International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 07 Issue 03, February, 2015

Pages: 13-16

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FINE NEEDLE ASPIRATION CYTOLOGY OF HEPATIC LESIONS IN IRAQI PATIENTS

Author: Esam Mohamed Abdul Raheem

Category: Healthcare

Abstract:Study design and Objective: This was a cross- sectional hospital-based descriptive study aimed to assess the role of Fine Needle Aspiration Cytology (FNAC) indiagnosis of the hepatic lesions in Iraqi patients Material and Methods: During a period of six months, percutaneous fine needle aspirations, either blindly or under ultrasoundguidance , were performed preoperatively on 34 patients with hepatic lesions attended Mosul hospitals. Results: Cytological diagnosis revealed 33 malignant lesions and one liver abscess. Diagnosis of all cases was confirmed by histopathological examination of tissue biopsies. The sensitivity, specificity, and overall accuracy of the technique were 100%. Conclusion: FNAC of the liver has proved to bereliable, accurate, safe, economic, and can save the patient unnecessary surgical approach.

Keywords: FNAC, Liver, Iraq

Full Text:

INTRODUCTION

Investigation of liver lesions detected by clinical and/or ultrasound examination may necessitate wide bore needle biopsy and even open liver biopsy. [1, 2]Such techniques may need hospitalization and application of anesthesia; they are associated with considerable rates of complications such as bleeding and tumor spread. [3, 4, 5]Fine needle aspiration of such lesions provides quick, easy, painless, and accurate method of preoperative diagnosis; in experienced hands, no complications are faced. [6, 7, 8] The aim of the current study was to evaluate the technique and assess its role in Iraqi patients with liver mass lesions. MATERIAL AND METHODS This was a cross- sectional hospital-based descriptive study conducted at Mosul City during the period between January and July 1998.Preoperativepercutaneous FNAC was performed on 34 clinically or ultrasonically detected hepatic mass lesions. The aspirates were obtained from patients in departments of pediatric surgery at Al-Khansahospital, general surgery at Al-Zahrawi hospital,and internal medicine at Ibn-Sina hospital. All patients were suspected of having malignancy. Verbal permission and approval for all aspirates were obtained from head departments at the mentioned hospitals and from patients and/or co-patients. Aspirations were done without any routine fasting or premedication. Prothrombin time, PTT, and platelet counts or any other laboratory investigations were not evaluated routinely before the procedure. Prior to the aspiration, labeled glass slides were put ready for the samples. The skin overlying the mass was cleaned with alcohol or iodine. Topical or local anesthesia was not administered. The technique was performed by the use of 10 ml disposable syringe with 21-22 gauge needles.Palpable lesions were aspirated directly without the need for ultrasound control (13 cases). Deeper and smaller lesions required more precise localization by ultrasound (21 cases); the largest and most superficial one was selected for aspiration. After localization of the mass, the needle was introduced into the lesion and negative pressure was applied; the needle was then moved back and forth and in different directions several times during maximumaspiration to soften the lesion. When material appeared into the needle, suction was stopped, and the needle was withdrawn.

No case needed more than one pass to get the material. The patient was kept lying down for 10 minutesand reexamined by ultrasound to notice any possible complications, such as bleeding or hematoma at the site of aspiration. Two to four thin or central concentrated smears were then made from each aspirate, fixed immediately into 95 % ethanol for 15 minutes and stained with Hematoxylin and eosin staining technique. Slides were then evaluated under a light microscope and results were compared with the histological diagnosis which was considered as the conclusive diagnosis. The histological diagnosis was made by open liver biopsy in 14 patients and by core needle biopsy in the remaining 20 patients.

RESULTS

All the aspirates were prepared, stained,and reported within 45- 60 minutes of obtaining the material.The patients included 30 adults and 4 children, 9 females and 25 males, ranged in age between 7 and 62 years. The presenting clinical findings were dyspepsia in 7 patients, palpable mass in 12 patients, general ill health with loss of weight in 10 patients, and in the remaining 5 patients the lesion was discovered accidently during follow up after resection of a malignant lesion. The cytological diagnosis of the aspirated hepatic lesions included 33 malignant lesions and one benign lesion; this is shown in table 1. The primary sources of the metastatic lesions are shown in table 2. The cytological diagnosis was consistent with the histological diagnosis in all cases. The sensitivity, specificity, and overall accuracy were 100%. A mild dizziness followed by fever was noticed in a 50 years old female with hepatic secondaries from carcinoma of the breast. The technique was acceptable by all the patients. Reexamination of the sites of aspiration by ultrasound showed no signs of bleeding or hematoma in any of the guided aspirations.

DISCUSSION

FNAC has proved to be effective preoperative diagnostic tool in superficial lesions [9, 10],however, it is now extended to diagnosesuch deep lesions as liver masses. In this site, its role as preoperative diagnostic method can be even more important than the superficial organs; it may save the patient a major surgical operation. In some cases the technique may abolish the need for surgery when the lesion is inoperable or the treatment of choice is radiotherapy or chemotherapy [11, 12, and 13]. The results of this study indicate that FNAC of the liver is very reliable and highly accurate in diagnosis of hepatic lesions, especially malignant ones.It is safe, quick, and economic technique. These results are compatible with several other studies performed on lesions of the liver [14 - 17]. The sensitivity, specificity, and overall accuracy of this study were similar to several studies. [18 - 21]. Comparing the accuracy of FNAC of liver lesions with the accuracy of tru-cut needle biopsy, it was found that FNAC is more accurate, safe, and economic. [4]. Ultrasound guidance during aspiration was especially important in small and deep lesions [22], added to that it is helpful in avoiding aspiration of hydatid cyst in which FNAC is contraindicated. [23]. The complications of FNAC of liver in this study were negligible. [24]. Bile peritonitis and intraperitoneal bleeding reported with core needle biopsy [5] were not observed in this study.

CONCLUSIONS

It can be concluded from this study that FNAC of the liver, especially when guided by ultrasound, is accurate,safe, quick and economic preoperative test. It is useful in differentiating neoplastic from nonneoplastic lesions, and benign from malignant ones.It is trusted by surgeons; they usually depend on FNAC results and refer the patient to treatment by radiotherapy or chemotherapy. It can help to predict the primary ofan aspirated metastatic tumor.

Source of Funding

This work was supported by the department of pathology college of medicine, Mosul university, Iraq.

Conflict of Interest

The author declares that there is no conflict of interest.

Author’s Contribution:

The author is responsible for conception and design of the study, data collection, interpretation of the findings, and review of the whole manuscript.

ACKNOWLEDGEMENTS

Author acknowledges the immense help received from the scholars whose articles are cited and included in references of this manuscript. The author is also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

References:

1. Lundquist A. 1970. Liver biopsy with a needle of 0.7 mm outer diameter. Acta Med. Scand; 188: 471-474.

2. Gilmore IT, Burroughs A, Murray-Lyon IM, Roger Williams, Jenkins D, and Hopkins A. 1995. Indications, methods, and outcomes of percutaneous liver biopsy in England and Wales: an audit by the British Society of Gastroenterology and Royal College of physicians of London. Gut, 36: 437- 41.

3. Edoute Y, Haim SB, and Malberger E. Liver histology and cytology in the diagnosis of malignant liver disease. 1990. Am J Gastroenterol, 85: 285-287.

4. Prior C, Kathrein H, Mikuz G, and Judmaier G. 1988. Differential diagnosis of malignant intrahepatic tumor by U/S guided FNAB and by laparoscopic / intraoperative biopsy: a comparative study. Acta cytol, 32: 892-895.

5. Haaga JR and Vanek J. 1979. CT-guided liver biopsy using the Menghini needle. Radiology, 133: 405-408.

6. Angeles AA, Dominguez G, and Fernandez M. 1994. Hepatic fine needle aspiration biopsy: experience in the study of hepatic masses at the Salvador Zubrian National institute of Nutrition. Rev. Invest. Clin, 46: 279-285.

7. Herszenyi L, Farinati F, Marafin C, and Cardin R. 1995. Fine needle biopsy in focal liver lesions: the usefulness of a screening programme and the role of cytology and micro histology. Ital. J. Gastroenterol, 27: 473-478.

8. Whitlatch S, Nunez C, and Pitlik DA. 1984. Fine needle aspiration biopsy of the liver: a study of 102 consecutive cases. Acta cytol. 28: 719-725.

9. Gupta RK, Naran S, Lallu S, and Fauck R. 2003. The diagnostic value of FNAC in the assessment of palpable supraclavicular lymph nodes: a study of 218 cases. Cytopathology, 14:201-7.

10. Sharma R and Mathur D. 2012. FINE NEEDLE ASPIRATION CYTOLOGY (FNAC) OF PALPABLE LESIONS OF HEAD AND NECK REGION. IJCRR. 4(22): 74-84.

11. Abdul-Raheem EM, Elfaki EM. The role of fine needle aspirationcytology in the diagnosis of deep-seated lesions in Sudanese patients. Int J Health Sci Res.2013; 3(10):1-9.

12. Nasuti JF, Gupta PK, Baloch ZW. 2002. Diagnostic value and cost-effectiveness of on-site evaluation of fine-needle aspiration specimens: review of 5,688 cases. Diagnostic Cytopathology. 27(1):1–4.

13. Rosa M. 2008. Fine-needle aspiration biopsy: a historical overview. Diagnostic Cytopathology. 36(11):773–775.

14. Matricardi L, Lovati R, Capra S, Casoni S, and Callea F. 1996. Peripheral intrahepatic cholangiocarcinoma: the role of imaging diagnosis and fine needle biopsy. Radiol. Med. Torino; 91: 413-419.

15. Hakim JG, Kiire CF, Weinig M, Gudza I, Muronda C, and siziya S. 1995. FNAC in the diagnosis of hepatocellular carcinoma. Cent. Afr. J Med. (Zimbabwe), 41: 237-241.

16. Khanna AK, Mishra MK, Khanna A, Mishra VK, Khanna S, et al. 1990. Fine needle aspiration cytology of abdominal masses. Journal of surgical oncology, 44:15–19.

17. Krishna SR, Ananthakrisnan N, Narasimhan R, and Veliath AJ. 1993. Accuracy of needle aspiration cytology of abdominal masses without radiological guidance. Indian J.Pathol. Microbiol, 36(4):442–52.

18. Perry MD and Johnston WW. 1985. Needle biopsy of the liver for the diagnosis of nonneoplastic liver disease. Acta cytol. 29: 385-390.

19. Giorgio A, Trantino L, Marmiollo N, Francica G, Scala E, Amoroso P, Nuzzo A, and Rizzatto G. 1995. Pyogenic liver abscesses: 13 years of experience in percutaneous needle aspiration with US guidance. Radiology, 1: 122-124.

20. Pinto MM, Avila NA, Heller CI, and Criscuomo EM. 1988. Fine needle aspiration of the liver. Acta Cytol. 32: 15 - 21.

21. Zornoza J, Wallace S, Ordonez N, and Lukerman J. 1980. Fine needle aspiration biopsy of the liver. AJR. 134: 331- 334.

22. Santos GC, Morini SR, Granero LC, Chojniak R, and Longatto-Filbo A. 1997. Computed tomography guided fine needle aspiration biopsy. Rev Paul Med, 115 (1): 1343-8.

23. Sinner WN, Nyman R, Linjawi T, and Ali AM. 1995. Fine needle aspiration biopsy of hydatid cysts. Acta Radiol. 36: 168-172.

24. Roy M, Dasgupta S, and Sanyal S. 1994. Fallacies of the FNAC of surgical lesions of liver. J. Indian Med Assoc. 92: 285-287.

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
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A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
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A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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