International Journal of Current Research and Review
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IJCRR - Vol 07 Issue 10, May, 2015

Pages: 01-05

Date of Publication: 30-Nov--0001


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AMELOBLASTIC FIBRO SARCOMA OF THE MANDIBLE IN A YOUNG MALE

Author: Balasubramanian A., N. S. Kannan

Category: General Sciences

Abstract:Aim: Aim of this study is to report a rare case of Ameloblastic Fibro Sarcoma (AFS) of mandible arising as a denovo malignancy and to review the literature with reference to so far reported cases, nomenclature, classification, differential diagnosis and management. Case report: A 14 year old male patient presented with complaints of a painless swelling of left side of the face since 1 year. Based on clinical presentation and investigation reports it was diagnosed as a case of AFS in left side of mandible arising as a denovo malignancy. He underwent left hemimandibulectomy 'en bloc' with part of the adjacent masseter and pterygoid muscles under general anaesthesia. Discussion: Ameloblastic Fibro Sarcoma (AFS) is one of the rare histopathology variety of odontogenic tumours. The first case of AFS was reported in 1887 by Heath. Since then only 91 cases have so far been reported. This number includes both denovo and sarcomatous transformation from pre-existing ameloblastic fibroma, occurring in different sites. The most common site affected is mandible [78%]. The mean age of patients with tumours arising denovo is 22.9 years. Ours is a case of AFS arising as a denovo malignancy in left side of mandible. Conclusion: We are presenting our case due to rarity and the limited information that exists regarding histopathology characteristics of AFS, lack of defined criteria for grading and biologic behaviour of these tumours, making the diagnosis eluding, treatment decision challenging and assessment of prognosis difficult.

Keywords: Odontogenic tumours, Denovo malignancy, Orthopantomogram, Hemimandibulectomy ‘en bloc’

Full Text:

INTRODUCTION

Ameloblastic Fibro Sarcoma (AFS) is one of the rare histopathology variety of odontogenic tumours. The first case of Ameloblastic Fibro Sarcoma (AFS) was reported in 1887 by Heath. Since then only 91 cases have so far been reported in literature. This number includes both denovo and sarcomatous transformation from pre existing ameloblastic fibroma, occurring in different sites. The most common site affected is mandible [78%]. The mean age of patients with tumours arising denovo is 22.9 years. Biopsy is required for preoperative diagnosis. The management of AFS should be wide surgical excision with surrounding soft tissue especially if there is cortical disruption as in our case, due to its propensity for high local recurrence. We report a rare case of Ameloblastic Fibro Sarcoma (AFS) in left side of mandible in a 14 year male, arising as a denovo malignancy and the literature is reviewed with reference to so far reported cases, nomenclature, classification, differential diagnosis and management.

CASE DETAILS

A 14 year old male patient presented in outpatient department with complaints of a painless swelling of left side of the face since 1 year (Figure 1a and 1b). Clinical examination revealed a swelling of 12 x 10cm involving the left side of the mandible with firm to hard consistency. Overlying skin appeared normal. On intraoral examination, the swelling was extending from the region of left lower canine tooth to the retro molar region and with lingual version of canine and premolars, medially displaced second premolar, loosening of first molar and  missing left lower second molar tooth. There was no cervical lymphadenopathy. Orthopantomogram (Figure 2) showed expansile lytic lesion involving the left side of the mandible extending from the area beneath the root of the left lower canine, posteriorly up to the condyle with resorption of roots of both the premolars, fracture of the 1st molar tooth, missing of second molar tooth and grossly displaced unerupted third molar tooth. Contrast Enhanced Computerised Tomography (CECT) of head and neck showed circumferential cortical expansion with thinning of the cortex and areas of cortical disruption involving the horizontal ramus, coronoid process and ascending ramus up to the condyle on the left side of the mandible (Figure 3a 3b and 3c). Other routine investigations were within normal limits. Incision biopsy revealed features of Ameloblastic Fibro Sarcoma. The case was posted for surgery and under general anaesthesia, left hemimandibulectomy ‘en bloc’ with part of the adjacent masseter and pterygoid muscles was done (Figure 4a 4b and 4c). Left lower jaw reconstruction was done with titanium plate. Post operative orthopantomogram is shown in (Figure 5). Postoperative period was uneventful and specimen (Table/Fig 6) sent for histopathology (Figure 7a, 7b and 7c) was reported as Ameloblastic Fibro Sarcoma with negative resection margins. Immunohistochemistry for Vimentin marker was positive. Immediate post operative picture is shown in (Figure 8a). Picture at one month follow up was aesthetically satisfying (Figure 8b). On one year follow up, the patient was hale and healthy and no recurrence so far. He is still under continuous follow up.

DISCUSSION

The first case of Ameloblastic Fibro Sarcoma (AFS) was reported in 1887 by Heath1 . So far, only 91 cases have been reported in the literature2-4. AFS is a rare mixed malignant odontogenic tumour composed of benign epithelial component and malignant ectomesenchymal component5 .Classification of malignant odontogenic sarcomas includes other odontogenic sarcomas, specifically two closely related entities that have similar histological features as AFS, ameloblastic fibrodentinosarcoma and fibro-odontosarcoma; These sarcomas have similar morphologic features of AFS; however, in addition they either have dysplastic dentin (fibro-dentinosarcoma) and/ or enamel and dentin (fibro-odontosarcoma) a feature not seen in AFS6,7. These tumours can arise either denovo8 constituting two thirds or as sarcomatous transformation of pre-existing ameloblastic fibroma forming remaining one third9 . They commonly occur in young adults, usually in third decade with a wide age range from 4 months to 89 years reported in the literature and have male predilection4,6-9. The mean age of patients with tumours arising denovo is 22.9 years and is 33 years for those derived from ameloblastic fibroma10. The age of our patient is below the mean age i.e. 14 years. The most common sites affected include mandible [78%], followed by maxilla [20%] and rarely skull base. Moreover, tumours affecting maxilla and mandible tend to occur more in the posterior aspect11. Using the term odontome for any tumour arising from the dental formative tissues, Broca12 suggested a classification of odontogenic tumours (OTs) in 1869. Since then it has undergone many modifications until 1966, when WHO established a Collaborating Centre for the Histological Classification of Odontogenic Tumours and Allied Lesions (including jaw cysts) headed by Dr Jens Pindborg13. In 1971, the first authoritative WHO guide to the classification of OTs and cysts appeared, followed in 1992 by a second edition. In 2002, Philipsen and Reichart produced a revision of the 1992-edition and in 2003, the editors of the WHO Blue Book series: ‘WHO Classification of Tumours’ decided to produce a volume on the Head and Neck Tumours including a chapter on Odontogenic Tumours and Bone Related Lesions. In July of 2005, this volume was published by International Agency for Research on Cancer (IARC), Lyon. Mosqueda-Taylor, in his article have concluded: ‘The lack of uniform criteria employed for their proper identification, as well as the histomorphologic similitude found among some of them which behaves in different way, and the scantiness of proper methods to determine their precise origin makes necessary to recognize that at present, in spite of having more or less strict diagnostic criteria which have been internationally accepted, there is a need to continue developing research in the epidemiological, clinico-pathological, morpho-physiological and therapeutical fields in this area of the maxillofacial pathology’14. Still many new findings and controversies are on the offing regarding odontogenic tumours and their classification14. Classification of malignant odontogenic tumours as per WHO Classification of Head and Neck Tumours is reproduced here for ready reference (Table 1)6 . Differential diagnosis of Ameloblastic fibro sarcoma. (Reproduced from WHO Classification of Head and Neck Tumours) is shown in (Table 2)6 . The natural history of these tumours is characterised by only local aggressiveness contributing to high rate of local recurrence with little propensity for regional and distant metastases. So far, in the literature, only one case had been reported to have metastases to mediastinum and liver. It is because of this behaviour these tumours are categorised as low to intermediate grade malignancy. The gross appearance of these tumours is fleshy with white to yellowish cut surface. Microscopically epithelial component resembles follicular ameloblastoma where the cells have palisading arrangement. These epithelial islands are separated by ectomesenchymal stroma, which forms the bulk of the tumour. Stroma is hyper cellular with polygonal to fusiform cells revealing cellular atypia and increased mitosis8,10. The common clinical features include swelling and pain. They can also present with mucosal ulceration, loosening of teeth and paraesthesia. Radiologically these tumours present as expansile radiolucent lesion with indistinct margins. Biopsy is required for preoperative diagnosis and it is often difficult to diagnose these tumours in preexisting ameloblastic fibromas wherein focal area of malignant degeneration is often missed in biopsies. In such instances, serial sectioning of the surgical specimen is mandatory to establish appropriate diagnosis. The management of AFS should be wide surgical excision with surrounding soft tissue especially if there is cortical disruption as in our case, due to its propensity for high local recurrence rate14. In mandibular AFS, it often results in segmental or hemimandibulectomy. The reconstructive options for resulting defects include mandibular reconstruction with plates or osteocutaneous free flaps. Some authors have recommended adjuvant chemotherapy and radiotherapy but their role is uncertain due to paucity of data in the literature. Radiotherapy may be of use in margin positive resections to decrease the local recurrence rate.

CONCLUSION

To conclude AFS are rare tumours and a high index of suspicion is needed before proceeding to dental extraction since these patients often present with dental pain. So far, only 91 cases have been reported in the literature. This number includes both denovo and sarcomatous transformation from pre existing ameloblastic fibroma, occurring in different sites. AFS of mandible as denovo malignancy below mean age group so far reported, continues to be a rare entity. All patients with ameloblastic fibroma treated by local excision/conservatively should be kept under close surveillance for detecting recurrence/malignant transformation, which may turn out to be AFS. These cases require to be treated by wide surgical resection en bloc with removal of surrounding tissue if tumour has perforated cortical plates. The rarity of AFS and the limited information that exists regarding histopathology characteristics, lack of defined criteria for grading and biologic behaviour of these tumours makes not only the diagnosis challenging and the treatment decision and assessment of prognosis difficult. Presentation of our case report may add up for further research.

ACKNOWLEDGMENT

Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors/editors/publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed. Authors are grateful to IJCRR editorial board members and IJCRR team of reviewers who have helped to bring quality to this manuscript.

Source of funding: Nil

Conflict of interest: Authors declare that they do not have any conflict of interest.

References:

1. Heath C. Lectures on certain disease of the jaws. Br Med J. 1887;2:5–13.

2. Hu YY, Deng MH, Yuan LL, Niu YM. Ameloblastic fibrosarcoma of the mandible: A case report and mini review. Exp Ther Med. 2014;8(5): 1463–6.

3. Pontes HA, Pontes FS, Silva BS, Cury SE, Fonseca FP, Salim RA, et al. Immunoexpression of Ki67, proliferative cell nuclear antigen, and Bcl-2 proteins in a case of ameloblastic fibrosarcoma. Ann Diagn Pathol. 2010;14(6):447–52.

4. Demoor-Goldschmidt C, Minard-Colin V, Cassagneau E, Supiot S, Oberlin O, D’hautuille C, et al. Ameloblastic fibrosarcoma of the mandible: report of 2 chemosensitive pediatric cases. J Pediatr Hematol Oncol. 2012;34(2):e72–6.

5. Dallera P, Bertoni F, Marchetti C, Bacchini P, Campobassi A. Ameloblastic fibrosarcoma of the jaw: report of five cases. J Craniomaxillofac Surg. 1994;22(6):349–54.

6. Barnes, L.; Eveson, J.; Reichart, P.; Sidransky, D. WHO Classification of Head and Neck Tumors Pathology and Genetics of Head and Neck Tumours; IARC Press: Lyon, France, 2005; pp. 283-328.

7. Gilani S M, Raza A, Al-Khafaji B M. Ameloblastic fibrosarcoma: A rare malignant odontogenic tumor European Annals of Otorhinolaryngology, Head and Neck Diseases. 2014;131(1):53–56.

8. Zabolinejad N, Hiradfar M, Anvari K, Razavi AS. Ameloblastic fibrosarcoma of the maxillary sinus in an infant: a case report with long-term follow-up. J Pediatr Surg. 2008;43:e5–e8.

9. Kobayashi K, Murakami R, Fujii T, Hirano A. Malignant transformation of ameloblastic fibroma to ameloblastic fibrosarcoma: case report and review of the literature. J Craniomaxillofac Surg. 2005;33(5):352–55.

10. Bregni RC, Taylor AM, García AM. Ameloblastic fibrosarcoma of the mandible: report of two cases and review of the literature. J Oral Pathol Med. 2001;30(5):316– 20.

11. Khalili M, Shakib P A. Ameloblastic fibrosarcoma of the upper jaw: Report of a rare case with long-term follow-up. Dent Res J (Isfahan).2013;10(1):112–5.

12. Broca P. Recherches sur un nuveau grupe des tumeurs désignées sousle nom d’odontomes. Gaz Hebd Sci Med. 1868;5:70-84 (Research on a new group of tumors designated under the name odontomas by Mr. Paul Broca, ... [1867 Edition]).

13. Pindborg JJ, Kramer IRH. Histological Typing of Odontogenic Tumours, Jaw Cysts and Allied Lesions. 11th ed. Geneva: World Health Organization; 1971.

14. Mosqueda-Taylor A. New findings and controversies in odontogenic tumors. Med Oral Pathol Oral Cir Bucal. 2008;13(9):E555-8.

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by situs slot and Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh et al. situs slot "Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma situs slot entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by situs slot et al entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09
Late to bed everyday? You may die early, get depression situs slot
Egg a day tied to lower risk of heart disease situs slot
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List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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