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IJCRR - 14(3), February, 2022

Pages: 12-18

Date of Publication: 01-Feb-2022


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Active & Intelligent Packaging Technologies: An Aspect of Food Safety Management

Author: Saikat Mazumder, Shalini Chanda, Amiya Bhaumik

Category: Healthcare

Abstract:Consumer demand for food safety is expected to be a primary driver of public policies and industry-led efforts to improvefoodsafetythrougheliminatingfoodquality information asymmetry. Food wastage in the food service industry accounts for roughly 30% of all food produced worldwide. Moreover, Every year, an estimated 600 million people become unwell as a result of consuming food contaminated with germs, viruses, poisons, or chemicals, with 4,20,000 people dying as a result. The majority of waste occurs as a result of inadequate packaging. For food manufacturers, modern packaging can be a long-term option for reducing food waste. Intelligent packaging is a useful tool in the battle against food waste since it may more accurately reflect the state of food commodities. We've covered the many types of active and intelligent packaging, as well as their techniques for protecting food during storage and the supply chain, in this post. According to our findings, smart packaging tries to protect the product from a variety of risks. Freshness indicators, in particular, can be an effective way to get safe food to consumers. Freshness indicators, in particular, can be an effective way to get safe food to consumers. The cost of employing modern packaging technology in developing nations is a source of worry. More research is also needed, and nanotechnology could be a beneficial tool for developing low-cost smart devices that can be integrated into smart or intelligent packaging to save money. Consumer demand for food safety is expected to be a primary driver of public policies and industry-led efforts to improve food safety through eliminating food quality information asymmetry. Food wastage in the foodservice industry accounts for roughly 30% of all food produced worldwide. Moreover, Every year, an estimated 600 million people become unwell as a result of consuming food contaminated with germs, viruses, poisons, or chemicals, with 4,20,000 people dying as a result. The majority of waste occurs as a result of inadequate packaging. For food manufacturers, modern packaging can be a long-term option for reducing food waste. Intelligent packaging is a useful tool in the battle against food waste since it may more accurately reflect the state of food commodities. We've covered the many types of active and intelligent packaging, as well as their techniques for protecting food during storage and the supply chain, in this post. According to our findings, smart packaging tries to protect the product from a variety of risks. Freshness indicators, in particular, can be an effective way to get safe food to consumers. Freshness indicators, in particular, can be an effective way to get safe food to consumers. The cost of employing modern packaging technology in developing nations is a source of worry. More research is also needed, and nanotechnology could be a beneficial tool for developing low-cost smart devices that can be integrated into smart or intelligent packaging to save money.

Keywords: Active packaging, Advanced packaging, Food safety, Food waste, Intelligent packaging, Sensor

Full Text:

Introduction

In the early times, humans used glass and wood containers for food packaging. Packaging as a term evolved from early mankind’s basic need to store and transfer their food from place to place. Although there is no record of when the very first packaging materials were used, researchers believed that leaves, animal skins, nuts, etc. were being used to store and transport goods during the nomadic era.1 Packaging keeps the product safe from the external environment and also performs four basic purposes such as protection, communication, convenience, and containment(fig-1).2, Packaging ensures the item against the outside environment communicates with the customer via written texts or graphics, making the handling better and effective with different types of containers.4 The expectations of consumers are continually changing. When new and revolutionary products emerge, so do the packaging techniques that accompany them. There have been several different ways to package goods in human history, each of which was an advancement in its own time. The emphasis on the customer has remained consistent in the evolution of product packaging.5 Smart packaging is still in its early stages of growth, but it has enormous potential.6 The advancement of smart packaging has progressed very rapidly. Just a couple of years back, smart packaging used to mean a label on a package with a tracking number, or even better, a barcode readable by a laser scanner. The Quick Response (QR) Code has become extremely common in recent years.7 This is an advancement in packaging that reflects the packaging industry's ability to adapt to customers' constantly changing expectations and concerns.5,7 The popularity of Active Packaging, over the years, has signaled a significant change in packaging systems shifting from passive to active. Previously, primary packaging materials were thought to be "passive," meaning they only served as an inert shield to ensure the item against oxygen and dampness. Active packaging was first implemented several years ago as powerful packaging technology, capable of performing all packaging functions.2 Smart packaging is one that includes both intelligent packaging as well as active packaging. Intelligent Packaging communicates with the consumer based on the information recorded.8

Literature Review

In recent times, consumers seek food that is both safe and convenient, as well as the food package should be made of recyclable or reused materials. Traditional packaging is becoming less capable of meeting all these demands, as a result of which consumers are switching to more functional packaging technology. Smart packaging is such a transformation of packaging technologies which is a combination of both active and intelligent packaging. As the consumer need is continuously changing so is the packaging technology to feed the world’s growing population a safe and healthy food that will be more natural and less processed for its preservation and handling. Active packaging increases food protection as well as its shelf lifeby adding antimicrobial emitters or oxygen scavengers directly in food packaging film or as sachets in food packets. In the case of intelligent packaging, it functions by interacting with the food product and providing information like ripeness or indicating the freshness of the food.9 These new emerging technologies can also help upgrade the traceability of any food product through its packaging.

Numerous studies are continuing forward in today’s world, but they are yet waiting for it to be combined into innovative solutions. The packaging technologies should be so implemented that its customer can continuously monitor the food quality until they are consumed as well as food degradation should be reduced when preserved. 10 The world of smart packaging is significantly growing and advancing in research. This period is characterized by a significant increase in the number of projects and a probable approach to overcome food preservation problems with the new technologies and improved frameworks.11

Problem statement

The food service sector accounts for food wastage around 30% of all food produced worldwide.12 This waste is produced from the food sector which includes below standard packaging or improper packaging that will not stand during transportation and distribution, specifically the perishable foods making it more vulnerable to lose. According to FAO, an absence of optimized packaging is one of the main factors responsible for food loss or waste, especially in developing countries.13 New solutions to food packaging technology can be a promising way to fight against food wastage and to feed the increasing population.

Methodology for advanced Packaging Technologies to Reduce Food Waste

Active Packaging

Active Packaging is a concept that is characterized as a mode of packaging in which the package, the product, and the environment interact to extend shelf life, improve protection, and enhance sensory properties while preserving the quality of the product.14 This includes the packaging of foods with materials that provide improved functionality, such as antimicrobial, antioxidant, or bio-catalytic functions. This can be accomplished by incorporating active compounds into the packaging materials or by the application surface alteration with the required functionality.15, 16, 17 This packaging utilizes technology that is intended to discharge or assimilate compounds from the food or the headspace of food packaging, which extends the shelf life of products by slowing down the degrading reactions of lipid oxidation, microbial development, moisture loss and benefit more effectively than conventional food packaging(fig-2).18

There are different types of Active Packaging available, but generally, they are categorized into three types i.e. scavengers, emitters, and adoptors.

Scavengers

Package scavengers have been in use for around many years in the shape of separate packets or sachets but presently this technology is integrated inside the packaging material. This integrated approach decreases the overall costs and makes it easily approachable for both the manufacturer and the consumer.18

Oxygen scavengers

Oxygen scavengers or oxygen absorbers are included in packaging so it reduces the oxygen level within the package. They are utilized to keep up product quality and to extend shelf life.20 There are numerous types of oxygen absorbers available for a wide range of applications.21, 22 The most commonly found substrate is iron followed by ascorbic acid and then other substances. These are incorporated into polymers as light-sensitive dyes.18 The shelf-life and nutritional value decrease with the increase in oxygen amount in the food packet as the oxygen react with vulnerable foods in the package, accelerating the degradation of numerous food products, rancidity in foods with high oil content, and also promoting microbial growth.23 The oxygen absorber scavenges this excess oxygen to slow down the oxidative reactions and also inhibits the microbial growth in the food package.18 Beer-cap seal contains oxygen-absorbing liners on the underside of Carlsberg FreshCap - ZerO2. This removes the headspace oxygen and extends the shelf life of beer by 15%.18, 24

Ethylene Scavenger

An ethylene scavenger can be a small sachet containing a suitable scavenging agent or an ethylene scavenger incorporated directly into the packaging material and the material should be greatly permeable to ethylene gases for its functioning.25 This can be further sub-divided into scavengers and absorbers, scavengers absorb water by chemical reaction whereas, absorbers absorb the ethylene from the surrounding atmosphere.26 They increase the shelf life by slowing the aging or ripening process and senescence.18 Fruit Brite by Hazel Technologies released 1-MCP (1-methyl cyclopropane)27 to diffuse ethylene blockers which extends the shelf life and the quality of the product 18, 27.

Moisture scavengers

Moisture scavengers regulate moisture in the headspace of any packaging and absorb the excess liquid weeping from a food product, thus increasing the shelf life of the product. High-capacity hydro-gels would be more effective in this case.18MoistCatch film by Kyodo Printing is a moisture scavenging film that is flexible and can be molded to any form.18, 28

Emitters

Emitters reduce the effect of microbial growth and activity, oxidative reactions, and even uncontrolled ripening in fruits. CO2, antimicrobial, antioxidants, etc. acts as emitters that enhance the shelf life of products.18, 29

Antioxidant

Oxidation in fats and oils produces off-flavor as well as reduces the shelf life and causes spoilage in food. This can be avoided by incorporating antioxidants in food with higher fat content. They neutralize the action of harmful free radicals. Common antioxidants found in foods are Vitamin C, Vitamin E, citric acid, etc. 29, 30

Antimicrobial Emitters

Antimicrobial emitters would include antimicrobial macromolecules having film-forming properties, sachet, using of bioactive agents in the packaging or on the surface of the packaging material. These are used to avoid microbial contamination in food products.31 Some antimicrobial emitters are ethanol, organic acids, essential oils, and polysaccharides.29, 32

            Basil, bay leaves, and cinnamon essential oils are effective against Clostridium sporogenes and E. coli, while cinnamaldehyde essential oil inhibits L. monocytogenes. Lipid oxidation is slowed by green tea extract. E. coli, Staphylococcus aureus, and Pseudomonas spp. are all inhibited by orange essential oil.18

CO2 Emitters

Carbon dioxide emitters are most commonly used in combination with modified atmosphere packaging gases like nitrogen or with oxygen absorbers.18, 29

Intelligent Packaging

Intelligent packaging is a system that utilizes communication to encourage decision-making for extending shelf life and overall food quality and protection.33 Intelligent packaging can carry out functions like sensing, detecting, tracing, warning about possible problems etc. Different Types of Intelligent Packaging are data carriers, Indicators and sensors.34, 35

Data carriers

Data carriers assist in the effective flow of information across the supply chain. The objective of data carriers is to ensure traceability, automation, fraud prevention, not to control product quality.36 They store and transmit information about storage, delivery, and other parameters to ensure this. As a result, they're often seen on tertiary packaging. Barcode labels and RFID (Radio Frequency Identification) tags are the most commonly used data carriers.37

Barcodes and QR Codes

Barcodes are cheap, simple to use, and commonly used to deal with supply chain management, stock logging, and checkout.36 In general, barcode scan be divided into two types: one-dimensional and two-dimensional. They have different storage capacities depending on the type. A series of parallel spaces and bars make up a one-dimensional barcode. Data is coded as a result of the various arrangements of bars and gaps. The coded information can be translated using a barcode scanner and an associated device.32

The combination of dots and spaces arranged in an array or matrix makes the two-dimensional barcodes occupy more memory power (such as packaging date, batch number, packaging weight, nutritional details, or preparation instructions). This is very convenient for both retailers and customers. An example of 2D barcodes is QR (quick response) Codes.37

Radio Frequency Identification (RFID)

RFID (Radio Frequency Identification) is a technology that uses radio waves to process data. RFID tags are advanced data carriers that can store up to 1 MB of data and capture real-time data without involving any touch or line-of-sight. These devices gather, store, and send real-time data to a user's information system RFID tags are more costly than barcodes and require a more efficient electronic information network.37 On the other hand, the details on these tags can be loaded electronically and updated at any time.38 RFID also has additional benefits for the entire food supply chain which include traceability, inventory control, and quality and safety promotion.39 An RFID device is made up of three parts: a tag, which is made up of a microchip linked to a tiny antenna, a reader, which sends the radio signal and collect responses from the tag, and middleware, that connects the RFID hardware to enterprise applications(fig -3).39, 40

Indicators

The existence or absence of a substance, the magnitude of a reaction between various substances, or the concentration of a specific substance is all determined by indicators. Changes are direct, which means different color intensities are used to visualize this detail.40 Depending on the indicator they are placed inside or outside of the package.32

Time Temperature Indicators (TTIs)

      1. Temperature Indicators (TTIs) Temperature plays an important step in determining the shelf life of any food product. Deviations in the temperature profile can stimulate the development or survival of microorganisms, resulting in product spoilage. Besides, improper freezing may denature meat or other products' proteins. Time-temperature measures may be used to determine if the cold chain or optimal temperature is adequately maintained in the food supply chain or not.37, 42

      2. are known as user-friendly and easily accessible devices due to their easy functionality.43 The Fresh-Check from Lifeline technologies is an example of a TTI predictor. It works by causing a color shift in the indication range as a result of a polymerization reaction. A clear center indicates a fresh TTI. If the active center's color matches the outer ring, the product should be consumed as soon as possible. The dark core of indicates non-fresh products.44 Some Commercially Available TTI are MonitorMark™,Timestrip®, Fresh-Check®,  Checkpoint®.

The 3M MonitorMark® (3M Co., St Paul, Minnesota)48 is a diffusion-based indicator label that is based on the color change of an oxidizable chemical system regulated by temperature-dependent permeation through a filter. A blue-dyed fatty acid ester diffusing around a wick activates the action. At a temperature-dependent rate, a viscoelastic material migrates into a diffusely light-reflective porous matrix. The tag configuration, which differs by polymer concentration and glass transition temperature, controls the response rate and temperature dependence and can be set to the desired range.46, 47 Timestrips® (Timestrip UKLimited, UK) are smart labels that keep track of how long a product has been open or in use. Food protection also necessitates temperature control at home. Timestrip® is a consumer-activated, single-use smart-label for tracking elapsed time on perishable items. It was created to allow customers to monitor the amount of time that had passed after activation.49, 50

Fresh-Check®TTI (Temptime Corp., Morris Plains, NJ, USA)(Fig: 4) is a solid-state polymerization reaction that produces a strong colored polymer. The TTI's answer is a color shift that can be measured as a decrease in reflectance.47

Freshness indicators

Freshness indicators track the consistency of food items as they are being stored and transported. Unfavorable conditions or a lack of durability may cause a loss of freshness. As a result, they send data on microbiological development, the presence of microbiological metabolites, and product chemical changes.47,51 Glucose, organic acids, ethanol, volatile nitrogen compounds, biogenic amines, carbon dioxide, ATP degradation products, and sulphuric compounds are examples of quality indicating metabolites.37,53 Freshness indicators must be mounted within the packaging to enable interaction with the compounds. Different methods may be used to detect this information depending on the reliable indicator (Table-1).54

Sensor

Sensors show the state of the food's quality concerning the indoor environment. Although the actual indicator shows the quality status, a sensor senses and responds to changes in the environment within the packaging.58

Gas sensor

The gas sensor detects carbon dioxide in the package as a sign of microbial growth, which shortens the food's shelf life.53 Non-dispersive infrared (NDIR) or chemical sensors are the most common types of CO2 sensors. NDIR sensors are spectroscopic sensors that use gas absorption at a specific wavelength to test CO2 content.57 Although this sensor reacts to the formation of a spoilage metabolite, it does not explicitly track a quality attribute. CO2 is a useful indicator of food quality and can be used as an indicator compound; however, it is not a quality attribute because CO2 does not cause bad taste or spoilage; quality loss is caused by microorganisms. It is a colorimetric indicator label that monitors the freshness of a dessert (fig- 5).58

Biosensor

Biosensors detect pathogenic bacteria on food that cause food safety issues. These are specifically monitoring the quality attribute of food. The Food Sentinel System™ (SIRA Technologies, California, USA) is an example of such a biosensor, which consists of a barcode that contains a membrane with antibodies that can bind to particular pathogens.47 The barcode changes color as the pathogenic bacteria develop during storage, resulting in a barcode that can no longer be scanned.58

Discussion: Smart packaging strives to protect products from a variety of risks while also allowing for more active and intelligent packaging applications to be commercially viable. It's critical to keep the ultimate cost of intelligent packaging systems to a small percentage of the overall package cost, as well as to overcome the inherent challenges of transitioning laboratory trials to industrial-scale manufacturing. Multiple functionalities can be combined into a single packaging, and single-use throwaway products can be replaced with long-lasting reusable devices.

Conclusions

Though the idea of intelligent packaging has not grown rapidly it is the technology of the future. Smart packaging aims to provide safety to the product from all kinds of hazards. To ensure that more active and intelligent packaging applications become commercially feasible and “into everyday packaging commodities” around the world, it is important to ensure that the final cost of intelligent packaging systems is a small fraction of the overall packaging cost and resolve the inherent difficulties in converting laboratory trials to industrial-scale production.  Incorporating multiple functions to be integrated into a single package and replacing single-use disposable products with long-lasting reusable devices. Significant technical advances are still needed to realize these growth goals. Only then it will provide a safe ground for monitoring the food item and controlling the distribution correctly.

Acknowledgement: Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors/editors/publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed

Source of Funding: Authors have no source of funding

Conflict of Interest: Authors have no conflict of interest

Authors’ Contribution: Saikat Mazumder, Shalini Chanda, Dr. Amiya Bhaumik have equally contributed in the study.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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