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IJCRR - 14(8), April, 2022

Pages: 26-30

Date of Publication: 19-Apr-2022


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Recent Insight and the Utility of Proniosom for the Treatment of Acne Vulgaris

Author: Shubhrajit Mantry, Siddhi Panhale, Alim Momin, Sahil Shaikh, Ganesh Dama

Category: Healthcare

Abstract:The dispersion of niosomes and liposomes are at significant risk of aggregation, fusion and encapsulated drug discharge. The proniosomal could be a dry granular substance that dissolves in water to generate a noisome suspension. Proniosomes offer an advantage over niosomes due to the reduction of physical instability issues such as agglomeration, amalgamation, and discharge or reactivity of the encapsulated medication. It is simple to carry, distribute, store, handle, and dose. Proniosome show equal or larger effectiveness in drug unhitch performance once placed next with developed typical niosomes. The most effective challenge with topical drug delivery is the differing types of nature of skin that restrict the entry of most medication. The proteasomes acted as a consequence of the most effective vesicles in dermal drug delivery due to their nanometer size, stability, and their elastic nature. They acted as a drug applicator to deliver entrapped drug molecules into or across the skin and, due to individual supermolecule elements, to inflated penetration into the horny layer and so the alteration of the physical object supermolecule lamellae within the layer of skin. Suspension technique, slow spray coating technique & Coacervation half separation technique unit the methodologies that unit accustomed formulate proniosome.

Keywords: Acne vulgaris, Antiacne activity, Transdermal route, Proniosomal gel, Niosomes, Skin

Full Text:

INTRODUCTION

The main issue with topical drug administration is the skin's barrier nature, which prevents most medicines from entering. The proniosomes acted because the best vesicles in dermal drug delivery because of their micro-millimeter size and their elastic nature.1 They acted as a drug applicator to deliver entrapped drug molecules into or across the skin and, thanks to the individual lipid parts, increased penetration into the stratum and, later, the alteration of the animate thing lipid lamellae among the skin layer. Most parts of proniosomes square measure a surface-active agent, membrane stabilizer, and carrier. Carriers allow the flexibleness within the magnitude relation of surface-active agent and different parts incorporated. They increase the extent and enhance economical loading e.g., sorbitol, mannitol, glucose, lactose. However, owing to its low bioavailability, it has a limited market presence. The stratum route is conventionally used because it is agreeable and safe, and it has more advantages than the traditional indeterminate quantity type, such as GI conflict, variable GI immersion, enhanced bioavailability, reduced frequency of administration, and improved patient adherence. Niosomes, or nonionic surface-active agent vesicles, are tiny lamellar structures formed by combining nonionic surface-active agent, cholesterin, and diacetyl phosphoric acid with the intention of future interaction in binary compound media. Throughout dispersion, each niosomes and liposome square measure at high risk of agglomeration, fusion, and run of encapsulated drug. A promising product, known as the proniosome, might be a dry granular substance that dissolves in water to form a noisome solution. Proniosomes provide several advantages over niosomes, including the reduction of physical instability issues such as aggregation, fusion, and run, as well as the chemical reaction of encapsulated drugs. It also allows for simple transport, distribution, storing conditions, and an unlimited amount. Proniosomes have shown similar or higher efficacy in drug unleash performance than regular niosomes. Proniosomes often contain non-polar surfactants such as span 20, 40, 60, 80, and 85, tween 20, 40, 60, 80, emulsifier, alcohol (ethanol, methanol, and isopropyl alcohol), and chloroform. The majority of surface-active agents that are used to make non-ionic surface-active agent vesicles have a solubility of coffee binary compound. However, in the presence of cholesterin, freely soluble non-polar surfactants such as tween will type the micelles on association.2

a) Cholesterol content in proniosomal formulations could affect vesicle stability and pore size.

b) Sterol-containing formulations improve drug defense potency as compared to formulations that only contain emulsifiers.

c) The use of an emulsifier in a composition necessitates particular handling during formulation and storage, making the product less stable and expensive.3

Acne vulgaris-

Skin inflammation is an ongoing disruption of the oil gland vesicle that affects the first half of a person's life. Acne causes a sort of lesions. It should leave scars once regression and it's outlined by the alteration of intervals of exacerbation and stability.4 Spontaneous regression generally happens once age twenty, however, some sufferers could preserve suffering at some stage in adult life. The foremost common drug won’t to the treatment for acne in an exceeding style of the stratum.  The rationale for mistreatment gel formulation they're typically additional active and stable and water-based gel is less botheration, therefore it's most well-liked than lotions.5

Causes-

1.     Excess production of sebum (oil) from the sebaceous gland.

              2.     Bacteria

3.     Hormonal imbalance

4.     Dead skin cells

5.     Ingrown hairs.6

 

MATERIALS OF PRONIOSOMES-

Surfactant-

Surfactants are surface-active organic molecules that are naturally amphiphilic. They must perform a variety of tasks, including solubilizing agents, wetting agents, emulsifying agents, and porousness enhancers. The HLB value of a wetting agent is important for the vesicle's dominant drug defense. Because deliquescent oleophilic balance is a compatible predictor of a wetting agent's potential to generate vesicles, hlb varieties four to eight were found to be balanced with vesicle production.7

Carrier-

The carrier used in the preparation of proniosomes allows for flexibility in the quantitative relationship of wetter and other included materials. Additionally to the current, it will increase the expanse and therefore economic loading. The carriers must be secure and non-toxic, free-flowing, have a low solubility in the loaded mixture resolution, and have a high water solubility for simple associations. The most often used carriers are mentioned as follow.

  1. Malodextrin

  2. Sorbitol

  3. Spray-dried lactose.

  4. Glucose monohydrate.

  5. Lactose monohydrate.

  6. Sucrose stearate.7

Solvent and Aqueous Phase-

Alcohol significantly impacts drug permeation rate and vesicle size in proniosomes. The size of vesicles generated from various alcohols varies, and they are arranged in the following order:

Ethanol > propanol > Butanol > isopropanol.

The aqueous phase in the preparation of proniosomes is phosphate buffer 7.4, 0.1 percent glycerol, and hot water.7

Lecithin- They are typically named looking on their supply of origin like soy phospholipid from soybeans and egg phospholipid from ingredient phosphatidyl B is such a significant part of phospholipid. Within the sac system, it acts as a variety of vital roles like:

A) It plays role as a permeation enhancer.

B) Prevents the escape of drugs.

C) increased the % drug defense thanks to high phase transition temperature soy phospholipid forms the vesicles of more in comparison to egg phospholipid whereas once we compared these 2 on the idea of the penetration capacity soy phospholipid could be a higher candidate to pick because it contains unsaturated carboxylic acid, oleic and linoleic acid, linoleic acid, polyunsaturated carboxylic acid} where also the egg phospholipid contains the saturated fatty acid.8

Cholesterol is a natural steroid that is employed as a membrane addition. Steroid’s area unit vital parts of a semipermeable membrane and the presence in membrane bring regarding significant changes concerning bilayer stability, thinness, and porosity. It avoids aggregation by including molecules that stabilize the system and prevent mixture formation due to repulsive steric or static forces. The sterol {content increase there's a vital big major increase in demurrer potency (%) however when an explicit limit additional sterol increase leads to a significant decrease in demurrer potency. The increase in demurrer potency indicates that sterol serves as a "vesicular cement" within the molecular cavity of the wetter bilayer, preventing the gel-to-sol transition and resulting in fewer leak vesicles. Therefore, an increase within the rigidity decreases the porosity of the entrapped drug and thence improves the demurrer potency. However, once sterol quantity was enhanced when an explicit limit, the other result occurred. The explanation behind shriveled demurrer potency could also be thanks to the explanation that a sterol molecule can contend with drug for house among the bilayer, take away drug from bilayer, and additionally to the current can disrupt the sac membrane structure.8

METHODS OF PREPARATION

Proniosomes prepared by three methods:

Slurry method-

Proniosomes are made by mixing the carrier with the entire wetting agent solution in a spherical flat-bottom flask attached to a rotating flash evaporator and vacuuming the mixture to create a dry, free-flowing molecule in powdered form. Finally, formulation should be kept in a firmly sealed instrument and refrigerated in a lightweight container. The time required to produce proniosomes is independent of quantitative relationship between wetting agent response and applicating material and appears to be steady. This approach is advantageous because it protects the active ingredients and surfactants from reactivity and oxidation due to the homogeneous coating on the carrier. On the side of that, the upper expanse ends up in an agent wetting agent and coating, which makes the rehydration method a lot of economical.9

Slow Spray Coating Method-

Proniosomes are made by spraying an organic solvent with a wetting agent onto an applicator and then evaporating of solvent. Because the carrier is solubilized in the organic solvent, this procedure must be repeated until the desired level of wetting agent loading is achieved. The wetting agent layer on carrier is extremely thin, allowing multilamellar vesicles to form the carrier dissolves. The niosomes that result have a consistent size saperation, similar to those produced by traditional techniques. The most significant benefit of this technology is that it provides a means for formulating hydrophobic medications in a high lipid suspension with or without the drawbacks of suspension instability or active ingredient subject to a chemical reaction. Because sorbitol carrier is soluble in solvent used for deposit wetting agent, this process was resulted to be time-consuming. It's also been discovered to obstruct the encapsulation of bound medications.9

Co-acervation - Phase Separation Method:

Proniosomal gels are ready by this technique that includes wetter, lipoid, and drug during a wide-mouthed glass ampule alongside a touch of alcohol on it. Warm the combination in a water tub at 60-70°C for 5 minutes, or until the wetter mixture is completely dissolved. Then the binary compound part is added to on top of the ampule and warm still a transparent answer is created that is then born again into the proniosomal gel on cooling.10

CHARACTERIZATION-

Determination of in-vitroAnti-acne activity-

Collection of bacterial strains- Aerobic bacteria: Staphylococcus epidermidis and anaerobic bacteria: P. the Microbial Type Culture Collection Centre provided the Acnes.11

Growth condition, culture medium- Fresh cultures of aerobic and anaerobic bacterias isolates were suspended in nutrient broth media and incubated. S. epidermidis is cultured in Mueller-Hinton (MH) agar medium and incubate for 24 hrs. at 37°C in aerobic conditions, and P. acnes are cultured in brain heart infusion (BHI) agar medium and incubated anaerobically with 1% glucose at 37°C for 48 hrs.12

Collection of fungal strain-

Growth conditions, inoculum preparation- The strain was grown on the potato dextrose broth (PDB) or potato dextrose agar (PDA) media follows incubation at 30°C in aerobic conditions during 2-7 days. 13

EVALUATION

Measurement of vesicle size and size distribution

The vesicle dispersions were diluted a hundred times within the same medium used for his or her preparation. Vesicle size was measured on a particle size instrument. The equipment consists of a He-Ne shaft of 632.8 nm centered with a minimum power of 5mW employing a Fourier lens to a degree at the center of multi-component detector and a little volume sample jailhouse (Su cell). The Microbial Type of Culture Collection Centre provided the Acnes. Hu C and Rhodes in 1999 according to that the common particle size of proniosomes derived niosomes is {approximately about close to just regarding some roughly more or less around or so} roughly whereas that of standard niosomes.15

Particle surface and shape morphological characteristic

The particle size of proniosomes is an incredibly necessary characteristic. Scanning microscopy was used to investigate the surface morphology (roundness, smoothness, and aggregation formation) and thus the size distribution of proniosomes (SEM). Proniosomes were soaked in water and applied on aluminum stubs with double-sided tape. The aluminum stub was placed within the chamber of a scanning negatron.15

Measurement of particle charge

Zeta potential analysis is finished for determinative the mixture properties of the ready formulations. The appropriately diluted proniosomes derived noisome dispersion was resolute victimization letter potential instrument supported activity lightweight Scattering and optical device Christian Johann Doppler Velocimetry technique. The temperature was set at 25°C. Vesicles and their dreadful letter directly from the measurement. Potential values with a variance of five measurements were obtained.16

Rate of hydration (spontaneity)

This technique contains a variety of tiny qualitative analysis tubes. During which one milliliter of dissolution medium and proniosomes square measure placed. From this technique direct dilution of proniosomes is feasible.16

Drug content

Drug content uniformity of proniosomal gel is resolute by analyzing the drug concentration. From the four completely different points of sample square measure taken. Then samples were dissolved in phosphate solution (pH 6) and stir it to dissolve the vesicles. The presence of drug contents was resolute in the victimization of the U.V photometer at a selected wavelength.17

Stability of proniosomes

The stability testing of proniosomes is vital to work out the action of a drug from vesicles. In this method, samples were sealed in twenty-milliliter glass vials and kept at refrigeration temperature (4°C - 8°C) and 30°C for ninety days. When ninety days, the association step was meted out, and in addition, because the mean of particle size and denial efficiency of every sample was resolute the results in square measure compared with freshly ready proniosomes-derived noisome.17

pH                                                                                                                                               

A digital pH meter was used to determine pH of proniosomal dispersion. Associate accurately weighed quantity of gel was spread in exceedingly refined water. Then calibrate the pH of proniosomes before use with a customary solution later which provides the pH of the gel.18

Viscosity

Viscosity was measured by employing a measuring system. In this, the associate accurately weighed the quantity of the gel was taken into a beaker, consistency was measured by rotating the spindle in an exceeding beaker.18

Discussion: According to evaluation of various paper the Proniosom are the best drug delivery system for the easy penetration of skin due to there smaller particle size and it gives a soothing and cooling effect to the skin and having less adverse effect.

CONCLUSION-

The dermal route is employed for local action only to treat different types of skin diseases such as acne vulgaris. This route can avoid systemic effects and therefore offers fewer side effects. On other hand, through transdermal delivery, we can deliver drugs for systemic action. But in both the dermal and transdermal delivery of drug, the skin prevents the penetration of drugs. The vesicular drug delivery can be utilized to overcome the problem. The objective of this project is to use proniosomes to target Anti-acne activity & improve stability of anti-acne drugs while administration. Proniosomal gel formulation is better comfortable, majorly used in drug targeting for controlled, sustained release of the drugs (hydrophobic and hydrophilic). Because it has the most desirable skin penetration and entrapment efficiency. They have good physicochemical properties while industrial manufacturing, handling, and storage. Overall, proniosomes are a very effective vesicular drug delivering system for various therapeutically active drugs. And they provide more satisfactory treatment than conventional drug delivery systems.

ACKNOWLEDGMENT

The authors express their heartfelt gratitude to Sharadchandra Pawar College of Pharmacy, Dumbarwadi, Otur, the college library, and all other sources for their cooperation and guidance in writing this review article.

Source Of Funding : There is no any source of funding for my review study.

Conflict of Interest: There are no conflicts of interest and disclosures regarding the manuscript.

Author’ Contribution: The concept and Design of the study were done by Siddhi Panhale, Shubhrajit

Mantry. Data acquisition and analysis were done by Siddhi Panhale. Manuscript preparation, editing done by Siddhi Panhale.

References:

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2.      Vora B, Khopade AJ, Jain NK. Proniosome-based transdermal delivery of levonorgestrel for effective contraception. J Control Release. 1998 Jul 31;54(2):149-65.

3.       Namdeo. A. Niosomes as drug carriers. Indian J pharm.sci 1996;58(2):41–6.

4.    Chien YW, Valia KH. Development of a dynamic skin permeation system for long-term permeation studies. Drug Development and Industrial Pharmacy. 1984 Jan 1;10(4):575-99.

5.      Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes—novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release. 2000 Apr 3;65(3):403-18.

6.       Tripathi KD. Essentials of medical pharmacology. JP Medical Ltd; 2013 Sep 30.

7.       Indira U, Uma Shankar MS. Proniosomes as a drug carrier: A review. Int J Pharm Sci Res. 2012;3(12):4617-25.

8.      Rahimi F, Bahramgur M, Amoabediny G, Bagheri Pebdeni A, Ebrahimi Hosseinzade B, Amoabediny Z. Synthesis and optimization of an effective dose of niosomal amikacin for antibacterial activity on Pseudomonas aeruginosa. Daneshvar Medicine. 2022 Feb 20;29(6):86-100.

9.        Tanwar H, Sachdeva R. Transdermal drug delivery system: A review. Int J Pharm Sci Res. 2016 Jun 1;7(6):2274.

10.      Upadhye S, Rafik IN. Proniosomes: A novel vesicular drug delivery system. Am. J. PharmTech res. 2020;10(2):260-73.

11.     Al Sabaa H, Mady FM, Hussein AK, Abdel-Wahab HM, Ragaie MH. Dapsone in topical niosomes for treatment of acne vulgaris. Afr. J. Pharmacy Pharmacol. 2018 May 22;12(18):221-30.

12.     Pate M, Jain S. AN INCLUSIVE REVIEW ON NOVEL DRUG DELIVERY STRATEGIES FOR AN EFFECTUAL DELIVERY OF BIO-ACTIVE DRUG MOLECULES IN THE TREATMENT OF ACNE. J. Adv. Sci. Res. 2021 Jan 2;11.

13.     Al Sabaa H, Mady FM, Hussein AK, Abdel-Wahab HM, Ragaie MH. Dapsone in topical niosomes for treatment of acne vulgaris. Afr. J. Pharmacy Pharmacol. 2018 May 22;12(18):221-30.

14.     Suva MA, Patel AM, Sharma N, Bhattacharya C, Mangi RK. A brief review on acne vulgaris: pathogenesis, diagnosis and treatment. Research & Reviews: Journal of Pharmacology. 2014;4(3):1-2.

15.     Radha GV, Rani TS, Sarvani B. A review on proniosomal drug delivery system for targeted drug action. Journal of basic and clinical pharmacy (JBCP). 2013 Mar;4(2):42.

16.      Suryawanshi SS, Patil PP, Gaikwad RG, Mali SS, Pol SL. PRONIOSOMES: MODERN DRUG DELIVERY SYSTEM

17.    Sachan A, Kumar S, Dwivedi T. A Review on Proniosome: As a Drug Carrier. Available online www.jocpr.com J. chem. pharm. res.[Internet] 2021(7):1–07.

18.     Venkatesh DN, Priyanka VS, Tulasi K, Kalyani K, Ali SA, Jilakara H. Proniosomes: A superior drug delivery system. Int J Pharm Sci Drug Res. 2014;6(3):178-82. 

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A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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