International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 6(23), December, 2014

Pages: 23-26

Date of Publication: 10-Dec-2014


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HEAT SHOCK PROTEIN (HSP60) IN PERIODONTAL DISEASE: A REVIEW

Author: Indumathy P., K. V. Arun, Sai Prashanth P.

Category: Healthcare

Abstract:Heat shock proteins are stress proteins that are produced by cells in response to environmental stress. They have various roles in the physiological as well as pathological processes of the body. These proteins have often been implicated in the pathogenesis of various diseases. This review discusses the role of heat shock proteins (Hsp 60) in the pathogenesis as well as treatment of periodontal disease.

Keywords: Heat shock protein, Periodontal disease, Immune response

Full Text:

INTRODUCTION
Periodontitis is defined as “an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the periodontal ligament and alveolar bone with pocket formation, recession, or both.1 When exposed to a large array of environmental stresses like temperature, pH, redox potential, prokaryotic and eukaryotic cells respond by inducing the synthesis of specific proteins known as stress proteins, or heat-shock proteins (Hsps) 2 Heat shock proteins have important functions in the cell such as folding, assembly, and translocation of polypeptides across membranes and play a main role in protein repair after cell damage. 3 The human and bacterial cognates of heat shock proteins are similar, sharing more than 50% sequence homology at the amino acid level. 3 During infection, Heat shock proteins from several bacterial species are recognized by the host as immunodominant antigens.4 Heat shock protein production by several periodontopathic micro-organisms has been extensively documented. The presence of these stress proteins has been demonstrated in tissue samples from periodontitis lesions. 5, 6 The sequence homology between the human Heat shock protein 60 (Hsp60) and that of the periodontopathic bacteria like Porphyromonas gingivalis or A actinomycetemcomitans at an amino acid level is 49% and 52%, respectively. 7 Despite being highly homologous between prokaryotic and eukaryotic cells, Hsp60s are considered to be very immunogenic, and immune reactions to microbial Hsp60s may be the cause for the initiation of chronic inflammatory diseases, wherein the autoimmune response to human Hsp60 could be touted as the main factor in pathogenesis of disease.8 This article throws some light on Heat shock proteins (Hsp60), and their role in the etiopathogenesis of periodontitis. A deep understanding of the same has the clinical implications of helping to identify patients who are at risk for developing periodontal disease based on their inability to mount an immune response to specific Hsp or Hsp epitopes. Also, P. gingivalis Hsp60 could potentially be developed as a vaccine to inhibit periodontal disease induced by multiple pathogenic bacteria.

HEAT SHOCK PROTEINS
Heat shock proteins participate in vital physiological processes in the cell such as folding, assembly, and translocation of polypeptides across membranes and play a role in protein repair after cell damage.3 There is a phenomenon termed heat shock response, wherein a cell that experiences increased temperature or any other stress factor, starts producing elevated amounts of heat shock proteins by enhanced transcription. 9

HISTORY
The heat shock response was discovered by Feruccio Ritossa, who observed an enlargement of special sections of Drosophila melanogaster chromosomes (heat shock puffs) after heat treatment of the flies.10 Ritossa subjected these flies to temperature shock induced specific gene activation; the first products of these genes was identified in 1974 and the term “heat shock protein” was adopted. 10 Hsp60 was first described in E.coli by Hendrix in 1979 and has been termed GroEL.11

CLASSIFICATION
Heat Shock Proteins are classified by their molecular weight, size, structure, and function.12

• sHsp - Prevent aggregation of other proteins by collecting protein “ garbage”, act as dustmen of cells

• Hsp60, Hsp70 - Assistance in protein folding and refolding

• Hsp90 - Stabilize substrate proteins and maintain their active, or inactive state, prevent the aggregation of other proteins

• Hsp100 - Desaggregation of proteins

HSPS AND AUTOIMMUNE RESPONSE
Three models have been proposed to link microbial infections to subsequent autoimmune reactions involving Hsps13 . These models are based on a. molecular mimicry between microbial Hsps and Hsps or constitutive proteins from the host b. inflammation-induced exposure of cryptic cell epitopes that could be a target for immune reactions c. antigen persistence in infected sites leading to chronic immunological reactions2 . Immune responses to bacterial Hsps may generate cross reacting immunity to self-Hsp and precipitate damaging inflammatory responses.8,14 Young and Elliott (1989)15 showed that through these cross-reactive epitopes, Tcells with specificity for self-Hsp can be activated during infection. The first report of antibodies against Hsps in a human disease is that of Jarjour et al (1991)16, who suggested that the difference in the levels of anti-Hsps antibodies seen between patients with diseases compared to healthy, could be an indicator of polyclonal B cell activation. 17

HSP60 AND PERIODONTITIS
Periodontitis is a chronic inflammatory disease characterized by mononuclear cell infiltration into the gingival tissues, leading to connective tissue destruction and alveolar bone resorption.8 Although periodontal bacteria like Porphyromonsa Gingivalis, and Aggregatibacter actinomycetem comitans are the causative agents in periodontitis, the progression of the disease and the amount of severity is known to be controlled by host immune responses.18 Pleguezuelos et al (2005)19 have hypothesized that pathogenic bacteria stimulate periodontal cells to increase Hsp60 expression that could in turn initiate macrophages, to start producing proinflammatory cytokines. Due to their high conservation among various microbial pathogens and their ability to induce very strong cellular and humoral immune responses, Hsp60s are thought to play a role as candidate antigens in periodontal disease. 8 A significant temperature elevation up to 2°C is observed in inflamed periodontal pocket.20 It is very well known that pro inflammatory cytokines are produced in periodontitis. These cytokines may cause an elevation of heat shock proteins levels in the inflamed periodontium. Lundqvist et al. (1994)5 found the expression of Hsp60 to be higher in gingival epithelial cells of inflamed tissue samples from periodontitis patients compared with samples from periodontally healthy individuals. Petit et al. (1999)21 suggested that the higher responsiveness to Hsp60 and Hsp70 observed in gingivitis subjects may prevent the conversion from gingivitis to periodontitis. Tabeta et al. (2000)14 reported that gingival tissue extracts from healthy or periodontitis patients contain antibodies to the Porphyromonas Gingivalis GroEL protein (Heat shock protein). Ueki et al (2002)7 demonstrated that Human Hsp60 is expressed abundantly in periodontitis lesions and, also stimulate tumour necrosis factor (TNF) - α production from macrophages Yamazaki et al (2002)8 demonstrated that Hsp60- specific T cells accumulated in the gingival lesions of periodontitis patients but not in gingivitis patients and that the T cell clones with an identical specificity to those in peripheral blood existed in periodontitis lesions. Choi et al (2004)22 showed that Porphyromonas gingivalis Hsp reactive T cell immune response might be involved in immunopathogenesis of periodontal disease. They suggested that T cells in the circulating peripheral blood may home to periodontal lesions where Porphyromonas .gingivalis have infiltrated potentially leading to T cell response cross reactive to mammalian Hsp of gingival fibroblasts. Pleguezuelos et al (2005)19 stated that exogenous HSP60 is capable of initiating an inflammatory response in oral keratinocytes by increasing the expression of proinflammatory cytokines Honda et al (2006)23 proved that Hsp60 expression was up-regulated significantly in periodontitis.

HSP60 VACCINE IN PERIODONTITIS
Heat shock protein (Hsp) can be possibly explored as a candidate for vaccination against periodontitis Choi et al (2005)26 found that P. gingivalis Hsp60 could potentially be developed as a vaccine against multiple periodontopathic bacteria Lee et al (2006)27 found that there was a very strong inverse relationship between post immune anti-P. gingivalis HSP immunoglobulin G (IgG) levels and the amount of alveolar bone loss produced by bacterial infections DISCUSSION Although infectious diseases, by and large have a microbial aetiology, it is now an established fact that the hosts immune response to this microbial assault can itself cause destruction to host tissues. Heat shock proteins are stress proteins, and many studies have demonstrated their increased levels in periodontal disease. They generate a strong pro inflammatory response, and further, there is also the possibility of a cross reactive immune response to mammalian Hsps , due to the strong homology between the bacterial and human Hsps. Since, other infectious diseases have been controlled in the past by administration of vaccines, Heat shock proteins could be considered as a potential candidate antigen to be used as a vaccine to control periodontal disease.

CONCLUSION
Knowledge about Hsp60 and further studies establishing their role in the etiopathogenesis of periodontal disease would aid in diagnosing and also treating periodontal disease. Source of Funding: None Conflict of Interest: None

References:

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2. Goulhen F,Grenier D, Mayrand D Oral microbial heat-shock proteins and their potential contributions to infections. Crit. Rev. Oral Biol. Med. 2003; 14:399–41.

3. Ellis JR, van Eden W, Young D. Stress proteins as molecular chaperones. . Stress Proteins in Medicine 1996:1-26.

4. Kaufmann SH Heat shock proteins and the immune response Immunol Today 1990; 11: 129-136.

5. Lundqvist C, Baranov V, Teglund S, Hammarstrom S, Hammarstrom ML Cytokine profile and ultrastructure of intraepithelial gamma delta T cells in chronically inflamed gingiva suggest a cytotoxic effector function J Immunol 1994; 153: 2302-2312.

6. Ando T,Kato T,Ishihara K,Ogiuchi H, Okuda K Heat shock proteins in the human periodontal disease process Oral Microbiol Immunol 1995 ; 39 :321-327.

7. Ueki K, Tabeta K, Yoshie H, Yamazaki K Self heat shock protein 60 induces tumor necrosis factor –alpha in monocytederived macrophage: possible role in chronic inflammatory periodontal disease Clin Exp Immunol 2002; 127:72-77.

8. Yamazaki K, OhsawaY, Tabeta. K, Ito H, Ueki K, Oda T, Yoshie H, Seymour GJ. Accumulation of Human Heat Shock Protein 60-Reactive T Cells in the Gingival Tissues of Periodontitis Patients. Infect Immun 2002; 70: 2492–2501.

9. Trivedi, V., Gadhvi, P., Chorawala, M., and Shah, G. (2010). Role of heat shock proteins in immune response and immunotherapy for human cancer. Int J Pharm Sci Rev and Res, 2, 57-62.

10. Tissieres A, Mitchell HK, Tracy UM. Protein synthesis in salivary glands of Drosophila melanogaster: Relation to chromosome puffs J Mol Biol 1974; 85: 389-398.

11. Hendrix RW Purification and properties of groE, a host protein involved in bacteriophage assembly J Mol Biol 1979; 129: 404-408.

12. Csermely P, Yahara I. Heat Shock Proteins. In: Keri G, Toth I, editors. Molecular Pathomechanisms and New Trends in Drug ResearchCRC Press, 2003 p. 67-75.

13. Rose NR The role of infection in the pathogenesis of autoimmune disease Semin immunol 1998 ; 10: 5-13.

14. Tabeta K, Yoshie H, Yamazaki K Characterisation of serum antibody to Actinobacillus actinomycetemcomitans GroEL – like protein in periodontitis patients and healthy subjects Oral Microbiol Immunol 2001; 16:290-295.

15. Young RA, Elliott TJ Stress proteins, infection and immune surveillance Cell 1989 ; 59:5-8.

16. Jarjour WN, Jeffries BD, Davis JS, Welch WJ, Mimura T, Winfield JB Autoantibodies to human stress proteins. A survey of various rheumatic and inflammatory diseases Arthritis Rheum 1991; 34:1133-1138.

17. Wu T, Tanguay RM Antibodies against heat shock proteins in environmental stresses and diseases: friend or foe? Cell Stress and chaperones 2006;11:1-12.

18. Seymour GJ, Gemmell E, Reinhardt RA, Eastcott J, Taubman MA Immunopathogenesis of chronic inflammatory periodontal disease: cellular and molecular mechanisms J Periodontal Res 1993;28: 478-486.

19. Pleguezuelos O, Dainty SJ, Kapas S, Taylor JJ A human oral keratinocyte cell line responds to human heat shock protein 60 through activation of ERK1/2 MAP kinases and upregulation of IL-1 β Clin Exp Immunol 2005; 141: 307-314

20. Amano A, Sharma A,Sojar HT, Kuramitsu HK, Genco RJ Effects of temperature stress on expression of fimbriae and superoxide dismutase by porphyromonas gingivalis Infect immun 1994; 62: 4682-4685.

21. Petit MD, Wassenaar A, van der Velden U, van Eden W, Loss BG Depressed responsiveness of peripheral blood mononu-clear cells to heat –shock proteins in periodontitis patients J Dent Res 1999; 78: 1393-1400.

22. Choi JI, Chung SW, Kang HS,Rhim BY, Park YM, Kim US, Kim SJ Epitope mapping of Porphyromonas gingivalis heat shock protein and human heat shock protein in human atherosclerosis J Dent Res 2004; 83:936-940.

23. Honda T, Domon H, Okui T , Kajita K, Amanuma R, Yamazaki K Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions Clin Exp Immunol 2006;144:35-40.

24. Yamazaki K, Ohsawa Y, Itoh H, Ueki K, Tabeta J, Oda T, Nakajima T, Yoshie H, Saito S, Oguma F, Kodama M, Aizawa Y, Seymour GJ T cell clonality to Porphyromonas gingivalis and human heat shock protein 60 s in patients with atherosclerosis and periodontitis Oral microbial Immunol 2004 ;19:160-167.

25. Ford P, Gemmell E, Walker P, West M, Cullinan M, Seymour G Characterisation of heat shock protein specific T cells in atherosclerosis Clin and Diag Lab Immunol 2005; 12:259- 267.

26. Choi JI, Choi KS, Yi NN, Kim US, Choi JS, Kim SJ. Recognition and phagocytosis of multiple periodontopathogenic bacteria by anti-Porphyromonas gingivalis heat-shock protein 60 antisera. Oral Microbiol Immunol. 2005 Feb; 20(1):51-5.

27. Lee JY, Yi NN, Kim US, Choi JS, Kim SJ, Choi JI. Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria. J Periodontal Res 2006; 41(1):10-14.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
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A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
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A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
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A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
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A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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