International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - Vol 06 Issue 06, March, 2014

Pages: 87-92

Print Article   Download XML  Download PDF


Author: Vaishali Keluskar

Category: Healthcare

Abstract:Oral cancer is a major global health problem andaffects more than 200000 people worldwide. These are often led by preexisting oral lesions termed as potentially malignant disorders of the oral mucosa. Oral cancer is associated with multiple risk factors. Though tobacco and alcohol consumption are the most common risk factors, studies have also revealed that DNA viruses, especially human papillomavirus (HPV) may be an important etiological factor for head and neck malignancy. HPV infection is a significant risk factor for cervical carcinoma; however the role of HPV in OSCC is less well defined. Hence this article throws a light on various studies which were done previously to show an association between HPV and potentially malignant disorders and oral cancers.

Keywords: Human papillomavirus (HPV), oral premalignant disorders, oral squamous cell carcinoma (OSCC).

Full Text:


Oral cancer is the 6 th most common malignancy in developed countries, representing almost 3% of all malignancies, accounting for 50% of all cancersespecially in India and other regions of Southeast Asia.. Besides the main risk factors of tobacco, smoking and alcohol, infection by human papillomavirus (HPV) and genetic alterations are likely to play an important role in these lesions. More than 90% of these malignancies are often preceded by preexisting oral lesions termed as potentially malignant disorders of the oral mucosa.1 In several epidemiological studies, the role of tobacco smoking and alcohol consumption as major risk factors for potentially malignant disorders and oral cancer is well documented.2 Literature reveals that oncogenic HPVs are main causative agent for cervical cancer, but its role in potentially malignant disorders and carcinomas of the oral cavity is less established.3Association of HPV with oral and pharyngeal carcinogenesis was first proposed in 1983 by Syrjanenet al. 4 HPVs are small (55 nm), nonenveloped, icosahedral, epitheliotropic DNA tumor viruses that are transmitted early in life. To date more than 75 different HPV genotypes have been cloned and characterized. 16 HPV DNA genotypes have been isolated from oral lesions among whichmajority are low risk HPVs (6, 11, 13, 32) associated with benign papillomatous lesions having little potential for malignant progression. Whereas highrisk HPV genotypes (16,18,31,32,33,35) are frequently associated with epithelial dysplasia and squamous cell carcinomaand have increasedmalignant potential.5


Various studies have been carried out to know the prevalence of HPV in the oral cavity, yetits role in oncogenic development is unclear. This could be attributedto varied studies carried out in diversepopulation, with different sample size and different assays to detect viral DNA.Hence a retrospective review of the existing epidemiologic data wascompiledto highlight the relationship of HPV in the development of potentially malignant disorders and OSCC. Syrjanen K and Syrjanen Set al. in 1983 assessed biopsies from 40 cases of OSCCand observedassociation of HPV with malignancy. Morphological signs of the flat-type HPV lesion were found in 4 cases (10%), inverted type in 3 cases (7.5%), and papillomatous type in 9 cases (22.5%). Epithelial cells (mostly koilocytes) showing HPV-positive nuclei were disclosed in 5 papillomatous lesions, in 2 inverted lesions and in 1 flat lesion. Thus according to them HPV could be the etiological factor for certain types of OSCC.4 Shroyer KR and Greer RO in 1991 compared the sensitivity of detection of HPV DNA in premalignant and malignant oral lesions by in situ hybridization (ISH) and polymerase chain reaction (PCR). As per his observations HPV DNA was found among 4 of 24 cases of epithelial dysplasia, 4 of 14 cases of verrucous hyperplasia, and 1 of 10 cases of squamous cell carcinoma. The 10 cases of smokeless tobacco keratoses and 3 cases of verrucous carcinoma were all negative for HPV DNA. According to them, PCR was an effective technique for identifying HPV 16 DNA from premalignant and malignant oral lesions.6 Young SK and Min KW et al. in 1991 evaluated potentially malignant and malignant lesions with biotinylated double-stranded DNA probesfor detection of HPV types 6/11, 16/18, and 31/33/35.According to his observations 62% (13/21) of oral squamous papillomas were positive for HPV DNA among which 6 and 11 HPV types demonstrated the strongest reactivity. Of the 13 cases, 10 also showed some reactivity with HPV- 16/18 and -31/33/35. This study thus confirmedthat HPV DNA is frequently found in oral squamous cell papillomas and may not be detected in keratotic, premalignant, or cancerous lesions of the oral mucous membranes.7 The studies by Chang et al in 1991, Yeudall in 1992 and Miller and Johnstone in 2001 detected many low risk types of HPV ( 6 and 11) with benign lesions and HPVs( 16,18 and 33) with malignant lesions.8-10 Shindoh Met al in 1992 studied an association of HPV DNAs in carcinomas of the oral cavity.According to their observations HPV-16 DNA sequences may have the capability to maintain the proliferative state of epithelial cells, and thus may contribute to the production of malignant phenotypes.11 Yeudall WA and Paterson ICet alin 1995 studied patients with tobacco history and their association with HPV. They suggested that though p53 mutation was a frequent genetic event in oral cancer, this does not preclude a papilloma viral etiology for these tumors. 12 Zhonghua Kou et. al. in1996 detected HPV 16 and 18 type DNA in OSCC and normal mucosa (NOM) by PCR, and thenanalyzed the PCR products using southern blot hybridization. They observed that the positive rates of HPV DNA were 47.8% (11/23) in OSCC, including HPV16 in 6 samples, HPV 18 in 3 samples and 16, 18 coinfection in 2 samples. Whereas HPV16 DNA was found to be 20% (2/10) in normal oral mucosa, thus suggesting that HPV may play a role in carcinogenesis of OSCC.13 Bustos D.A et al in 1999 studied association of HPV with cervical and oral cancer.According to their observations, HPV DNA in cancer biopsy specimens were detected less frequently among tobacco smokers and pan chewers and more frequently among heterosexuals or those who practiced oral sex.14 Martha Bouda et. Al. in 2000 conducted a study to examine HPV infection in oral hyperplasias, dysplasias and squamous cell carcinomas as well as in normal oral mucosa by nested polymerase chain reaction (NPCR) , type specific PCR (TS– PCR), restrictionfragment length polymorphism RFLP) analysis, dot blotting (DB), and nonisoropic in situ hybridization (NISH). They suggested that, association of high risk HPV types with oral carcinogenesis and high percentage in hyperplasias and dysplasias to be an indicator of an early involvement of HPV in oral neoplasia.15 Scully et. al. in 2000 also suggested that viral factors like HPV may contribute to the etiology of OSCC.16 Klussmann JP and Weissenborn SJ et. al. in 2001 reported 25 Head and Neck Squamous Cell Carcinomas (HNSCCs) (26%) to be HPV positive. The frequency of HPV positive lesions was 18% in the oral cavity, 45% for oropharynx, 25% for hypopharynx, 8% for nasopharynx, and 7% for larynx.17 Nagpal et. al. in 2002 analyzed the genetic predisposition of Indian population to HPV infection and oral carcinogenesis. They screened 110 patients of oral cancer, who were highly addicted to betel quid and tobacco chewing for HPV 16/18 infection and its association with polymorphism at p53 codon. Total 37 patients (33.6%) showed the presence of HPV 16 in 22.7%, HPV 18 in 14.5% and HPV 16/18 coinfection in 10%.18 Hansson BG and Rosenquist K et. al. in 2005 demonstrated a strong association between infection with high-risk types of HPV and oral and oropharyngeal squamous cell carcinoma (OOSCC), suggesting that high-risk HPV types play a key role in carcinogenesis.19 Syrjanen S. et. al. in 2005 were the first to present evidence on the involvement of HPV infections in both laryngeal and oral carcinogenesis. Until 2002, 4768 oral carcinomas had been analysed for HPV DNA, and 22% were reported to contain HPV. Tonsillar carcinomas appeared to have the highest prevalence of HPV among all non genital cancers. By the end of 2002, 422 cases of tonsillar carcinoma were analyzed for the presence of HPV DNA, with the overall detection rate of 51%. HPV 16 was the most prevalent type found in 84% .The role of HPV in laryngeal squamous cell papilloma and recurrent respiratory papillomatosis (RRP) is well - established, whereas the role of HPV in laryngeal carcinomatosis remains controversial. The molecular mechanism of HPV-associated carcinogenesis of the head and neck is still not understood.20 KoppikarP et. al. in 2005 studied HPV DNA in oral carcinoma by polymerase chain reaction (PCR) amplification and reported that HPV contributed to carcinogenesis. High risk HPVs are predominantly found in oral cancer and may play a role in its progression, while low risk subtypes are usually associated with oral precancerous lesions.21 Chen PC and Pan CC et. al. in 2006 analyzed the association of potentially malignant lesions with HPV. According to them HPV 16 and 18 were frequently identified with all potentially malignant lesions, whereas HPV 6 and 11 were found only in squamous papilloma. HPV 18, betel quid chewing and smoking were significantly associated with leukoplakia and squamous papilloma, while only betel quid chewing and smoking were significantly associated with oralsubmucous fibrosis (OSMF).22 Chen SL et. al. in 2007 suggested that the role of HPV infection is due to oncoproteins E6 and E7 which inactivate p53 and pRB respectively. The oncogene E5 has also been found to transform cells by modulating growth factor receptors, thus suggesting that several oncoproteins contribute in carcinogenesis.23 Katie M. Applebaum and C. Sloane Furniss et. al. in 2007 suggested HPV 16 seropositivity and alcohol and tobacco use to be associated with risk of Head and Neck Squamous Cell Carcinoma. According to them, the strongest risk factors by tumor site were smoking for laryngeal cancer, alcohol for cancer of the oral cavity, and HPV16 for pharyngeal cancer. For pharyngeal cancer, risk increased with increasing alcohol consumption and smoking among HPV16-seronegative subjects but not among HPV16-seropositive subjects. Among light drinkers or never smokers, HPV16 seropositivity was associated with a 30-fold increased risk of pharyngeal cancer. They concluded thatalcohol or tobacco use does not further increase risk of HPV16-associated paryngeal cancer and the risk of Head and Neck Squamous Cell Carcinoma associated with smoking, alcohol, and HPV16 differs by tumor site.24 Liang XH and Lewis J et. al. in 2008 carried out a study to examine the prevalence and significance of HPV infection and its clinical significance in patients with oral tongue cancer. They suggested that the incidence of HPV in oral tongue cancer was low and was unlikely to play a significant role in etiology, pathogenesis and clinical outcomes of oral tongue cancer, as there was a rising trend of oral tongue cancer in the young populations.25 Scapoli L and Palmieri A et. al. in 2008 carried out a study to evaluate the presence of high-risk tHPV in a large, well defined sample of oral squamous-cell carcinoma. Data obtained from 314 oral squamous-cell carcinoma, indicated that the prevalence of high - risk HPV was as low as 2% and thus did not support a major role of HPV in the etiology of oral squamous-cell carcinoma. 26 Jalouli J and Ibrahim SO et. al. in 2010 illustrated human simplex virus (HSV), HPV and Epstein Barr virus (EBV) infections to be common and may influence oral health and cancer development. According to them, there was a high prevalence of HPV in Oral Sub Mucous Fibrosis and the etiologic implication of this finding warrants further studies.27


The role of HPV in Oral Squamous Cell Carcinoma has gained attention due to biological similarities between the epithelium of the cervix and the oral cavity. HPV is an important risk factor for potentially malignant disorders and Oral Squamous Cell Carcinomas. HPV 16 and 18 were detected more frequently in Oral Squamous Cell Carcinoma than potentially malignant disorders and absent in the normal samples. This suggests an association of the virus with oral carcinogenesis. Data pertaining to prevalence of HPV in patients with Oral Squamous Cell Carcinomas. without history of smoking, alcohol or betel nut habit is limited. Hence, further studies need to be carried out to find the prognostic value of HPV infection as a biomarker for early diagnosis ofpotentially malignant disorders and Oral Cancer.




1. Ajay K Chaudhary, Shruti Pandya, Ravi Mehrotra, Alok C Bharti, Mangal Singh and Mamta Singh. Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma. Virology Journal 2010;7:253.

2. Giuseppe Pannone, Angela Santoro, SilvanaPapagerakis, Lorenzo Lo Muzio, Gaetano De Rosa and PantaleoBufo.The role of human papillomavirus in the pathogenesis of head and neck squamous cell carcinoma: an overview. Infect Agent Cancer. 2011;6:4.

3. Daniel Tena Gomez and Juana Lopez Santos. Human papillomavirus infection and cervicalcancer: pathogenesis and epidemiology. Communicating Current Research and Educational Topics and Trends in Applied Microbiology pp680-689.

4. Syrjanen K, Shrjanen S, Lamberg M. Morphological and immunohistochemical evidence suggesting HPV involvement in Oral squamous cell carcinogenesis. Int J Oral Surg 1983; 12:418-24.

5. Craig SM, Dean K. White, Lexington Ky. Human papillomavirus expression in oral mucosa, premalignant conditions, and squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 1996;82:57-68.

6. Shroyer KR and Greer RO. Detection of human papillomavirus DNA by in situ DNA hybridization and polymerase chain reaction in premalignant and malignant oral lesions. Oral Surg Oral Med Oral Pathol Oral RadiolEndod1991;71:708-13.

7. Young SK, Min KW. IN situ DNA hybridization analysis of oral papillomas, leukoplakias, and carcinomas for human papillomavirus. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 1991;71:726-9.

8. Chang F, Syrjanen SM, Kellokoski J, Syrjanen KJ. Human papillomavirus (HPV) infections and their associations with oral disease. J Oral Pathol Med 1991;20:305-17.

9. Yeudall WA. Human papillomaviruses and oral neoplasia. Oral OncolEur J Cancer 1992;28:61-66.

10. Human papillomavirus as a risk factor for oral squamous cell carcinoma: A meta-analysis, 1982-1997. CS Miller, BM Johnstone. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 2001 Jun;91(6):622-635.

11. Shindoh M, Sawada Y, Kohgo T, Amemiya A, Fujinaga K. Detection of Human papillomavirus DNA sequences in tongue squamous cell carcinoma utilizing the polymerase chain reaction method. Int J Cancer 1992 50 167-71.

12. Yeudall WA, Paterson IC, Patel V, Prime SS. Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant Eur J Cancer B Oral Oncol. 1995;31:136-43.

13. Zhonghua Kou Qiang Yi XueZaZhi.Study of HPV in oral squamous cell carcinoma. Cancer 1996 Nov;31(6):375-7.

14. Bustos DA, Pavan JV, Carricart SE, Talavera AD, Secchi D, Carrica V, Panico RL, Gendelman H. Human papillomavirus detection in oral cancer lesions in the city of Cordoba. Rev FacCien Med UnicNac Cordoba. 1999;56:65-71.

15. Bouda M, Gorgoulis VG, Kastrinakis NG, Giannoudis A, Tsoli E, DanassiAfentaki D, Foukas P, Kyroudi A, Laskaris G, Herrington CS, Kittas C: "High risk" HPV types are frequently detected in potentially malignant and malignant oral lesions, but not in normal oral mucosa. Mod Pathol 2000;13:644-53.

16. Scully C, Field JK, Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN):1. carcinogen metabolism, DNA repair and cell cycle control. Oral Oncol 2000;36:256-63.

17. Klussmann JP, Weissenborn SJ, Wieland U, Dries V, Kolligs J, Jungehuelsing M, Eckel HE, Dienes HP, Pfister HJ, Fuchs PG. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas Cancer.2001;92:2875-84..

18. JK Nagpal, S Patnaik, BR Das. Prevalence of high-risk human papilloma virus types and its association with P53 codon 72 polymorphism in tobacco addicted oral squamous cell carcinoma (OSCC) patients of Eastern India. Int J Cancer 2002 Feb 10;97(5):649-653.

19. Hansson BG, Rosenquist K, Antonsson A, Wennerberg J, Schildt EB, Bladström A, Andersson G. Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. ActaOtolaryngol. 2005;125:1337-44.

20. Syrjänen S. Human papillomavirus (HPV) in head and neck cancer.J ClinVirol. 2005; 32:S59-66.

21. Koppikar P, De villiiersfm, Mulherkar R. Identification of human paillomaviruses in tumour of the oral cancer in an Indian community. In t J Cancer 2005;113:946-50.

22. Chen PC, Pan PCC, Kuo CC, Lin Cp. Risk of oral non malignant lesion associated with human papillomavirus infection, betel quid chewing, and cigarette smoking in Taiwan: An integrated molecular and epidemiological study. Arch Pathol Lab Med. 2006;130:57-61.

23. Chen SL, Lin ST, Tsai TC, Hsiao wc, Tsao YP. ErbB4-induced expression and phosphorylation of c-Jun ia abrogated by human papillomavirus type 16 E5 protein. Oncogene 2007;26:42-53.

24. Katie M .Applebaum , C . Sloane Furniss , Ariana Zeka , Marshall R . Posner , Judith F . Smith , Janine Bryan , Ellen A . Eisen , Edward S . Peters , Michael D . McClean , Karl T . Kelsey. Lack of Association of Alcohol and Tobacco withHPV16-Associated Head and Neck Cancer J Natl Cancer Inst 2007;99:1801–10.

25. Liang XH, Lewis J, Foote R, Smith D, Kademani D. Prevalence and significance of human papillomavirus in oral tongue cancer: the Mayo Clinic experience. J Oral Maxillofac Surg. 2008;66:1875-80.

26. Scapoli L, Palmieri A, Rubini C, Martinelli M, Spinelli G, Ionna F, Carinci F. Low prevalence of human papillomavirus in squamous-cell carcinoma limited to oral cavity proper. Mod Pathol. 2009;22:366-72.

27. Jalouli J, Ibrahim SO, Sapkota D, Jalouli MM, Vasstrand EN, Hirsch JM, Larsson PA. Presence of human papilloma virus, herpes simplex virus and Epstein-Barr virus DNA in oral biopsies from Sudanese patients with regard to toombak use.J Oral Pathol Med. 2010;39:599-604.


Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021

Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to for more details.

Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

RSS feed

Indexed and Abstracted in

Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.


International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal


148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

Copyright © 2022 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions

Fatal error: Uncaught Error: Function name must be a string in /home/u845032518/domains/ Stack trace: #0 /home/u845032518/domains/ include() #1 {main} thrown in /home/u845032518/domains/ on line 487