampicin, Pyrazinamide followed by 4 months Isonex, and Rifampiciin. Relapses/ Defaulters managed by 2 (HRZES), 5(HRE). Randomised controlled trials have demostrated convincingly that tubercular lymphadenopathy can be treated by short course of chemotherapy. In adults the results of 9 months of INH, Rifampicin accompanied by Ethambutol for initial 2 months did not differ significantly from those receiving prolonged therapy of 18 months.(17) Equally good results were achieved by using a regimen of RMP and INH for 6 months supplemented by PZA during initial 2 months. (18) Paradoxical expansion of lymph node may be  seen during first 2 months of treatment in up to 20% of cases, but the occurrence thereof doesn't indicate failure of chemotherapy. (19) Excision as treatment option is particularly suitable in Non tubercular mycobacterial infections, where the therapeutic response to chemotherapy is frequently suboptimal. (20) Incisional Biopsy should be avoided because it tends to result in sinus formation. (21)

CONCLUSION

Presentation of tuberculosis is not only as pulmonary but cervical lymphadenopathy also a common presentation. Most common cause of cervical lymphadenopathy was found to be tubercular followed by reactive lymphadenitis , metastatic deposits and Lymphomas.Cervical lymphadenopathy was commonly affect Younger Age Group(15-30years) Diagnostic accuracy of FNAC in tubercular lymphadenitis was 95.41% in our study which emphasises importance of FNAC as simple, cheap and excellent first line diagnostic step. Posterior Triangle of neck was most commonly involved. Commonest presentation of tubercular lymph nodes was multiple matted lymph nodes. In our study most of patients presented as 2-4 cms size lymph nodes. Various complications like appearance of fresh nodes, abscess, sinus etc are seen in more in defaulter/poor compliance patients as compared to patients who were regularly taking ATT. This study also emphasizes that complications can be minimized by regular anti tubercular treatment, good patient compliance & regular follow up specially for development of fresh complications.

References:

REFERENCES

1. Dandapat MC, Mishra BM, Dash Spectal peripheral lymph node tuberculosis: a review of 80 cases BrJ. Surg. 1990; 77: 911-912.

2. Memish ZA MahMW, Mahmood SA etal.Clinico diagnostic experience with Tuberculouslymphodenitis in Saudi Arabia. ClinMicriobiol Infect 2000:6:137-141.

3. Diagnosis and therapy of Lymph Node Tuberculosis .Praxis (Bern 1994) 1999 Jan 21, 88(4) 105-112.

4. J.laryngolotol 2009 July, 123 (7) Khan R, Harris SH, Vama AK, Syed A .Dept. of Pathology, JN Medical College, AMU.

5. ”Fine Needle Extra thoracic aspiration in HIV associated sputum Negative Tuberculosis”.Lancet 1992Dec 19- 26,340(8834-8835):1504-5

6. KhanAcl, Nawaz G. Khan Ar. An audit of 75 cases of cervical lymphadenopathy. J. Med.Sci. 2011; 19:95-97.

7. Olu, Eddo An, Ohanaka CE Peripheral lymphadenopathy in Nigerian adults. J pak Med Assoc 2006, 56, 405-408.Lancet 1992 Dec 19-26, 340 (8834-8835): 15.4-5.

8. Golden MP and VikramHR (2005) Extra Pulmonary tuberculosis: An overview Am. Fam. Physician 72: 1761-1768.

9. Shubha AB, Sapna H, Dinesh RB (2010) Tubercular lymphadenitis presenting a diagnostic Dilemma – a case report Int J Dent.Clin 2:48-52.

10. Mair IW Elverland HH. Cervical mycobacterial Infection J.Larygolotolo 1975:89.933-939.

11. Cervical Tuberculous lymphadenopathy: Changing Clinical patterns, and concepts in management. B Jha A Das N Nagarker R Gupta and S Singhal Post Grad. Med J. 2001 March 77 (905) 185-187

12. Ord RJ, Matz GJ. Tuberculous cervical lymphadenitis. Arch otolaryngnol 1974; 99:327-329.

13. Schroeder KE, Elverland HH, Mair IW, Liavaag PG GranulomAtous Cervical lymphadenitis J.Otolaryngol 1979:8:127-131

14. Wong ML, Jafe KBN Cervical mycobacterial disease. Trans Am AcadOpthalmootolary 1974; 78:75-87.

15. PamraSP, MathurGP, a Cooperative study of Tuberculous cervical lymphadenitis, Indian J Med Res.1974; 62:1631-1646

1 6. Peripheral L.Node Tuberculosis: A review of 80 cases BJS vol. 77, Issue 8, pages 911-912 Aug 1990 professor M.C.Dandapat, BM Mishra , S.P. Dash, P.K.Kar.

17. Campbell JA The Treatment of Superficial Tuberculous lymphadenitis. Tubercle 1990,71:1-3.

18. Campbell JA, Ormerod IP Friend JAR, etal. Six months versus nine months chemotherapy for Tuberculosis of lymph nodes: preliminary results Resp Med 1992, 86:15-19.

19. Goldmacher H, Taule C, Krolger C, etalAssesment of LN tuberculosis in Northern Germany, A clinical review Chest 2002:121:1177-1182.

20. Lindeboom JA, Kunper FJ, Prins J Metal. TuberculosIs Clinical Infect Dis 2006, 43 :1547-1551.

21. Marais BJ, Wright CA, Schaaf HS. Tuberculous lymphadenitis as a cause of cervical lymphadenopathy in children from Tuberculous endemic area. Paed.InfDis J 2006, 25:142-146

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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