International Journal of Current Research and Review
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IJCRR - 14(7), April, 2022

Pages: 12-16

Date of Publication: 05-Apr-2022


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Postnatal Growth of Intrauterine Growth Restricted Newborns

Author: Khayer MA, Dey SK, Akhter S, Malek A, Binte S

Category: Healthcare

Abstract:Introduction: Intrauterine growth restriction plays a significant role in short and long term adverse outcome. It is reflected in the relatively high incidence of neurodevelopmental impairment and somatic growth failure. Growth in the first year of life gets an opportunity to recover its growth deficit of intrauterine life and to catch up with its normal birth weight siblings Objective of the Study: To assess the postnatal growth of intrauterine growth-restricted newborns at 3, 6 and 9 months of age. Methodology: A Prognostic cohort study was conducted at the Department of Neonatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh from 1st April 2017 to 20th September 2018. It involved monitoring of 31 intrauterine growth-restricted newborns and 39 normal birth weight neonates over a period of 9 months. Follow up were done at 3, 6 and 9 month of age. At every visit weight, length, occipitofrontal circumference and chest circumference were measured. Data was analyzed using SPSS 20 and plotted in tables and graphs. Data imputation was done for the missing data. Multiple regression analysis was done for confounder of growth when data was statistically significant. Results: Mean birth weight was 1748 \?437.09 g and 2893.54\?467.07g, birth length 44 \?4.2439 cm and 49.26\?1.634cm, birth occipitofrontal circumference 30.76 \?2.380 cm and 34.35\?1.083cm, birth chest circumference 24.39 \?1.940 cm and 29.15\?2.933cm in IUGR and control group respectively which was statistically significant. There were catch-up weight gain in 3, 6 and 9 months of age in IUGR group but it was less than the normal birth weight group during the followed-up period. During the follow-up period, cacth up growth in length was achieved in first 9 months of age. During the first 3 months there were no catch-up growth in IUGR babies head circumference but it increases in normal rates. Mean chest circumference values at 3 months were statistically significant and after multiple regression analysis, it is significant for birth length. In general, IUGR babies when compared with the control group remained small in all the four growth parameters but it had catch-up growth in first 9 months of age. Conclusion: During the follow-up period, a catch-up of growth was achieved regarding weight, length, OFC and chest circumference but the growth parameters were lower than the appropriate for gestational age birth weight newborns.

Keywords: Postnatal Growth, Intrauterine Growth, Restricted Newborns, Normal birth weight, Retardation, Circumference.

Full Text:

 Introduction

Intrauterine growth retardation, the terminology for infants whose birth weight is below 10th percentile for gestational age occurs in 3% to 10% of all pregnancies.1-3 Newborns whose head circumference (HC), length and weight (Wt) are all proportionately reduced < 10 percentile for gestational age are considered to be symmetrical IUGR.2 When newborns weight is reduced out of proportion to length and head circumference are considered as asymmetrical IUGR.2 Growth in the first year of life is crucial not just for the time being but it has a lifelong implication for IUGR infant because it gets an opportunity to recover its growth deficit of intrauterine life in this period and to catch up with its normal birth weight siblings. In IUGR babies, especially preterm babies and those without congenital anomalies, the growth is very fast in first year of life.4 When adequately fed, they do not lose weight and start gaining weight after 2 to 3 days of age. Their initial weight gain is rapid which subsequently slows down after three months of age.5  It has been shown that bodyweight of small for gestational age infant at 2 years of age is about 10% lower as compared to appropriate for gestational age of identical maturity.5,6 Such low birth weight survivors demonstrate significant growth retardation as reflected by body weight, length, chest circumference, in comparison to normal weight peers7. These children with poor growth have high rate of mortality and morbidity and they suffer from motor and developmental delay.8,9 Infrequently infants with IUGR grow poorly and do not demonstrate catch-up growth and these infants may benefit from recombinant human growth hormone therapy beginning at 4 years of age.9 The clinical consequences may not be apparent until later in development; therefore, it is crucial to follow-up these infants. There is a paucity of studies regarding growth and development of IUGR babies in Bangladesh. So the objective of this study was to assess the postnatal growth of intrauterine growth-restricted newborns.

Materials and Methods

 This Prognostic cohort study was conducted from 1st April 2017 to 20th September 2018 in the department of neonatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Prior approval from Institutional Review Board (IRB) was taken for this research work. All IUGR (weight <10th percentile) infants admitted in this NICU during study period were included in this study. Appropriate for gestational age neonates were included as control group. Neonates with multiple gestation, congenital malformation and TORCH infection were excluded. After taking informed written consent from the parents / guardians, meticulous history of the newborn were taken, physical examination were done and required information were recorded in a data collection form. Newborn gestational age was calculated based on 1st day of last menstrual period, antenatal ultrasonogram and by modified New Ballard scoring. Gestational age and sex of both groups were matched. Anthropometry like weight, length, chest circumference and head circumference were measured at 3, 6, and 9 months of age and done by the investigator. The newborns weight were taken without clothing soon after birth on an electronic scale with a precision of 10 g [Model 914, SALTER]. The length were measured by infantometer in cm ; Occipital Frontal Circumference  (OFC) and chest circumference were measured by measuring tape in cm. Follow up were ensured by time to time communication with the parents/ legal guardian.

After collection, data were entered into a personal computer and were edited, analyzed, and plotted in tables and graphs. Categorical and continuous variables were expressed as number (percentage) and mean± standard deviation (SD) respectively. Comparisons were performed by chi-square test for categorical variables, and independent t-test for quantitative variables. Multiple regression analysis was done for confounder of growth when data was statistically significant. In this follow-up study, losses of follow-up were adjusted by simple mean imputation method. P < 0.05 was considered statistically significant. Data was analyzed using the IBM SPSS (statistical package for social sciences) Statistics version 20.0 (IBM Corp., Armonk, NY, USA).

Results

Among total eligible 49 IUGR infants 34 were finally analysed and they were compared with 39 appropriate for gestational age infants. There was no statistically significant difference between IUGR and control group in baseline characteristics except birth weight (table -1 & fig-1).  There was statistically significant difference in anthropometric parameters at birth between two groups (table-2). When the weight gain and length during the first nine months of life for IUGR babies were compared with appropriate for gestational age babies, it was found that there was no significant difference in both groups (table-3 & fig-2).  When OFC and chest circumference were compared between two groups, there was a statistically significant difference at 3 months of age but at 6 and 9 month of age it was not found statistically significant (table—3). When multiple regression analysis was done for OFC it was significant for both birth weight and length (table-4 & fig-3); when multiple analysis was done for chest circumference it was significant for only birth length (table-5 & fig-4).

Discussion

The outcome of IUGR babies depends on whether it was symmetrical or asymmetrical, cause of IUGR and duration of exposure and severity of IUGR. In this study, there was no significant difference regarding weight gain between IUGR and appropriate for gestational age group which demonstrated that weight gain was more in IUGR group but it did not crosses the appropriate for gestational age group. Different studies found that there is catch-up weight gain occurs in first years of age which was similar to our result.10-15 Meharban et al.7 also found that bodyweight of small for gestational age infants were about 10% lower as compared to appropriate for gestational age of similar maturity. Current study showed that catch-up growth in length occurred more in the IUGR group in first 9 months of age compared to the appropriate for the gestational age group. Low et al.16 showed that rate of length growth was greater than weight gain during the initial 3 months in the IUGR babies which was similar to our study.  Bhatia et al.10 showed a spurt in length increases between 6 to 9 months of age which correlates to our study. Other studies also concluded that length increases significantly in the first years of life which is similar to our study1, 11-17. The study results showed head circumference at 3 months was statistically significant (p = 0.018) which indicates there was no catch-up of growth but it increases in normal rates; and after multiple regression analysis it demonstrated that if birth weight and length were more, head circumference were more. Low et al.16 showed that IUGR infants had smaller head circumference in relation to appropriate for gestational age babies which were similar to our study. At 6 to 9 months it was not statistically significant which indicates that catch-up of head circumference occurs at 6 and 9 months of age. Srivastava et al.15 showed that growth of head circumference occurred in IUGR infants throughout the first 9 month of age compared to appropriate for gestational age infants which is similar to our study. Many other studies found that catch-up growth of head circumference occurs in the first years of life which is similar to our study.1,10-17 At 3 month the mean chest circumference value was statistically significant and after multiple regression analysis it was also significant for birth length. It indicated that birth length influences the growth of chest circumference in first 3 month life. Low et al.16 found that chest circumference had increases in the first 3 month of age but it is at its normal rates which is similar to our results. At 6 and 9 months, catch up growth of chest circumference occurred but it was lower than the appropriate for gestational age infants which correlate with other studies.15,16

Conclusion

So we concluded that catch-up of growth was achieved regarding weight, length, OFC and chest circumference at 9 months of age. However head circumference and chest circumference growth were delayed in first 3 months of age. The growth parameters at 9 months were lower than the appropriate for gestational age birth weight babies.

Recommendation

  • A large sample size and follow-up for an extended period is required.

  • Comparison among IUGR and appropriate for gestational age babies need to be gestational age-specific.

Conflict of interest: Nil

Source of Funding: Nil

Author contributions: Conceptualization: Mohammad Abul Khayer, Sanjoy Kumer Dey, Shaheen Akhter

Writing-original draft: Mohammad Abul Khayer

Writing-review & editing: Mohammad Abul Khayer, Sanjoy Kumer Dey

All authors contributed to the final version of the manuscript.

All authors read and approved the final manuscript.

Acknowledgment: Care providers of the Department of Neonatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Ethical Clearance: Ethically approved by the department.

References:

  1. Lee PA, Chernausek SD, Hokken-Koelega AC, Czernichow P; International Small for Gestational Age Advisory Board. International Small for Gestational Age Advisory Board consensus development conference statement: management of short children born small for gestational age. Pediatrics. 2003: April 24-October 1, 2001. 111(6 Pt 1):1253-1261.

  2. Gomella, T. L., Cunningham, M. D., Eyal, F. G., Tuttle, D. Management, procedures, on-call problems, diseases, and drugs. Neonatology: (2013). 

  3. Gibson, AT, Carney, S, Cavazzoni, E, Wales, JKH. Neonatal and postnatal growth..Horm Res. 2000; vol.53, pp: 42-49.

  4. Madhur, B, Rupali, B. Physical growth of LBW babies in first six month of life longitudinal study in a rural block of Assam. Natl J Community Med. 2014; Vol.5, issue 4, pp: 397-400.

  5. Meharban, S. Care of the newborn eight edition. CBS publishers and distributors, New Delhi, India. 2015

  6. Gerdes M, Bernbaum J. Follow-up care of the low birth weight infant..Indian J Pediatr. 1998; vol. 65, pp: 829-39.

  7. Bhargava, S K, Kumari, S, Choudhury, P,  Bhutani, R, Sachdev, H P S. A Longitudinal study of physical growth of small for date infants from birth to six years.  Nutr Res. 1985; vol. 5, pp: 707-713.

  8. Grantham-McGregor, SM. Developmental potential in the first 5 years for children in developing countries. Lancet. 2007; vol. 369, pp: 60-70

  9. Kliegman, RM, Stanton, BF, St. Geme, JW, Schor, NF. Nelson Textbook of Pediatrics, first South Asia edition. Elsevier. 2015

  10. Bhatia, BD, Agarwal, KN, Jain, NP, Bhargava, V. Growth pattern of Intrauterine Growth Retarded Babies in First Nine Months of Life. Acta Paediatr. 1984; vol. 73, pp:  189-196.

  11. Aviva Fattal V, Hagit TA, Yael, L, Ronny, G, Rina, E, Shaul, H. Growth Patterns in Children with Intrauterine Growth Retardation and Their Correlation to Neurocognitive Development. J Child Neurol. 2009; vol.24, pp: 846.

  12. Holmes, GE, Miller, HC, Hassanein, K, Lansky, SB, Goggin, GE. Postnatal somatic growth in infants with atypical fetal growth patterns. Am j Dis. Child. 1970; vol.131, pp: 1078-83.

  13. Jose, V, Velizan, J, Smeriglio, V. Postnatal experiences of intrauterine growth retarded infants’, Intrauterine growth retarded workshop series. Lancet Glob Health. 1989; vol. 18, pp: e681-691.

  14. Santosh, K, Sudarshan, K, Panna, C, Rita, B, Sachdev, HPS. A longitudinal study of physical growth of small for date infants from birth to six years. www.academia.edu. 2012.

  15. Srivatava, AK, Agarwal, VK, Gupta, SK, Mehrotra, SN. A longitudinal study of Physical growth and morbidity pattern of small for date babies from birth to six months of life. Indian J. Pediatr.. 1978; vol. 45, pp: 1-10.

  16. Low, JA, Galbraith, RS, Muir, D, Killen, H, Karchmar, J, Campbell, D. Intrauterine growth retardation: A preliminary report of long term morbidity. Am. J. Obstet. Gynecol. 1978; vol. 130, pp: 534.

  17. Karlberg, J, Albertsson-Wikland, K. Growth in the full term small for gestational age infants: from birth to final height. Pediatr Res. 1995; vol. 38, pp: 733-739.

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Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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