International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 6(10), May, 2014

Pages: 51-56

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THE EFFECTS OF AQUEOUS EXTRACT HIBISCUS SABDARIFFA ON SPERMATOGENESIS AND SPERM PARAMETERS OF MICE

Author: Omer H. Arabi, Mutman A. Kahil, Nasir A. Ibrahim

Category: Healthcare

Abstract:This study was aim to evaluate the effect of aqueous fruit extract of Hibiscus sabdariffa Linn on spermatogenesis and sperm of mice. Adult male mice (n=30) included in the present study. The mice were eight weeks old and their average weight was 28\?3g. Male mice housed in temperature controlled rooms (25\?C) with constant humidity (40-70%) and 12h/12h light/ dark cycle according experimental protocols. Thereafter, the mice were randomly divided into control (n=10) and experimental group (n=20). The control group received daily 8 ml distilled water, group-1 of the experimental group received 50 gm/Kg/BW and group-2 received 100 gm/Kg/BW of aqueous extract of Hibiscus sabdariffa. The experiment extended for 21 days. The results of this study showed that there was an increase in the average body weight in the experimental groups compared with the control group with a significant difference (p< 0.05). While the testis weight, sperm counts, sperm motility and viability decreased in the experimental groups compared with the control group with a significant difference (p< 0.05). The effect of Hibiscus sabdariffa on Sex hormones the study showed that there was significant different (p> 0.05) in FSH; LH and testosterone hormones when compared with control In study of testis histology showed a significant decrease in the lumina spermatozoa. The study concluded that Hibiscus sabdariffa has adverse effect on spermatogenesis and sperm parameters of mice.

Keywords: Aqueous, Hibiscus sabdariffa, spermatogenesis, sperm parameters, mice

Full Text:

INTRODUCTION

The roselle (Hibiscus sabdariffa) is a species of Hibiscus native to the Old World tropics, used for production of bast fiber and as an infusion (Chau, J. W et. al. 2000). The calyces, which are rich in phenolic compounds contain gossypetin, glucoside, hibiscin, hibiscus anthocyanin and hibiscus protocatechuic acid, diuretic and choleretic effects, decreasing viscosity of the blood, reducing blood pressure and stimulating intestinal peristalsis (Ali and Salih, 1991; Owulade et al., 2004). Tseng et al., (1996) found that the mechanism of this protective effect associated with the scavenging of free radicals Hibiscus protocatechuic acid also inhibits lipopolysaccharide induced rat hepatic damage. Although the mechanism of action of H. Sabdariffa as a cholesterol-lowering agent was not elucidated in this work, it hypothesized, albeit with no experimental evidence, that the extract may contain some compounds that activate hormonal secretions, such as adrenocortical

hormones, which stimulate the metabolic pathway of cholesterol by conversion into other compounds. The anti cholesterol action of Hibiscus sabdariffa (0.5% or1%) confirmed in rabbits fed cholesterol for 10weeks. This treatment was effective in reducing the serum concentrations of triglycerides, total cholesterol and low-density lipoprotein cholesterol, and in mitigating atherosclerosis in the aorta (Chen et al., 2003). Kanokwan Sukjail and Ampa Luangpirom (2010) studied aqueous seed extract of Hibiscus sabdariffa in male rats, and found that all treated groups showed decreasing of sperm concentration, percentage of normal motile sperms and vital sperms, while the percentage of abnormal sperms increased. The lactogenic effect of ethanol seed extract of Hibiscus sabdariffa was also found in both sexes of albino rats, and median lethal dose (LD.50) of this extract was above 5000 mg/kg BW of rats (Gaya I, et al.2008). In Nigeria, Hibiscus sabdariffa Linn. Seed tea was use traditionally to enhance lactation in case of poor milk production in human (Gaya I, et al.2008).

MATERIALS AND METHODS

Experimental animals Adult mice (n=30) included in the present study. The mice were 8 weeks old with average weight 28±3g each. Male mice housed in temperature controlled rooms (25°C) with constant humidity (40-70%) and 12h/12h light/ dark cycle according experimental protocols. All animals treated in accordance to the Principles of Laboratory Animal Care. All mice fed a standard diet. The daily intake of animal water monitored at least one week before start of treatments to determined the amount of water needed per experimental animal. Thereafter, the mice were randomly divided into control (n=10) and experimental groups (n=20). The control group received daily 8 ml distilled water. However, the experimental groups split into two groups each included ten mice. Group-1, received 50 gm/Kg/BW and group-2, received 100vgm/Kg/BW of Hibiscus sabdariffa for 21 consequence days.

Epididymis sperm count, viability and motility

Sperms from the cauda epididymis released by cutting into 2 ml of medium containing 0.5% bovine serum albumin .After 5 min incubation at 37°C (with 5% CO2), the cauda epididymis sperm reserves determined using the standard hemocytometric method and sperm motility analyzed with microscope (Olympus IX70) at 10 field and reported as mean of motile sperm according to WHO method.

Hormones measured

Serum collected at termination used for assaying for total testosterone, FSH and LH. Testosterone, FSH and LH measured using a commercial ELISA kit.Which is based on competive binding of hormones on immbilised antibody. Horse radish peroxidase was use for color development and absorbance at 420nm measured on a plate reader. Value are reported as ng/ml of serum.

Histology and Light microscopy

The testes fixed in 10% formalin and embedded in paraffin. Five-micron thick sections prepared and stained with Hematoxylin and Eosin (H&E). The specimens examined under Olympus/3H light microscope-Japan

Statistical analysis

Statistical comparisons were made using the ANOVA test for comparison of data in the control group and the experimental groups. The results expressed as mean ± S.E.M (standard error of means). Significant difference is written in parentheses.

RESULT

Spermatogenesis and Sperm Parameters:

Effects of Hibiscus sabdariffa on Spermatogenesis and Sperm Parameters summarized in table.1.&2 the obtained data shows that there were statistically high significant (p<0.05) decrease in body, testis weight, sperm counts, sperm motility and viability in all experimental groups, including50gm/Kg/BW and 100gm/Kg/BW the roselle - treated compared with the control group. In sex hormones the study showed that there was significant different (p< 0.05) in FSH, LH and testosterone hormones when compared with control. Histology investigations Histological observations regular seminiferous tubule with normal germinal epithelium morphology in control sections (Figure.1.). Treated mice showed regular seminiferous tubule with normal germinal epithelium morphology. Sperm presence in lumen and was significantly decrease in the lumina spermatozoa at 50 mg/ kg/BW and 100 mg/ kg/ BW concentration of Hibiscus sabdariffa (Figure. 2. A and B).

DISCUSSION

Herbal medicine is based on the premise that plants contain natural substances that can promote health and reduce illness (Craig, 1999). Titilayo O.et al, (2008) who report that the rat received 2000 mg/kg dose of 50% ethanol extracts experienced consistent loss of weight. There were statistically high significant decrease in body, testis weight, sperm counts, sperm motility and viability in present study. This result was consistence by Kanokwan Sukjail and Ampa Luangpirom (2010) who studied the effect of aqueous seed extract of Hibiscus sabdariffa Linn, in male rates and found that impairment of spermatogenesis by decreasing of sperm concentration, percentage of normal motile sperms and vital sperms, while the percentage of abnormal sperms increased. Also, finding by Yomna, I (2010) whom were found that the effect of different doses of H. sabdariffa Linn. either cold or boiled, alter normal sperm morphology and testicular ultrastructure and adversely influence the male reproductive fertility in albino mice. In the present study sex hormones FSH, LH and testosterone was significant different. This result was not consistenc with result obtained by Omotuyi, et al (2010) whom reported that Serum

levels of follicle stimulating hormone (FSH) in male rabbits administered 200 mg/kg body weight oral doses of anthocyanin preparations with time. In water control group, FSH rose steadily from day 0 to day 7, remained fairly constant till day 21 and decreased rapidly to the lowest on day 28. Groups administered with anthocyanin-extract showed gradual rise from day zero to day 28. Serum FSH of anthocyanin control increased gradually from day 0 to day 21 and decreased slightly on day 28 and Serum levels of testosterone in male rabbits administered 200 mg/kg body weight oral doses of anthocyanin preparations with time. The water-control group showed fairly constant testosterone levels throughout the experimental period. For anthocyanin control group, testosterone levels decreased from day 0 to day 21 and increased to the peak on day 28. Anthocyanin extract showed decreased serum testosterone from day 0 to day 7 and increased steadily to the peak value on day 28. This trend is similar to that of group administered wholeextract. In histological investigation the lumen of seminiferous tubules showed a significant decrease in the lumina spermatozoa.This result was not similar with the result obtained by Orish E, et al (2004) who found that in the study testicular effects of sub-chronic effect of Hibiscus sabdariffa (HS) calyx aqueous extract on the rat testes. 1.15 g/kg dose group showed distortion of tubules and a disruption of normal epithelial organization, while the 2.3 g/kg dose showed hyperplasia of testis with thickening of the basement membrane. The 4.6 g/kg dose group, on the other hand, showed disintegration of sperm cells. The effects observed with most of the plant and plant-based products have been attributed to the antispermatogenic and/or antisteroidogenic properties of one or more active ingredients. (Shereen C, et al, 2010)

CONCLUSION

The results of this study showed that there is an increase in the average body weight in theexperimental groups with a significant difference (p<0.05). While the testis weight, sperm counts, sperm motility and viability decreased in the experimental groups with a significant difference (p<0.05). Sex hormones FSH, LH and testosterone was significant different (p<0.05) In histological study showed that the lumen of the seminiferous tubules was a significant decrease in the luminal spermatozoa. The study concluded that Hibiscus sabdariffa has adverse effect on spermatogenesis and sperm parameters of mice.

ACKNOWLEDGEMENT

This work was kindly sponsored by University of Gezira. The authors would like to express their gratitude to the Center of Biotechnology and Bioscience, Faculty of Engineering and Technology, University of Gezira.

 

References:

REFERENCES

1. Ali, M. B. and Salih, W. M. (1991). Investigations of the antispasmodic potential of Hibiscus sabdariffa calyces. Journal of Ethnopharmacol 31: 249–257.

2. Chau, J. W.; Jin, M. W.; Wea, L. L.; Chia, Y. C.; Fen, P. C.; Tsui, H. T. (2000). "Protective effect of Hibiscus anthocyanins against tertbutyl hydroperoxide-induced hepatic toxicity in rats". Food and Chemical Toxicology 38 (5): 411–416.

3. Chen, C-C., Hsu, J-D., Wang, S-F. (2003). Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterolfed rabbits. Journal of Agric Food Chem. 51: 5472–5477.

4. Craig, W.J. (1999). Health-promoting properties of common herbs. Am J ClinNutr.70(suppl): 491S-499S.

5. Kanokwan Sukjail and Ampa Luangpirom (2010). Effect of aqueous hibiscus sabdariffa linn. seed extracton plasma prolactin and seminal qualiry in male mice. " 4'h Sino-Thai Intemational conference.

6. Gaya I, Mohammad, O.M.A', Suleiman, A.M., Maje, M.l. and Adekunle, A.B. (2008). Toxicological and lactogenicstudies on the seed of Hibiscus sabdariffa Linn. (Ma\vaceae) extract on serum Prolactin Levels Of Albino Wistar Rats. Journal of Endocrinology 5(2). 1540-2606.

7. Omotuyi1, I,O., Ologundudu1, A. Onwubiko V. O., Wogu M. D. and Obi F. O.(2010)

8. Hibiscus sabdariffa Linn anthocyanins alter circulating reproductive hormones in rabbits (Oryctolagus cuniculus). Journal of Diabetes and Endocrinology Vol. 1(3), pp. 36-45,.

9. Orish E, Danladi C and Onyenmechi J.(2004).Testicular effects of sub-chronic administration of Hibiscus sabdariffa calyx aqueous extract in rats. J Reproductive Toxicology, 18, 2: 295–298

10. Owulade MO, Eghianruwa KI, Daramola FO. (2004). Effects of aqueous extracts of Hibiscus sabdariffa calyces and Ocimum gratisimum leaves in intestinal transits in rats. Journal of Biomed Res. 7: 31–33.

11. Tseng, T.H., Hsu, J.D., Lo, M.H., Chu, C.Y., Chou, F.P and Huang, C.J. (1998). Inhibitory effect of Hibiscus protocatechuic acid on tumour promotion in mouse skin. Cancer Letter. 126 (2): 199-207

12. Shereen C, Selvaraju V, Rajamanickam J. and Premendu P.(2010). Effects of plants and plant products on the testis. Asian Journal of Andrology 12: 468–479.

13. Titilayo O. Fakeye , Anirban Pal, D. U. Bawankule, N. P. Yadav and S. P. S. Khanuja (2008). Toxic Effects of Oral Administration of Extracts of Dried Calyx of Hibiscus sabdariffa Linn. (Malvaceae). Phytotherapy Res. DOI: 10.1002.

14. Yomna ,I (2010). Effect of extract of Hibiscus on the ultrastructure of the testis in adult mice. Acta Histochemica 114,( 4), 342–348

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Awards, Research and Publication incentive Schemes by IJCRR

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

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A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
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A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
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A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
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A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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