International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 13(23), December, 2021

Pages: 80-85

Date of Publication: 01-Dec-2021


Print Article   Download XML  Download PDF

Histopathological Study of Endoscopic Upper Gastrointestinal Tract Biopsy

Author: Shaikh Imran Y., Savalia Charmi H., Gandhi Minesh B, Shah Cherry K

Category: Healthcare

Abstract:Introduction: Upper gastrointestinal tract disorders are one of the most commonly encountered problems in clinical practice.1Endoscopic procedure is performed for a variety of benign and malignant lesions. The definitive diagnosis of upper gastrointestinal tract disorders rests on histopathological confirmation and is one of the bases for proper management and treatment. Objective: To determine the spectrum of histopathological lesions of the upper gastrointestinal tract. To establish endoscopic biopsy as an effective tool in the proper diagnosis of various upper gastrointestinal tract lesions. Material & Method: A retrospective study of 212 upper gastrointestinal endoscopic biopsies &histopathological assessment was done at the department of pathology, Smt. NHL Municipal Medical College and Sheth VS general hospital from Sep 2018- Feb 2020. Results: Of the total 212 cases of the oesophagus, stomach and duodenal biopsies, 66.98%were non-neoplastic lesions and 33.02 were neoplastic lesions. The most common malignancy was squamous cell carcinoma in the oesophagal biopsy. In stomach biopsy chronic gastritis (37.5%) was the most common lesion. In duodenal biopsy chronic nonspecific duodenitis (75%) was the most common lesion. Conclusion: In our study, the commonest site for upper gastrointestinal tract biopsy was the duodenum (34.38%) with 75% nonneoplastic lesions, followed by oesophagus (33.01%) 31.4% non-neoplastic and 68.57% neoplastic lesions. The least common site for biopsy was the stomach (30.1%).In the stomach, non-neoplastic lesions were more common.

Keywords: Endoscopy, Biopsy, Histopathology, Upper gastrointestinal tract, Non-neoplastic lesions, Neoplastic lesions

Full Text:

INTRODUCTION:

Upper gastrointestinal tract disorders are one of the most commonly encountered problems in clinical practice with a high degree of morbidity and mortality. Endoscopic biopsy is a common procedure performed in hospitals for varieties of benign & malignant lesions.

Oesophagus and stomach can be sited for a wide variety of infections, inflammatory disorders, vascular diseases, mechanical conditions, toxic and physical reactions including radiation injury and neoplasm.

Histopathological study of the biopsy specimen is used to confirm the endoscopic diagnosis in suspected malignancies /to rule out malignancy in the endoscopically appearing benign lesion.

Endoscopic biopsies are also used for monitoring the course, to determine the extent of the disease, response to therapy and early detection of complications.2

AIMS AND OBJECTIVES:

To determine the spectrum of histopathological lesions of the upper gastrointestinal tract.

To establish endoscopic biopsy as an effective tool in the proper diagnosis of various upper gastrointestinal tract lesions.

MATERIAL & METHODS:

The present study included 212 endoscopic biopsies of the upper gastrointestinal tract. They were taken from patients who were clinically diagnosed to have upper gastrointestinal tract lesions at the department of gastro medicine at Smt. NHL MMC and Sheth VS general hospital from Sep 2018- Feb 2020.

The endoscopic equipment used for endoscopy & biopsy was OLYMPUS CF-H170L/I. Key benefits of this instrument are HDTV image quality, narrow-band imaging (NBI), close focus, variable stiffness, water jet and waterproof connector.

The biopsy specimen was put in saline and placed in filter paper with mucosal surface upwards. The filter paper was immersed in 10% formalin for fixation then the tissue was routinely processed and embedded in paraffin. 5 micron thick sections were cut perpendicular to the mucosal surface. 4-5 sections were prepared on each slide. Each section was stained with H&E and studied microscopically and the attempt was made to diagnose the lesion on gross visualization during endoscopy and to correlate them histopathologically. Special stain Giemsa stain was used to look for H. Pylori infection. Alcian blue(at ph 2.5) & PAS stain was used to detect acid mucin in true goblet cells in Barrett’s oesophagus.

Results:

As cited in table 1 out of a total of 212 GI endoscopic biopsies, 125(58.96%) were from males and 87 (41.03%) were from females with M: F ratio being 1.4:1. Age of patients ranged between 16-72 years with the majority of patients being in the age group between 40-60 years(57.5%) and 2nd most common age group is 20-40 (32.08%)years followed by >60years (8.9%) and <20 years (1.41%).

The site-wise distribution of endoscopic biopsies were duodenum 76 (35.85%), esophagus 70 (33.02%)and stomach 66(31.13%)cases(Table 2). The most common site was the duodenum followed by the oesophagus and stomach.

As cited in table 3 out of 70 cases of oesophagal biopsies, there were 48 neoplastic lesions and 22 non-neoplastic lesions. Squamous cell carcinoma was the most common neoplastic lesion with 40 cases. The majority of oesophagal squamous cell carcinoma were moderately differentiated with 31(77.5%) cases followed by poorly differentiated with 4 cases, basaloid pattern with 3 cases and 1 case of well-differentiated and spindle cell sarcomatoid carcinoma of each. Chronic active esophagitis was the most common non-neoplastic lesion. There were 3 cases of Barrett’s oesophagus & 2 cases of eosinophilic esophagitis.

In gastric biopsies, non-neoplastic lesions were more than neoplastic lesions. The most common non-neoplastic lesion was chronic gastritis with 25 (52.08%) cases. There were 13 cases of gastric ulcer, 5 cases of chronic superficial gastritis, 3 cases of polyp and 1 case each of H.Pylori gastritis and tuberculous inflammation. Adenocarcinoma was the most common malignant lesion with 18 cases. Concerning differentiation, cases of moderately differentiated carcinoma were more common followed by signet ring adenocarcinoma and poorly differentiated adenocarcinoma.

The most common site for biopsy was duodenum 76 cases (35.85%). The majority of cases were non- neoplastic74 (97%). Among non-neoplastic lesions, chronic nonspecific Duodenitis was the most common with 57cases (77.03%), followed by 3 cases of celiac sprue and Lymphangiectasiaeach, 2 cases of Crohn's disease and 1 case of Strongyloides stercoralis.

DISCUSSION:

Upper gastrointestinal tract endoscopy is the investigation of choice in patients with Upper Gastrointestinal tract disorders. The present study was conducted on 212 cases of Upper Gastrointestinal tract endoscopies.

 In the present study majority of the upper gastrointestinal tract, biopsies were from the duodenum (35.85%) followed by the oesophagus (33.02%) and stomach (31.13%).  The majority of patients were in the age group of 4th to 6th decade of life. These findings are comparable to findings of studies by Krishnappa R et al.3 and Katiyar V et al.19

In present study majority of the patients were males with an M: F ratio of 1:4 to 1. These results are almost comparable to study by Hussain et al.8, Abilash SC et al.13, Shanmugaswamy et al.14, Sheikh BA et al.15and Guliaet al.16, Katiyar V et al.19, Krishnappa R et al.3, sheikh BA et al.24, Panjeta S et al.22&Shennak MM et al.18

Duodenal lesions: In our study majority of cases were from the duodenum(76)with duodenal biopsies involving the first two parts of the duodenum revealing non-neoplastic lesions(74) 97.36% more than neoplastic lesions(2)2.63%. This observation is comparable to studies conducted by Sheikh BA et al.15&Krishnappa R et al.3 Among non-neoplastic lesions chronic nonspecific duodenitis was the leading diagnosis which is comparable with the study by Khadinge et al.17 This may be because the duodenum has rapidly regenerated epithelial lining which can be easily affected by any inflammatory insult. Among malignant lesions, both were found to be adenocarcinoma which is comparable with findings of the study conducted by Sheikh BAet al.15 which also shows adenocarcinoma is the most common malignancy of duodenum.

Oesophagal lesions: In the present study out of 70 cases with oesophagal lesions, 68.57% were neoplastic lesions and 31.42% were non-neoplastic lesions. These findings are comparable to study conducted by Bukhari U et al.20 In neoplastic lesions the most common carcinoma was squamous cell carcinoma with 40 cases(83.33%) which is comparable with the study by Abilash SC et al.13, Shanmugasamy et al.14, Bukhari U et al.20, Krishnappa R et al.3, and khan N A et al.21followed by adenocarcinoma with 1  case. Most patients with oesophagal carcinoma were found between4th-6th decades of life which is comparable to study by Krishnappa R et al.3, Panjeta S et al.22, Khan N A et al.21, Khandige et al.17 and Guliaet al.16The overall late age of presentation of oesophagal cancer can be due to absence of serosa and distensibility of the oesophagus which delays the symptoms of oesophagal cancer until the tumour is advanced. Oesophagal malignancy shows a male preponderance with M: F ratio being 2:1 which is comparable to a study by Krishnappa R et al.18 In our study majority of neoplastic lesions were seen arising from the middle oesophagus 77.5% which suggest the middle oesophagus was the commonest site followed by the lower oesophagus 22.5%, these results were comparable to study by Krishnappa R  et al.3, Katiyar et al.19 and Abhilashet al.13Squamous cell carcinoma of the oesophagus endoscopically presented as ulcer proliferative growth in (37.5%)15 cases, ulcerated in(25%) 10 cases, ulcer infiltrative in (17.5%)7 cases, stenosing in (12.5%) 5 cases and proliferative in (7.5%) 3 cases. Among-neoplastic lesions eosinophilic esophagitis endoscopically presented as the feminization of the oesophagus. On microscopic appearance, there were 16 eosinophils/HPF.

Stomach lesions:  Among 66 cases of gastric biopsies 72.7% (48)cases were non-neoplastic and 27. 2%(18) cases were neoplastic. The higher number of non-neoplastic lesions these findings are comparable to studies by Thapa R et al.23, Sheikh BA et al.15 and Krishnappa R et al.3The most common non-neoplastic lesion was chronic non-specific gastritis with(52.08%) 25 cases followed by a gastric ulcer with 13 cases. Adenocarcinoma was the most common neoplastic lesion in our study with the major sub-site being the pyloric antrum of the stomach followed by the body of the stomach. These findings were comparable to study by Sheikh B A et al.15 and Thapa R et al.23 Majority of people having gastric malignancy were in the age group of 41-60 years which was similar to study by Khandige et al.17 Majority of neoplastic lesions were found in male with M: F ratio being 1.3:1which was comparable to study conducted by Thappa R et al.23 and Krishnappa R et al.3 Adenocarcinoma of stomach endoscopically presented as ulcerative growth 50%, ulceroproliferative growth 27.77%, proliferative growth 16.66% and ulcer infiltrative growth 5.55% comparable to study by Krishnappa R et al.3  

CONCLUSION:

In our study duodenum was the most common site of upper gastrointestinal biopsy followed by the oesophagus and stomach. Histologically diagnosed chronic nonspecific duodenitis was the most common lesion from the duodenum.

Squamous cell carcinoma was the most common malignancy histologically diagnosed from the oesophagus. Dysphagia was the common clinical presentation of Squamous cell carcinoma.

In the stomach chronic non-specific gastritis was the most common diagnosed non-neoplastic lesion.

Thus, Endoscopic biopsy permits diagnosis of a specific entity & act as a planning tool for surgical and medical therapy.

Upper gastrointestinal tract endoscopy is the effective and appropriate initial investigation to assess patients with Upper gastrointestinal tract symptoms. Histopathology is the gold standard for the diagnosis of endoscopically detected lesions.

Acknowledgement

The authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors/editors/publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

Source of funding

There is no source of funding.

Conflict of interest

There are no conflicts of interest.

Author's contribution:

Dr. Shaikh Imran Y: Concepts, design, the definition of intellectual content, literature research, data analysis, statistical analysis,

 Dr. Savalia Charmi H: data acquisition, manuscript preparation, manuscript editing

Dr. Gandhi Minesh B: manuscript review

Dr. Shah Cherry K: manuscript review

 

Out of total of 212 GI endoscopic biopsies, 125(58.96%) were in males and 87 (41.03%) were in females with M: F ratio being 1.4:1.

Age of patients ranged between 16-72 years with the majority of patients being in the age group between 40-60 years(57.5%) and 2nd most common age group is 20-40 (32.08%)years followed by >60years (8.9%) and <20 years (1.41%).

The site-wise distribution of endoscopic biopsies were duodenum 76 (35.85%), oesophagus 70 (33.02%) and stomach 66(31.13%) cases. The most common site was the duodenum followed by the esophagus and stomach.

Out of 70 cases of oesophagal biopsies, there were 48 neoplastic lesions and 22 non-neoplastic lesions. Squamous cell carcinoma was the most common neoplastic lesion with 40 cases. The majority of oesophagal squamous cell carcinoma were moderately differentiated with 31(77.5%) cases followed by poorly differentiated with 4 cases, basaloid pattern with 3 cases and 1 case of well-differentiated and spindle cell sarcomatoid carcinoma of each. Chronic active esophagitis was the most common non-neoplastic lesion. There were 3 cases of barret's oesophagus & 2 cases of eosinophilic esophagitis.

In gastric biopsies, non-neoplastic lesions were more than neoplastic lesions. The most common non-neoplastic lesion was chronic gastritis with 25 (52.08%) cases. There were 13 cases of gastric ulcer, 5 cases of chronic superficial gastritis, 3 cases of polyp and 1 case each of H. Pylori gastritis and tuberculous inflammation. Adenocarcinoma was the most common malignant lesion with 18 cases. Concerning differentiation, cases of moderately differentiated carcinoma were more common followed by signet ring adenocarcinoma and poorly differentiated adenocarcinoma.

With 76 cases duodenum is the most common site for biopsy. The majority of cases were non-neoplastic (74). Among non-neoplastic lesions chronic non-specific Duodenitis was the most common with 57(77.03%) cases followed by 3 cases of celiac sprue and Lymphangiectasia each, 2 cases of Crohn's disease and 1 case of Strongyloides stercoralis.


 

References:

[1] Shah JM, Atit NB, Shah FR, kakadiya SR. interpretation of upper gastrointestinal tract endoscopic biopsies - A retrospective study Int JSci Res. 2015;4:9.

[2] Mustapha SK, Bolori MT, Ajayi NA, Nggada HA, Pindiga UH. Endoscopic findings and the frequency of H.pyloriamong dyspeptic patients in northeastern Nigeria. HMRJ. 2007;5:78-81.

[3]Krishnappa R, Horakerappa MS, Karar A, Mangala G. A study on histopathological spectrum of upper gastrointestinal tract endoscopic biopsies. Int J Med Res Health Sci. 2013;2:418-24.

[4] Bhat Nhistopathological spectrum of upper gastrointestinal tract endoscopic biopsies- 1-year prospective study. Br Biomed Bull;6(2):315.

[5]Sonu HU, Borchard F. Cancer of the distal esophagus and cardia: incidence, tumour infiltration and metastatic spread. Ann Surg. 1986;203(2):188-95.

[6] Wang J, Noffsinger A, Stemmermann G, Fenoligo-Preiser C. Esophagus squamous cell carcinoma arising in patients from the high-risk areas of north china lack an association with. Epstein Barr virus. Cancer Epidemiol Biomarkers Prev. 1999;8(12):1111-4.

[7] Afroz Ahmed M, Bharathi. Histopathological study of neoplastic lesions of the upper gastrointestinal tract by endoscopic biopsy [thesis] submitted to Rajiv Gandhi University of Health Sciences, Karnataka April-2012.

[8] Hussain SI, ReshiR, Akhter G, Beigh A. Clinico histopathological study of upper gastrointestinal tract endoscopic biopsies. IJCRR. 2015;7(16):78-85.

[9]Devi Leena KR and Suvarna N. Pattern of gastrointestinal tumours in north Kerala. Indian J Cancer. 1980;17(159):163.

[10] Durrani AA, YaqoobN,Abbasi S, SiddiqM, MoinS. The pattern of upper gastrointestinal malignancies in northern Punjab. Pak J Med Sci. 2009;25(2):302-7.

[11] Sujata M, PatilP.V. Upper gastrointestinal endoscopic biopsies - A histopathological study. A one-year cross-sectional study [thesis] submitted to KLE'S Dr. PrabhkarKoreHospital, Belgium, KLE University. KarnatakaBelgaum; 2011

[12] Memon F, Balovch K, Memon AA. Upper gastrointestinal endoscopic biopsy;  Morphological spectrum of lesions. Prof Med J. 2015;22(12):1574-9.

[13] Abilash S, Kolalladan HG, Shreelakshmidevi S, Balamurunganvelu S. Histopathological spectrum of upper gastrointestinal tract mucosal biopsies: A retrospective study. Sch J ApplMed Sci. 2016;4(5E):1807-13.

[14]Shanmugasamy K, Bhavani K, K. AV, NarshimN R, Kotasthane DS. Clinical correlation of Histopathological spectrum of upper gastrointestinal tract endoscopic biopsies with Histopathological findings and to study Histopathological profile of neoplastic and non-neoplastic lesions (April); 2016.

[15] Sheikh BA, Hamdani SM, Malik R. Spectrum of neoplastic lesions of upper gastrointestinal tract- a study of endoscopic. Glob J Med Public Heal. 2015;4(4):1-8.

[16]Gulia CSP, Noorunnisa MN, Balkrishna CD, Balagurunathan K. Interpretation of upper gastrointestinal Tract Mucosal Biopsies -A Study Conducted in Teaching Hospital in Puducherry, India. Int J Heal Sci J. 2012;1(3):17-24.

[17] Change S, Shetty S, Thapa R. The conceding of upper gastrointestinal lesion endoscopic biopsy: a bare minimum for diagnosis. Int J Sci Res.2015;4(2): 264-6.

[18] Shennak MM, Al sheik TM. Upper gastrointestinal diseases in symptomatic Jordanians: A prospective endoscopic study. Ann Saudi Med 1997;17(4):471-4.

[19]Katiyar V, Gupta E, Bhuyan RK. The pattern of upper GI disorders based on endoscopy in a tertiary care hospital of Assam: A record-based study. Int J Sci Res. 2014;3(6):35-6.

[20]Bukhari U, Siyal R, Memon FA, Memon JH. Esophageal carcinoma: a review of endoscopic. biopsies. Pak J Med Sci. 2009;25:845-8.

[21] Khan NA, Maqbool LM, Afroz F, Kharadi MY. Clinicopathological profile of carcinoma esophagus and esophagogastric junction in Kashmir. JK Pract. 2004;11(3):182-5.

[22] Panjeta SG, Chaudhary M, Noorunnisa N, Balakrishna CD. Interpretation of upper gastrointestinal tract endoscopic mucosal biopsies - A study 77 conducted; SN1  in a teaching hospital in Puducherry, India. Int j Med Health Sci. 2012;1(3):17-24.

[23] Thapa R, Lakhey M, Yadav PK, Kandel P, Aryal C. Histopathological study of endoscopic biopsies. J Nepal Med Assoc. 2013;52(190):354-6.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions