International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - Vol 13 Issue 17, September, 2021

Pages: 126-130

Date of Publication: 12-Sep-2021


Print Article   Download XML  Download PDF

Study of Relation between Serum Albumin and Glycosylated Hemoglobin Levels in Patients of Type 2 Diabetes Mellitus

Author: Stuti PU, Shilpa CP

Category: Healthcare

Abstract:Introduction: Diabetes mellitus (DM) can affect people throughout the world, Even though diabetes has been known for a long time, only in the last few decades discoveries have provided measures to minimize morbidity and mortality. Objective: Study of relation between serum albumin and glycosylated haemoglobin levels in patients of type 2 Diabetes mellitus. Method: The present study can be stated as a Hospital-based cross-sectional, observational study design. The study was carried out in the patients admitted in the ward who are diagnosed cases of type 2 DM, in Krishna hospital and Medical Research Centre, Karad. Result: It was observed that along with type 2 DM, hypertension was the most common comorbidity, present in 35.64% of the patients. The second most common comorbidity found was obesity, present in 25.74% of the patients. Conclusion: It was observed that patients who had higher levels of glycosylated haemoglobin had relatively lower levels of serum albumin and patients who had lower levels of glycosylated haemoglobin had normal or near-normal serum albumin levels.

Keywords: Serum Albumin, Glycosylated Hemoglobin, Type 2 Diabetes Mellitus, Hypertension, Obesity

Full Text:

 INTRODUCTION

Diabetes mellitus (DM) can affect people throughout the world, Even though diabetes has been known for a long time, only in the last few decades discoveries have provided measures to minimize morbidity and mortality. Diabetic ketoacidosis, which is a major fatal complication of diabetes, its occurrence has decreased due to the discovery of insulin. However, Diabetes is characterized by metabolic abnormalities along with long-term microvascular and macrovascular complications. The prevalence of diabetes in developing countries is on the rise. It not only multiplies the risk of coronary artery disease but also increases the incidence of Cerebrovascular accidents. End-stage renal disease and also non-traumatic limb amputations.1 Chronic complication of diabetes is often present at the time of diagnosis of Diabetes mellitus. Presently data are scarce when it comes to the occurrence of complications relating to chronic. This case should be specific to diabetic patients at the time of diagnosis.2By educating the high-risk persons about diabetes-related complications, they can be encouraged for seeking medical consultation earlier. Diabetes-associated complications can be prevented only up to a certain point. Also, once the complications are set in, treating hyperglycemia alone itself is not sufficient and even if we treat aggressively, these complications will go on progress further. This emphasizes more aggressive screening for both microvascular as well as macrovascular complications at the time of diagnosis.3 In type 2 diabetes mellitus HbA1c testing is used to measure diabetic glycemic control Diabetic control is categorized as Poor control – HbA1c level >9%, Moderate control – HbA1c level between 7 to 9% Good or desired levels HbA1c level - <7%, However, many factors are known to affect HbA1c values for example – Hemoglobin variants like Hbs, Hbc, Various drugs, anaemia, uremia, and one of them being albumin level. The serum albumin levels are not routinely monitored in all diabetic patients. Albumin levels are routinely monitored only in diabetic nephropathy. Hence identification, critical evaluation and follow-up of serum albumin, as well as HbA1c in type 2 DM, is important.

The present study aimed at analyzing the relation between albumin and HbA1c in Type 2 diabetes patients and its correlation with the severity of the disease. So that timely preventive disability as similar studies was lacking in this particular geographical area. Also, this information will help healthcare professionals to approach management more aggressively to prevent these complications from occurring. Most of the studies in India have been done in cities where people are more educated and aware of the disease. Very little data is available about diabetes and its complication from a rural area in India. A high prevalence of such complications, if documented, will help convince the physicians of the importance of screening for all type 2 diabetics at regularly and to appropriate implement treatment without delay. In the study conducted by Shalbha Tiwari et al.4 929 patients were screened, out of which 319 patients were excluded. A significant negative correlation between HbA1c and albumin concentration (r= -0.284; p< 0.001) was observed in the study.5 The results suggested that the HbA1c and albumin association existed only at non-hyperglycemic fasting blood glucose levels, but not at hyperglycemic ranges, this leads to speculation whether this means that higher glucose levels were able to glycate both haemoglobin and albumin. Whether this increase in HbA1c attributable to lower albumin might still link to diabetic complications is an issue that deserves further study.

It is well known that HbA1c may falsely overestimate prediabetes in Indians, and this had been attributed to iron deficiency anaemia and other factors.6, 7 In the study conducted by Sarojini C et al on 50 subjects, 8 the subjects were divided into two groups. This study concluded that serum albumin negatively correlates with HbA1c concentrations, so average glucose levels from the HbA1c concentration, which may efficiently inform patients their glycemic control needs to be further investigated.9

OBJECTIVE

Study of relation between serum albumin and glycosylated hemoglobin levels in patients of type 2 Diabetes mellitus.

METHOD

The present study can be stated as a Hospital-based cross-sectional, observational study design. The study was carried out in the patients admitted inward who are diagnosed cases of type 2 DM, in Krishna hospital and Medical Research Centre, Karad. The study was conducted over 18 months (1st Dec 2018 to 31st May 2020). This study was approved by Institutional Ethics and Protocol committee. ( protocol number 0253/2018-2019). A total of 101 patients were enrolled in the present study. The sample size is calculated by using Pearson’s correlation coefficient from a previous study conducted by S. Tiwari et al, where a significant negative correlation between HbA1c and serum albumin was observed with r= -0.284

Sample size = N = [(Zα+Zβ)/C]2 + 3

The standard normal deviate for α = Zα = 1.960 The standard normal deviate for β = Zβ = 0.842 C = 0.5 * ln[(1+r)/(1-r)] = 0.292

So,

Total sample size = N = [(Zα+Zβ)/C]2 + 3 = 95

Inclusion Criteria:

  1. Males and females aged more than 18 years who are known cases of type 2 DM

Exclusion Criteria:

1. Patients diagnosed with Type 1 Diabetes mellitus.

2. Patients with severe anaemia.

3. Renal impairment (with serum creatinine > 2mg/dl)

4. Pregnancy.

5. Chronic liver disease. (Total bilirubin > 3mg/dl)

6. Hypertriglyceridemia.

7. Iron or vitamin B12 deficiency.

Demographic information such as age, gender, past medical history, personal history and general examination findings such as weight, height, BMI were recorded with the help of standard, pre-validated semi-structured case record proforma. All enrolled patients underwent the following investigations-

  • Haemoglobin by fully automated 3 part cell analyzer

  • Total leukocyte count by fully automated 3 part cell analyzer

  • Platelet count by fully automated 3 part cell analyser

  • Urine routine and microscopy examination.

  • Blood urea by Urease-GLDH method

  • Serum creatinine by Modified JAFFE’S method

  • Random blood sugar by Hexokinase-mediated reaction

  • Fasting blood sugar by Hexokinase-mediated reaction

  • Postprandial blood sugar by Hexokinase-mediated reaction

  • Liver function tests by calorimetry

  • Serum albumin by bromocresol green assay

  • HbA1c by immune turbidimetry method.

All CBC parameters were performed in an automated 3 part analyzer by Nihon Kohden (Model number MEK 6420P)

STATISTICAL ANALYSIS

The statistical analysis was performed using the statistical package for social science (SPSS) 21(trial version) for windows. The data was recorded in the study Performa sheet and was entered into the statistical software for further evaluation. The data was arranged in the form of tables and groups for frequency analysis. Data were expressed as mean values ± standard deviations (SD), the percentage for continuous variables. Frequency and proportions were reported for categorical variables. A Chi-square test was used and The ‘P’ value of <0.05 was considered statistically significant.

RESULTS

The majority of the study subjects in the study belonged to the age group of 56 to 65 years (33.66%)          74(73.27%) patients were male and 27(26.73%) patients were female, with a male to female ratio of 1:0.36The duration of type 2 DM was observed to be between 11 to 15 years in 33.66% of the patients and 6 to 10 years in 32.67% patients. It was observed that along with type 2 DM, hypertension was the most common comorbidity, present in 35.64% of the patients. The second most common comorbidity found was obesity, present in 25.74% of the patients. The mean fasting blood sugar level was found to be 140mg/dl, with a minimum value of 90mg/dl and a maximum value of 256mg/dl. The mean postprandial blood sugar level was found to be 202 mg/dl, with a minimum value of 100mg/dl and a maximum value of 299 mg/dl. The mean glycosylated haemoglobin was found to be 8.1%. It was observed that 47.5% of the patients had glycosylated haemoglobin levels between 7 to 9%. 30.7% of the patients had glycosylated haemoglobin levels less than 7% and 21.8% patients had levels more than 9%. In the study the glycosylated haemoglobin levels were compared with the age of the patient using Pearson’s correlation method, It was observed that there is weak negative correlation ( r- valve is 0.165 and  ‘P’-value is 0.099)The mean serum albumin level was found to be 3.12 gm/dl 53.5% subjects had serum albumin levels below 3gm/dl, while 22.8% subjects had levels between 3 to 3.5, and 23.8% subjects had albumin levels more than 3.5gm/dl. In the study, the serum albumin levels were compared with the age of the patient using Pearson’s correlation method, and a weak positive correlation was observed (r value is 0.026 and P-value is 0.798)In the study the mean albumin levels and HbA1c groups were compared, it was observed that the group in which HbA1c was less than 7 had mean albumin concentration 3.89 ± 0.86, the group of patients which had HbA1c between 7 to 9 had mean albumin concentration 2.97± 0.51, and the group of patients who had HbA1c more than 9 had mean albumin concentration 2.48 ± 0.67.The present study aimed at seeing the relation between serum albumin and HbA1c levels in patients of type 2 Diabetes mellitus. A negative correlation was observed among both the parameters (r-value is -0.12)

DISCUSSION

Comorbidities

In the present study, the subjects were assessed according to the presence of comorbidities. It was observed that hypertension was the most common comorbidity present in 36 (35.64%) study subjects while, 26 (25.74%) study subjects were overweight, 15 study subjects (14.85%) had IHD and 12 (11.88%) study subjects had CVA and COPD each. Sarojini C et al, in the study conducted on 50 subjects included study subjects with BMI more than 26 and waist circumference more than 102 centimeters.9In the study by Shalbha Tiwari et al, the most common comorbidity seen in the study subjects of Diabetes mellitus was hypertension, seen in 30% subjects, which is similar to the present study.10

Haemoglobin levels

In the present study, the study subjects were assessed according to their mean haemoglobin levels. The mean haemoglobin level observed was 12.661 ± 1.4345 g/dl.

Blood sugar levels

Fasting and post-meal blood sugar levels were done for all the study subjects. It was observed that the mean fasting blood sugar level was 140.633 ± 23.93, and the mean Postprandial blood sugar level was 202.19 ± 28.74 mg/dl. In the study by Sarojini c et al, the mean fasting blood sugar level observed was 125.68 ± 23.97 mg/dl and the mean Postprandial blood sugar level was 189.78 ± 23.45 mg/dl.[9]In the study by Shalbha Tiwari et al, the mean fasting blood sugar level observed was 117.86 ± 49.83 and the mean postprandial blood sugar level was 169.49 ± 85 mg/dl The findings were similar to the present study.10

HbA1c levels

In the study, the study subjects were categorized according to their HbA1C levels. It was observed that the mean HbA1c level was 8.175±1.7053. It was observed that 48 (47.5%) study subjects had HbA1c levels between 7 to 9, whereas 31(30.7%) study subjects had a value less than 7, and 22(21.8%) subjects had values more than 9. In the present study, the HbA1c levels were compared with the age of the subjects. A weak negative correlation among both the parameters (r-value is -0.165 and p-value is 0.099).In the study by Sarojini C et al, 60% of study subjects had HbA1c more than 7% which is similar to the present study 40% of patients had HbA1c less than 7% which is similar to the present study.[9]In the study by Santiago Rodriguez et al, it was observed that 44.6% of study subjects had HbA1c less than 7%, 18.6% of study subjects had HbA1c between 7 to 9% and 36.8% of patients had HbA1c more than 9% which is similar to the present study.11

Serum Albumin levels

In the present study serum albumin levels were assessed for the study subjects. It was observed that the mean albumin level was 3.122± 0.83. 54(53.5%) subjects had serum albumin levels below 3 mg/dl, while 23(22.8%) subjects had levels between 3 to 3.5, and 24(23.8%) subjects had albumin levels more than 3.5. In the present study serum albumin levels were compared with the age of the subjects. A weak positive correlation among both the parameters(r-value is 0.026 and p-value is 0.798). In the study by Shalbha Tiwari et al. 33% of study subjects had serum albumin levels of more than 4mg/dl, which is more than the present study. 33% of study subjects had serum albumin levels less than 3.5mg/dl which is less than the present study.10 In the study by Sarojini C et al, 40% of study subjects had serum albumin levels less than 3.5mg/dl which is similar to the present study.

According to Shobha Tiwari et al. and Santiago Rodriguez et al. higher serum albumin levels may decrease HbA1c levels and that lower serum albumin levels may raise HbA1c levels which were reported earlier in Western studies. In this study also there is a significant negative correlation between HbA1c and serum albumin noted, this may be due to serum albumin was to compete with haemoglobin for glycation and lower HbA1c negatively. As we did not measure glycated albumin levels, we can only speculate that this could be due to higher albumin levels competing with haemoglobin to get excessively glycated. As this study has several limitations, the finding of an association of statistically increasing HbA1c with low albumin tertiles, suggest that albumin could be one more factor that alters HbA1c levels. This further strengthens the current understanding that only HbA1c may not be as reliable in diagnosing diabetes in Indian subjects. It can be believed that such studies in Indian subjects, could lead to new approaches in studying how glucose and proteins might interact with one another, and such studies could have an impact on understanding hyperglycemia and its estimation.

In Table 1, various studies which have similar objectives have been compared.

CONCLUSION

In the present study, the population was largely confined to the 5th and 6th decades with the predominance of the male gender. Hypertension was the most common comorbidity seen along with type 2 diabetes mellitus. Obesity was the second most common comorbidity. In this study a comparison between serum albumin and glycosylated haemoglobin was done, it was observed that patients who had higher levels of glycosylated haemoglobin had relatively lower levels of serum albumin and patients who had lower levels of glycosylated haemoglobin had normal or near-normal serum albumin levels.

Conflict of Interest: There is no conflict of Interest 

Source of Funding: No Source of Funding

Authors Contribution: This is a collaborative work among all authors. Dr. Stuti Pradeep Ugile, and Dr. Shilpa C. Patil performed the statistical analysis, wrote the protocol, and wrote the first draft of the manuscript. Dr. Stuti Pradeep Ugile, and Dr. Shilpa C. Patil managed the literature searches. All authors read and approved the final manuscript

References:

[1]  Harrison’s Principle of Internal Medicine, 20th edition, chapter 396 - Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology, by lvin C. Powers; Kevin D. Niswender; Carmella Evans-Molina.

[2] Sosale A, Prasanna Kumar K, Sadikot S, Nigam A, Zargar A, Singh S et al. Chronic complications in newly diagnosed patients with Type 2 diabetes mellitus in India. Ind J Endocrin Metab. 2014;18 (3):355-60.

[3] Kumar M, Rawat R, Verma V, Zafar K, Kumar G. Chronic complications in newly diagnosed patients with type 2 diabetes mellitus in the rural area of western Uttar Pradesh, India. Int J Res Med Sci. 2016;4 (6):2292-2296.

[4]  Shalbha Tiwari, Manish Bothale, Imtiaz Hasan, Mahesh J. Kulkarni, Mehmood G. Sayyad, Rita Basu, Ananda Basu, AmbikaGopalakrishnan Unnikrishnan,. Association between serum albumin and glycated haemoglobin in Asian Indian subjects. Ind J Endoc Metab. 2015, Jan-Feb, 19(1) 52-55.

[5] Shalbha Tiwari, Manish Bothale, Imtiaz Hasan, Mahesh J. Kulkarni, Mehmood G. Sayyad, Rita Basu, Ananda Basu, AmbikaGopalakrishnan Unnikrishnan,. Association between serum albumin and glycated haemoglobin in Asian Indian subjects. Ind J Endoc Metab. 2015, Jan-feb, 19(1) 52-55.

[6]Hardikar PS, Joshi SM, Bhat DS, Raut DA, Katre PA, Lubree HG, et al. Spuriously high prevalence of prediabetes diagnosed by HbA1c in young Indians partly explained by haematological factors and iron deficiency anaemia. Diab Care. 2012;35:797-802.

[7] Ramachandran A, Snehalatha C, Smith Shetty A, Nanditha A. Predictive value of HbA1c for incident diabetes among subjects with impaired glucose tolerance – analysis of the Indian Diabetes Prevention Programmes. Diabet Med. 2012;29:94-98.

[8] Sarojini C. Role of albumin in the estimation of HbA1c in south Indian subjects. Int J Sci Res. 2016; 5(4): 629-634.

[9] Sarojini C. Role of albumin in the estimation of HbA1c in south Indian subjects. Int J Sci Res. 2016;5(4)179-183.

[10] Shalbha Tiwari, Manish Bothale, Imtiaz Hasan, Mahesh J. Kulkarni, Mehmood G. Sayyad, Rita Basu, Ananda Basu, AmbikaGopalakrishnan Unnikrishnan. Association between serum albumin and glycated haemoglobin in Asian Indian subjects. Ind J Endocri Metab. 2015; 19(1): 52-55.

[11]Santiago R, Javier RI, Dolores M. Plasma Albumin Concentration Is a Predictor of HbA1c Among Type 2 Diabetic Patients, Independently of Fasting Plasma Glucose and Fructosamine. Diabetes Care. 2005;28(2):185-191.

[12] Xiao jing Feng, Influence of serum albumin on HbA1c and HbA1cdefined glycemic status: a retrospective study.2015;46(12):571-574.

[13] Masafumi Koga, Jun Murai, Hiroshi Saito, Soji Kasayama, Glycated Albumin and Glycated Hemoglobin Are Influenced Differently by Endogenous Insulin Secretion in Patients With Type 2 Diabetes, American diabetes association, Diabetes Care. 2010 Feb; 33(2): 270-272.

[14] Vinay N Minocha, Kavita Pal and Robert Zaiden, The association of serum albumin and glycated haemoglobin with all-cause mortality in patients with breast cancer, Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium. 2014;12: 9-13.

[15] Po-Chung Cheng, Shang-Ren Hsu, and Yun-Chung Cheng, Association between Serum Albumin Concentration and Ketosis Risk in Hospitalized Individuals with Type 2 Diabetes Mellitus, J. Diabetes Res, 2016;23(5): 126-129.

 [16]F A Nazki, A Syyeda, S Mohammed, F A Nazki, A Syyeda, S  Mohammed. Int J Biochem. 2017; 3(9): 497-501.

[17] Rosemary Adamma Analike, Assessment of glycated haemoglobin, total protein and albumin levels in patients with type 2 diabetes mellitus visiting NAUTH, Nnewi, Ind J Pathol Oncol, 20196(4):700-703

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2022 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions