International Journal of Current Research and Review
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IJCRR - 13(16), August, 2021

Pages: 99-104

Date of Publication: 30-Aug-2021


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Efficacy of Cervical Manipulation on Hand Grip Strength and Upper Limb Function: A Randomized Controlled Trial

Author: Anjali A, Malik M, Gera C, Kaur J

Category: Healthcare

Abstract:Background: Non-specific neck pain is the most common health concern among the general population. It leads to functional disabilities of the upper limb and pain. Assortment of approaches includes manual therapy that has been used for the management of neck pain. Improving Grip strength, reducing functional disabilities of the upper limb and reducing pain intensity are important objectives in the treatment of non-specific neck pain. Methods: A randomized, controlled trial with concealed allocation, intention-to-treat analysis and blinded assessors in which patients were randomly allocated into 2 groups; the Experimental group (n=26) and the Control group (n=26). Patients in the experimental group were received the cervical manipulation session; hot pack and TENS for two weeks. Patients in the control group were received the hot pack and TENS alone for two weeks Participants were recruited from different clinics and hospitals of Hisar. The outcomes were DASH Score and handgrip strength. All subjects were evaluated at the baseline and post-session (after 2 weeks). Results: A total of 52 subjects have participated in the study, including 18 males and 33 females. The mean ages of the subjects were 33.05 years old. Data analysis was done by using paired t-test. This study resulted that the grip strength and DASH Score after the intervention were significantly improved in the experimental group as compared to the control group. In addition, the performance of handgrip strength [left (p≤0.000) (95% CI= -13.11, -9.85) and right (p≤0.000) (95% CI= -12.57, -9.85] and upper limb functions [DASH Score (p≤0.000) (95% CI= -14.25, -19.46] was superior in experimental group as compared to that of the control group. Ethics and Dissemination: The proposed examination was done after moral endorsement from the Institutional Ethics Committee, Departmental Research Committee, and B.O.S. & R. of the Department of physiotherapy, G.J.U.S&T, Hisar in September 2019, Vide letter no. PTY/2019/1014, dated 11.09.19. Conclusion: Cervical manipulation can improve the Handgrip strength and upper limb functions in non-specific neck pain.

Keywords: Cervical manipulation, Manualtherapy, Grip-strength, Upper limb function, Non-specific neck pain, DASH score

Full Text:

Introduction

“Non-specific neck pain (NP) is characterized as pain in the back and parallel part of the neck between the superior nuchal line and the spinous process of the thoracic vertebra without any signs or indications of major basic pathology and no significant impedance with exercises of everyday life just as with the absence of neurological signs and explicit pathologies like fracture and tumor”.1 Non – explicit neck pain may radiate down to the shoulder, arm, and fingers giving "a tingling sensation", crunching sound when turning the neck, functional limitation, and pain while moving the neck.2 Upper appendage disability can be estimated utilizing the inability of the arm, shoulder, and hand (DASH) scale which is a reliable outcome measure in estimating upper appendage incapacity in vague neck pain. Handgrip strength can be evaluated by estimating the measure of static power that the hand can press around a dynamometer.3

The primary symptom of non-specific neck pain is the pain around the cervical area, occipital area, suboccipital muscles, shoulders, and upper appendages. Numbness, paresthesia, tingling, and weakness also occur in upper appendages. Tenderness is also present, mainly in the lower cervical areas (C5-C6), where disc degeneration is progressively obvious.4 The cause of neck pain can be disc herniation, extreme movement of the cervical spine, long-term awkward posture and lifestyle choices, and tissue injury in the neck. Cervical stability continuously diminishes and can prompt the loss of cervical lordosis.5Assortment of approaches has been successful for the management of neck pain. These strategies of treatment include home exercise programs, manual therapy, endurance training, strength training, and electrotherapy modalities.6

Manual therapy such as cervical mobilization and cervical spinal manipulation (CSM) are used as an effective treatment of patients with neck pain and headache. CSM is defined as low amplitude and high-velocity thrust that is applied passively to articular surfaces of a joint within its anatomical limit to restore functions and to reduce pain. 7 Manipulation of the spine involves a high–velocity thrust that is applied through either a long or short lever arm. The “long lever” method involves numerous vertebral articulations at the same time (e.g. rotatory manipulation of the thoracolumbar spine) while the “short–lever” method includes a low amplitude thrust that is aimed at a particular degree of the vertebral segment. Manipulation has been utilized in the treatment of muscle tension-type headache, migraine, neck pain, and stiffness. Mobilization includes low-velocity passive movement which can be halted by the patient. The speed of the technique (not really the measure of power), in this manner, separates manipulation from mobilization.8 Literature suggests that the use of manual therapy (manipulation & mobilization) can reduce pain and functional limitation in patients suffering from non-specific neck pain.

The present study was done to evaluate the efficacy of cervical manipulation on handgrip strength and upper limb functions in patients of non-specific neck pain. The study includes Grip strength as an outcome measure because in this study we want to show the impact of neck pain on handgrip strength and if the neck disability index was considered as an outcome measure then the focus of the study would be neck disability instead of handgrip strength. As the title of the study was "Efficacy of Cervical Manipulation on Hand Grip Strength and Upper Limb Function" in this study grip strength took as a primary outcome measure.

Methodology:

A randomized controlled preliminary was conducted after approval from the Institutional Ethics Committee of the Department of Physiotherapy, G.J.U.S&T, Hisar. The RCT was registered with the Clinical trial registry of India (Registration no. CTRI/2020/01/022638.

Consent was taken from each participant. Following study enrollment and completion of baseline evaluation, members were arbitrarily designated into the experimental or control group using computer-generated random number tables and delineated by gender.

Sample size calculation

The sample size was calculated using (Minimally Clinical Important Difference) MCID of DASH score=13.0 along with standard deviation of DASH score=17.6 from previous studies considering a dropout rate of 5%. 9 Using the following formula.10

Here,  is standard normal variate as in most of the  studies P esteems are viewed as huge underneath 0.05, thus 1.96 is utilized in the equation

p = Expected extent in population dependent on past investigations or pilot considers

d = Standard deviation.

Selection criteria 

Patients suffering from non-specific neck pain were included in this study. In the study patients with radicular and without radicular pain, were included. Patients having a complaint of neck pain with age group between 18-65 years who did not receive any concomitant intervention for neck pain were included in this study. Patients having a past history of stroke or transient ischemic attack, severe neck pain due to infection, fracture, progressive neurological deficiency, herniated nucleus pulposus, and myelopathy were excluded from selection criteria. 

Procedure:

 52 subjects took part in the examination, including 19 guys and 33 females. The participants were randomly allocated into 2 groups i.e. Experimental group (n=26) and the Control group (n=26) respectively as explained in the flowchart of Figure -2. Grip strength was evaluated by using a handheld dynamometer and upper limb functions were assessed by the DASH (disabilities of the arm, shoulder, and hand) scale. To measure grip strength we used a Jamar hydraulic dynamometer that is an easy, fast, and reliable method. The Jamar hydraulic dynamometer was seen as exceptionally dependable (ICC= 0.98) i.e. 98% and substantial (ICC =0.99) i.e. 99% for estimating handgrip strength. 11 The dynamometer was lightly held around the readout dial by the examiner to prevent inadvertent dropping. As shown in Figure-1 the subjects were in a sitting situation with their shoulder adducted, impartially pivoted elbow flexed at 90° lower arm in nonpartisan position, wrist between 0-30° dorsiflexion and 0-15° ulnar deviation for each strength test scores were recorded for each treatment. The therapist was standing in front of the subject.

Assessment and examination: Patients were thoroughly assessed and examined by using palpation and prone leg length test to evaluate cervical malalignment. Functional movements were examined for any limitation and dysfunction. Special tests like Spurling test and slump test were used to exclude specific pathologies. 

Intervention: Before giving any intervention, the pre-intervention data was collected in which the handgrip was measured Experimental group received sessions of cervical manipulation, hot pack, and TENS for two weeks, thrice weekly. Cervical manipulations include Axis lateral correction techniqueAtlas correctionand Diagonal correction atlantoid arch“The Pistol”- Ventral malaligned vertebraeRotational adjustment of the axisRotational correction of C3-C6 and C7 rotation correction.

The subjects in the Control group received only a hot pack and TENS for two weeks, thrice weekly. After 2 weeks post-intervention of handgrip strength and upper limb functions were re-evaluated. Data so obtained was analyzed for any statistical significance.

Data analysis:

Outcome measures were analyzed for any statistical significance. SPSS latest version 26 programming was utilized to break down the information. Assessment for the differences between pre-and post- grip strength and DASH score of experiment and control group was done by Paired t-tests. The mean change in grip strength and DASH score between groups was compared to the independent t-test. P esteem was set at ≤ 0.05 level. 95% certainty 95% confidence interval was also Calculating

Results:

A total number of 52 patients with non-specific neck pain were randomized into experimental (n=26) or control groups (n=26). Intention to treat analysis was done. The mean age of patients in the experimental group was 31.15 and in the control group was 35.12. Three patients dropped out of the study. The post-intervention data were collected for ‘Intention to treat analysis. Baseline characteristics were similar between the two groups

Baseline Comparisons-

As shown in Table 1 the baseline comparisons of outcome measure between the Experimental and Control Group. Baseline data was analyzed for any statistically significant difference. The Analysis shows that the baseline data was similar (p-value= 0.113, 0.130 and 0.04 respectively)

Data normality was evaluated through Kolmogorov-Smirnov (K-S) test andLilliefors corrected K-S test. Results showed that the data was normally distributed.

  1. Pre-Post comparison-

Results show a statistically significant improvement in the Experimental group as compared to the control group. As shown in Table-2 the grip Strength left (p≤0.000) (95% CI= -13.11, -9.85) and right (p≤0.000) (95% CI= -12.57, -9.85) as well as DASH Score (p≤0.000) (95% CI= -14.25, -19.46) were improved significantly in experimental Group. However, there was no significant improvement in the control group.

  1. Comparison between Groups:

The examination between the experimental and control groups as shown in Table 3. Results show a statistically significant improvement of Experimental group (p≤0.00)in terms of grip strength right (MD=10.96; 95% CI= 7.65, 11.49), left (MD=11.42; 95% CI= 7.94, 11.75) and DASH score (MD=-16.85; 95% CI= 10.34, 15.52) as compared to control groupin grip strength right (MD=1.38), left (MD=1.57) and DASH score(MD=-3.92).

DISCUSSION:

The essential goal of this examination was to explore the impact of cervical manipulation on handgrip strength and upper limb functions. Effect of grip strength was evaluated using a hand-held dynamometer and upper limb function was evaluated using DASH questionnaires. DASH is a valid and reliable tool for testing upper limb disability.3

Data was analyzed by using a t-test and significant positive improvements in handgrip strength and upper limb functions were observed. Results of the present study suggest that cervical manipulation is effective in the improvement of grip strength and upper limb function in patients with non-specific neck pain. The Experimental group had a statistically significant increase in grip strength and decreases in hand and shoulder disability. The grip strength is a decline in subjects suffering from severe neck pain. 12 Reduction of hold quality and continuance is because of the impedance with the capacity of the nervous system to start hand muscle through motor units. Besides, the fear-avoidance reaction was found in patients with incessant neck torment inspired by a paranoid fear of injury prompts disuse atrophy and decreases the inability to produce and retain force.2

Cervical manipulation can be beneficial in non-specific neck pain patients. Spinal manipulation works via neurophysiological and biomechanical mechanisms. During manipulation, the application of mechanical force may start many neurophysiological reactions that cause an increase in range of motion and decrease in pain.13 The experimental group end up being more helpful in all terms in treating mechanical Neck Pain and pain referred to the upper limb. Firstly, this can be since grip strength had straightforwardly identified with neck pain as grip strength was diminished in neck pain with serious neck disability. Hence, neck pain, grip strength, and neck inability are negatively correlated. 14 Grip strength was influenced by motor control. The neck muscles in the presence of neck pain and isometric muscle fatigue affect the handgrip. 15

Results showed a significant decrease in the DASH Score of the experimental group i.e. improvement in useful exercises as per DASH with (p<0.001), therefore demonstrating the efficacy of cervical manipulation in improving functional abilities of patients with non-specific neck pain. The current examination had both abstract and target result measures and their outcomes are statistically significant. All the manipulative therapies not to have a similar impact and the differentiation may be mediated by neurological or biomechanical factors inalienable to each technique. Furthermore, the present study included TENS and Hot pack along with the manipulation.2Heat is mediated by calcium channels by increasing intracellular calcium. This influences the pain by generating action potentials and stimulation of sensory nerves. As heat relaxes the muscles and increases the circulation of the surface so manual treatment can be done effectively. Apart from this, TENS activates the descending pain suppression system by stimulating large diameter afferent fibres that leads to a reduction in pain. 16In this present study, the subjects of the experimental group were treated with cervical spine manipulation showed more improvement in handgrip strength and reduced disability of the upper appendage in subjects with vague neck torment when contrasted with Control Group.17

Future studies can be done to optimize the doses of cervical manipulations. Future examinations should likewise be possible to research the biomechanical instruments of manipulation. More ever, study the impacts of power application (sum and rate) and manipulation technique on spine kinematics during manipulation and to explore the relationship between these variables just as clinical and useful results after high – speed low amplitude manipulation. This was a solitary driven examination and extend or long-term follow-up impacts were not checked. Besides, the impacts of just six sessions were evaluated. On the off chance that more meetings were incorporated, the patients would get totally recuperated. Intense and ceaseless cases dependent on the span of indications were not independently arranged.

Conclusion:

This study concluded that the experimental group showed significant improvement in increasing Grip strength and reduced upper arm disability in patients with non-specific neck pain as compared to the control group. Hence, cervical manipulation can be an effective treatment in patients with non-specific neck pain. This study is clinically significant as manual therapy can be used as adjuvant therapy in the management of non-specific neck pain all over the world. Also, this study is cost-effective and reduces the dependency on drug dosages.

Declaration of Conflict of Interest: The authors declare that there is no conflict of interest.

Funding: This trial did not receive any grant from funding agencies in the public, commercial or not-for-profit sector.

Acknowledgement:

The authors acknowledge the support from the staff and O.P.D. of the Department of Physiotherapy, GJUS&T, Hisar and its supporting staff.

Authors Contribution:

Authors Anjali and Malik M contributed to patients’ recruitment, data collection. Gera C and Kaur J participated in the design of the study; Malik M carried out clinical tests; Gera C and Kaur J drafted the manuscript and Anjali and Malik Mperformed the statistical analysis.

All authors read and approved the final manuscript

References:

1.       Hidalgo B, Hall T, Bossert J, Dugeny A, Cagnie B, Pitance L. The efficacy of manual therapy and exercise for treating non-specific neck pain: A systematic review. J Back Musculoskelet Rehabil. 2017;30(6):1149–69.

2.       Gauns S V, Gurudut P V. A randomized controlled trial to study the effect of gross myofascial release on mechanical neck pain referred to the upper limb. International Journal of  Health Sciences (Qassim). 2018; 12(5): 51–59.

3.       Roh YH. Clinical evaluation of upper limb function?: Patient’s impairment, disability and health-related quality of life. Journal of Exercise Rehabilitation 2013;9(4):400-405.

4.     López-de-Uralde-Villanueva I, Sollano-Vallez E, Del Corral T. Reduction of cervical and respiratory muscle strength in patients with chronic nonspecific neck pain and having moderate to severe disability. Disability and Rehabilitation. 2018;40(21):2495–504. https://doi.org/10.1080/09638288.2017.1337239

5.    Mahmoud NF, Hassan KA, Abdelmajeed SF, Moustafa IM, Silva AG. The Relationship Between forwarding Head Posture and Neck Pain?: a Systematic Review and Meta-Analysis. Current Reviews in Musculoskeletal Medicine 2019;12:562–577. https://doi.org/10.1007/s12178-019-09594-y.

6.   Hurwitz EL, Morgenstern H, Harber P, Kominski GF, Yu F, Adams AH. A Randomized Trial of Chiropractic Manipulation and Mobilization for Patients With Neck Pain?: Clinical Outcomes From the UCLA Neck-Pain Study. American Journal of Public Health | 2002;92(10):1634–41.

7.    Kranenburg HA, Schmitt MA, Puentedura EJ, Luijckx GJ, Schans CP Van Der. Adverse events associated with the use of cervical spine manipulation or mobilization and patient characteristics: A systematic review. Musculoskeletal Science and Practice. 2017; 28:32-38.http://dx.doi.org/10.1016/j.msksp.2017.01.008

8.   Griswold DW, Learman K, Kolber MJ, Relief P, Cleland JA. Pragmatically Applied Cervical and Thoracic Non-thrust versus Thrust Manipulation for Patients with Mechanical Neck Pain?: A Multicenter Randomized Clinical Trial. Journal of Orthopaedic & Sports Physical Therapy.2018;48(3):137-145.

9.     Koorevaar RCT, Kleinlugtenbelt Y V., Landman EBM, van’t Riet E, Bulstra SK. Psychological symptoms and the MCID of the DASH score in shoulder surgery. Journal of Orthopaedic Surgery and Research 2018;13(1):1-7. https://doi.org/10.1186/s13018-018-0949-0.

10.  Charan J, Biswas T. How to calculate sample size for different study designs in medical research? Indian Journal of Psychological Medicine. 2013;35(2):121–6.

11.    Bellace J V., Healy D, Besser MP, Byron T, Hohman L. Validity of the Dexter Evaluation System’s Jamar dynamometer attachment for assessment of handgrip strength in a normal population. J Hand Ther. 2000;13(1):46–51.

12.  Kalra S, Pal S. Correlational study of chronic neck pain and handgrip strength in physiotherapy practitioners.International Journal of Yoga, Physiotherapy and Physical Education.  2017;2(4):30–2.

13.   Anderst WJ, Ms TG, Ms. CL, Bs SR, Dc KG, Dc MS. Intervertebral Kinematics of the Cervical Spine Before, During and After High-Velocity Low Amplitude Manipulation.The Spine Journal.2018 Dec;18(12):2333-2342. https://doi.org/10.1016/j.spinee.2018.07.026

14.   Ramdati V, Soni N. THE CORRELATION BETWEEN CHRONIC NECK PAIN AND HAND GRIP STRENGTH INDENTISTS OF GUJARAT.International Journal of Current Advanced Research.2019;8(09):8–10. DOI: http://dx.doi.org/10.24327/ijcar.2019.3899.20029

15.    Egwu MO, Ajao BA, Mbada CE, Adeoshun IO. Isometric Grip Strength and Endurance of Patients With Cervical Spondylosis and Healthy Controls: A Comparative Study. Hong Kong Physiother J. 2009;27(1):2–6. Available from: http://dx.doi.org/10.1016/S1013-7025(10)70002-6

16.    Vance CGT, Dailey DL, Rakel BA, Sluka KA. Using TENS for pain control: the state of the evidence. Pain Management. 2014;4(3):197–209.

17.   Bautista-Aguirre F, Oliva-Pascual-vaca Á, Heredia-Rizo AM, Boscá-gandía JJ, Ricard F, Rodriguez-Blanco C. Effect of cervical vs. thoracic spinal manipulation on peripheral neural features and grip strength in subjects with chronic mechanical neck pain: a randomized controlled trial.European Journal of physical and rehabilitation Medicine 2017 June;53(3):333-41 doi: 10.23736/s1973-9087.17.04431-8.

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A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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