International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 13(19), October, 2021

Pages: 90-93

Date of Publication: 11-Oct-2021


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Prevalence of Testosterone Hormone Deficiency and its the Correlation with Other Clinical Parameters in (Chronic Kidney Disease) CKD Patients on Hemodialysis

Author: Chaudhary Vinit Ramesh, Gharge Sushilkumar Sunil

Category: Healthcare

Abstract:Introduction: Chronic kidney disease (CKD) is a wide range of metabolic alterations and hormonal disorders leading to endocrine dysfunctions often leads to worse outcomes. One such abnormality is a variable degree of hypogonadism and androgen deficiency. Aim: The present study aim was to study the CKD Patients. Methods: This observational study was conducted on a cohort of 50 CKD patients from June 2020 to July 2020. All clinically stable patients for the last six months and on hemodialysis were included. Results: This observational study consisting of 50 CKD patients with 30 (60%) of them in stage 5, 17 (34%) of them in stage 4, and 3 (6%) of them in stage 3 CKD. Testosterone deficiency was found in 32 (64%) patients. Conclusion: Testosterone is inversely associated with CKD stages, blood urea levels, creatinine is positively associated with haemoglobin level and duration of dialysis.

Keywords: Testosterone hormone deficiency, CKD patients, Hemodialysis, Haemoglobin level, Renal, Endocrine dysfunction, Hypogonadism

Full Text:

Introduction:

One of the common features among renal patients especially chronic kidney disease (CKD) is a wide range of metabolic alterations and hormonal disorders leading to endocrine dysfunctions. 1These are often associated with worse outcomes. One such abnormality is a variable degree of hypogonadism and androgen deficiency. Testosterone deficiency has been reported to be present in 26-66% of patients with CKD.2 Androgen deficiency leads to abnormal spermatogenesis, steroidogenesis, erectile dysfunction, decreased libido, and infertility. 3 It has been observed that deterioration of renal function leading to sexual dysfunction is not correctable by even dialysis. Sometimes, they deteriorate and male patients who are on dialysis can become impotent too. 4 Studies have proven that low levels of testosterone have led to many other changes in the body like anaemia, cognitive impairment, cardiovascular disease, and increased mortality. 1,5,6,7 This study was conducted to build on the previous evidence in the Indian scenario. By this study, we aim to estimate the prevalence of testosterone hormone deficiency and its correlation with other clinical parameters in a cohort of CKD patients on hemodialysis at our institute which is a tertiary care centre in the southern part of Maharashtra state.

Methods:

This observational study was conducted on a cohort of 50 CKD patients from June 2020 to July 2020. All clinically stable patients for the last six months and on hemodialysis were included. Endogenous testosterone level, hemoglobin, urea, creatinine, electrolytes (sodium and potassium), total proteins, albumin, and globulin levels were measured. Written informed consent was taken from all patients. Data entry and analysis was done in SPSS version 22.0 (IBM). Statistical significance was considered with a     p < 0.05. An independent sample t-test was used to determine the difference between laboratory parameters in testosterone deficient and normal groups. Pearson’s correlation coefficient and scatter plots were used to determine the relationship between testosterone levels and other clinical parameters as well as the duration of dialysis.

Results:

This observational study consisting of 50 CKD patients with 30 (60%) of them in stage 5, 17 (34%) of them in stage 4, and 3 (6%) of them in stage 3 CKD. The description of the study participants is given in Table 1. The mean age of participants in our study was 47.36 ± 14.44 years. Testosterone deficiency was found in 32 (64%) patients. The mean testosterone level was 267.22 ± 152.54 mg/dl. In the testosterone deficient group, it was 174.62 ± 87.42 and in the testosterone normal group it was 431.84 ± 91.09 mg/dl.

On applying, independent sample t-test, there was a significant difference in the laboratory parameters like haemoglobin (p<0.001), creatinine (p=0.045) and urea (p=0.013) in the testosterone deficient and testosterone normal group. (Table 1) In the testosterone deficient group, 20 patients belonged to stage 5, 10 belonged to stage 4, and 2 belonged to stage 3 CKD. A difference was observed between CKD stages and testosterone levels and the difference was near significant (p=0.06). Also, an inverse correlation was observed between the stage of CKD and testosterone levels (r = - 0.328 and p =0.02). [Figure 1] Correlation was also used to study the relationship between testosterone levels and other parameters. We found a significant positive correlation between haemoglobin levels and testosterone levels (r=0.744, p <0.001). We also found negative correlation between testosterone levels and blood urea levels (r = - 0.499 and p < 0.001).This has been represented in scatter plots. (Figure 2 and 3) There is a weak correlation (r=0.261) between testosterone levels and duration of dialysis but the p-value is near significant (p=0.067). (Figure 4) There is no correlation between testosterone levels and other parameters.

Discussion:

This observational study consists of 50 CKD patients with 60% of them in stage 5, 34% of them in stage 4, and 6% of them in stage 3 CKD. Endocrine dysfunctions in CKD is associated with the worst outcomes. Testosterone deficiency has been reported to be present in 26-66% of patients with CKD.2 In men undergoing hemodialysis subnormal total testosterone concentrations have been reported as 44–57%.1,8,9 In our study the testosterone deficiency was found in 64% of patients. Albaaj et al. 2006 reported 26.2% of patients had significantly low testosterone levels and another 30.3% had low-normal levels.10 Carrero et al., 2009, reported the median value of testosterone as 286 (206 to –346) ng/dl and the deficiency (<288ng/dl) in 52% of men. Gungor et al., 2010 reported the mean testosterone level in their study to be 8.69 ± 4.10 (0.17 to 27.40) and testosterone deficiency (<10 nmol/L) in 66% of the patients of CKD on hemodialysis.11 Carrero et al., 2011 in another study reported the presence of testosterone deficiency in 44% of the patients and testosterone insufficiency (10– 14 nmol/L) in 33%.1 Ekart et al., 2014 reported the prevalence of testosterone deficiency to be 13.8% and insufficiency to be 3.5 % in men on hemodialysis for CKD.12 Cigarrán S et al., 2017, reported mean testosterone levels as 8.81 ± 6.61 ng/ml in CKD patients and testosterone deficiency in 39.5% patients on hemodialysis and 5.6% of peritoneal dialysis.13 Testosterone levels are correlated with the stage of CKD.8-16 In our study we found a significant, inverse correlation between stages of CKD and testosterone levels (r = - 0.328 and p =0.02). In a study by Yilmaz et al., 2011, on 239 referred patients to a renal centre, they reported the prevalence of subnormal testosterone as 17, 17, 34, 38, and 58% in stage 1-5 of CKD.16The prevalence was higher in CKD stage 4 and 5 similar to our study. Dhindsa et al., 2015, reported that hypogonadotropic hypogonadism was present across all stages of CKD in the range of 32-46%. In the case of stages 4 and 5 of CKD, around 90% were either hypogonadal and/or had compensated hypogonadism. All these were also typed, 2 diabetics. Khurana et al., 2014, found a 53% prevalence of subnormal testosterone concentrations among 2419 patients with CKD stage 3 or 4.15

Testosterone deficiency leads to abnormal spermatogenesis, steroidogenesis, erectile dysfunction, decreased libido, and infertility.3 Studies have proven that low levels of testosterone have led to many other changes in the body like anaemia, cognitive impairment, cardiovascular disease, and increased mortality. 5,6,7 Our study builds upon this previous evidence. While some studies may show an inverse relation with testosterone levels, we found no relationship between age and testosterone levels. Even Bello et al., 2014, reported no significant interaction between age and serum testosterone levels. In our study, we found a significant positive correlation between haemoglobin levels and testosterone levels. We also found a negative correlation between testosterone levels and blood urea levels. There is a weak correlation between testosterone levels and duration of dialysis but the p-value is near significant. There is no correlation between testosterone levels and other parameters. Previous literature shows testosterone-deficient patients are more likely to be anaemic.2,5,7 Carrero et al., 2012, reported that patients with testosterone <10 nmol/L were around five times more likely to be anaemic (Hb < 13.0 g/dL) than patients with sufficient testosterone.17 Ekart et al., 2014 also reported a significant positive correlation between testosterone and haemoglobin in all male patients (r=0.25). Other studies like Bain et al.5 and Iglesias et al.2 also reported similar results. But, some studies like Albaaj et al. and Cigarrán S et al. have also reported no relationship between testosterone and other biochemical parameters like haemoglobin level, parathyroid hormone, creatinine clearance, duration of dialysis.

Conclusion:

Our study contributes to estimating the burden of testosterone deficiency in CKD patients and its relationship with other biochemical parameters in patients of hemodialysis. We found that testosterone is inversely associated with CKD stages, blood urea levels, creatinine is positively associated with haemoglobin level and duration of dialysis.

However, our study has certain limitations like a small sample size and the non-availability of a control group. Also, all patients were on hemodialysis so the effect of the dialysis technique cannot be commented upon. Larger studies that can be extrapolated on the patients of hemodialysis are needed.

 Acknowledgement: We acknowledge the contribution of our university and department for the unending support.

Conflict of Interest: There is no conflict of Interest 

Source of Funding: No Source of Funding

Authors Contribution: This is a collaborative work among all authors. Chaudhary Vinit Ramesh, Gharge Sushilkumar Sunil performed the statistical analysis, wrote the protocol, and wrote the first draft of the manuscript. Gharge Sushilkumar Sunil managed the literature searches. Both the authors read and approved the final manuscript.

 

Figure 4: Scatter plot showing a positive correlation between the duration of dialysis and testosterone levels in study participants.

References:

1. Carrero JJ, Qureshi AR, Nakashima A, Arver S, Parini P, Lindholm B, Bárány P, Heimbürger O, Stenvinkel P. Prevalence and clinical implications of testosterone deficiency in men with end-stage renal disease. Nephrology Dialysis Transplantation. 2011 Jan 1;26(1):184-90.

2. Iglesias P, Carrero JJ, Díez JJ. Gonadal dysfunction in men with chronic kidney disease: clinical features, prognostic implications and therapeutic options.  J. Nephrol.. 2012 Feb;25(1):31.

3. Swerdloff RS, Wang C. Three-year follow-up of androgen treatment in hypogonadal men: preliminary report with testosterone gel. The ageing male. 2003 Jan 1;6(3):207-11.

4. Sherman FP. Impotence in patients with chronic renal failure on dialysis: its frequency and aetiology. Fertility and sterility. 1975 Mar 1;26(3):221-3.

5. Bain J. Testosterone and the ageing male: to treat or not to treat?. Maturitas. 2010 May 1;66(1):16-22.

6. Jones TH. Testosterone deficiency: a risk factor for cardiovascular disease?. Trends in Endocrinology & Metabolism. 2010 Aug 1;21(8):496-503.

7. Carrero JJ, Stenvinkel P. The vulnerable man: impact of testosterone deficiency on the uraemic phenotype. Nephrology Dialysis Transplantation. 2012 Nov 1;27(11):4030-41.

8. Bello AK, Stenvinkel P, Lin M, Hemmelgarn B, Thadhani R, Klarenbach S, Chan C, Zimmerman D, Cembrowski G, Strippoli G, Carrero JJ. Serum testosterone levels and clinical outcomes in male hemodialysis patients. Am. JKidney Dis.2014 Feb 1;63(2):268-75.

9. Kyriazis J, Tzanakis I, Stylianou K, Katsipi I, Moisiadis D, Papadaki A, Mavroeidi V, Kagia S, Karkavitsas N, Daphnis E. Low serum testosterone, arterial stiffness and mortality in male haemodialysis patients. Nephrol Dialysis Transpl. 2011 Sep 1;26(9):2971-7.

10. Albaaj F, Sivalingham M, Haynes P, McKinnon G, Foley RN, Waldek S, O’donoghue DJ, Kalra PA. Prevalence of hypogonadism in male patients with renal failure. PostgradMed J. 2006 Oct 1;82(972):693-6.

11. Gungor O, Kircelli F, Carrero JJ, Asci G, Toz H, Tatar E, Hur E, Sever MS, Arinsoy T, Ok E. Endogenous testosterone and mortality in male hemodialysis patients: is it the result of ageing?. Clin J Am Soc. Nephrol.. 2010 Nov 1;5(11):2018-23.

12. Ekart R, Taskovska M, Hojs N, Bevc S, Hojs R. Testosterone and haemoglobin in hemodialysis male and female patients. Artificial Organs. 2014 Jul;38(7):598-603.

13. Cigarrán S, Coronel F, Florit E, Calviño J, Villa J, Tabares LG, Herrero JA, Carrero JJ. Testosterone deficiency in dialysis patients: Differences according to the dialysis techniques. Nefrología (English Edition). 2017 Sep 1;37(5):526-30.

14. Dhindsa S, Reddy A, Karam JS, Bilkis S, Chaurasia A, Mehta A, Raja KP, Batra M, Dandona P. Prevalence of subnormal testosterone concentrations in men with type 2 diabetes and chronic kidney disease. Eur J Endocrinol. 2015 Sep 1;173(3):359-66.

15. Khurana KK, Navaneethan SD, Arrigain S, Schold JD, Nally Jr JV, Shoskes DA. Serum testosterone levels and mortality in men with CKD stages 3-4. Am. JKidney Dis.. 2014 Sep 1;64(3):367-74.

16. Yilmaz MI, Sonmez A, Qureshi AR, Saglam M, Stenvinkel P, Yaman H, Eyileten T, Caglar K, Oguz Y, Taslipinar A, Vural A. Endogenous testosterone, endothelial dysfunction, and cardiovascular events in men with nondialysis chronic kidney disease. Clin J Am. Soc. Nephrol. 2011 Jul 1;6(7):1617-25.

17. Carrero JJ, Bárány P, Yilmaz MI, Qureshi AR, Sonmez A, Heimbürger O, Ozgurtas T, Yenicesu M, Lindholm B, Stenvinkel P. Testosterone deficiency is a cause of anaemia and reduced responsiveness to erythropoiesis-stimulating agents in men with chronic kidney disease. Nephr Dial Transpl. 2012 Feb 1;27(2):709-15..

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Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


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A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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