International Journal of Current Research and Review
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IJCRR - 14(8), April, 2022

Pages: 54-57

Date of Publication: 19-Apr-2022


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Fungal Endocarditis in an Alport's Syndrome Patient with Chronic Kidney Disease on Regular Hemodialysis

Author: Nithin Bharadwaj, Chandra Shekara Reddy, Arun Srinivas, Siddarth Kumar Chawath, Lakshminarayan Achar

Category: Healthcare

Abstract:Introduction: Fungal Endocarditis is rare and fatal. Most prevalent in immunosuppressed and Intravenous Drug Abusers. Candida and Aspergillus species are most common etiologic Fungi. Case presentation: A Seventeen-year-old male with known Hypertensive, Seizures and Alport Syndrome of Stage V Chronic Kidney Disease, admitted with history of fever and chills for 2weeks. On regular hemodialysis via right Internal Jugular Vein Permcath, inserted 6 months ago. Clinical examination was unremarkable except for tachycardia and hypotension. Serial blood cultures were negative for any growth. But 2D Echocardiography confirms the presence of mobile vegetative mass attached to the Tricuspid Valve (TV), which extends and then obstructs the Right Ventricular Outlet Tract (RVOT). With worsening symptoms and failed initial management, he was admitted first time and underwent removable of Permcath, TV Vegetectomyand then Pericardial patch augmentation of Septal Tricuspid Leaflet and Alferi type of TV repair. Both Permcath tip and excised mass were sent for Histopathological Examination (HPE), confirming Fungal infection with Magnusiomyces Capitatus, which belongs to Blastoschizomyces capitatus. Responds to Inj. LoposomalAmhotericin B and Voroconazole. But within few weeks, he developed Severe Tricuspid Regurgitation and Right heart failure with gross Ascitis. Then readmitted for a second time and underwent immediate symptomatic relief by Ascitic tapping followed by TV Replacement with 31 mm of St. JUDE Mechanical Valve. Perioperative management was challenging and stabilized gradually and involves a multispecialty team approach. Discussion: Fungal endocarditis is a serious condition. Combined aggressive Medical and Surgical therapy will have a better outcome

Keywords: Antifungal Agents, Fungal Endocarditis, Right Heart Failure, Tricuspid Valve Replacement, Ascitic tapping, Multispecialty team approach

Full Text:

Introduction

Fungal endocarditis (FE) remains the rare most serious form of infective endocarditis, with a high mortality rate of about 50%.1,2,3 It is highly challenging to identify the source, establish a diagnosis and to apply specific treatment. This is because of the high mortality rate and complexity of FE will lead to lack of prospective randomized clinical trials for FE management.

Case Report

We report a case of Fungal Endocarditis in a Seventeen-year-old male patient. He suffers from Hypertension, Seizure disorder and Alzheimer’s Syndrome with Chronic Glomerulonephritis with Stage 5D chronic kidney disease. He inherited Alport’s Syndrome from his mother. She also had CKD, both were on regular hemodialysis. His female sibling was free from Alport’s Syndrome. Alport’s Syndrome - X-linked Genetic disorder mainly affects kidney. He undergoes hemodialysis via Permcath, which was placed 6 months ago at the Right Internal Jugular vein. He was admitted twice with the intractable clinical course for Fungal Endocarditis management and stays in the hospital for nearly about 92 days.

First Admission: He was clinically presented with a history of fever, chills and tachycardia. All of his investigations were unremarkable except-Anemia(5.5 gms/dl). Thrombocytopenia (17000 cells /cumm) and 2D Echocardiography confirms the presence of a mobile mass attached to the Tricuspid Valve (TV) leaflet as shown in Figure 1

The presence of Fever with chills and tachycardia, rapid growth of mass and presence of indwelling catheter confirms Infective Vegetative mass and hence Intra Cardiac mass as the differential diagnosis was ruled out. Serial blood cultures were revealed no growth, probably because of prior of medications. He failed to respond initial use of broad-spectrum antibiotics and antifungal treatments on an outpatient basis. As constitutional symptoms persist and increased Right Ventricular Outlet Tract obstruction by TV vegetative mass, with no option left out relatives were counselled, consented and admitted for high-risk TV mass removal surgery. Prior to surgery, CT Thorax was done which showed an extension of TV mass as in Figure 2. Also, he receives Six units of Leucodepleted Packed Red Blood Cells and Four units of Single Donor Platelet during the periprocedural period for correction of Anemia and Thrombocytopenia. Immediately after admission, Permcath was removed as it may be the only source of infection. Then Left Femoral HD catheter was placed for regular in-hospital temporary hemodialysis. Under General Anesthesia with Cardio-Pulmonary Bypass and Mechanical Ventilation support, TV mass ( Size - 3 X 4 x 5 cms ) was removed by TV Vegetectomy and then Pericardial patch augmentation of Septal Tricuspid Leaflet and Alferi type Tricuspid Valve repair ( by TV edge to edge stich ) was done. Both Permcath tip and TV mass were sent for histopathological examination(HPE) analysis. Both confirms Fungal Endocarditis (Fungal IE) as shown in Figure 3 - Magnusiomyces Capitatus belongs to Blastoschizomycescapitatus. Figure 3 -also shows gross anatomy of the excised mass. Along with regular medications. he was treated with Inj. Loposomal Amhotericin B, Tab. Voriconazole and other supportive measures. Then gradually weaned from Mechanical Ventilation support and extubated. Before first discharge, temporary Left Femoral Hemodialysis catheter was removed and new Left Brachiocephalic Fiastulae was created for future permanent hemodialysis. Prior to first discharge 2D Echo shows Moderate TR as shown in Figure 4.

Second Admission: Within few weeks, he was readmitted with worsened breathing difficulty and gross ascites. 2D Echo shows Dilated RA, RV, Severe TR and RV dysfunction as in Figure 5. Immediately he underwent therapeutic Ascitic fluid aspiration and aspirated 3.5 liters of Ascitic fluid to get immediate symptomatic relief. As TV destruction continued, Tricuspid Regurgitation worsens and so Tricuspid Valve Repair (TVR) was advised. Again relatives were counseled, consented and admitted for high-risk 2nd Surgery. Again, under General Anesthesia with Cardio-Pulmonary Bypass and Mechanical Ventilation support - underwent successful TV Replacement surgery with 31 mm of St. JUDE Mechanical Valve. He had delayed the weaning process from Mechanical Ventilation support due to intractable Seizures, treated with IV Sodium Valproate. We also encountered and managed some of the other complications that include Valproate induced Pancreatitis - treated conservatively, Left Femoral Artery Pseudoaneurysm and Hematoma - managed with direct Thrombin injection and Pseudoaneurysmal repair & large Left thigh hematoma evacuation and also had anteriorly popped outed Sternal wire, which was later removed directly. He was then gradually stabilized. Throughout his hospitalizations, he underwent regular hemodialysis initially via a temporary Left Femoral Hemodialysis catheter and later with permanent Left Brachiocephalic Fiastulae. At 2nd discharge, 2D Echo has shown definitive improvement as shown in Figure 6 with mild TR and without RV dysfunction. Multi-Specialty consultations was done including Diet, Psychiatry and Genetic counseling. Plan for Renal Transplantation after stabilization at later date.

Discussion

Fungal endocarditis (FE) is fatal, usually being diagnosed postmortem.1 FE is most prevalent in patients who are immunocompromised, intravenous drug abusers, prolonged use of antibiotics, parenteral nutrition or any intracardiac devices.1,2 The diagnosis of FE is challenging due to its slow growth.1,2 Neither any specific tests nor any diagnostic criteria were available for Fungal IE.2

High mortality rate and complexity of FE may lead to lack of prospective randomized clinical trials for FE management.2 Current guidelines recommend initial or induction therapy with Amphotericin B (AMB) with or without Flucytosine combined with surgical removal of vegetations, followed by chronic suppressive therapy with oral fluconazole.1,2  Voriconazole is for both first-line for induction and long-term suppression therapy for treating Aspergillus endocarditis.2 Duration of antifungal therapy is usually 6-8 weeks depending upon clinical improvement.2  Combined treatment appears to be superior to monotherapy, before the onset of valve destruction, fatal embolic strokes or chordal rupture causing valvular insuffiency.1,4In the presence of Fungal Endocarditis, Indications and Timing of surgery is very important. Indications and Timing of Surgery in the presence of Fungal Endocarditis were listed in Table 1 - a Consensus on Surgical Treatment of Infective Endocarditis by American Association for Thoracic Surgery Guidelines.5

Conclusions

Fungal endocarditis(FE) is a serious health condition. Early diagnosis and intensive management are essential. Combined Medical and Surgical therapy will have better outcomes. Consensus on FE management is evolving.

Learning Points

  • Aggressive and early combined Medical and Surgical therapy for FE is essential.

  • A multi-Specialty approach is often required.

  • Dietary Consultation and Psychiatry Counselling are equally important.

Acknowledgments

We acknowledge the immense help received from the scholars whose articles are cited and included in the references of this manuscript. We are also grateful to the authors/editors/publishers of all those articles, journals and books from which the literature for this article has been reviewed and discussed.

Conflict of interest: No conflict of interest

Source of funding: None

Authors contribution:

Nithin Bharadwaj contributes to complete conceptualization and data collection, Chandra Shekara Reddy creates complete manuscript preparation and editing, Arun Srinivas as the corresponding author and provides complete guidance and proof correction of manuscript, Siddarth Kumar Chawath guides complete journal search and publication guidelines and Lakshminarayan Achar permits to access complete surgical notes and figures / photos.

References:

  1. Yuan SM. Fungal endocarditis. Braz. J. Cardiovasc. Surg. 31 (3) • May-Jun 2016 • https://doi.org/10.5935/1678-9741.20160026  

  2. Pasha AK, Lee JZ, Low SW, Desai H, Lee KS, Al Mohajer M. Fungal endocarditis: update on diagnosis and management. Am. J. Med. 2016 Oct 1;129(10):1037-43

  3. Tacke D, Koehler P, Cornely OA. Fungal endocarditis. Current opinion in infectious diseases. 2013 Dec 1;26(6):501-7.

  4. Pang PY, Sin YK, Lim CH, Tan TE, Lim SL, Chao VT, et al. Surgical management of infective endocarditis: an analysis of early and late outcomes.  Eur J Cardiothorac Surg. 2015 May 1;47(5):826-32.

  5. Writing C, Pettersson GB, Coselli JS, Hussain ST, Griffin B, Blackstone EH. 2016 The American Association for Thoracic Surgery (AATS) consensus guidelines: surgical treatment of infective endocarditis: executive summary. J Thorac Cardiovasc Surg. 2017; 153:1241-58.

     DOI: https://doi.org/10.1016/j.jtcvs.2016.09.093

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

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A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
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A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
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List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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