International Journal of Current Research and Review
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IJCRR - 7(21), November, 2015

Pages: 33-40

Date of Publication: 11-Nov-2015


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MEDICATION ADHERENCE AND ITS CORRELATES AMONG DIABETIC AND HYPERTENSIVE PATIENTS SEEKING CARE FROM PRIMARY HEALTH CENTER, INDIA

Author: Pruthu Thekkur, Mahendra M. Reddy, Gomathi Ramaswamy, Bijaya Nanda Naik, Subitha Lakshminarayanan, Ganesh Kumar Saya

Category: Healthcare

Abstract:Introduction: Low adherence to prescribed medication in patients with non communicable diseases (NCDs) increases risk of hospitalization and premature mortality. Assessing adherence to medications and its correlates among NCD patients can help in delivering targeted interventions. Objectives: To assess the level of low adherence to prescribed medications and associated factors among diabetic and/or hypertensive patients registered in NCD clinic at a Rural Health Center in South India. Methodology: A facility based cross-sectional study was conducted in a RHC of Puducherry, India. All the patients who registered and attended clinic for follow up in August 2014, with either hypertension and/or diabetes and received drug for more than four weeks prior to contact were included in study and adherence was assessed using Morisky Medication Adherence Scale (MMAS-8) questionnaire. The data was entered in Microsoft Excel and was analyzed using SPSS version 20. Results: Of the 281 included in the study the mean (SD) age was 57.4 (11.9) years and 169 (59.8%) were females. Among these 281, 155 (55.1%) had only hypertension, 46 (16.4%) had only diabetes and 90 (28.5%) had both hypertension and diabetes. Low adherence to medication was seen in 47 (16.7%) participants. In the model factors like education of 1-5years (OR-2.68, CI-1.03\?6.98)), education of >6 years (OR-3.50, CI-1.34\?9.14), having only diabetes (OR-3.78, CI-1.28-11.17) and tobacco use (3.51, CI-1.24\?9.96) were independently associated with low adherence. Conclusion: Around one-sixth of the patients with either diabetes and/or hypertension were found to be less adherent to prescribed medication. Higher education levels, use of tobacco and having only diabetes were identified independently as risk factors for low adherence.

Keywords: Diabetes Mellitus, Hypertension, Medication compliance, Non communicable diseases, Primary health care

Full Text:

INTRODUCTION

Non Communicable Diseases (NCD) mainly comprises of cardiovascular diseases (CVD), chronic respiratory diseases, cancer, diabetes and mental illness. By 2020, NCD’s are expected to contribute to 60% of the global disease burden and 73% of the total mortality.[1] Developing countries like India are undergoing epidemiological transition from communicable to non-communicable diseases.[2] NCD account for 53% of all deaths in India and are estimated to increase up to 67% in 2030.[3] Hypertension and diabetes are the common chronic morbidities which can lead to life-threatening complications like CVD.[4] Systematic review and meta-analysis on prevalence of hypertension in India, 2014 shows overall prevalence of 29.2% in adults aged more than18 years and 27.6% and 33.8% in rural and urban respectively.[5] With 66.8 million affected by diabetes, India ranks second globally.[6] In India, urban and rural divide in non-communicable disease prevalence is reducing and is expected to diminish very soon.[7] With increasing NCD burden in India, Ministry of Health and Family Welfare has launched a national program namely, National Program for Prevention and control of Cancer, Diabetes, Cardiovascular diseases and Stroke (NPCDCS) in the year 2010. It was initiated in 100 backward and remote districts in 21 states as a pilot phase and it is proposed to cover all the districts in the country in a phased manner by the end of 12th five year plan. Under NPCDCS, NCD clinics are functioning in Primary Health Centers (PHC) where investigations and treatment are provided free of cost.[8] Though such facilities are provided in PHC, monitoring of patient’s adherence to health advice plays an important role in determining the outcome of these chronic conditions. Adherence is defined as “the extent to which a person’s behavior such as taking medication, following a diet and/or executing lifestyle changes corresponds with the agreed recommendations from a health care provider”.[9] Among these factors, adherence to treatment is an important factor in prevention of complications. Non-adherence to treatment plays a major role in increasing the all-cause hospitalization, mortality and out of pocket expenditure among patients with diabetes and/ or hypertension.[10] A study conducted at a tertiary care hospital in South India among diabetic in-patients showed that only 49.3% were adherent to prescribed medications.[11] Similarly, a study among hypertensive patients in South India showed that 45.8% were having low adherence.[12] In India, studies assessing adherence to medication among patients with diabetes and hypertension are mostly limited to patients attending tertiary care facilities.[11-13] But, it is important to assess adherence to treatment and its correlates in those patients attending PHCs as most of them are yet to develop complications. Identifying the non-adherent patients and factors associated with non-adherence will help in guiding targeted interventions in future among these patients to improve adherence and avert complications that may arise due to non-adherence. With this background, the present study was conducted among patients with either diabetes and/or hypertension registered in NCD clinic at a Rural Health Center (RHC), to assess a) the adherence to prescribed medications and b) socio-demographic and treatment factors associated with low adherence.

METHODOLOGY

Study setting: During the month of August 2014, a facility based cross-sectional study was conducted among patients with either hypertension and/or diabetes seeking healthcare from the NCD clinic, Rural Health Center (RHC), Ramanathapuram. The RHC is a Primary Health Center located in Puducherry, India and is 16 kilometers away from the Puducherry main town. It is attached to a tertiary care research institute and is also functioning under the Government of Puducherry. It caters to the health needs of 9852 individuals residing in four socio-demographically and economically similar villages namely Ramanathapuram, Thondamanatham, Thuthipet and Pilayarkuppam. Majority of people in these villages have low economic status, low education status and are dependent on agriculture for living as is the scenario in most of the Indian villages. People here mainly depend on RHC for their health needs. RHC, Ramanathapuram provides round the clock health services which include OPD services from 9 am to 4.30 pm and emergency services in remaining hours. Special clinics for Non Communicable Diseases (NCD), Antenatal care and Well Baby care are scheduled on Wednesday, Thursday and Friday respectively. The study was carried out among patients attending NCD clinic at RHC, Ramanathapuram. Patients with at least one chronic disease condition like hypertension, diabetes mellitus, coronary heart disease, rheumatic heart disease, asthma, thyroid disorders, epilepsy and psychiatric disorders are registered in NCD clinic. The registered 415 patients are divided into batches of around 105 and each batch visits RHC for consultation and follow-up once in a month. Consultation, drugs for 28 days and necessary laboratory services are provided free of cost during this monthly follow-up visits. Patients are reviewed every Wednesday by trainee doctors under the supervision of medical officer in charge of RHC. During each monthly visit, the details on management are updated in the comprehensive patient case sheets by attending medical doctor. The patients are advised regarding need for regular follow-up visits and lifestyle modifications to combat non communicable disease. The pharmacist educates patients regarding dose and regimen of the prescribed medication to be followed during the course of next four weeks.

Study population: We included all the patients with either diabetes and/or hypertension who are already registered and attending NCD clinic at RHC, Ramanathapuram during the month of August 2014 and had received drugs for at least past four weeks. The patients were interviewed after obtaining a verbal informed consent during their visit to NCD clinic.

Study tool and Study variables: Pretested, semi-structured interview schedule was used to collect information. Pre testing was done in four patients who had both diabetic and hypertension and in three patients who had diabetes alone. It was done in those who attended NCD clinic at a tertiary care hospital. No major changes noted during pre testing of questionnaire. The interview schedule had three components socio-demographic details, details of treatment received and adherence to medication. The component of socio-demographic details included age, gender, village, education, occupation, marital status and also lifestyle behaviors like alcohol use and tobacco use. The treatment details had variables like type of morbidity, duration of treatment, number of drugs received and dosage. The details of treatment received were extracted using patient case sheets. The adherence to medication was captured with the eight-item Morisky Medication Adherence Scale (MMAS-8) which has eight questions and was graded as low adherence, moderate adherence and good adherence. MMAS-8 is validated in India and other parts of world in different languages with reliability value (α) of 0.83. MMAS scores can range from 0 to 8, with low adherence defined as MMAS scores less than 6; moderate adherence as scores of 6 to less than 8, and good scores as a score of 8.[14-16] The questions were translated and back translated to Tamil and English respectively by two separate bi-linguistic persons for content verification. The interview schedule was administered by trained MBBS interns who were well versed in local language Tamil. The study protocol was approved by the concerned clinic administration panel.

Operational Definitions:

Adherence to medication: Patients having a score of 8 were considered to have good adherence. Patient with scores of 6-7 were considered to have moderate adherence. Patient with scores of 6 years (OR-3.50, CI-1.34–9.14), having only diabetes (OR-3.78, CI-1.28-11.17) and tobacco use (3.51, CI-1.24–9.96) were independently associated with low adherence (Table 3).

Duration of Disease: Duration of either diabetes or hypertension whichever was detected first in the patient. For ex: Patient is having Hypertension and Diabetes since two years and one year respectively, then duration of disease is considered as two years.

Dosage: Patients dosage is considered Once Daily, Twice Daily or Thrice Daily if he/she is consuming at least one drug once in a day, two times a day or three times a day respectively.

Number of drugs: Total number of different drugs that the patient has been prescribed by attending medical doctor to consume per day.

STATISTICAL METHODS

The data was entered in Microsoft Excel and was analyzed using IBM developed SPSS version 20. The continuous data like age, duration of disease and number of drugs received were converted into categorical data according to relevance. All the categorical data were presented as percentages. The association between low adherence and categorical variables like age group, gender, education status, occupation, type of disease, duration of disease, dosage and number of drugs was tested using univariate logistic regression. The variables with P value less than 0.1 in univariate logistic regression were taken for multivariate logistic regression and considered as significant when P value was less than 0.05.[17] The strength of association was mentioned in terms of odds ratio.

RESULTS

Out of 305 registered patients with either hypertension and/ or diabetes, eight patients were put on treatment during month of August and 16 patients did not attend clinic during month of August. Hence, 281 patients were included for assessing adherence to medication and its correlates. Of the 281 participants, mean (SD) age was 57.4 (11.9) years and 169 (59.8%) were females. Among participants, 165 (58.7%) were uneducated and 129 (45.9%) were homemakers. Of the total, 36 (12.8%) and 29 (10.3%) participants reported current use of alcohol and tobacco respectively. Socio-demographic details of study participants are shown in Table1. Of the participants, 155 (55.1%) had only hypertension and 90 (28.5%) had both hypertension and diabetes mellitus. Diabetes mellitus alone was found in 46 (16.4%) of the study participants. Mean (SD) duration of the treatment was 5.2 (4.7) years. The duration of treatment ranged from one month to 30 years. Asthma, epilepsy or hypothyroidism in form of comorbidity was present in 19 (6.8%) of the participants. Of the total, 114 (40.6%) were consuming drugs only once in a day and around 164 (58.4%) had to consume two to three drugs per day. Morbidity profile of study participants are shown in Table 2. High, moderate and low adherence to medication was seen in 100 (35.6%), 134 (47.7%) and 47 (16.7%) participants respectively. The proportion of low adherence was found to be higher in those having only diabetes (27.7%) compared to those having only hypertension (17.4%) or having both disease conditions (8.8%) and was found to be statistically significant. Lesser age, higher education, being housewife, tobacco use and having only diabetes were significantly associated with low adherence to medication on univariate logistic regression. Variables like age, gender, education, occupation, alcohol use, tobacco use, type of morbidity and duration of morbidity had p value 6 years (OR-3.50, CI-1.34–9.14), having only diabetes (OR-3.78, CI-1.28-11.17) and tobacco use (3.51, CI-1.24–9.96) were independently associated with low adherence (Table 3).

DISCUSSION

Our study conducted among patients with either hypertension and/or diabetes followed up in a rural PHC showed that 16.7% of the study participants had low adherence to medication. Patients with better education, using tobacco and having only diabetes were found to be independent risk factors for low adherence to prescribed medication in our study. Arulmozhi and Mahalakshmy, in a study from Puducherry using MMAS-8 scale reported low adherence to medication in 39% patients.[11] Age <60 years, shorter duration of disease (<1 year) were found to be associated with low adherence to medication on univariate analysis similar to our study. This study was conducted among diabetes in-patients who have got complications and are admitted to hospital unlike in our study where patients are not having any complications. Steps taken to improve adherence in patients without complications like in our study can lessen the chances of them developing in the future. A community based cross-sectional study conducted in rural village of Kerala showed 74% of diabetic patients to be less adherent to medication (using MMAS-8).[18] Similarly another community based cross-sectional study conducted in a rural village of Tamil Nadu showed 75.9% of the hypertensive patients to be less adherent to medication (using MMAS-4).[19] The proportion of low adherence was found to be comparatively low in our setting as RHC is a model training center with patients exposed to repeated education programs and other quality assurance methods. In the same study, factors related to lifestyle like smoking and alcohol and factors related to medication like increase in number and frequency of drugs were associated with low adherence. A facility based cross-sectional study conducted in a public primary care clinic in China showed 32.6% of the hypertensive patients to have low adherence to medication.[20] As in our study MMAS-8 was used to assess adherence and a score of less than six was considered to be less adherent. Younger age, shorter duration of treatment and being employed were associated with low adherence. Even in our study, patients with younger age and shorter duration of treatment had higher risk for low adherence. The strengths of the present study are as follows; firstly this study reported adherence among patients with diabetes and/ or hypertension attending a public, primary health center (PHC). The majority of these patients seek care from PHC and also the national program promotes follow-up of these patients at PHC’s. Hence, detecting the adherence level and its correlates at a PHC will help to find at risk groups for targeted interventions. Secondly, we used MMAS-8 questionnaire which has been widely used to measure adherence to medication; hence it has better internal validity and also comparability. Thirdly, we were also able to cover around 90% of the eligible study population. The study being conducted in a treating health center may be biased on the assessment of adherence to medication due to social desirability. To partly overcome this, separate counter was set up and the interviews were conducted on a one to one basis by non-treating trainee doctors. The sample size was smaller to detect statistical significance for all the associated factors with low adherence. As the study was conducted over only one month period, the patients who were not able to attend the clinic in that month were missed, though this proportion was less than 10%. Our study has few implications. Firstly, the study results shows that there is a great need on the part of health care providers to not only prescribe medications but also make sure they are adherent to the prescribed drugs. Secondly, focused health education sessions addressing the importance of adherence to medications need to be carried out regularly. These sessions can be planned during the NCD clinic day which is now incorporated in all PHC’s of the country. Lastly, this study emphasizes the need for more studies addressing the cost-effectiveness of improvement in adherence and thus reducing the complications and also health care costs. There are very few studies which explore the adherence to medication in hypertensive and diabetic patients. Also before planning specific interventions there is need for finding causal effect of the factors which are associated with low adherence. In our study, educated had low adherence to medication; hence qualitative studies will help to find the reason for this low adherence in educated. Without these prior information, health promotion programs will not be able to address the real need of the targeted groups.

CONCLUSION

Among the diabetic and/or hypertensive patients around onesixth were found to be less adherent to prescribed medications in a rural PHC of South India. Higher education levels, use of tobacco and having only diabetes mellitus were identified independently as risk factors for low adherence to medication. The specific interventions targeted at improving the adherence to medication should focus mainly on these risk groups.

ACKNOWLEDGEMENT

We acknowledge the help of MBBS trainees – Vivot, Koninica, Krishna Sai, Yeshashvi,Kilambi, Jyoti Puja, KojYasa and Jyoti Baghela for help in data collection and data entry. Authors acknowledge help of medical officer of RHC, Dr. Prarthana for allowing to carry out this study. Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

References:

1. World Health Organization. 2008-2013 Action plan for the global strategy for the prevention and control of noncommunicable diseases. WHO. Available from: http://www.who.int/nmh/publications/9789241597418/en/. [Last accessed on 2015 Sep 05]

2. World Health Organization. Health Transition. WHO. Available from: http://www.who.int/trade/glossary/story050/en/. [Last accessed on 2015 Sep 05]

3. Reddy K. Srinath and Sailesh Mohan. Chronic diseases in India: Burden and implications. Chronic Diseases in India. Swiss Re - Center for Global Dialogue 2014. Available from: http://cgd. swissre.com/global_dialogue/topics/Cardiovascular_risks_in_ HGM/Chronic_Diseases_in_India_Burden_and_Implications. html. [Last accessed on 2015 Sep 05]

4. Cade WT. Diabetes-Related Microvascular and Macrovascular Diseases in the Physical Therapy Setting. Phys Ther 2008;88(11):1322–35.

5. Anchala R, Kannuri NK, Pant H, Khan H, Franco OH, Di Angelantonio E, et al. Hypertension in India: a systematic review and meta-analysis of prevalence, awareness, and control of hypertension. J Hypertens 2014;32(6):1170–7.

6. IDF Diabetes Atlas update poster, 6th ed. Brussels, Belgium. International Diabetes Federation;2014.

7. Ramachandran A, Shetty AS, Nandhitha A, Snehalatha C. Type 2 diabetes in India: challenges and possible solutions. Available from: http://www.apiindia.org/medicine_update_2013/chap40. pdf. [Last accessed on 2015 Sep 05]

8. National Program for Prevention and Control of Cancer, Diabetes, Cardio Vascular Diseases and Stroke (NPCDCS): Operational Guidelines (Revised: 2013-17). Directorate General of Health Services Ministry of Health and Family welfare Government Of India;2013:22.

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10. Ho PM, Rumsfeld JS, Masoudi FA, McClure DL, Plomondon ME, Steiner JF, et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Archives of internal medicine 2006;166(17):1836–41.

11. Arulmozhi S, Mahalakshmy T. Self Care and Medication Adherence among Type 2 Diabetics in Puducherry, Southern India: A Hospital Based Study. J Clin Diagn Res JCDR 2014 Apr;8(4):UC01–3.

12. Kumar N, Unnikrishnan B, Thapar R, Mithra P, Kulkarni V, Holla R, et al. Factors associated with adherence to antihypertensive treatment among patients attending a tertiary care hospital in Mangalore, South India. Int J Curr Res Rev 2014;6(10):77–85.

13. Hema K, Padmalatha P. Adherence to medication among Hypertensive patients attending a tertiary care hospital in Guntur, Andhra Pradesh. Indian J Basic Appl Med Res 2014;4(1):451–6.

14. Morisky DE, Ang A, Krousel-Wood M, Ward H. Predictive Validity of a Medication Adherence Measure for Hypertension Control. Journal of Clinical Hypertension 2008;10(5):348-354.

15. Krousel-Wood MA, Islam T, Webber LS, Re RS, Morisky DE, Muntner P. New Medication Adherence Scale Versus Pharmacy Fill Rates in Seniors With Hypertension. Am J Manag Care 2009;15(1):59-66.

16. Morisky DE, Di Matteo MR. Improving the measurement of self-reported medication nonadherence: Final response. J ClinEpidemio 2011; 64:258-263

17. Mickey RM, Greenland S. The impact of confounder selection criteria on effect estimation. Am J Epidemiol 1989;129(1):125– 37.

18. Sankar UV, Lipska K, Mini GK, Sarma PS, Thankappan KR. The adherence to medications in diabetic patients in rural Kerala, India. Asia Pac J Public Health 2015;27(2):NP513–23.

19. Venkatachalam J, Abrahm SB, Singh Z, Stalin P, Sathya GR. Determinants of Patient’s Adherence to Hypertension Medications in a Rural Population of Kancheepuram District in Tamil Nadu, South India. Indian J Community Med 2015;40(1):33–7.

20. Lee GKY, Wang HHX, Liu KQL, Cheung Y, Morisky DE, Wong MCS. Determinants of Medication Adherence to Antihypertensive Medications among a Chinese Population Using Morisky Medication Adherence Scale. PLoS One 2013;8(4). Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636185/.

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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