International Journal of Current Research and Review
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IJCRR - 14(2), January, 2022

Pages: 85-92

Date of Publication: 16-Jan-2022

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A Neuropharmacological Review of Alzheimer's Disease

Author: Shubham S. Bagade, Laxmikant B. Borse, Atul R. Bendale, Anil G. Jadhav

Category: Healthcare

Abstract:Alzheimer is one of the most frequent diseases that affect nerve cells in various sections of the brain. Pathologically, it occurs due to intracellular neurofibrillary tangles and extracellular amyloid protein depositions that result in the obstruction of neural transmission, culminating in this neurodegenerative illness. Additionally, food and nutrition are essential for developing and preventing Alzheimer's. The biomarker utilized for detecting the disease should be able to differentiate between different causes of dementia and detect it early. Use of Induced Pluripotent Stem Cells shows to be a successful treatment for the condition mentioned. There are three main hypotheses presented as a cause of AD: the cholinergic, tau and amyloid hypothesis. Additional risk factors include advancing age, genetics, head trauma, vascular illnesses, infections, and the environment in general. The two types of approved medications to treat AD (NMDA antagonists and cholinesterase inhibitors) are successful in treating the symptoms of AD, but are not cures or preventatives of the disease. Current AD research targets multiple processes, such as the aberrant tau protein metabolism, \?-amyloid, inflammatory response, and cholinergic and free radical damage, to find viable therapeutics capable of preventing or changing the progression of Alzheimer's disease. This review's purpose is to illustrate the pathway that leads to this condition and oncology treatment for it.

Keywords: Alzheimer’s disease, Acetyl cholinesterase inhibitors, N-methyl D-aspartate receptor antagonist, Beta amyloid, Neurofibrillary tangles

Full Text:


            Alzheimer’s Disease is the main cause of Dementia which contributes about 60% - 80% of total Dementia patients provided by WHO.1,10,13 Dementia is one of the prime causes in individuals around the globe for impairment and dependence. AD is a psychological condition that progresses with the age destroying memory, thinking skills, cognitive abilities and eventually the ability to carry out simple daily tasks. AD is an illness that impairs the central nervous system mainly affecting the temporal lobe, entorhinal cortex and hippocampus and in progression affecting the cerebral cortex of the brain which may be responsible for language, reasoning and social behavior leading to death with the advancement of the disease.1 The main condition in the disease is Amyloid plaques, neurofibrillary tangles and Lewy bodies appear in the brain.4 AD involves the medial temporal lobe, which houses the entorhinal cortex and hippocampus. Anterograde episodic memory loss is produced by the collapse of these mechanisms, and this shows up as forgotten daily minutiae.3,4

While the issue may seem benign, the symptoms may be seen by family members and the patient. Cognitive deficits which are severe enough to affect daily functioning are the current criteria for diagnosing AD (MCI- Mild Cognitive Impairment). An estimated 10% of MCI patients may develop AD annually.11,12 AD damages cognitive and functional ability over time, including visuospatial and executive function. The latter years of the disorder are associated with an increase dependency and neurological damage (akinetic mutism). Lack of mobility often results in 6–12-year deaths from lung or venous embolism. AD is diagnosed based on the patient's clinical findings. Neuroimaging is used to diagnose out those other maladies that could cause Alzheimer's-like symptoms. Shortly, laboratory tests, such as analysis of biomarkers, genetic testing, and molecular/functional neuroimaging, will likely be added into diagnostic criteria for AD to improve the sensitivity of diagnosis, notably in the initial and latter course of the disease.

Causes of AD are poorly analyzed as no perfect treatment is available to eradicate the disease. Only the progress of the disease can be slowed by medications and treatment. The pharmacological treatment available for AD is acetylcholinesterase inhibitors, antioxidants, NMDA channel blocker and other pharmacological treatments.6,9,14 The management of the disease and how medicines engage with the brain during treatment are crucial. Different aspects are discussed regarding the neuropharmacology of AD from the available literature.


In 1906, German psychiatrist and pathologist Dr. Alois Alzheimer noticed the changes in brain tissues of a female patient who died of irrefutable mental illness and reported the first case of the disease named after him. In next five years, eleven new cases of the same illness were reported just using the terminology Alzheimer’s Disease.11 The name Senile Dementia of Alzheimer’s type(SDAT)  was initially used to describe AD in individuals aged 65 years and well above, On the contrary, Classical Alzheimer's disease is used to describe patients who were younger. As time passed, the term Alzheimer's disease was used in medical literature to describe people of every age with a consistent pattern and neuropathology of typical symptoms. Nearly 47 million individuals worldwide were impacted by dementia in 2015, with a forecasted 75 million in 2030, and 131 million in 2050.13 The annual patient count is estimated at 4.6 million cases globally, which is identified as one new case every seven seconds.  Figure 1.1 shows the progression of AD.


Alzheimer's disease is acquired in about 2% of instances in progenies (autosomal dominant). Early-onset familial Alzheimer's disease is a kind of Alzheimer's disease that starts early and progresses quickly.18Early-onset Alzheimer's disease, known as younger-onset Alzheimer's or early-onset AD, is Alzheimer's disease that develops before completing age 65. It is a rare type of Alzheimer's disease, accounting for only around 5–10% of all the cases of Alzheimer's.19 Roughly 60% have a favorable family history and 13% are autosomally dominated by AD.20 The majority of occurrences of early-onset Alzheimer's, on contrary, exhibit the same characteristics as the "late-onset" type and are not generated by genetic mutations. Early-onset familial AD can be directly linked to mutations in one of three genes which are named as an amyloid-beta precursor protein (APP) and presenilins PSEN1 and PSEN2.44 The majority of APP and presenilin gene mutations increase the formation of amyloid beta (Aβ)42, a tiny protein that is the principal component of amyloid plaques. Some mutations just change the ratio between Aβ42 and the other main forms, specifically Aβ40, without enhancing Aβ42 levels. ABCA7 and SORL-1 are two more genes linked to autosomal dominant AD.2,4,15,21

The majority of Alzheimer's cases are not inherited and are termed to as sporadic Alzheimer's disease, in which environmental and genetic conditions play an important role. In contrast to familial Alzheimer's disease, the majority of sporadic Alzheimer's disease (AD) cases develop after the age of 65.18 The start of sporadic Alzheimer's disease is delayed in fewer than 5% of instances. APOEε4 is the most powerful genetic risk factor for sporadic AD.22 APOEε4 is one of the four apolipoprotein E alleles (APOE). The ε4 allele affects the activity of APOE in lipid binding proteins in lipoprotein particles.16,22 Between 40 and 80% of persons with Alzheimer's disease have at least one APOEε4 allele.22,44 several alleles in the genome elevates the threat of AD. APOE, which codes for the lipid carrier protein apolipoprotein E (ApoE). The ApoE-4 allele increases the risk of AD thrice. Although the population is just 25%, they represent half of all Alzheimer's cases.10


Amyloid Hypothesis

For more than 25 years, the amyloid hypothesis (also known as the amyloid cascade hypothesis, the Aβ hypothesis, and so on) has been the leading explanation for the neurophysiology of Alzheimer's disease.16 The most direct anti- Aβ therapeutic technique is to limit Aβ production by attacking β - and γ -secretase.17 The original amyloid cascade theory said that “Aβ is the causative agent in Alzheimer's Disease pathogenesis, and that neurofibrillary tangles, cell death, vascular damage, and dementia come up as a direct outcome of its deposition”.23 Despite the fact that the majority of data still supports Aβ as the key initiator of the complicated pathogenic cascade in AD, more and more evidences show that Aβ serves as a trigger in the early disease process and seems to be required but not sufficient in the late stage of AD.25

Tau Hypothesis

Tau is found in neurofibrillary tangles, which are another intracellular characteristic of AD. Tau aggregation in pathological situations will damage neuron axons, resulting in neurodegeneration.40Phosphorylation, arginine monomethylation, lysine acetylation, lysine monomethylation, lysine dimethylation, lysine ubiquitylation, and serine are all forms of tau modifications.26 Tau-targeting medicines remain difficult to develop due to an insufficient information of Alzheimer's disease, a lack of reliable and specific biomarkers for diagnosis and response monitoring, and a restriction of the blood-brain barrier.27

Cholinergic Hypothesis

As the Neurochemistry involves study of the brain and neurotransmitters. The primary neurotransmitter deficit in AD is acetylcholine.28Neuronal loss causes cholinergic insufficiency that give cholinergic innervation to the cerebral cortex, notably those in the basal forebrain (the nucleus basalis of Meynert). Central cholinergic antagonists, such as atropine, can induce disorientation, which resembles AD dementia. This "cholinergic hypothesis" asserts, deficiency of ACh causes AD symptoms. It is essential to mention that even if "cholinergic deficiency syndrome" is equivalent to Parkinson's disease, the situation in AD is significantly more complex.31 Cortical and hippocampal targets that receive cholinergic input are destroyed, as are other neurotransmitter systems such as glutamate, 5-HT, and neuropeptides. To treat this, the cholinergic hypothesis was initially investigated in AD therapy with cholinesterase inhibitors. The first anti-AD medication accessible in the clinic was Tacrine, a cholinesterase inhibitor.30


Alzheimer's disease symptoms develop gradually over time. Anyone whose symptoms worsen fast should consult a doctor in order to treat AD. There might be causes for the worsening of symptoms that can be addressed. Generally, symptoms of AD are described in 3 stages- first stage (early symptoms), Middle stage (mild or moderate symptoms) and late stage (severe symptoms).

Early Stage

Memory lapses are the primary sign of AD in its early stages.For example, someone with early AD may forget recent conversations or events, misplace items, may fail to remember the names of place and objects, have difficulty thinking of the right word, ask questions repeatedly, exhibit terrible judgment or having difficulty in making decisions, and become less flexible and more hesitant to try new things.54The progressive deterioration of learning and memory in patients with AD finally leads to a confirmed diagnosis. Language, executive function, perception (agnosia), and movement execution (apraxia) impairments are more common in a small number of people than memory impairments.56Not all the memory capability is adversely impaired by AD. Episodic memories, semantic memory, and implicit memory are less altered than fresh facts or memories.55

Middle Stage

Memory impairments will worsen as Alzheimer's illness progresses. Additional symptoms such as increased confusion and disorientation may develop – for example, getting lost or roaming and not knowing the time, obsessive, repetitive, or impulsive behavior, delusions or feeling paranoid and suspiciousness about caregivers or family members, problems associated with language or speech (aphasia), disturbed sleep, mood changes (hallucinations).54 Progressive deterioration finally inhibits independence, with patients unable to do the majority of everyday tasks. Speech issues emerge as a result of a difficulty to retain language, resulting in frequent erroneous word replacements (paraphasias). Reading and writing abilities are also deteriorating.55 As time passes and AD worsens, convoluted motor sequences are less synchronized, increasing the risk of falling. Long-term memory, which was initially robust, begins to deteriorate.56

Late stage

This is the last and the most severe stage of AD. The symptoms of AD get progressively severe in the latter stages, which can be frustrating for the person with the disease, as well as their caregivers, friends, and family. Hallucinations and delusions may appear and disappear during the disease, but they might worsen as the condition advances. People suffering from AD might become aggressive, demanding, and distrustful of those around them at times.55 People in the latter phases of AD may require full-time care as well as aid with eating, moving, and personal care.54 Language is limited to basic sentences or even single words, eventually leading to total aphasia. Although aggression may persist, excessive apathy and tiredness are far more prevalent symptoms. People suffering from AD will eventually be unable to execute even the most rudimentary duties independently; their muscular mass and mobility will decrease to the extent that they are clothed and cannot feed themselves. The cause of mortality is frequently an external issue, such as pressure ulcer infection or pneumonia, rather than the disease itself.55,56


AD is currently an untreatable disease. Currently, therapy plans for AD rely on symptomatic relief, with no focus on improving the target molecules. Effects and symptoms of AD can be slowed but cannot be eradicated completely. For the cure of AD, Firstly, cholinesterase antagonists such as Donepezil, Rivastigmine and Galantamine are used. Secondly, NDMA drug-like Memantine is given in the treatment of AD. Combination therapy is usually preferred for increased efficacy and relief.

Cognitive symptoms treatment

AD treatment relies on the optimization of cholinergic transmission. Tacrine, the first medication approved to treat AD, is currently being used relatively rarely due to its many side effects. Reversible cholinesterase antagonists (Catalysts for cleavage of acetylcholine into choline as well as acetate in the synaptic cleft) block cholinergic neurotransmission. For mild to severe AD, cholinesterase inhibitors are the first-line treatment.32 Lewy body dementia and vascular dementia are both treatable with cholinergic inhibitors.

Galantamine, a cholinesterase inhibitor, which has a dual form action mechanism. Aricept is the brand name for Galantamine, which was approved in 1996. It is acetylcholine esterase’s reversible inhibitor that enhances the intrinsic effect of acetylcholine on the nicotinic receptor, resulting in enhanced cholinergic neurotransmission into CNS.56 Galantamine is centrally and peripherally operating inhibitor which inhibit acetylcholinesterase in the muscles and the brain, boosting cholinergic tone. Galantamine operates as a positive allosteric modulator in neurons for nicotinic acetylcholine receptors. It is usually given in the forms of tablets or disintegrating tablets. In clinical tests of AD, Galantamine, on the other hand, encouraged improvements in cognition, global function, activities of daily living, and behavioral symptoms.53

NAMENDA is a drug used in combination with cholinesterase inhibitors to treat AD. Alzheimer's and Parkinson's are treated with it as well. N-methyl-D-aspartate receptor antagonists like Memantine are non-competitive drugs. It binds to the Mg2+ binding site on the channel, limiting activation without causing harm. Clinical deterioration is greatly slowed by the use of memantine.5,33 The drug's genuine disease-modifying effect, reduced excitotoxicity, or clinical effects are all uncertain. Headaches and dizziness are the only serious effects of using memantine.5Behavioral and psychological symptoms of dementia (BPSD), particularly during the late phase of the disease, are not uncommon in dementia. Pharmacological and non-pharmacological options should be used concurrently. They have a minor influence, and they leave many symptoms untreated, such as agitation.34 Alzheimer's patients are frequently taking medications, therefore additional treatment choices are necessary when behavioral indications develop.51

Use of a Selective serotonin reuptake inhibitors (SSRI) or an atypical antipsychotic is frequently used to treat behavioral disorders.35 The effects of these drugs on AD pathology are not well-documented. Studies asserts that stimulants have a short-term influence on cognitive functions and behavioral manifestations. Treatment delay may be implemented on a case-by-case manner. Most of the current clinical research focuses on the synergistic benefits of inhibiting cholinesterase with alterations to specific cholinergic receptors.39

Agonists for Muscarinic Receptors

Mucosal agonists are prescribed for xerostomia, urinary bladder problems, and bronchial hyperreactivity.41 Glaucoma and miotic drugs are commonly used to treat it. The involvement of cognition in muscarinic receptors is growing. Cognitive impairment induced by AD has long been treated with M1 agonists. Many other receptor subtypes appear to be engaged in the modulation of cognitive function, at least in animal models.42 Other mechanisms for selectively activating specific muscarinic receptor subtypes, such as allosteric agonists and positive allosteric modulators (PAMs), have been researched because of the absence of efficacy and substantial peripheral side effects of currently available muscarinic agonists.43 Schizophrenic and substance abuse problems as well as pain control medications all benefit from selective muscarinic subtype activators.

An example is Xanomeline, a muscarinic agonist that possesses Muscarinic-1 and Muscarinic-4 subtype selectivity and was being investigated for AD as well as schizophrenia. Anticholinesterase drugs inhibit the AchE enzyme. Cholinergic nerve terminals collect ACh and hence can elicit symptoms in the PNS and CNS that are similar to excessive cholinergic receptor stimulation.44 Many non-cholinergic toxins have also been widely used as toxicants, including agricultural pesticides, herbicides, and chemical warfare "nerve agents."

Other therapeutic strategies for treatment

While no medicine has been proved to preserve neurons, there are two potential conceptual approaches to the therapy of AD. Firstly, Treatment that helps prevent the onset of the disease by isolating the primary progenitors or targets and reduces secondary pathologies of the disease, retards disease progression or postpones disease onset, leads to the cessation or even repair of neuronal damage after disease onset, and ultimately prevents the development of AD is one approach; secondary approach is symptomatic treatment. Neurotrophins, antioxidants, statins, non-steroidal anti-inflammatory drugs (NSAIDs), hormone replacement treatment, excitotoxicity blocking, vaccination testings, immunotherapy, and secretase effectors, 7-Methoxytacrine have all been researched, but their usage remains disputed. As a result, greater research into preventative and disease-modifying therapy options is required for the elimination of AD in the general population. Beside cognitive symptoms treatments and use of muscarinic agonists other therapeutic strategies are being researched.

Use of antioxidants

Melatonin, it is a hormone derived from mammals that is primarily synthesized in the pineal gland. It collects O2 and N2-based reactants produced in mitochondria by increasing the production &activity of Glutathione peroxidase, Superoxide dismutase, and NO synthetase, and it also contributes to the diminution of oxidative damage in cells.56 In currently undergoing researches, antioxidant melatonin has been demonstrated to prevent Aβ-induced toxicity and ameliorate tau hyperphosphorylation.57 Melatonin improved the learning and memory impairments present in an APP695 transgenic mouse model through in vivo, and also inhibited Aβ-induced apoptosis in AD cell models such as mouse microglial BV-2 cells, rat astroglioma C-6 cells, and PC-12 cells through in-vitro.58 In another investigation, melatonin reduced NADPH oxidase phosphorylation via a PI3K/Akt-dependent signaling pathway in microglia vulnerable to Aβ1–42.57 According to some research, melatonin reduced Aβ burden in juvenile APP Tg2576 mice models but had zero effects on F2-IsoPs or Aβburden in older plaque-bearing mice.56

Selegiline (L-deprenyl) is a monoamine oxidase-B inhibitor with antioxidant effects that can be used to treat neurodegenerative disorders. It has the ability to rapidly produce the powerful vasodilator nitric oxide, notably in cerebral blood vessels.51 It may also protect the vascular endothelium from the harmful effects of Aβ peptide and improve the function or survival of nigral neurons by blocking oxidative deamination.52 Sano et al. demonstrated in 1997 that therapy with Selegiline (10 mg/day) decreases neuronal destruction and delays the course of AD in patients having moderately severe impairment.37 These data imply that the administration of Selegiline may postpone clinically significant functional impairment in AD patients.


1)AD, the most common form of dementia, has a multifactorial etiology, and the current therapy (AChEIs and memantine) cannot interrupt its progress and fatal outcome. This is reflected in the research programs oriented toward the development of new therapeutics able to operate on multiple targets involved in the disease progression.

2) The patents from 2016 to the present regarding the use of AChEIs in AD concern the development of new AChEIs, multitarget or multifunctional ligands, or the associations of AChEIs with other compounds acting on different targets involved in the AD.

3)The development of new multitarget AChEIs promises to identify compounds with significant therapeutic potential. However, it requires more time and effort to obtain drugs with the optimal pharmacodynamic profile. Otherwise, the research on new combinations of existing drugs with known pharmacodynamic and ADME profiles could shorten the time and reduce the costs of developing a new AD treatment. From the analyzed data, it seems more likely that a response to the urgent need to develop effective treatments for AD therapy could come more quickly from studies on drug combinations than from the development of new AChEIs.


Studies reveal that the cause of AD as a neurodegenerative condition includes extracellular amyloid plaques, intracellular neurofibrillary tangles, synaptic degradation, and neuronal death. 70% of AD risk at any given age is due to heredity. Apo lipoprotein E is the most general genetic risk factor for AD (ApoE). Aside from the genetic and biochemical aspects, a deficiency in vitamin D seems another cause of AD. In addition, brain glucose metabolism decreases in AD, which results in diabetes. Unfortunately, the currently available medications for therapy (AChEIs and memantine) only target symptoms and not the underlying cause of the condition. As a result, the possibility of new drugs that operate at the origin of the disease process and can block the gradual buildup of Aβ has been raised. It has been noted that several non-targeted therapies, such as anti-inflammatory treatment, metal chelation, antioxidant supplements, and epigenetic alterations, are more damaging than beneficial, making it impossible to predict if their correct use would enhance clinical outcomes or not. To summarize, stem cell therapy and biomarkers could be new strategies in the early diagnosis and treatment of AD. Several potential clinical trials are now undertaken, which may give new diagnostic targets and support in the resolving of the difficult AD issue.

Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors/editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed."


The authors declare that no funding was provided for this editorial.


The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.


Shubham S Bagade (corresponding author)

    1. Collected the data and performed the analysis of the data.

    2. Wrote the entire manuscript

    3. Contacting with the journal for manuscript publication.

    4. designed the model and the computational framework and analysed the data.

    5. Drafted the manuscript and designed the figures.

Laxmikant B. Borse

  1. Contributed in data collection and analysis.

  2. Collecting key points from different journals and books

  3. Directing the project.

Atul R. Bendale

  1. Convinced and designed the analysis of the data

  2. Working on task to keep a plagiarism-free manuscript

  3. designed and directed the project

Anil G. Jadhav

  1. contributed to the final version of the manuscript and supervised the project.

All authors provided critical feedback and helped shape the research, analysis and manuscript.


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Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021

Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to for more details.

Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

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IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.


International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal


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