International Journal of Current Research and Review
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IJCRR - Vol 13 Issue 13, July, 2021

Pages: 205-209

Date of Publication: 05-Jul-2021


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Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study

Author: Suvarna Sunder J, Seema Abid Hussain, Ullah Tareen Sabahat, Prabu Mahin Syed Ismail, Shetty Akhil, Patel Pawan

Category: Healthcare

Abstract:Introduction: Treatment of necrotic tooth requires extensive management due to chances of fracture. Revascularization is the procedure for the management of immature necrotic tooth. Aim: The study was done to assess endodontic revascularization of the necrotic permanent anterior tooth with Platelet Rich Fibrin (PRF), Platelet Rich Plasma(PRP), and blood clot. Materials & Methods: Thirty patients within the age range 15-25 years with the non-vital maxillary anterior tooth with or without periapical pathology and immature apex were selected and subjected to revascularization endodontics PRF, PRP and blood clot. Healing, root lengthening, apical closure and dentinal wall thickness was determined. Results: Group I used PRF, group II used PRP plus collagen and group III used blood clot. Group I had 6 males and 4 females, group II had 5 males and 5 females and group III had 4 males and 6 females. There was excellent healing seen in 80% in group I, 30% in group II and 10% in group III. Mann Whitney U test showed a significant difference (P 0.05) Conclusion: It was concluded from the present study that PRP had superior result in terms of apical closure, root lengthening and dentine wall thickness compared to the blood clot and PRF.

Keywords: Apical closure, Endodontics, Necrotic teeth, PRP, Revascularization

Full Text:

Introduction

Treatment of necrotic tooth requires extensive management since chances of fracture through small roots as well as thin dentinal walls is more.1 The most commonly employed procedure for the closure of immature root apex is apexification. Stem cells are totipotent cells that help in the proliferation and production of cells, capable of differentiating into specialized cells.2

Adult stem cells and embryonic stem cells are two types of stem cells that help in pulp revascularization. The common site of their occurrence is pulp, apical papilla and periodontal ligament.3 These clonogenic cells induce dentin-pulp regeneration after they get differentiated into appropriate cells. Development of a complete tooth from a stem cell will be possible in the future. Stem cells after differentiating odontoblasts induce hard tissue apposition.4

Revascularization is the procedure for the immature necrotic tooth. It helps in the completion of root formation of the immature necrotic tooth.5 Most commonly used material for it is mineral trioxide aggregate (MTA) and calcium hydroxide (Ca (OH)2). The results of the treatment lead to the fracturing of teeth in 30% of cases. Hence there is a shift in the management of immature necrotic teeth.6

The formation of a functional pulp-dentin complex is regarded as a substitute method to exchange the conventional apexification method to initiate root formation and dentinal walls thickening in the case of the immature non-vital tooth.7 Recent studies showed blood clot as a material in regenerative endodontics which acts as scaffold leading to enhance the concentration of growth micromolecules.8 Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) both comprise of increased concentration of growth factors and increase the cell proliferation over time when compared to the blood clot.9 The present study aimed at assessing endodontic revascularization of necrotic permanent anterior with PRF, PRP and blood clot.

Methodology

Study design

Thirty patients within the age range 15-25 years of either gender were selected among those reporting to the Endodontic department. Inclusion criteria were non-vital maxillary anterior tooth due to either trauma or caries, a tooth with or without periapical pathology and immature apex. Exclusion criteria were patients beyond the age group, a tooth with mature apex.

The sample was decided based on significance level: 0.05, power: 80% and the number of immature teeth as 30. The study commenced with approval from higher authorities and written consent from selected patients.

Methods

In all patients’ teeth were carefully examined clinically by an Endodontist. All procedures such as pulp vitality test, palpation, percussion test, depth of clinical pocket and occurrence of sinus were performed. Radiographic analysis with digital intra-oral radiographs was performed such as the presence of radiographic bone loss, widening of periapical pathology etc.

All strict asepsis was procedures such as isolation of tooth, access cavity formation, working length determination, biomechanical preparation, irrigation with sodium hypochlorite (NaOCl) was performed. Canals were dried using sterile paper points followed by the use of triple antibiotic dressing paste to medicate the canals.

Over root canal medicament, the cotton pellet was inserted followed by insertion of temporary filling material, Cavit. Over it, glass ionomer cement (GIC) was placed and patients were recalled after 2 weeks. On recall visit, if the tooth found to be asymptomatic, Cavit was removed. Triple antibiotic dressing paste was removed with the irrigation of 2.5% sodium hypochlorite and saline. Following this, three groups were made based on the material used. In group I, PRF clot as the scaffold was used, in group II, PRP plus collagen as the scaffold was used which was pushed towards the apical area and in group III, a blood clot was used. Bleeding at the apical end was induced with a 20K- file. After seeing frank bleeding in the canal, a tight cotton pellet was introduced in the coronal portion of the canal and pulp chamber for about10 minutes to induce the clot formation in the apical two-thirds of the root canal. Patients were recalled at regular intervals on 6, 12 and 24 months to assess tooth clinically and radiographically. Signs of healing, apical closure, increase in root length and dentinal wall thickness was recorded.

Statistical analysis

Results of the study were expressed as percentages. Mann Whitney U test was applied for the assessment. The significance of the study was labelled at 0.05, highly significant at 0.01.

Results

Table 1 shows that group I used PRF, group II used PRP plus collagen and group III used blood clot. Group I had 6 males and 4 females, group II had 5 males and 5 females and group III had 4 males and 6 females.

Table 2 indicates, assessment of healing after revascularization. Group II (PRP) had 70% good, 30% excellent healing, whereas Group III (blood clot) group had 60% good, 10% excellent healing. Group, I (PRF) had 80% excellent healing compared to other groups. Table-3 indicates the outcome of root lengthening. Group II had good (80%) root lengthening compared to Group III (29%) and Group I (10%).

Apical closure found to be good in 45% and excellent in 20% in group I, good in 60% and excellent in 20% in group II and good in 20% and fair in 80% in group III. Mann Whitney U test showed a significant difference (P<0.05) (Table 4). Dentinal wall thickening was fair in 35%, good in 40% and excellent in 60% in group I, 40% in group II and 25% in group III. It was good in 20%, 30% and 40% in group I, II and III respectively with a non-significant difference (P> 0.05) (Graph 1).

Discussion

Regenerative Endodontics is a widely used treatment option nowadays. Dentinal wall thickening and root lengthening are extensively seen with it as compared to apexification.10 The occurrence of sufficient occlusal seal is possible with it, helping in inhibition of re- infection.11 Immature non-vital maxillary anterior tooth is not suitable for endodontic therapy due to its thin dentinal walls.12 PRF offers superior results in terms of apical closure and root lengthening. Revascularization of immature, necrotic maxillary anterior teeth proved to be beneficial for the regeneration of apical tissue to initiate apexogenesis.13 A study by Windley et al.,14 assessed the usefulness of antibiotic paste in the disinfection of immature dog teeth with apical periodontitis.  It was ascertained that disinfection of canal, insertion of scaffold matrix for permitting tissue growth and effective coronal seal against micro-organism can be the deciding pints in endodontic revascularization of necrotic immature teeth. This is a novel procedure in endodontics.8 In the present study, we attempted to assess endodontic revascularization of necrotic permanent anterior with PRF, PRP and blood clot.

In this study, we enrolled 30 teeth which had 18 males and 12 females. age group 15-25 years comprised of 10 males and 7 females and 20-25 years had 8 males and 5 females. Group I used PRF, group II used PRP plus collagen and group III used blood clot. Group I had 6 males and 4 females, group II had 5 males and 5 females and group III had 4 males and 6 females. Rizk et al.,15 conducted a study on 30 patients for determining pulp revascularization process in maxillary necrotic permanent immature central incisors in which group I was treated with PRP and group II with PRF scaffolds. Results showed significant improvement in the increase in bone density and reduction in apical diameter. PRP found to be an alternative to PRF in the revascularization process.

We found that excellent healing was seen in 80% in group I, 30% in group II and 10% in group III. This can be explained by the fact that the PRF serves as a matrix onto which vital cells from the peri-apical is seeded to re-establish pulp vascularity.16

In this study it was observed that apical closure found to be good in 45% and excellent in 20% in group I, good in 60% and excellent in 20% in group II and good in 20% and fair in 80% in group III. The concept of revascularization has been explained by numerous researchers. It is hypothesized that at the apical end of the root canal, a small amount of vital pulp tissue containing dental pulp stem cells (DPSCs) remains which retain tissue regeneration potential and can multiply into the newly formed blood clot matrix. It tends to differentiate into odontoblasts and deposits tertiary or tubular dentin.17

We observed that dentinal wall thickening was fair in 35%, good in 40% and excellent in 60% in group I, 40% in group II and 25% in group III. It was good in 20%, 30% and 40% in group I, II and III. The revascularization procedure is possible due to the presence of stem cells in the apical papilla of incompletely developed teeth.18 The presence of collateral circulation at the apical papilla region promotes survival during the process of pulp necrosis. It also promotes the regeneration of pulpal tissues. In the presence of surviving epithelial cells from Hertwig’s roots sheath, it may differentiate into primary odontoblasts to induce root formation completion.19

Narang et al.20 compared regenerative procedure in 20 patients using MTA, blood clot, PRF and PRP in group I, II, III and IV respectively. It was found that 98% of cases in Group III showed excellently, 60% in Group II and 80% in Group IV showed good results in terms of periapical healing. 90% in Group III showed excellently, 40% in groups II and IV showed good results in terms of root lengthening with the non-significant difference between group (P> 0.05). Apical closure found to be good in 66.7%, 40% and 60% in group II, III and IV respectively. Revascularization accompanied with PRP contributed improved results than blood clot group.
The constraint of the present research is the smaller sample size. Only PRF and PRP material was included in this study. The inclusion of more materials could have shown better results.

Conclusion

A successful revascularization procedure in necrotic permanent anterior teeth was observed both clinically as well as radiographically. It was concluded from the present study that PRP had superior result in terms of apical closure, root lengthening and dentine wall thickness compared to the blood clot and PRF.

Conflict of interest: Nil

Source of funding: Self

Acknowledgement: Nil

Authors contribution

  1. Dr. Suvarna Sunder J- review

  2. Dr. Seema Abid- editing

  3. Dr. Sabahat Ullah Tareen - manuscript writing

  4. Dr. Prabhu Mahin S- evaluation

  5. Dr. Akhil  Shetty- assessment

  6. Dr. Pawn Patel- data collection

References:

  1. Zhang  P C. Yelick AM. Vital pulp therapy-current progress of dental pulp regeneration and revascularization. Int J Dent. 2010, Article ID 856087, 9 pages.

  2. Thomson S, Kahler B. Regenerative endodontics— biologically-based treatment for immature permanent teeth: a case report and review of the literature. Austr Den J. 2010; 55: 446–452.

  3. Nosrat A. Seifi, and S. Asgary. Regenerative endodontic treatment (revascularization) for necrotic immature permanent molars: A review and report of two cases with a new biomaterial. J End 2011; 37: 562–567.

  4. Shah A. Logani U. Bhaskar, and V. Aggarwal. Efficacy of revascularization to induce apexification/apexogenesis in infected, non-vital, immature teeth: A pilot clinical study. J Endod. 2008; 34: 919–92.

  5. Garcia-Godoy F, Murray PE. Recommendations for using regenerative endodontic procedures in permanent immature traumatized teeth. Dent Traumatol 2012;28:33-41.

  6. Langer and J. P. Vacanti. Tissue Engg Sci. 1993; 260: 920–926.

  7. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:638-46. 

  8. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e37-44.

  9. El Ashiry EA, Farsi NM, Abuzeid ST, El Ashiry MM, Bahammam HA. Dental pulp revascularization of necrotic permanent teeth with immature apices. J Clin Ped Dent. 2016;40(5):361-6.

  10. Bonte E, Beslot A, Boukpessi T, Lasfargues JJ. MTA versus Ca (OH)2 in apexification of non-vital immature permanent teeth: A randomized clinical trial comparison. Clin Oral Investig. 2015; 19: 1381–1388.

  11. Huang GT. A paradigm shift in endodontic management of immature teeth: conservation of stem cells for regeneration. J Dent. 2008; 36:379-386.

  12. Yang M. Regenerative endodontics: a new treatment modality for pulp regeneration. JSM Dent. 2013; 1:1011.

  13. Prescott RS, Alsanea R, Fayad MI, Johnson BR, Wenckus CS, Hao J, et al. In vivo generation of dental pulp?like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice. J Endod. 2008;34:421?6.

  14. Windley W. Teixeira F, Levin L, Sigurdsson A, Trope M. Disinfection of immature teeth with a triple antibiotic paste. J Endod. 2005; 31:439- 443.

  15. Rizk HM, Al-Deen MS, Emam AA. Comparative evaluation of Platelet Rich Plasma (PRP) versus Platelet Rich Fibrin (PRF) scaffolds in regenerative endodontic treatment of immature necrotic permanent maxillary central incisors: A double-blinded randomized controlled trial. Saud Dent J. 2020 Jul 1;32(5):224-31.

  16. Ding RY, Cheung GS, Chen J, Yin XZ, Wang QQ, Zhang CF. Pulp revascularization of immature teeth with apical periodontitis: a clinical study. J Endod 2009; 35: 745-749.

  17. Sunitha Raja V, Munirathnam Naidu E. Platelet-rich fibrin: Evolution of a second-generation platelet concentrate. Ind J Dent Res. 2008;19:42-6. 

  18. Marx RE. Platelet-rich plasma (PRP): What is PRP and what is not PRP? Impl Dent. 2001;10:225-8. 

  19. Lucarelli E, Beretta R, Dozza B, Tazzari PL, O'Connel SM, Ricci F, et al. A recently developed bifacial platelet-rich fibrin matrix. Eur Cell Mater. 2010;20:13-23.

  20. Narang I, Mittal N, Mishra N. A comparative evaluation of the blood clot, platelet-rich plasma, and platelet-rich fibrin in the regeneration of necrotic immature permanent teeth: A clinical study. Contemp Clin Dent. 2015;6:63-8.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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