International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 6(6), March, 2014

Pages: 26-32

Print Article   Download XML  Download PDF

EFFECTIVENESS OF MITOMYCIN-C APPLICATION AS AN ADJUNCT IN SURGERIES FOR RECURRENT PTERYGIUM - A META ANALYSIS

Author: Narendra P. Datti, Nagesha C. K., Rashmi N. R., Shalini

Category: Healthcare

Abstract:Background: Recurrent pterygium poses distinct problem like high postoperative recurrences and many surgical approaches have been tried to decrease recurrences. Currently, mitomycin C (MMC) application and amniotic graft are used as adjunct apart from the standard limbal-conjunctival autograft. Aim of study: Aim of this study is to determine through meta-analysis, the risk of recurrences and frequency of post operative complications associated with MMC application over bare sclera or along with amniotic graft for recurrent pterygia. Method: A thorough search of online resources for randomised controlled clinical trials comparing bare sclera technique with or without MMC and amniotic graft with or without MMC application was done. The purpose was to determine the pooled odds ratio and 95% confidence interval for post operative pterygium recurrence. Results: Among 5 studies, 2 studies comparing bare sclera technique with or without MMC showed pooled odds ratio of 0.105 with 95% CI 0.0131 to 0.847. Study comparing amniotic graft with or without MMC showed odds ratio 0.298 with CI of 0.0817 to 1.089. Conclusion: Application of MMC on bare sclera reduced recurrence rate to 10% and on amniotic graft it reduced to 30% with no added serious complications.

Keywords: Mitomycin-C, Amniotic graft, Bare sclera, Recurrent pterygia, Meta-analysis.

Full Text:

INTRODUCTION

Pterygium is a fibrovascular growth arising from the conjunctiva onto the cornea. A number of surgical techniques have been described for primary pterygium excision including bare sclera technique1 , bare sclera resection with mitomycin-c (MMC) application2 , conjunctival autograft3 and recently amniotic membrane grafts4 . The treatment with these adjuncts have significantly reduced but not eliminated the problem; as far as the recurrent pterygium is concerned, there are greater challenges associated with treatment5 . Added to high recurrence rate, is the problem of deciding on the best approach of its surgical excision, since a recurrent pterygium is usually associated with subconjunctival fibrosis and/or corneal thinning and scarring. Mitomycin-C is an antitumor agent that acts by inhibiting DNA synthesis. The mechanism of action seems to be inhibition of fibroblast proliferation at the level of episclera6 . Adjunct MMC for pterygium surgery was first described by Kunitomo and Mori7 in Japan in 1963 and in US by Singh et al8 in 1998 as postoperative topical MMC with concentration of 0.4-1mg/ml. At present, MMC is being mainly used after pterygium excision as an intraoperative application to bare sclera for the management of both primary and recurrent pterygium.9 In order to further reduce the recurrence and postoperative complications, an intraoperative MMC treated sclera is normally covered with a conjunctival or amniotic membrane graft4 . Despite the fact that studies on MMC have shown rare but significant conjunctival, scleral, and corneal toxicity10, its use as an adjunct in primary or recurrent pterygia surgeries seems to be beneficial in few randomised clinical trials11-15 . We conducted a Meta-analysis of published randomised clinical trials analysing the recurrence rates and frequency of postoperative complications with MMC application over bare sclera or along with amniotic graft for recurrent pterygia. The purpose of this study was to determine the pooled odds ratio and 95% confidence intervals for postoperative pterygium recurrence.

MATERIALS AND METHODS

Selection strategy and selection criteria Following an established protocol, a survey of published studies comparing at least two of the three surgical techniques in the treatment of recurrent pterygium – bare sclera resection, bare sclera resection with MMC application and amniotic membrane transplantation with MMC – was conducted through an electronic search. We have not analysed technique of limbalconjunctival autograft with MMC here, because of paucity of Randomised Controlled Trials analysing its effect with or without MMC for recurrent pterygium surgery. Randomised controlled trials (RCTs) that compared above mentioned techniques and reported recurrence rates and post operative complications were included. Exclusion criteria included non-randomised, non-controlled trials, studies with other adjunct techniques and unpublished data. Clinical trials were identified through (1) Electronic search of PUBMED, Science direct, MD consult, Google scholar, MEDLINE and EMBASE. (2) Manual searches of the reference list of original article reports through electronic search. Searches were conducted using the keywords “recurrent pterygium”, “Mitomycin-C”, “Amniotic membrane”. The computerised search covered the period from 1980 to October 2013. Two reviewers (N.D and C.K.N) confirmed study eligibility and extracted data independently, and data were pooled using standard Meta-analysis techniques.

RESULTS

Total five eligible studies were identified, two that compared bare sclera resection with or without MMC application11,12, three studies that compared amniotic graft placement with or without MMC13,14,15. For statistical analysis and to maintain homogenicity in studies, 5 studies were divided into 2 groups. 1st group consisted of two studies of bare sclera technique with or without MMC and 2nd group with three studies consisting of amniotic membrane transplantation with or without MMC. Table 1 provides characteristics of clinical trials comparing mitomycin C on bare sclera and on amniotic graft. Table 2 provides a description of the population characteristics of studies included, follow-up periods and recurrence definition. Table 3 and 4 show recurrence rates and complications encountered in different surgical techniques. 3 studies were from English literature and 2 studies from Chinese literature. Full text was available in 3 studies and in 2 studies, only abstract was available. The results of meta-analysis showed that recurrence rate of bare sclera with MMC were 8% which was lower than bare sclera alone group with 47% recurrence rate. Amniotic Membrane Graft with MMC group was associated with lower recurrence rate (9%) compared to AMG group alone (25.5%). Heterogenecity was found between the studies in group 1 and group 2. In group 1, Q=5.2422 with significant P value (p=0.0220) and in group 2, Q=5.9912 with significant P value (p=0.05). The heterogenecity between the studies were taken into consideration and analysed with due care by random effect analysis of raw data. Narendra P. Datti et. al. EFFECTIVENESS OF MITOMYCIN-C APPLICATION AS AN A

DISCUSSION

Pterygium, a worldwide degenerative corneal disease with multifactorial etiology, is particularly common in tropical and subtropical countries.16 Although different treatment regimens have been proposed for the treatment of pterygium, the main complication of pterygium treatment is recurrence.17,18 Recurrent pterygium is more difficult to control, and various treatment modalities including radiotherapy19, antimetabolite or antineoplastic drugs2 , conjunctival flap3 , and conjunctival or limbal autograft transplantation have been proposed. 4 Now a days, conjunctival10 or limbal autografts and amniotic membrane transplants5 have been commonly used alone or combined with MMC11 as adjuvant treatment for recurrent pterygium. Use of antimetabolites, especially intraoperative administration of MMC, may be performed in conjunction with amniotic membrane transplantation.13,14 Covering bare sclera with amniotic membrane may decrease the risk of scleral ulcer formation as a late complication with the use of antimetabolites.20,21 This study provides evidence of the inherent risk of pterygium recurrence after excision of recurrent pterygium with or without mitomycin C application over bare sclera or amniotic graft. Analysis of group 1 studies showed that for every 100 recurrences in bare sclera alone group, there were only 10 recurrences with application of MMC with a 95% confidence interval of 0.0131 to 0.847 (Pooled OR=0.105). These results show dramatic change in recurrence rate with MMC application.(Graph:1) Analysis of group 2 studies showing role of MMC on amniotic grafts in preventing recurrences, showed pooled odd’s ratio of 0.298 with 95% confidence interval of 0.0817 to 1.089. This implies for every 100 recurrences in Amniotic Membrane Graft alone group, there were only 30 recurrences if MMC was added in AMG. Only one study13 revealed no difference with addition of MMC compared to Amniotic Membrane Transplant alone. The association between exposure (MMC) and control group (AMG alone) was less strong compared to group 1 studies but still carried high significant value in terms of recurrence rates.(Graph:2) We have found that bare sclera or AMG augmented with MMC was associated with a lower recurrence rate than either of it alone in recurrent pterygium surgeries. An interventional prospective case series comparing limbal-conjunctival autograft (L-CAT) with or without MMC showed least recurrence rate in MMC group.16 L-CAT theoretically is a natural substitute to cover bare sclera and hence associated with low recurrences but recurrent surgeries on conjunctiva pose difficulties in harvesting healthy conjunctival graft. We have not analysed this technique here because of paucity of RCTs analysing its effect with or without MMC for recurrent pterygium surgery. As per complications are concerned, Superficial punctate keratitis was found in only one study in MMC group. Otherwise the mentioned complications (table 4) are nonspecific and do not seem directly related to the effects of MMC. Moreover these complications are more in control group than treatment group suggesting protective role of MMC in preventing complications other than recurrences. There are many case series, prospective studies and reports of complications arising from MMC application21-24; no such serious complications like scleral or corneal melt were reported in our study group. The reason could be difficult to analyse but needs more data to conclude these findings. As per quality assurance and strength of studies is concerned, heterogenecity was found, which do weaken the result. Things like unpublished data, research in langauge other than English, Chinese and publication bias might appear like an island in a sea of darkness which may partly make the analysis incomplete. Hence, we tried doing a good home work before interpreting the findings.

CONCLUSION

 To summarise, this is the first ever Meta analysis done, analysing the surgeries for recurrent pterygium using MMC as adjuvant. From above analysis, it is clear that MMC application over bare sclera stood highly scientific and rationale. So, we should strongly discourage bare sclera technique alone in a recurrent pterygium surgery. This fact is more or less well established from other meta analyses which tested MMC effectiveness on primary pterygium surgery.25,26 With respect to the surgeries with amniotic graft concerned, addition of MMC as an adjunct overweighs advantages compared to complications per se due to MMC. Hence, MMC is strongly recommended in high risk groups. There appears to be low magnitude of recurrence both in control and cases of group 2 studies. Here, amniotic graft has major contribution in low recurrence but addition of MMC makes the figures encouraging. In this regard, new research should focus on long term effects of mitomycin-C in recurrent pterygium surgeries.

ACKNOWLEDGEMENT

Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

References:

REFERENCES

1. D’Ombrain. The surgical treatment of pterygium. Br J ophthalmol 1948;32:65-71.

2. Singh G, Wilson CS, Foster CS. Mitomycin eye drops as treatment for pterygium. Ophthalmology1998;95:813-21.

3. Kenyon K, Wagoner MD, Heltinger ME. Conjunctival autograft transplantation and recurrent pterygium. Ophthalmology1985;92:1461-70.

4. Katrircioglu YA, Altiparmak VE, Duman S. comparison of three methods for the treatment of pterygium: amniotic membrane graft, conjunctival autograft, and autograft plus mitomycin C. orbit.2007;26:5-13.

5. Shimazaki J, Shinozaki N, Tsubota K. transplantation of amniotic membrane and limbal autograft for patients with recurrent pterygium associated with symblepharon. Br J.ophthalmol.1998;82:235-240.

6. Donnenfeld ED, Perry HD, Wallerstein A, et al. Subconjunctival mitomycin c for the treatment of ocular cicatricial pemphigoid. Ophthalmology.1999;106(1):72- 8;discussion79.

7. Kunitomo N, Mori S. studies on pterygium. Report N. A treatment of pterygium by mitomycin C instillation. Acta Soc ophthalmol Spn.1963;67:601-607.

. Singh G, Wilson MR, Foster CS. Mitomycin eyedrop as treatment for pterygium. Ophthalmology.1998;95(6):813-821.

9. Ang LP, Chau JL, Jan DT. Current concepts and techniques in pterygium treatment. Curr opin ophthalmol.1998;82:235-240.

10. Muthu FM, Sobaei G, Jatar T, Yildirim E. A comparitive study of recurrent pterygium surgery:limbal conjunctival autograft transplantation versus mitomycin C with conjunctival flap. Ophthalmologgy.1998;106(4):817-821.

11. Leonardo Mastropasqua, Paolo Carpineto, Marco Ciancaglini, Pier Enrico Gallenga. Long term results of intraoperative mitomycin C in the treatment of recurrent pterygium. British Jounal of Ophthalmology 1996; 80: 288-291.

2. Nitin verma1 , Jambi arringa garap1 , Rosilyn marisi and Apisai kerek1 . Intraoperative use of mitomycin C in the treatment of recurrent pterygium. PNG Med J 1998 Mar;41(1):37-42.

13. Ma DH, See LC, Hwang YS, Wang SF. Comparison of amniotic membrane graft alone or combined with intraoperative mitomycin C to prevent recurrence after excision of recurrent pterygia. Cornea. 2005 Mar;24(2):141-50.

14. Shi CN, Zhou GL. Application of mitomycin C in amniotic membrane traansplantation to treat recurrence pterygium. Cuangzhou Med J (chin)2006;37(5):37-39.

15. Li SZ. Effect analysis of amnion membrane transplantation combined with mitomycin C in the treatment of pterygium. J bethune military medical college (chin)2007;10(5):290-291.

16. Mohamed A Fakhry. The use of mitomycin C with autologous limbal-conjunctival autograft transplantation for management of recurrent pterygiumClinical Ophthalmology 2011:5 123–127.

17. Starck T, Kenyon KR, Serrano F. Conjunctival autograft for primary and recurrent pterygia: surgical technique and problem management. Cornea 1991;10:196 –202.

18. Mahar PS, Nwokora GE. Role of mitomycin C in pterygium surgery. Br J Ophthalmol 1993;77:433–5.

19. MacKenzie FD, Hirst LW, Kynaston B, Bain C. Recurrence rate and complications after beta irradiation for pterygia. Ophthalmology 1991;98:1776–80; discussion 1781.

20. Rubinfeld RS, Pfister RR, Stein RM, et al. Serious complications of topical mitomycin-C after pterygium surgery. Ophthalmology 1992;99:1647–54.

21. Dunn JP, Seamore CD, Ostler HB, Nickel BL, Beallo A. Development of scleral ulceration and calcification after pterygium excision and mitomycin therapy. Am J Ophthalmol 1991;112:343–4.

22. Rubinfeld RS, Pfister RR, Stein RM, Foster CS, Martin NF, Stoleru S et al. Serious complications of topical mitomycin-C after pterygium surgery. Ophthalmology 1992 Nov;99(11):1647-54.

23. Shabbir Saifuddin, Alaa El Zawawi. Scleral changes due to mitomycin C after Pterygium excision: A report of two cases. Indian J Ophthalmol 1995;43:75-6.

24. B Safianik, I Ben-Zion, and H J Garzozi. Serious corneoscleral complications after pterygium excision with mitomycin C. Br J Ophthalmol2002March;86(3):357-8.

25. Yin-Wei Song, Ai-Hua Yu, Xiao-Jun Cai. Effectiveness of amniotic membrane transplantation combined with mitomycin C in the treatment ofpterygium: a meta-analysis. Int J Ophthalmol2010;3(4):352-355.

26. Juan Camilo Sánchez-Thorin, Guillermo Rocha, Julie B Yelin. Meta-analysis on the recurrence rates after bare sclera resection with or without mitomycin C and conjunctival autograft placement in surgery for primary pterygium. Br J Ophthalmol 1998 82: 661- 665.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions