International Journal of Current Research and Review
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IJCRR - vol 06 issue 07, April, 2014

Pages: 74-78

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TRANSITIONAL CELL CARCINOMA OF THE OVARY: A RARE CASE REPORT

Author: Madhavan Manoharan, Sridevi Manian, Deepa Ganesh

Category: Healthcare

Abstract:Introduction: Transitional cell carcinoma of the ovary is a rare, recently recognized, subtype of ovarian surface epithelial carcinoma. Transitional cell carcinoma is sufficiently different from malignant Brenner tumour (MBT) in that it is reasonable to suppose that ovarian TCC arises directly from pluripotential surface epithelium of the ovary and from cells with urothelial potential, rather than from a benign or proliferative Brenner tumor precursor. Case presentation: We present a case of TCC of the ovary, managed by total abdominal hysterectomy and bilateral salpingo-oophorectomy with omentectomy. Conclusion: Primary TCC of the ovary is a rare subtype of epithelial ovarian tumours and their response to chemotherapy is better than that for other types of ovarian cancers.

Keywords: Transitional cell carcinoma, malignant Brenner tumour, pluripotential surface epithelium, total abdominal hysterectomy, bilateral salpingo-oophorectomy with omentectomy.

Full Text:

NTRODUCTION

Transitional cell carcinoma (TCC) of the ovary is a rare subtype of ovarian surface epithelial tumours. Incidence of occurrence is less than 1% of Primary ovarian carcinomas1 . Admixture of other types of surface epithelial tumours, including serous, endometrioid and undifferentiated carcinoma are common, but transitional cell carcinoma pattern must predominant (>50%)of the tumour to make the diagnosis2,3 .

CASE PRESENTATION

A 40-year-old woman presented with history of lower abdominal pain and dysuria on and off. On per abdominal examination, there was a pelvic mass on the right side. Ultra sonogram of the abdomen showed a pelvic mass measuring 31 × 35 mm with homogeneous echogenicity. Abdominal computed tomography also showed a right adnexal mass measuring 4×3 x2 cm separate from ovary. A possibility of fibroid in the right broad ligament was considered. There was no lymphadenopathy present. The liver and kidneys were unremarkable. Routine laboratory results were all within normal ranges. Initial investigation of tumour marker showed increased serum CA-125 (70.3 U/mL; normal, 0-35 U/mL). She underwent surgery under the impression of malignant ovarian tumour. A solid mass, arising from the right ovary was found. The other ovary, uterus, both tubes and broad ligaments were within normal limits. Therefore, a staging laparotomy including total abdominal hysterectomy, bilateral salpingooophorectomy and omentectomy was performed. No lymph nodes were present. Intraoperative, a small amount (about 100 ml) of fluid was found in the pelvic cavity and the same was sent for cytological examination.

PATHOLOGICAL EXAMINATION

Uterus with cervix measured 7.5x4.5x3 cm. Cervix appeared hypertrophied. Cut section showed a thinned out endometrium and an intramural fibroid measuring 1.5cm in diameter. Each fallopian tube measured 5cm in length. The right ovarian mass measuring 6.5x3x2 cm was sent detached. The external surface was nodular. Cut surface was solid and yellowish (Figure 1). The left ovary measured 3.5x1.5x1cm. Cut section appeared within normal limits. Microscopic examination of the right ovarian mass showed a malignant tumour. The tumour was composed of oval to round cells with moderate amount of cytoplasm, vesicular to hyper chromatic nuclei and prominent nucleoli. The tumour cells were arranged in nesting pattern, broad papillae, glandular pattern and focal area shows cystic change lined by tumour cell (Figure. 2, Figure. 3). The tumour cells were separated by fibrous stroma and many punched out micro spaces were present (figure. 4). Mitosis was focally high, 5/10 HPF. There was no benign, metaplastic or proliferating Brenner component found in the tumour. The left ovary showed metastatic deposit of the tumour (Figure. 5). The tumour cells are strongly positive for CK 7 (Fig. 6). Sections of omentum showed lobules of adipose tissue with a focus of dystrophic calcification. No evidence of metastasis was present. The cytological examination of the fluid showed no malignant cells. The final diagnosis was transitional cell carcinoma of right ovary with metastasis to left ovary.

DISCUSSION

TCC of the ovary is a recently recognised subtype of ovarian surface epithelial carcinoma4 . It was first defined by Austin and Norris5 and added to the histologic classification of ovarian tumours by the World Health Organisation/International Society of Gynaecologic Pathologists 5 . Transitional cell tumour of ovary is a category of ovarian tumours that have epithelial cells resembling those of transitional cell neoplasms of urinary tract. They consist of Brenner tumour (benign, proliferating and malignant) and transitional cell carcinoma. World Health Organization classification defines ovarian transitional cell tumours as those “containing epithelial cells resembling urothelial transitional cells” and TCC as an invasive tumour that lacks a component of benign Brenner tumour and is characterized by “the presence of papillae lined by malignant cells of transitional cell type or nests of such cells in a fibrous or fibromatous stroma.” Ovarian TCC was thought to arise directly from the pluripotential surface epithelium of the ovary and from cells with urothelial potential, rather than from a benign or proliferative Brenner tumour precursor. Incidence of TCC is less than 1% of ovarian tumours. 10 to 15% of advanced stage ovarian carcinoma contains a TC component2 . They predominantly occur in post-menopausal age group, and the mean age is 56 years1 . The mean size of the tumour is 10 cm. In most of the patients, they are solid and cystic. But it can also present as purely solid or purely cystic with soft, fleshy or papillary areas often with haemorrhage and necrosis6 . They are unilateral or bilateral.Bilateralism is seen in 15 to 20% of cases (1). In our patient, the tumour was grossly seen only in the right ovary. The contralateral ovary appeared normal in size. However, it showed tumour deposit microscopically and hence considered as metastasis. The most important microscopic feature is the „punched out? micro spaces (87%). Other common features are large cystic spaces (73%) and large blunt papillae (63%). The less commonly occurring microscopic features are slit-like fenestrations (49%), bizarre giant cells (35%), small filiform papillae (18%), gland-like tubules (17%), and squamous differentiation (13%), and psammoma bodies (4%). The lining cells are crowded, highly stratified, polygonal to spindled cells with scant eosinophilic or clear cytoplasm and mild to severe nuclear atypia. Necrosis is common. In addition to not having a benign Brenner tumour component, TCC lacks the prominent stromal calcification which is mainly seen in malignant Brenner tumour7 . The micro spaces present in TCC may be mistaken for an endometrioid or a serous carcinoma. The former will show squamous differentiation associated with endometriosis whereas the latter will show complex papillae lacking transitional like cells and often contain Psammoma bodies1 . The ovarian TCC can be differentiated from an urothelial tumour metastatic to the ovary with the help of clinical findings and immunohistochemistry. Though both tumours can express cytokeratin 7, the ovarian TCCs are negative for cytokeratin 20 which is usually detected in bladder TCCs. Unlike bladder TCCs, ovarian TCCs are positive for Wilms tumour antigen (WT1)1, 2, 6 . It is well known that primary ovarian TCC has a better prognosis than all other types of ovarian carcinomas following standardized chemotherapy8 . Hence it becomes essential that the ovarian TCC has to be diagnosed correctly.

CONCLUSION

This case report will bring awareness of the rare and recently introduced entity, so that a tumour with urothelial features will be diagnosed properly and appropriately managed.

 

References:

REFERENCES

1. Christopher P. Crum. Transitional cell tumours. In DiagnosticGynaecologic and Obstetric Pathology, 2nd Edition. Marisa R. Nucci, and Kenneth R. Lee, 2011, 882-887.

2. AncelBlaustein. Transitional cell tumours. In Blaustein'sPathology of the Female Genital Tract, 5th Edition .Robert J. Kurman, 2002, 881-884

3. Christopher D. M. Fletcher. Transitional cell tumours. In Diagnostic Histopathology of Tumors , 4th Edition, William R. Schmitt , Kathryn DeFrancesco, 2013, 685-686, Volume 1.

4. Satoshi Ichigo, Hiroshi Takagi, KazutoshiMatsunami, Takayuki Murase, Tsuneko Ikeda, Atsushi Imai. Transitional cell carcinoma of the ovary (Review). Oncology Letters. 2011:3-6.doi: 10.3892/o1.2011.453

5. Austin RM, Norris HJ. Malignant Brenner tumor and transitional cell carcinoma of the ovary: a comparison. Int J GynecolPathol. 1987;6:29–39. doi: 10.1097/00004347- 198703000-00004

6. Scully RE. Histological Typing of Ovarian Tumours, 2nd ed. Berlin: Springer-Verlag, 1999.

7. Juan Rosai.Transitional cell tumours. In Rosai and Ackerman's Surgical Pathology, 10th Edition. Michael Houston, Joanne Scott, 2011, 574- 1576, Volume 2.

8. Eichhorn JH, Young RH. Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis. Am J SurgPathol. 2004;28:453–63. doi: 10.1097/00000478-200404000-00004

9. Kommoss F, Kommoss S, Schmidt D, Trunk MJ, Pfisterer J, du Bois A. ArbeitsgemeinschaftGynaekologischeOnkolog ieStudiengruppeOvarialkarzinom. Survival benefit for patients with advanced-stage transitional cell carcinomas vs. other subtypes of ovarian carcinoma after chemotherapy with platinum and paclitaxel. GynecolOncol. 2005;97:195–9. doi: 10.1016/j.ygyno.2004.12.047

10. Satoshi Ichigo, Hiroshi Takagi, KazutoshiMatsunami, Takayuki Murase, Tsuneko Ikeda, Atsushi Imai. Transitional cell carcinoma of the ovary (Review). Oncology Letters. 2011:3-6.doi: 10.3892/o1.2011.453

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
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A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
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A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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