International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 06 Issue 12, June, 2014

Pages: 49-55

Date of Publication: 23-Jun-2014


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EFFECT OF BODY MASS INDEX ON FOLLICLE STIMULATING HORMONE, LUTEINIZING HORMONE, PROLACTIN AND FASTING BLOOD GLUCOSE LEVELS IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Author: V. Rajitha, G. Rekha, K.Y.Manjunath

Category: Healthcare

Abstract:Background: Obesity is a modern day scourge which plays havoc on the menstrual life of women in the reproductive age group. Disorders of menstrual cycle affect the women psychologically as well as physically. To estimate the obesity of an individual a cost effective method is to calculate the BMI (Body Mass Index). This is a reliable tool in early detection of Obesity and its associated disorders. In women of the reproductive age group an increased Body Mass Index results in alteration of hormonal levels resulting in altered menstrual cycles. In women with polycystic ovarian syndrome, the hormonal levels are so altered that many cycles are anovulatory. Estimation of Body Mass Index and comparing them with the hormonal levels will provide a fair idea in understanding the disease process. Materials and Methods: The test subjects were 79 apparently healthy women volunteers. They were divided into two groups based on menstrual history. Nineteen subjects were in control group and sixty were in the test group. BMI was calculated for both the groups. Blood levels of FSH, LH and Fasting Blood Glucose was estimated after obtaining consent and withdrawal of blood was done under aseptic precautions. The resultant measurements were subjected to statistical analysis, Results: The mean BMI of the test group was 25.48 Kg/m2and the mean BMI of the control group was 23.07Kg/m2. The Mean FSH levels in test group 7.88 mIU/ml and in the control group it was 8.95mIU/ml. The mean Prolactin levels in the test group were 16.635 ng/ml and in the control group it was 10.35 ng/ml. The mean LH levels in the test group were 6.53mIU/ml and in the control group it was 3.76mIU/ml. The mean fasting blood glucose levels in the test group was 94 mg/dl and in the control group it was 84 mg/dl. Conclusion: It is evident from the present study that the mean hormonal levels of LH and Prolactin and the fasting blood glucose levels are significantly higher in persons with polycystic ovarian syndrome and the FSH levels are lower in persons with polycystic ovarian syndrome which indicates that there could be always increased number of anovulatory cycles in such individuals.

Keywords: Body mass index, Follicle stimulating hormone, Luteinizing hormone, Prolactin, Glucose, polycystic ovarian syndrome.

Full Text:

INTRODUCTION

Polycystic ovarian syndrome is one of the most common endocrine disorder affecting 5-10% of women in their reproductive age group.1 Polycystic ovarian syndrome is an ill defined symptom complex, imbalance of different hormonal functions which can affect ovarian homeostasis resulting in anovulation which will manifest as Polycystic ovarian syndrome.2According to National Institute of Health in 1990Polycystic ovarian syndrome is defined based on diagnostic criteria such as presence of hyperandrogenism, chronic oligo-anovulation and exclusion of other diseases like prolactinemia, thyroid disorders and non classical adrenalhyperplasia.3 Polycystic ovarian syndrome patients usually over weight, LH: FSH ratio was less than 2 which is significantly higher amongpolycystic ovarian syndrome patients4 . Fifty percent (50%) of polycystic ovarian syndrome women are overweight / obese. Body mass index is a commonly used measure for excess body weight.Body mass index and mean age of menarche were significantly higher in Chinese women.5 The percentage of women affected bypolycystic ovarian syndrome and obesity presenting with glucose intolerance is rather high, ranging from 20 to 49%1 .Dysglycemia is also one of the important factors as most of the polycystic ovarian syndrome cases are prone to Diabetes Mellitus. Obese women with polycystic ovarian syndrome showed insulin resistance and fasting hyper insulinemia.6 Nowadays physicians check fasting blood glucose levels as a factor when diagnosing polycystic ovarian syndrome. Women with polycystic ovary syndrome should undergo fasting plasma glucose test and Glucose Tolerance Test to rule out diabetes mellitus as a factor for anovulatory cycles. A high glucose level indicates insulin resistance, which in turn contributes to central obesity in polycystic ovarian syndrome.7 The present study was performed to correlate Body mass index with LH, FSH, Fasting blood glucose levels and mean age of menarche between apparently normal women and women with polycystic ovarian disease.

MATERIAL AND METHODS

This cross-sectional study was performed on 60 afflicted Polycystic ovarian syndrome women volunteers and 19 control women volunteers from the gynaecology outpatient department of Vinayaka Mission Hospital and J.S.Hospital, Salem, Tamil Nadu, India between March 2013 to March 2014. The ethical clearance was obtained from the Institutional ethics committee of VMKV Medical College for conduct of the study. The control group consisted of apparently normal 19 women and test group consisted of 60 women with polycystic ovarian disease. The following parameters were studied 1. Age of menarche 2. Body Mass Index 3. Follicle stimulating hormone levels 4. Luteinizing hormone levels 5. Prolactin levels 6. Fasting Blood Glucose The Body mass index was calculated using the formula: weight in Kilograms/Height in meters2. According to the Asia–Pacific criteria of Body mass index for obesity subjects were divided into four groups. 8 Group 1: Less than 18.0kg/m2 Group 2: Between 18.1 and 22.9kg/m2 Group 3: Between 23.0 and 24.9 kg/m2 Group 4: Greater than 25 kg/m2 Body mass index (BMI) with body fat as Standard Consensus Statement for Indian population was considered, Normal BMI: 18.0 -22.9kg/m2 , Over weight: 23.0-24.9 kg/m2 , Obesity: ≥25kg/m2 as cut off for BMI.9 Based on above classification of BMI Group 1 is less than normal weight, Group 2 is normal weight, Group 3 is overweight, Group 4 is obese. To analyze FSH, LH, Prolactin and Fasting blood glucose levels around 5ml of blood sample was collected under aseptic conditions. FSH, LH, Prolactin levels were analyzed with the help of“Tosoh AIA360 Analyzer Kit” with fully automated analyzer equipment, Fasting blood glucose levels were analyzed with “BioSystem Kit” with Bio system A-15 fully automated analyzer in both test and control groups. To determine the follicular status of the test and control groups, ultrasonography was performed. Based on the following criteria, the EuropeanSociety of Human Reproduction and Embryology/American Society for Reproductive Medicine in 2003 (Rotterdam PCOS ConsensusWorkshop Group, 200410 the test subjects were selected. Inclusion Criteria for Test subjects 1. Age:17years to 40 years 2. Oligomenorrhoea or Anovulation (Less than eight menstrual cycles in a year).9 3. Clinical and biochemical signs of hyperandrogenism. 4. Polycystic ovaries (presence of 12 or more folliclesin each ovary measuring 2–9 mm in diameter and/or increased ovarian volume of 10 ml) Exclusion Criteria for Test subjects 1. Women below 17 years and above 40 years. 2. Pregnant and Lactating mothers 3. Other etiologies (e.g. congenital adrenal hyperplasia, androgen-secreting tumors and Cushing’s syndrome) 4. Patients using drugs affecting sex hormones and blood glucose levels. Inclusion Criteria for control group 1. Women aged between 17-40 Years 2. Regular menstrual cycles between 21 to 35 days. 3. Normal ovaries Exclusion Criteria for control group 1. Women below 17 years and above 40 years 2. Pregnant and Lactating mothers. Statistical Analysis The resultant parametrical measurements were subjected to statistical analysis to validate the significance of the study using SPSS version 16.

RESULTS

The mean age of menarche in both the test group and control group was 13 years. The mean BMI of the test group was 25.48 Kg/m2 . The mean BMI of the control group was 23.07Kg/m2 . The Mean FSH levels in test group 7.88 mIU/ml. The mean FSH levels in the control group was 8.95mIU/ml. The mean Prolactin levels in the test group were 16.635 ng/ml. The mean Prolactin levels in the control group were 10.35 ng/ml. The mean LH levels in the test group were 6.53mIU/ml. The mean LH levels in the control group were 3.76mIU/ml. The mean fasting blood glucose levels in the test group was 94 mg/dl. The mean fasting blood glucose levels in the control group was 84 mg/dl. The cumulative mean of all these parameters is depicted in Table-1. The FSH to LH ratio was in the test group was 1.46 and in the control group it was 3.56 (Table-4). Paired samples “t” test was performed to validate the study and its significance (Table-2). Also comparison of the parameters of test and control groups is depicted in (Table-3).

DISCUSSION

Polycystic ovarian disease can cause either primary or secondary infertility if the primary cause like dyslipidemia, insulin resistance and hyper androgenemic causes remain untreated. 11 In the present study the fasting blood glucose levels in the test group was having marginal increase than the control group which is indicative of a rising insulin resistance. Categorization of obesity should be ethno centric as the body fat percentage varies in ethnic populations and treatment modalities also will change accordingly5 . In our study obese women with polycystic ovaries were more than in the control group. However in a study with a small sample size, the prevalence of polycystic ovaries can be moderate.12 and concomitant presence of obesity will worsen the outcome of a metabolic disorder.13 Luteinizing hormone effect in polycystic ovarian syndrome in patients with an increased body mass index, this mediation of hormonal control is done in the pituitary gland and not in the hypothalamus.14 In the present study, the luteinizing hormone levels were higher than the control group which could be contributing to polycystic ovarian disease. Low levels of follicular stimulating hormone were found in women with polycystic ovaries which suggest that there is anovulation in these women.15 It is evident from the present study that the levels of follicular stimulating hormone are lower in women with polycystic ovarian syndrome than in the control group. In most of the studies hyperprolactinemia was an exclusion criterion for polycystic ovarian disease and in the present study where Prolactin levels were also measured and the Prolactin levels were significantly higher in the test group than the control group which indicates that Prolactin levels will be elevated in women with polycystic ovarian disease. In a study conducted in Bangladesh, it has been concluded that a there is a definitive link between body mass index, insulin resistance with the fertility levels.4 In the present study the authors agree with the findings of the study as the parameters measured and the results obtained from the present study were also similar. CONCLUSION Polycystic ovarian syndrome affected women who are obese will have elevated and abnormal hormonal levels as evident from the present study. The Body Mass Index causes disturbances in the menstrual cycle of women with polycystic ovarian syndrome. Anovulatory cycles of women affected by polycystic ovarian disease will reduce fertility levels. Obese women in the reproductive age group with menstrual cyclic disturbances should undergo hormonal profiling and fasting blood glucose to rule out insulin resistance. Since the sampling size of the present study is modest a larger sample size is being done to categorically validate the above findings. However the results of the study can be taken as guideline when investigating obese women with polycystic ovarian disease.

ACKNOWLEDGEMENTS

The authors sincerely wish to thank the management, administrators and the Professor and Head of the department of Anatomy of Vinayaka Missions Kirupananda Variyar Medical College, Salem for their whole hearted support and permissions to utilize their resources and conduct this study. The authors acknowledge the great help received from the scholars whose articles cited and included in references of this manuscript. The authors are also grateful to authors/editors/publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed. Authors are grateful to IJCRR editorial board Members and IJCRR team of reviewers who have helped to bring quality to this manuscript.

 

References:

REFERENCES

1. Dunaif A. Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis. Endocr Rev. 1997;18:774– 800.

2. Stein IF, Leventhal ML. Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol. 1935;29:181.

3. Zawadski JK, Dunaif A Diagnostic criteria for Polycystic ovary syndrome: Towards a rational approach. In: Dunaif A, Givens JR, HaseltineF(Eds). Polycystic ovary syndrome. Boston: Blackwell Scientific 1992;377.84

4. Ferdousi Begum., Clinical and Hormonal profile of Polycystic ovary syndrome. South Asian Federation of Obstetrics and Gynecology, May- August 2009;1(2):22-25

5. XiaoliChen,Renmin Ni, Yaqin Mo, Lin Li and Dongzi Yang. Appropriate BMI levels for PCOS patients in Southern China.Human Reproduction, Vol.25,No.5 pp 1295- 1302,2010 

6. Dale PO, Tanbo T, Vaaler S, Abyholm T. Body weight ,hyperinsulinemia and gonadotropin levels in the Polycystic ovarian syndrome: evidence in two population Fertility and Sterility. 1992,58(38):487-491

7. McKeigue PM, Shah B, Marmot MG.Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet .1991;337:382-6.

8. The World Health Organization Western Pacific Region, the International Association for the Study of Obesity, and the International Obesity TaskForce. The Asia–Pacific Perspective: Redefining Obesity and its Treatment. Melbourne: Health Communications Australia, 2000.

9. Misra A, Chowbey P, Makkar BM, Vikram NK, Chadha D, et al. Consesus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. J Assoc Physicians India. 2009;57:163-70

10. The Rotterdam ESHRE/ASRM-sponsored PCOS Consensus WorkshopGroup. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19:41–47.

11. SunitaJ.Ramanand, Balasaheb B Ghongane, et al. Clinical characteristics of polycystic ovary syndrome in Indian women. Indian J EndocrinolMetab. 2013 Jan-Feb: 17(1): 138- 145.

12. Bulent O. Yildiz, Eric S. Knochenhauer, et al. Impact of Obesity on the Risk for Polycystic Ovary Syndrome. J ClinEndocrinolMetab. Jan 2008; 93(1): 162-168.

13. Barber TM, McCarthy MI, Wass JA, Franks S 2006; Obesity and polycystic ovary syndrome. ClinEndocrinol (Oxf) 65:137-145. [PubMed].

14. Pagan YL, Srouji SS, Jimenez Y, et al. Inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome: investigation of hypothalamic and pituitary contributions. J ClinEndocrinolMetab 2006 Apr; 91(4):1309- 16.

15. Jan Holte, Torbjorn Bergh, et al. The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopauseal women. Clinical Endocrinology Volume 41, Issue 4, 1994: 473-481.

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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