International Journal of Current Research and Review
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IJCRR - Vol 13 Issue 13, July, 2021

Pages: 200-204

Date of Publication: 05-Jul-2021


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Rheumatic Manifestations in Human Immunodeficiency Virus/ Autoimmune Deficiency Syndrome Patients in Jammu Region

Author: Vinod Kumar, Ritu Bhagat, Ahmar Javid

Category: Healthcare

Abstract:Introduction: AS there is sparse data on rheumatic manifestations in HIV/AIDS in India and no prospective study on Rheumatic manifestations in HIV/AIDS patients has been conducted earlier in the J&K state, which also has a high population of HIV+ patients, hence it was decided to undertake a prospective clinical study. The present study shall highlight the rheumatic manifestations in HIV/AIDS patients in Jammu and this, in turn, will help physicians to target therapy accordingly to minimize the morbidity and mortality attributed to rheumatic disorders in HIV. Aim: To study the Rheumatic manifestations in HIV/AIDS patients in the Jammu region. Method and Materials: The present study was carried out on 413 patients during their visits to Voluntary Training and Counselling Centre in Government Medical College, Jammu for a period of two years from 2017 to 2019. Results: There were 283 males (68.5%) and 130 females (31.4%) of the 413 HIV/AIDS patients. There were 83 (20%) subjects in WHO stage II, thirty-one (7.5%) in stage III, whereas 299(72.3%) in stage IV. Conclusion: Rheumatic disorders affect a significant proportion of HIV/AIDS patients. In the present study, the prevalence was 62.2%. Males were affected more than females. Arthralgia was the most common complaint in our study (35.7%).

Keywords: Autoimmune deficiency syndrome, Human immunodeficiency virus, Fibromyalgia

Full Text:

Introduction:

Infection by Human Immunodeficiency Virus (HIV) is characterized by a wide array of clinical manifestations, including flu-like illness in the initial stages to a multitude of clinical complications involving almost every major organ system in the body1. HIV-associated rheumatic manifestations may occur at any time of the clinical spectrum but tend to be more prevalent in later stages including AIDS1. The first reports of HIV-associated rheumatic diseases emerged in the mid-1980s, with the description of polymyositis, vasculitis, reactive arthritis and HIV-associated Sjogren’s syndrome i.e. diffuse infiltrative lymphocytosis syndrome (DILS)2,3,4,5. By 1988, it was recognized that a wide spectrum of rheumatic diseases complicated HIV infection6,7,8,9. HIV-associated rheumatic manifestations are 10

-arthralgia

-painful articular syndrome

-seronegative spondyloarthropathy

-HIV-associated arthritis

-connective tissue like disorders

-miscellaneous.

Material and Method: The present cross-sectional study was conducted in the Postgraduate Department of Medicine, GMC Jammu which involves finding  Rheumatological manifestations in HIV/AIDS patients in the Jammu region during a period of two years from October 2017 to September 2019. 413 subjects included in the study were patients already diagnosed with HIV/AIDS according to WHO criteria.

Inclusion criteria:

The patients were selected for study from the following:

  1. Voluntary Counselling and Training Centre, GMC Jammu

  2. Patients detected to be HIV+ while being treated in GMC and its associated hospitals, Jammu (outdoor).

  3. Patients referred to HIV/AIDS/ART centre GMC, Jammu from various peripheral health institutions.

Exclusion criteria:

  1. HIV/AIDS + patients with co-morbid conditions like cirrhosis, diabetes mellitus, underlying malignancies.

All individuals were administered a questionnaire based on the World Health Organisation-International League against Rheumatism (WHO-ILAR), Community Oriented Programme for the control of rheumatic disorders (COPCORD) and Core Questionnaire (CQC). The purpose of the questionnaire was to screen persons with rheumatic complaints. Positive respondents were subjected to clinical examination within one week of administrating the questionnaire. In most cases, it was conducted on the same day. The points in the questionnaire were further clarified by taking the pertinent history. Physical examination was conducted with particular stress on the musculoskeletal system. No ethical clearance was required for this study and written consent was obtained from each subject for their participation in the study.

Plan of Analysis: The data obtained were analyzed with the help of computer software SPSS 12.ver. for windows and presented as mean and standard deviations. The statistically significant difference among the groups was assessed by the use of the Chi-Square test and the ‘to test. A p-value of <0.05% was considered statistically significant unless specified otherwise.

Result: Present study was undertaken to determine the point prevalence rates of major rheumatic disorders in HIV/AIDS patients in Jammu for two years from 2017 to 2019.  The burden of HIV/AIDS in the community is large, not only in developed countries but also in developing countries. Since rheumatological complaints are very common in HIV/AIDS patients, so the physician is encountering an increased number of rheumatological diseases in HIV/AIDS patients in their practice.  The following observations were made and shown in Table 1. There were 283 males (68.5%) and 130 (31.4%) females. Out of these 3 were homosexual and 11 were IV drug abusers, 381 were heterosexual. 83 were in clinical stage II, 31 were in stage III and 299 were in stage IV.      

 

In materno-fetal transmission, there were 16 males and 2 females. In IV drug abuser 11 males only. In heterosexual here were 253 males and 128 Females. In homosexual, there were 3 males only ( Table 2).
 

In clinical stage II, there were 54 males and 29 females. In clinical stage II, There were 14 males and 17 females. In clinical stage IV, there were 215 males and 84 females ( Table 3).

 

 There were a total of 257 subjects with rheumatological manifestations. Out of these, there were 193 males and 64 females.

In arthritis, there were 52 males and 13 female wherein in arthralgia there were 68 males and 24 females. In myalgia, there were 26 males and 7 females. In painful articular syndrome, there were 13 males and 2 females. In low backache, there were 26 male and 11 females. In gout, there was 1 male. In fibromyalgia, there were 7 males and 6 females. In Zidovudine induced myopathy there was 1 female.

Out of 65 subjects (25.2%) spondyloarthropathy were found  in 45 (69.2%) subjects, HIV associated arthritis in 15 (23.0%) subjects and septic arthritis in 5(7.6%) subjects. Out of 45, there were 37 males (82.2%) and 8 (17.7%) females. Two of the reactive arthritis patients were male children in the age group of 5 & 9. Out of 43 undifferentiated spondyloarthropathies, 35 (81.3%) males and 8 (18.6) were females. Out of 15 HIV -associated arthritis there were 12 (80%) males and 3 (20%) females.

Discussion:

A total of 257 rheumatic complaints were reported in this study and that is a prevalence of 62.2%. As reported by Xuan Zhang et al.11 rheumatic manifestations were found in 54.08%. Simms et al.12 reported rheumatic manifestations in 71.2% of the subject. Buskila et al.9 reported rheumatic manifestations in 66.1% of patients. Rogeaux et al.13 reported rheumatic manifestations in 79.1% of patients.  Medina et al.14 reported rheumatological manifestations in 63% of cases. Munoz et al.8 reported rheumatological manifestations in 11% of patients. Narayanan et al.15 reported rheumatological disorders in 2% of cases. Achuthan et al.16, reported rheumatic disorders in 7.8% of cases. Vaidya et al.17 reported rheumatological complaints in 4% of cases.

Arthritis was found in 65 subjects 25.2%. There were 52 males (80%) and 13 (20%) females. Berman et al.18 reported arthritis in 24% of cases. Buskila et al.9 reported arthritis in 19% of cases. Medina et al.14 reported arthritis in 18% of patient. Krishnan et al.19 reported arthritis in 62% of cases. Marquez et al.20 reported arthritis in 13.3% of cases. Buskila et al.9 reported spondyloarthropathy in 15.2% of cases. Rogeaux et al.13 reported spondyloarthropathy in 20% of patients. Krishan et al.19 found spondyloarthropathy up to 28.1%. Blanche et al.21 reported spondyloarthropathy in 78.9% of HIV infected patients. Blanche et al.22 in Rwanda found spondyloarthropathy in 38.4% of patients.

In our study HIV – associated arthritis was found in 15 (23.0%) of subjects.  Krishnan et al.19 found HIV – associated arthritis in 17.2%) of cases. Blackout et al.23 reported in 35% of cases. Blanche et al.22 reported HIV –associated arthritis in 15.3% of cases. Njobvu et al.24 reported HIV –associated arthritis in 22.7% of cases. Blackout et al.25 reported  HIV –associated arthritis in 82% of the subject. Virtanen et al.26 reported HIV –associated arthritis in 46.6% of cases.

Septic arthritis was found in 5 (7.6%) of cases In our study, whereas Bileckot et al.25 reported septic arthritis in 5.1% of cases. Krishnan et al.19 reported septic arthritis in 3.4% of cases. Rogeaux et al.13 reported no case of septic arthritis. Cuellar et al.10 reported a prevalence of 1-4 % of septic arthritis. Blanche et al.22 reported septic arthritis in 34.6% of cases. Monteagudo et al.27 reported septic arthritis in 0.9% of cases.

Berman et al.6 reported Reiter's syndrome in 9.9%> of cases. Rogeaux et al.13 reported Reiter's syndrome in 1.6% of cases. Munoz et al.8 reported in 0.5%> of cases. Medina et al.14 reported  in 8%  of cases. Andrew28 reported a prevalence of 0 to 10%. Krishnan et  al.19 reported  Reiter’s syndrome in 7.1% of cases. Blackout et al.25 reported no case of Reiter's syndrome. Njobvu et al.24 reported Reiter's syndrome in 2% of cases.  Virtanen et al.26 reported a prevalence of 20%. Massabki et al.29 reported in 2% of cases. Stein et al.30 in 37.5% of cases, In the present study no case of Reiter’s syndrome was found.

Arthralgia was found in 92 cases (35.7%). Out of these 68 (73.9%) were males and 24 (26.0%) were females. Berman et al.6 reported arthralgia in 34.6% of cases. Buskila et al.9 reported arthralgia in 15.2% of cases. Rogeaux et al.13 in 12.4% of cases. Munoz et al.8 reported arthralgia in 4.5% of cases.  Medina et al.14 reported in 45% of cases. Krishnan et al.19 reported arthralgia in 21% of cases. Kanokwan et al.31 reported arthralgia in 26% of cases. Monteagudo et al.27 reported arthralgia in 12.2% of cases.  Virtanen et al.26 reported arthralgia in 20% of cases.

The painful articular syndrome was diagnosed in 15 (5.8%>) patients of whom 13 (86.6%) were males and 2 (13.3%) were females. Berman et al.6 reported Painful articular syndrome in 9.9%> of cases. A painful articular syndrome is not reported by Krishnan et al.19 as well as Achuthan et al.16. Celular et al.10 reported painful articular syndrome in 10%> of cases. Rogeaux et al.13 reported painful articular syndrome in 4.1 % of cases.

myalgia was found in 33 (12.8%) cases. Monteagudo et al.27 reported myalgia in 12.2% of cases. Krishnan et al.19 reported myalgia in 14%  of cases. Buskila et al.9 found myalgia in 35% of cases. Virtanen et al.26 in 6.6% of cases. Massabki et al.29 reported it in 28% of cases. Low backache was found in 37 subjects (14.3%). Berman et al.6 reported low backache in (14.2%) of cases. Rogeaux et al.13 reported low backache in 36.6%) of cases. Krishnan et al.19 reported no case of low backache. Virtanen et al.26 reported no case of low backache. Kanokwan et al.31 reported no case of low backache.

Fibromyalgia was found in 13 subjects (5%) in our study. Out of the 7 (53.8%) were males and 6 (46.1%) were females. Simms et al.12 reported a prevalence of 11% for fibromyalgia in HIV positive patients and 41% of HIV patients with musculoskeletal symptoms. Krishnan et al.19 reported no case of fibromyalgia. Virtanen et al.26 reported no case of fibromyalgia. Kanokwan et al.31 reported no case of fibromyalgia.

Zidovudine induced myopathy was reported in one (0.3%) patient in the present study and no case of polymyositis or dermatomyositis was found. Xuan et al.11 reported Zidovudine induced myopathy in 35% of cases. Krishnan et al.19 reported polymyositis in 3.4% of cases.  Johnson et al.32 reported biopsy-proven myositis in 20%.  Xuan et al.11 reported myositis in 8.16% of cases. Massabki et al.29 reported polymyositis in 1.1 % of cases. Johnson et al.32 reported myositis in 0.22%> of cases. Narayanan et al.15 reported no case of polymyositis.

No case of Sjogren’s syndrome/ diffuse infiltrative lymphocytosis syndrome has been reported in our study. Buskila et al.9 reported Sjogren's syndrome in 1.9%> of subjects. Rogeaux et al.13 reported no case of Sjogren syndrome / DILS in their study of 121 subjects. Munoz et al.8 reported no case of DILS/Sjogren's syndrome in 556 HIV +ve patients. Williams et al.33 found diffuse infiltrative lymphocytosis syndrome in 3%o of subjects. Krishnan et al.19 reported no case of DILS/ Sjogren syndrome in 29 HIV+ve subjects. Johnson et al.32 found concomitant diffuse infiltrative lymphocytosis syndrome in 9.3% of patients who were having myositis. Xuan et al.11 reported 11.2% of cases with Sjogren like syndrome/Diffuse infiltrative lymphocytosis syndrome.

No case of vasculitis was found in our study. Berman et al.6 found a prevalence of 0.9%. Simpson et al.34 reported no case of vasculitis Buskila et al.9 reported in 1.9% cases. Rogeaux et al.13 reported vasculitis in 0.8% of cases.  Munoz et al.8 reported vasculitis in 0.4%o of cases. Krishnan et al.19 reported no case of vasculitis. Marquez et al.20 reported no case of vasculitis in their 75 patients.  Xuan et al.11 reported vasculitis in 20.41% of cases including Bechet like disease, Henoch-Schonlein purpura and digital gangrene. Stein et al.30 reported no case of vasculitis. Otero et al.35 reported vasculitis in 8 patients. Kanokwan et al.31 reported vasculitis in 18%o of subjects. Manteagudo et al.27 reported vasculitis in 0.9% of cases. Massabki et al.29 reported vasculitis in 1% of cases. Narayanan et al.15 reported no case of vasculitis in their 469 HIV positive patients.

No case of SLE like disease was found in our study. Berman et al.6 reported no case of SLE like a disease. Buskila et al.9 reported no case of SLE. Elizabeth et al.36 reported that the prevalence of lupus In HIV is very low and from 1988-2002 only 30 cases were reported. Munoz et al.8 reported no case of lupus in 556 HIV positive patients. Krishnan et al.19 reported no case of lupus. Marquez et al.20 reported no case of lupus in their study. Xuan et al.11 reported a lupus-like disease in 10.2% of subjects.

 A case of gout is found in our study (0.3%). No case of gout was reported by Buskila et al.9.  Berman et al.6 reported no case of gout. Krishnan et al.19 reported no case of Gout.  Basu et al.37 retrospectively did chart review and reported no case of gout during 1997, 3% of cases during 1998, 2% of cases during 1999, 2% of cases during 2000, 4% of cases during 2001, 3% of cases during 2002, 2% of cases during 2003, 2% of cases during 2004 and 2% of cases during 2005.

Conclusion: As rheumatic manifestations are very common in HIV/AIDS patients. The present study is to define the occurrence of various Rheumatic manifestations in HIV/AIDS patients. The present study was conducted on 413 subjects during their visit to Voluntary Training and Counseling Centre in Government Medical College Jammu, J&K. There were 283 males (68.5%) and 130 females (31.4%) of the 413 HIV/AIDS patients. There were 83 (20%) subjects in WHO Stage II, thirty-one (7.5%) in Stage III, whereas 299 (72.3%) in Stage IV. In the present study, the prevalence was 62.2%. Males were affected more than females. Arthralgia was the most common complaint in our study (35.7%). A rare case of gout (0.03%) is found in our study.

Acknowledgement: Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors/ editors/ publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

Source of funding: nil

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
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A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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