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IJCRR - Vol 13 Issue 17, September, 2021

Pages: 98-104

Date of Publication: 12-Sep-2021


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Formulation and Characterization Floating Matrix Tablets of Methimazole

Author: Bhambar Kunal V, Pande Shrikant D., Bhambar Rajendra S., Gadakh Pravin P.

Category: Healthcare

Abstract:Introduction: Methimazole is an active pharmaceutical ingredient effectively utilized in hyperthyroidism. Methimazole inhibits peroxidase as well as iodine interactions with thyroglobulin to produce triiodothyronine with thyroxine. Methimazole shows very low protein binding (1-10%) bounds to plasma proteins and is easily metabolized by the liver. Gastro retentive drug system improve the pharmacotherapy of the stomach by local release of therapeutic agent results in high concentrations of drug at the gastric mucosa, which further sustained for long Aim: In this investigation, efforts were given to developing a sustained release floating matrix tablet of Methimazole. Methodology: Floating matrix tablets of methimazole were prepared by utilizing the direct compression method. Sodium bicarbonate and citric acid were used as gas-forming agents. HPMC K100M along with Ethylcellulose used to retard drug release from the dosage form. Result: Floating matrix tablets of methimazole were evaluated for different quality control tests to improve the quality of the product. In dissolution study of the floating matrix of methimazole formulation Floating matrix tablet (FLM4) shows maximum drug release 96.88 % at the end of 12 hours while FLM-1 shows least 84.33 %. Conclusion: In vitro release study of methimazole floating matrix tablets shows that polymer percentage used in the formula is enough to extend the release of the drug for at least 12 hr.

Keywords: Floating Matrix tablet, Methimazole, Sustained Release, FLM, HPMC K100M, Ethyl Cellulose

Full Text:

INTRODUCTION:17

In a Conventional drug delivery system, periodic doses of therapeutic agents are required. Most of the drugs are formulated by conventional methods for effective drug administration, but some therapeutic agents are unstable or have narrow therapeutic ranges so require modification. These problems were overcome by developing sustained release gastro retentive drug delivery. Gastro retentive drug delivery promising approach not only retard the drug release but also retain the dosage form in the stomach. Gastro retentive drug delivery effectively improves absorption of the drug due to increased residence time in the stomach. Methimazole is absorbed through the whole Gastrointestinal tract and bioavailability is 80-95%. Methimazole is a biologically active agent widely used in hyperthyroidism. It prevents iodine and peroxidase. Methimazole has a biological half-life of 5 to 6 hours so it requires three times a day dosing. Hence an attempt was made to develop floating matrix tablets of Methimazole to improve all characteristics.1,2,3

MATERIAL AND METHODS:

Methimazole was purchased from Innova Laboratories, Division of Innova Remedies Pvt. Ltd. Nagpur. HPMC K100M, EC was procured from Molychem, Mumbai. All other reagents and materials were of analytical grade.7

Formulation of Methimazole Floating Matrix Tablets.1

The direct compression technique was used to formulate the Methimazole tablets for all batches containing methimazole. Sodium bicarbonate was passed through # 36 sieves. Magnesium stearate and Citric acid were passed through # 60 sieves. Required quantity of drug and all other ingredients were weighed and transferred into a polythene bag and blended for 10 minutes. The blend was compressed on a 10-station rotary press using round-shaped punches. Punches measuring 10 mm were used for compression of the tablets. Table1 consist of formulas for the preparation of floating matrix tablets which include Ethylcellulose, HPMC K100M and gas-forming agents like citric acid and sodium bicarbonate.

Evaluation of Floating matrix tablet

a. Physical Evaluation:

The prepared tablets were examined visually for cracks, depressions, pinholes, colour and polish. 1,2,3,8

b. Size and shape:

 Vernier callipers are used for determining the thickness of the tablet.

c. Test for hardness:

 Monsanto hardness tester is used for the determination of the hardness of the tablet.

d) Weight variation: 11.12,17

To determine weight variation Twenty tablets were weighed individually and the average weight was calculated from the total weight of all tablets.  The individual weights of tablets were compared with the average weight of tablets. The percentage difference in the weight variation should be within the permissible limits (±7.5%). The per cent deviation was calculated using the following formula.    

        

e) Friability test:

Friability of the tablets was measured by using Roche friabilator. Ten tablets were weighed collectively and placed in the friabilator chamber and rotated at 25 rpm. After 100 rotations (4 minutes), the tablets were taken out from the friability and intact tablets were again weighed collectively. The permitted friability limit is 1.0%. The per cent friability was determined using the following formula.

Where W1 = weight of the tablets before the test

             W2 = weight of the tablets after test

f) Content uniformity13

Randomly selected 20 tablets were used to calculate average weight. All tablets were crushed in a mortar and weighed accurately for analysis. In a conical flask, samples were transferred and diluted with 0. 1NHCL. The sample content was shaken and kept for 30 minutes for the complete dissolution of the drug. After filtration dilutions were made. Drug content was estimated against blank as a reference at λ max 251.5 nm

g) In Vitro Drug Release (Dissolution Studies): 14,15,16

In vitro drug release study of the samples was carried out using USP – type I dissolution apparatus (Basket type). The dissolution medium, 500 ml of simulated gastric fluid (without enzyme), was placed into the dissolution flask maintaining the temperature of 37 + 0.5 0C and rpm of 100.  One Methimazole matrix tablet was placed in each basket of the dissolution apparatus. The dissolution was carried out for 12 hours.  During dissolution 5 ml sample was withdrawn after every 1 hour up to 12 hours manually. During sampling sample was filtered.  The fresh dissolution medium (37oC) was added every time to maintain shrink condition.  Collected samples were analyzed at 251.5 nm using 0.1 N HCl as blank. The cumulative percentage drug release was calculated using PCP Disso v3 software.

h) In Vitro Buoyancy Study: 5,6,17

The matrix tablet of methimazole was kept in a 100 ml beaker containing 0.1 N HCL. The time required for the tablet to rise in surface and float was determined as floating lag time. The duration in which dosage form constantly remained on the surface of the medium was determined as the total floating time.

i) Water Uptake Study (Determination of Swelling Index) 6.7

The swelling index of matrix tablets of methimazole was determined in distilled water at room temperature. The water uptake study of the tablet was done using the USP II dissolution apparatus. The medium used for the study was 500ml distilled water with a revolution of 100 rpm. The temperature of the medium was maintained at 37+ 0.5 0C throughout the study. After 12 hours the tablets were withdrawn, blotted to remove excess water and weight. The swelling characteristics of the tablets were expressed in terms of water uptake (WU) as,

Fourier Transform-Infra red spectroscopy (FT-IR) of Methimazole Floating Matrix Tablet:

The FT-IR spectrum of formulation FLM4 was recorded using spectrophotometer Fourier Transform-Infra red spectroscopy (Shimadzu 84005) using the KBr pellet technique.

Differential Scanning Coulometry (DSC) of Methimazole Floating Matrix Tablet:

DSC analysis of formulation FLM4 was performed using Shimadzu-Thermal Analyzer DSC 60 on 2-5mg samples. Samples of Methimazole Floating Matrix Tablets were heated in an open aluminium pan at a rate of 10°C/min. This study was conducted over a temperature range of 30 to 300°C under a nitrogen flow of 2 bar pressure.

In-vitro drug release Kinetics study of Methimazole Floating Matrix Tablet:4,5

In-vitro drug release Kinetics study of Methimazole Floating Matrix Tablet was studied using USP dissolution apparatus II and result getting by this study was analysed for different kinetic models such as zero order, first order, Higuchi, Hixson Crowell and Korsmeyer- Pappas.

Optimization of Methimazole Floating Matrix Tablet: 9,10,11

22 Factorial Design for Methimazole Floating Matrix Tablet:

A 22 factorial design was used in this study and 2 factors were evaluated, each at 2 levels shown in table no.7. Experimental trials were performed at all 4 possible combinations. The conc. of Ethylcellulose and HPMC K 100 M were selected as independent variables. The response % release was selected as dependent variables. The resulting data analyzed statistically using analysis of variance (ANOVA)were fitted into Design Expert 8.0.3 software. The data were also subjected to 3-D response surface methodology to determine the influence of HPMC, Na-CMC and Avicel on dependent variables. Tablet weight was not constant because that would require the use of diluents for weight adjustment, which in turn may have caused variation in the release profile. Thus, did not alter the number of diluents in the formulation to nullify any effect due to a change in the proportion of diluents

Y = b0 + b1X1 + b2X2 + b3X1X2

Y is the dependent variable; b0 is the arithmetic mean of responses of 4 runs. bi (b1, b2, b3, and b12) is the estimated coefficient for the corresponding factor Xi (X1, X2, X1X2) which represent the average result of changing 1 factor at the time from its low to high value. The interaction term (X1X2) shows the response changes when 2 factors are simultaneously changed.

RESULT

Organoleptic Properties:

After evaluation floating matrix tablets were white having a smooth surface in appearance. When the variation in the drug-polymer ratio will affect. The thickness of all the formulations and ranges from 4.8-5.2 mm. After performing the weight variation test the average percentage deviation of all the formulations was found to be less than 5 %. It was found that all batches show per cent drug content of more than 98%. The tablet hardness of all the formulations was found in the range of 5.5-5.7 kg/cm2. Another measure of tablet hardness was friability. Compressed tablets that lose less than 1 % of their weight are generally considered acceptable. For all formulations tried here the weight loss was less than 1 % hence acceptable shown in table no 2. All the formulations FLM-1 to FLM-4 float in one minute but FLM-4 takes minimum time as it contains the minimum amount of polymers. All the formulations FLM-1 to FLM-4 remain buoyant for more than 20 hours and lag time for floating was less than one minute shown in tables no 4 and 3 respectively. A swelling index was performed for formulation (FLM-4) shown in figure no.1. Complete swelling of the tablet takes place at the end of 10 hours after that the weight of the tablet decreases. The absorption bands shown by FLM-4 are characteristic of the groups present in the molecular structure of Methimazole. The presence of absorption bands corresponding to the functional groups present in the structure of Methimazole and the absence of any well-defined unaccountable peaks is a confirmation of the purity of the formulation shown in figure no.2. The DSC curve of Methimazole shows a sharp endothermic peak at 191.26 0 C corresponding to its melting and indicating its crystalline nature shown in figure no 3. Drug release studies were performed to determine the release of the drug is slow enough for at least 12 hr shown in figure no.4. The dissolution curve of formulation FLM4 shows maximum drug release i.e. 96.88% at the end of 12hours while FLM1 shows the least i.e. 84.96 % shown in table no.5. The value of release exponent, n, obtained from the Korsmeyer equation was greater than 0.5 for FLM1, FLM2, FLM3and FLM4 shown in table no.6. The Model F-value of 73.90 implies the model is significantly shown in table no.8. Percentage release graph for 22 factorial design and 3D graph response surface methodology of % release for methimazole floating matrix tablets shown in figure no 8 and 9 respectively. 3D graph of % Desirability for methimazole floating matrix Tablets as per 22 factorial design shown in figure no.10. Predicted Vs. actual values of % release of methimazole floating matrix tablets shown in figure no. 11

 Final Equation in Terms of Coded Factors:

% release   = 86.40375 - 0.50125* A - 2.49875* B + 2.85625 * A * B

Final Equation in Terms of Actual Factors:

% release   = 344.76 - 2.62075* Ethyl cellulose - 2.8205* HPMC K100M + 0.0285625* Ethyl cellulose* HPMC K100M

DISCUSSION

Due to the entrapment of drugs within polymers, there was a shift in melting point was observed. The highest R2 value was obtained for the Higuchi model, so diffusion was the predominant release mechanism for matrix tablets. Release exponent, n, obtained from the Korsmeyer equation was greater than 0.5 indicate non-Fickian transport (Anamolous) so the final mechanism of drug release was swelling or chain relaxation of polymers followed by diffusion and erosion. Values of p-value less than 0.0500 indicate model terms are significant.  In this case B, AB is the significant model term. Values greater than 0.1000 indicate the model terms are not significant. Adequate Precision measures the signal to noise ratio. A ratio greater than 4 is desirable. This model shows a ratio of 20.829 indicates an adequate signal.

Conclusion:

The general tablets parameters i.e. hardness, friability, weight variation, the thickness was found within specifications. Floating lag time was within 1 minute and the total floating time was 22 hours for all the developed formulations. For floating matrix tablets, the formulation FLM4 shows the highest drug release 96.88% as containing the minimum amount of polymers and FLM1 shows the lowest drug release 84.96% as containing the maximum amount of polymers.

ACKNOWLEDGEMENT: The Authors are thankful to Innova Laboratories, Division of Innova Remedies Pvt. Ltd. Nagpur for providing the sample of Methimazole.

CONFLICT OF INTEREST AND SOURCE OF FUNDING: NIL

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


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A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
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A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
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A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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