International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 06 Issue 23, December, 2014

Pages: 75-79

Date of Publication: 10-Dec-2014


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SEED SPROUTING: A WAY TO HEALTH PROMOTING TREASURE

Author: Omi Laila, Imtiyaz Murtaza

Category: General Sciences

Abstract:Seed sprouting is gaining importance commercially because it not only improves the nutritional and antioxidant value of seeds but also removes some anti-nutrients like enzyme inhibitors in them and thus makes them safer for diet. Sprouts are the richest source of proteins, carbohydrates, fats, vitamins, minerals as well as secondary metabolite composition (including phenols, flavonoids, steroids and alkaloids) and thus serve as a better source of nutrients and antioxidant rich phytochemicals as compared to seeds. Improvement of nutritional and nutraceutical value of seeds by sprouting is beneficial for human health and can be incorporated in Pharmaceutical preparations or can be directly consumed as a functional food. Such dietary constituent are preferred over drugs as comparatively they pose very little or no possible side effect even though consumed for long time. Due to their simple and inexpensive solutions to the global health problems their use in prevention and treatment of common oxidative stress linked diseases such as diabetes, cardiovascular disease and certain cancers is emerging. However, there remains much work to be done for an optimal outcome and in gaining their dietary acceptability as drug if handled properly in accordance to safety guidelines

Keywords: Seed sprouting, Bioactive compounds, Oxidative stress, Antioxidant activity, Functional food

Full Text:

INTRODUCTION
Sprouts are four to ten days old seedlings formed from seeds during germination and are termed to be authentic “super” foods, that are really easy to grow, and don’t require an outdoor garden. Sprouts mainly originate from the Leguminosae family and there are different varieties of sprouts existing in the market, such as the alfalfa, mung bean, radish, and soy sprouts [1]. As the sprouts are consumed at the beginning of the growing phase, their nutrient concentration remains very high [2]. They have long been used in the diet as “health food”. It has been widely reported that sprouts provide higher nutritive value than raw seeds and their production is simple and inexpensive [3]. Although the use of sprouts as a food source for man is as old as the use of seeds, it is only in recent times that science has begun to unravel the chemistry of a sprouting  seed, and its potential significance in both human and animal nutrition. Epidemiological studies have shown that consumption of sprouts may help to protect against certain chronic diseases and cancers. Due to the high content of bioactive agents that function as natural antioxidants and aid in cancer prevention[4]. Thus, consumption of sprouts can bring about a host of IJCRR Section: General Science health benefits. However, due to number of outbreaks associated with sprouts due to presence of pathogenic organisms, proper safety guidelines should be followed.

DISCUSSION
Nutritional benefits of sprouts When a seed sprouts, the original composition essentially changes during the germination process and the nutrientdensity of a seed is enhanced at the expense of calories. The stored food and enzymes needed for growth of the mature plant are mobilized. The protein, carbohydrate and fat are broken down to free amino acids, simple sugars and soluble compounds [5]. The quantity of the protein fraction significantly changes; the proportion of the nitrogen containing fractions shifts towards the smaller protein fractions, oligo-peptides and free amino acids. Beyond this, the quantity of the amino acids (some of them increase, others decrease or do not alter) is altered and some of the non-protein amino acids are also produced during germination. In consequence of these changes, the biological value of the sprout protein increases, and greater digestibility has been also established in the animal experiments. The vitamins including A, B-complex (B-12), C, E and K, increase to meet the growth needs of a young plant whereas, the essential minerals including calcium, magnesium, iron and zinc are supplied in organic form, “chelated” for better assimilation [6]. The composition of the triglycerides also changes, owing to their hydrolysis to free fatty acids originates and can be considered as a certain kind of pre-digestion. Generally, the ratio of the saturated fatty acids increases compared to unsaturated fatty acids, and the ratio within the unsaturated fatty acids shifts to the essential linoleic acid. The quantity of the anti-nutritive components such as the flatulence-producing α-galactosides, trypsin and chymotrypsin inhibitors, which affect the digestion of proteins, are reduced after germination, while as the utilization of the macro and micro elements are increased due to germination [7,8]. Furthermore, in addition, to being a rich source of nutritional compounds, the sprouts contain as many phytochemicals (sulphoraphane, sulphoraphene, isothiocyanates, glucosinolates, enzymes, antioxidants, vitamins) as an entire plant. Research has shown that phytochemical rich foods possess diverse disease preventive and health promoting properties [9]. Therefore, the improvement of nutritional and nutraceutical value of seeds will be beneficial for human health [10]. In the last decades of the past century, the attention of experts dealing with the healthy nutrition turned more and more towards the determination of the biological value of the nutritionally rich sprouts [11]. Thus, overall germination can lead to the development of such functional foods that have various positive effects on the humans and thus can be helpful in maintaining the proper health [12]. Enhanced phytochemical composition of seeds due to sprouting During the recent years, an increased interest in the area of research related to secondary metabolite production during the germination process has arisen, which can have valuable health promoting properties and can act as bioactive or functional components in foods. All this requires knowledge and know-how of the germination process and the biochemistry behind it. Among the secondary products of plant metabolism, phenolic compounds have attracted more and more attention as potential agents for preventing and treating many oxidative stress-related diseases [13]. Several studies have been conducted to compare the phenolic content, flavonoid content, antioxidant activity and antioxidant enzyme activity in seeds and sprouts of various leguminous plants. In a recent study, Chon et al [6] studied the effect of sprouting on total phenols and antioxidant activity of soybean, mungbean and cowpea and observed that sprouting increased the nutritive value of seeds, in terms of phenolics and flavonoids in a natural way. The total phenols content and total flavonoid levels were found to be highest in soybean sprout extracts, followed by cowpea and mung bean sprout extracts while DPPH (1,1-diphenyl-2-picryl hydrazyl radical) free radical scavenging activity was higher in cowpea or mung bean sprouts than in soybean sprouts. Similar kind of results were also obtained [14] while demonstrating the effect of sprouting on phenolic content and antioxidant activity in chickpea seed. Guoet al [15] also reported that germination dramatically increased total phenols, total flavonoids and antioxidant activity in mung bean sprouts in a time dependent manner, upto 4.5, 6.8 and 6 times higher respectively than the original concentration of mung bean seeds. In another important study, total phenolics, quercetin and ascorbic acid in buckweed sprouts were reported to be maximized on 8th day of germination, when compared to their un-germinated counterparts [16]. Likewise, fenugreek sprouts have also been found to show significant increase in their total phenol content as well as their antioxidant activity through elicited sprouting [10, 17, 18]. Natural elicitors also play a great role in increasing the phytochemical content in sprouts. Recently, Perez-Bablibrea et al [19] proved that elicitation of broccoli sprouts with salicylic acid solution increased their flavonoids. In the salicyclic treatments flavonoids content including rutin and quercetin of buckwheat sprouts was found to maximise drastically on seventh day during the germination process [20]. Literature survey also suggests that the germination caused a clear increase of saponin content of seeds as the germination proceeds. In one of the studies, Jyothi et al [21] reported that compared to seeds, the saponin content was increased to almost 3.2 times after soybean germination. In parallel to this, while studying the sapogenin make up of fenugreek plant at various stages of growth along with the different parts of the seeds, the seedlings were found to have the highest diosgenin (and other steroid sapogenin) content, compared to all other stages of growth [22]. In a recent report, Guajardo-Flores [23] concluded that the saponin concentration was increased in sprouts and cotyledons of germinated black beans to 1.9 and 2.1-fold, respectively. Germination, in addition to cause increase in protein content, dietary fibre, vitamins and bioavailability of trace elements and minerals, is one of the most common processes for the reduction of some anti-nutritive compounds, [24]. In one of the study, in comparison to their seeds, the anti-nutritional factors of lupin sprouts including oligosaccharides (RFOs),alkaloids, globulin and residual fraction content showed a clear decrease during the germination process whereas, a distinct increase of their non-protein fraction was observed [25]. A decrease in trigonelline content (alkaloid) in germinating beans, lentils and peas as well as in cotyledons of germinating mungbean (Phaseolusaureus) seeds has also been documented [26]. Kamal and Ahmad [27] also observed a time dependent decrease of alkaloid content in Nigella Sativa during germination.

Health benefits of sprouts Currently, there is much work underway to develop proper treatments for various oxidative stress related diseases. The seeds and sprouts represent excellent examples of such functional foods, defined as lowering the risk of various degenerative diseases including diabetes and several types of cancers [6]. Therefore, the consumption of seeds and sprouts has become increasingly popular among people interested in improving and maintaining their health status by changing dietary habits. A number of reports documented till date supports that sprouts can act as a potential anti-diabetic functional food. One of the recent studies on phenolic enriched pea sprouts suggests them to possess much higher hypoglycemic activity than their seeds, in relation to diabetes management. Sprouts including mung bean sprouts [28, 29], broccoli sprouts [30], sunflower sprouts [31], buckwheat sprouts [32], Macunapruriens sprouts [33] and chickpea sprouts [34] have been demonstrated to exhibit a strong antidiabetic activity under in vivo conditions. In a four weeks randomized double-blind clinical trial, broccoli sprouts have been found to improve insulin resistance among type 2 diabetic human patients [30]. Similarly, anti-diabetic mung bean sprouts improves glucose tolerance and increases insulin immunological reactivity as five weeks dietary intake of mung bean sprout has been reported to lower blood glucose, cholesterol and triglycerides in diabetic KK-A(y) mice [35]. Likewise, wheat sprouts are reported to be therapeutic for diabetes through the stimulation of insulin secretion [34]. As dietary sprouts possess potential benefits to ameliorate blood glucose levels, and reduces the production of hazardous AGEs that damage tissue physiology. Thus, consumption of sprouts in diet can be also helpful to decrease the incidence of secondary complications associated with diabetes [37]. In this regard, sunflower sprouts are anti-glycative and it potentially inhibits the formation of advanced glycation end products and strongly scavenges damaging free radicals caused by excess blood glucose [38]. Sprouts are also known to improve serum lipid profile and protect against coronary diseases. In one of the study, buckwheat sprouts on the eighth day of germination are reported to contain optimal nutrients for lowering plasma cholesterol and triglyceride levels (39). The sprouts of broccoli [40], alfalfa [41], chickpea [34], and radish [42] also significantly improve fat metabolism, reduces blood cholesterol and lowers blood glucose levels. They are known to significantly increase the survival rates by reducing inflammatory hazards that precede obesity [43]. Dietary sprouts also possess protective effects against various types of cancers. Broccoli sprouts have been found to inhibit the development and growth of lung cancer, skin tumour urinary bladder cancer, prostate cancer cells, ovarian cancer and breast cancer [44, 45, 46]. Likewise, Japanese radish sprouts are reported to prevent breast cancer and flaxseed sprouts inhibit human breast cancer cell growth [47]. Similarly, antidiabetic mung bean sprouts suppresses human melanoma tumour and anti-diabetic wheat sprouts induces apoptosis of human cancer cells [48]. Thus, when handled and distributed in accordance to safety guidelines, sprouts are affordable and accessible solutions to the global burden of chronic diseases.

CONCLUSION
The present review indicates that germination can lead to the development of such type of foods which have various positive effects in the humans. If proper interventions are utilized to minimize pathogenic microbes and other risks in sprouts, such metabolites enriched foods can be incorporated in pharmaceutical preparations for maintaining optimal human health or can be directly consumed as a functional food. However, there remains much work to be done as their mechanism of action to protect against a certain kind of disease at a cellular, biochemical and molecular level have not been comprehensively defined. A better knowledge on the chemistry of bioactive compounds synthesised during sprouting process, their isolation, their characterisation and finally their molecular interactions with target may have much higher impacts for novel drug discovery.

ACKNOWLEDGMENT
Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed

References:

1. Yang Y, Meier F, Ann Lo J, Yuan W, Sze V L P, Chung H J, and Yuk H G. Overview of Recent Events in the Microbiological Safety of Sprouts and New Intervention Technologies. Comp Rev Food Sci Food Safety 2013; 12: 265-280.

2. Marton M, M´andoki Zs, Csap´o-Kiss Zs, Csap´o J. The role of sprouts in human nutrition. A review Acta Univ Sapientiae Alimentaria 2010; 3: 81–117.

3. Bodi E, Fekete I, Andrasi D, and Kovacs B: The role of selenium-enriched food sprouts with respect to our daily selenium needs. Eur Chem Bull 2013; 2(1): 46-48.

4. Yang Y, Meier F, Ann JL, Yuan W, Sze VLP, Chung HJ, and Yuk HG. Overview of Recent Events in the Microbiological Safety of Sprouts and New Intervention Technologies. Compr Rev Food Sci Food Safety 2013; 12: 265-280.

5. Penas E, Gomez R, Fras J, Vidal-Valverde C: Efficacy of combinations of high pressure treatment, temperature and antimicrobial compounds to improve the microbiological quality of alfalfa seeds for sprout production. Food Control 2009; 20:31–9.

6. Chon S: Total polyphenols and bioactivity of seeds and sprouts in several legumes. Curr Pharm Des 2013; 19 (34): 6112-6124.

7. Kuo Y-H, Rozan P, Lambein F, Frias J, Vidal-Valverde C: Effects of different germination conditions on the contents of free protein and non-protein amino acids of commercial legumes. Food Chem 2004; 86: 537–545.

8. Marton M, Mandoki Z, Csapo-Kiss Z, Csapo J: The role of sprouts in human nutrition: A review. Acta Univ Sapientiae Alimentaria 2010;3: 81-117.

9. Saxena M, Saxena J, Nema R, Singh D, and Gupta A: Phytochemistry of Medicinal Plants. J Pharm Phytochem 2013; 1(6): 168-182.

10. Gawlik-Dziki U, Swieca M, Dziki D, and Sugier D: Improvement of nutraceutical value of broccoli sprouts by natural elicitors. Acta Sci Pol Hortorum Cultus 2013; 12(1): 129- 140.

11. Penas E, Gomez R., Frias J, Vidal-Valverde C: Application of high- pressure on alfalfa (Medigosativa) and mung bean (Vignaradiata) seeds to enhance the microbiological safety of their sprouts. Food Control 2008; 19: 698-705.

12. Sangronis E and Machado C J. Influence of germination on the nutritional quality of Phaseolus vulgaris and Cajanus cajan LWT 2007; 40: 116-120.

13. Gan R-Y, Xu X-R, Song F-L, Kuang L, and Li H-B: Antioxidant activity and total phenolic content of medicinal plants associated with prevention and treatment of cardiovascular and cerebrovascular diseases. J Med Plants Res 20104; 22: 2438-2444.

14. Tarzia B G, Gharachorlooa M, Bahariniab M, and Mortazavic S A: The effect of germination on phenolic content and antioxidant activity of chickpea. Iranian J Pharm Res 2012; 11 (4): 1137-1143.

15. Guo X, Li T, Tang K, and Liu R H: Effect of germination on phytochemical profiles and antioxidant activity of mung bean sprouts (Vignaradiata). J Agric Food Chem 2012; 60 (44): 11050–1105.

16. Liu H Y, Qiu N X, Ding H H, and Yao R Q:.Polyphenols content and antioxidant capacity of chinese herbals suitable for medical or food uses. Food Res Int 2008; 41: 363-370.

17. Randhir R, Lin Y T, Shetty K: Stimulation of phenolic antioxidant and antimicrobial activities in dark germinated mung bean sprouts in response to peptide and phytochemical elicitors. Process Biochem 2004; 39: 637–646.

18. Mandal P, and Gupta S K: Improvement of antioxidant activity and related compounds in fenugreek sprouts through nitric oxide priming. Int J Pharm Sci Rev Res 2014; 26(1): 249-257.

19. Perez-Balibrea S, Moreno D A, García-Viguera C: Improving the phytochemical composition of broccoli sprouts by elicitation. Food Chem 2011; 129: 35–44.

20. Brajdes C, and Vizireanu C:.Sprouted buckwheat: An important vegetable source of antioxidants. The annals of the University Dunarea de Jos of Galati Fascicle VI– Food Tech 2012; 36(1): 53-60.

21. Jyothi T C, Kanya T C S, and Rao A G A: Influence of germination on saponins in soybean and recovery of soy sapogenol I. J Food Biochem 2007; 31(1): 1–13.

22. Kor N M and Moradi K: Physiological and pharmaceutical effects of fenugreek (Trigonellafoenum-graecum L.) as a multipurpose and valuable medicinal plant. Global J Med Plant Res 2013; 1(2): 199-206.

23. Guajardo-Flores D, García-Patiño M, Serna-Guerrero D, Gutiérrez-Uribe J A, Serna-Saldívar S O: Characterization and quantification of saponins and flavonoids in sprouts, seed coats and cotyledons of germinated black beans. Food Chem2012; 134: 1312–1319.

24. Singh P K, Gautam A K, Panwar H, Singh D K, Srivastava N, Bhagyawant S S and Upadhayay H: Effects of germination on antioxidant and anti- nutritional factors of commonly used pulses. Int J Res Chem Environ 2014; 4 (2): 100-104.

25. Katarzyna C, Karolina Z A, Danuta C, Piotr G, Andrzej F and Krzysztof G:.Changes in the alkaloid, galactoside and protein fraction content during germination of different lupin species. Acta Societatis Botanicorum Poloniae 201; 79 (1): 11-20.

26. Zheng XQ, Hayashibe E, Ashihara H: Changes in trigonelline (N-methylnicotinic acid) content and nicotinic acid metabolism during germination of mung bean (Phaseolus aureus) seeds. J Exp Bot 2005; 6(416):1615-23.

27. Kamal A, and Ahmad I Z: Phytochemical studies of different phases of germination of nigella sativalinn - a medicinally important plant. Int J Pharm Sci 2014; 6(4): 318- 323.

28. Yao Y, Chen F, Wang M, Wang J and Ren G: Antidiabetic activity of Mung bean extracts in diabetic KK-Ay mice. J Agric Food Chem 2008; 56 (19): 8869-73.

29. Yeap S W, Ali N M, Yusof H M, Alitheen N B, Beh B K, Ho W Y, Koh S P and Long K: Antihyperglycemic effects of fermented and non-fermented mung bean extracts on alloxan-induced diabetic mice. J Biomed Biotechnol 2012; 2: 1-7.

30. Bahadoran Z, Tohidi M, Nazeri P, Mehran M, Azizi F and Mirmiran P: Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. Int J Food Sci Nutr 2012a; 63 (7): 767-771.

31. Sun Z, Chen J, Ma J, Jiang Y, Wang M, Ren G and Chen F: Cynarin-rich sunflower (Helianthus annuus) sprouts possess both antiglycative and antioxidant activities. J Agric. Food Chem 2012; 60 (12): 3260–3265.

32. Watanabe M, and Ayugase J: Effects of buckwheat sprouts on plasma and hepatic parameters in type 2 diabetic db/ dbmice. J Food Sci 2010; 75: 294-299.

33. Randhir R., Kwon Y I and Shetty K: Improved health-relevant functionality in dark germinated Mucunapruriens sprouts by elicitation with peptide and phytochemical elicitors. Bioresour Technol 2009; 100: 4507 – 4514.

34. Mao X, Zhang L, Xia Q, Sun Z, Zhao X, Cai H, Yang X, Xia Z, and Tang Y: Vanadium-enriched chickpea sprout ameliorated hyperglycemia and impaired memory in streptozotocininduced diabetes rats. Biometals 2008; 21(5): 563-70.

35. Yao Y, Shan F, Bian J, Chen F, Wang M, and Ren G: D-chiroInositol-Enriched Tartary Buckwheat Bran Extract Lowers the Blood Glucose Level in KK-Ay Mice. J Agric Food Chem 2008; 56: 10027–1003.

36. Lee S H, Lim SW, Lee Y M, Lee H S, Kim D K: Polysaccharide isolated from Triticumaestivum stimulates insulin release from pancreatic cells via the ATP-sensitive K+ channel. Int J Mol Med 2012; 29(5): 913-919.

37. Hegab Z, Gibbons S, Neyses L and Mamas M A:Role of advanced glycation end products in cardiovascular disease. W J.Cardiol 2012; 4(4): 90-102.

38. Sun Z, Chen J, Ma J, Jiang Y, Wang M, Ren G, Chen F. Cynarin rich sunflower (Helianthus annuus) sprouts possess both antiglycative and antioxidant activity. J Agri Food chem 2012; 60(12):3260-3265.

39. Lin LY, Peng CC, Yang YL, Peng RY. Optimization of bioactive compounds in buckwheat sprouts and their effect on blood cholesterol in hamsters. J Agric Food Chem. 2008 ;56(4):1216-23.

40. Bahadoran Z, Mirmiran P, Hosseinpanah F, Rajab A, Asghari G and Azizi F: Broccoli sprouts powder could improve serum triglyceride and oxidized LDL/LDL-cholesterol ratio in type 2 diabetic patients: A randomized double-blind placebo controlled clinical trial. Diabetes Res Clin Pract 2012; 96: 348–354.

41. Shi Y, Guo R, Wang X, Yuan D, Zhang S, Wang J, Yan X and Wang C:The regulation of alfalfa saponin extract on key genes involved in hepatic cholesterol metabolism in hyperlipidemicrats. PLoS ONE 2014; 9 (2): e88282.

42. Taniguchi H, Kobayashi-Hattori K, Tenmyo C, Kamei T, Uda Y, Sugita-Konishi Y, Oishi Y and Takita T: Effect of japanese radish (Raphanussativus) sprout on carbohydrate and lipid metabolisms in normal and streptozotocin-induced diabetic rats. Phytother Res 2006; 20(4): 274-8.

43. Hong Y H, Chao W W, Chen M L, Lin B F: Ethyl acetate extracts of alfalfa (Medicagosativa L.) sprouts inhibit lipopolysaccharide-induced inflammation in vitro and in vivo. J Biomed Sci 2009; 14(16): 64.

44. Abdulah R, Faried A, Kobayashi K, Yamazaki C, Suradji E W, Ito K, Suzuki K, Murakami M, Kuwano H, and Koyama H: Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells. BMC Cancer 2009; 30(9): 414.

45. Zhang Y, Munday R, Jobson H E, Munday C M, Lister C, Wilson P, Fahey J W and Mhawech-Fauceglia P: Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleraceaitalica) sprouts. J Agric Food Chem 2006; 54(25): 9370.

46. Wang F and Shan Y: Sulforaphane retards the growth of UM-UC-3 xerographs, induces apoptosis, and reduces survivin in athymicmice. Nutr Res 2012; 32(5): 374-80.

47. Lee J, Cho K Flaxseed sprouts induce apoptosis and inhibit growth in MCF-7 and MDA-MB-231 human breast cancer cells. In Vitro Cell Dev Boil Anim 2012; 48(4):244-250.

48. Bonfili L, Amici M, Cecarini V, Cuccioloni M, Tacconi R, Angeletti M, Fioretti E, Keller J N and Eleuteri A M: Wheat sprout extract-induced apoptosis in human cancer cells by proteasomes modulation. Biochimie 2009; 91(9): 1131-44.

 

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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