International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - Vol 13 Issue 13, July, 2021

Pages: 154-158

Date of Publication: 05-Jul-2021


Print Article   Download XML  Download PDF

To Assess Efficacy and Safety of 0.1% Tacrolimus Ophthalmic Ointment in Refractory Cases of VKC

Author: Agarwal P, Tayal SD, Gautum A

Category: Healthcare

Abstract:Introduction: Vernal kerato-conjunctivitis (VKC) is a chronic, bilateral allergic inflammation of the conjunctiva and cornea. For refractory cases, oral or subtarsal corticosteroids are indicated, immunotherapeutic agents like cyclosporine are also used. Recently Tacrolimus is used for the treatment of refractory VKC. It is an immunomodulator with more potency than cyclosporine. Aim & Objective: To assess efficacy and safety of 0.1% tacrolimus ophthalmic ointment in refractory cases of VKC Material and Methods: Present study was a prospective study carried out on refractory cases of vernal kerato-conjunctivitis. Patients were divided into two groups. Group A Patients received Tacrolimus 0.1% ophthalmic ointment twice daily and anti-allergic medications and Group B patients received only allergic medication. Patients were followed up for up to 6 months. At every follow-up, symptoms and signs of both groups were compared. Results: Mean age of the patients in group A was 14.5\?2.4 years and in the group, B was 15.4\?3.1 years. Males predominated females in both groups. Patients with tacrolimus treatment showed a statistically significant decrease in symptom score and sign score over 6 months. (p< 0.05). Conclusion: Tacrolimus ophthalmic ointment 0.1% is well tolerated and effective in improving objective clinical signs and subjective symptoms of severe VKC refractory to topical antiallergic agents.

Keywords: Tacrolimus, Vernal kerato-conjunctivitis, Refractorycases, Steroid, Cyclosporine

Full Text:

Introduction:     

Vernal kerato-conjunctivitis (VKC) is a chronic, bilateral allergic inflammation of the conjunctiva and cornea. Prevalence of VKC is more in the 3-25 years age group with peak incidence at 11-13 years.1 Patient commonly present with itching, slight drooping of the upper lid, ropy discharge, photophobia and blurry vision.2Signs observed in VKC are cobblestone papillae on the upper tarsal conjunctiva, discrete or confluent papillary hypertrophy on limbal conjunctiva, white chalky appearing concretions, called Horner-Granta's dots, corneal erosions and shield ulcer.3Histopathologically it is characterized by a dense inflammatory infiltrate consisting of eosinophils, lymphocytes, basophils, dendritic cells and macrophages within microvessel, outside microvessel and in the epithelium. Lymphocytes are aggregated to form follicles. 4

Treatment modalities included measures to control inflammation. Various pharmacological agents used are topical steroids, mast cell stabilizers and topical Non-steroidal anti-inflammatory drugs.5Most of these treatments are ineffective in refractory VKC. Refractory VKC is defined as symptoms and signs that are persistent after conventional treatment. For refractory cases, oral or subtarsal corticosteroids are indicated, immunotherapeutic agents like cyclosporine are also used,6  but chronic use of topical corticosteroids may increase intraocular pressure (IOP) and susceptibility to opportunistic infections.

Novel treatment therapy for severe allergic ocular diseases with potent anti-inflammatory effects as well as sufficient safety is thus needed. Recently Tacrolimus is used for the treatment of refractory VKC. It is an immunomodulator with more potency than cyclosporine. It suppresses T-cell activation, T helper cell-mediated B-cell proliferation, and formation of cytokines, especially interleukin-2.7 In ophthalmology, tacrolimus has mainly been used to suppress immune reactions in corneal and limbal transplantations, uveitis, and allergic eye disease. 8-10

The good safety profile of 0.1% tacrolimus ophthalmic suspension based on the low blood concentration of tacrolimus, coupled with demonstrated better efficacy, make it an important tool for treating severe allergic conjunctivitis. Therefore we chose 0.1% tacrolimus ointment in this study.

Side effects noted in the use of tacrolimus ointment are burning sensation, activation of herpes simplex dendritic keratitis and development of molluscum contagiosum11,12.

Material & methods: Present study was a prospective study carried out to assess the efficacy of 0.1%tacrolimus ophthalmic ointment in refractory cases of VKC at the Department of Ophthalmology at Saraswathi Institute Of Medical Sciences. Patients were enrolled from November 19 to September 2020. The study population was refractory cases of vernal keratoconjunctivitis.

Inclusion criteria: 1. Patients with VKC refractory to conventional treatment for 3 weeks 2. Patients willing to participate in the study  and followup

Exclusion criteria:

 1. Patients with trachoma 2. Patients with infectious diseases of eye 3. Patients with hypersensitivity to tacrolimus 4. Patients who had less than 6 months follow up 5.Systemic administration of immunosuppressants within 2 weeks before study.6.pregnant or lactating females7.patients with any cardiac, renal or hepatic disease or diabetes.

This study was conducted in compliance with the Declaration of Helsinki. The study was approved by the ethical committee of the institute. A valid written consent was taken from patients after explaining the study to them.

Total of 66 patients was included in the study. Out of 66 patients, 6 patients lost to follow up so data of 60 patients was included in the study. Patients were divided into two groups randomly. Group A patients received Tacrolimus0.1%( Talimus-Ajanta Pharmaceuticals, India ) twice daily and anti-allergic medications (sodium cromoglycate eye drop, ketotifen fumarate eye drop) and Group B patients received only antiallergic medications (sodium cromoglicate eye drop, ketotifen fumarate eye drop). All participants were followed up for 6 months.

 At every follow-up, symptoms and signs of vernal keratoconjunctivitis were noted. Five symptoms ( itching, discharge, lacrimation, photophobia, foreign body sensation ) were scored (0 to3) depending on severity. Total score for symptoms(0 to 15)was noted at the initiation of treatment (Baseline),  2wk, at one month,3 month and six months.

Slit-lamp examination findings were used to grade (0=none, 1=mild, 2=moderate and 3=severe) each of the eight clinical signs. Score range (0 to 24). (table 1). For each patient, the eye with a higher total score for clinical findings was selected for efficacy assessment. The reduction in total signs and symptoms scores (from baseline) was used as the determinant of efficacy.

To assess the safety and side effects of the treatment, intraocular pressure, lens opacification, secondary infections, or other possible complications were assessed. Data were entered in an excel sheet and analysed by SPSS version 20.

Results:

In our study, we studied 60 patients. Group A patients received Tacrolimus 0.1%Ophthalmic ointment twice daily and anti-allergic medications(sodium cromoglycate eye drop, ketotifen fumarate eye drop). Group B patients received anti-allergic medications(sodium cromoglycate eye drop, ketotifen fumarate eye drop) only.

 In group A there were 18 males and 12 females and in group B there were 20 males and 10 females. Both the groups were comparable concerning age. The mean age of the patients in group A was 14.5±2.4 years and in the group, B was 15.4±3.1 years. The age of the patient ranged from 1 -27 years.

Table 2 shows the comparison score of symptoms in group A and group B. Participants were followed at 2 weeks, 1 month, 3 months and 6 months. Symptom score ranged from 0-15. In the group, A mean score of symptoms at baseline was 10.56±1.73. It decreased over follow up and was found to be 5.93±0.78 (2 weeks), 4.23±0.67 (1 month), 2.86±0.68 (3 months) and 1.7±0.65 (6 months). Thus in the group, A patients showed a significant decrease in symptom score over the follow-up period

In Group B, the mean symptom score at baseline was 10.53±1.67. At 2 weeks it was 8.73±1.28. The score decreased to 7.93±1.04 at 1 month, 7.13±0.77 at 3 months and 6.8±0.71 at 6 months. We observed decreased symptom score in Group B over follow up to 6 months.

In the comparison of both the groups, we found patients in Group A showed a more significant decrease in symptom score as compared to Group B.Resuts were statistically significant (p<0.05)

Table 3 shows comparison score of signs in group A and group B. we assessed the 8 clinical signs with the score ranging from 0-24.

In Group A, the mean sign score at baseline was 19.56±1.95. At 2 weeks it significantly decreased to 9.93±1.31. The score decreased to 5.96±1.24 at 1 month, 3.36±1.03 at 3 months and 1.66±0.6 at 6 months. Group A patients showed a significant decrease in sign score.

In group, B the mean score of symptoms at baseline was 19.5±1.94. It decreased over follow up and was found to be 17.13±1.94 (2 weeks), 15.4±1.47 (1 month), 14.16±1.55 (3 months) and 13.6±1.52 (6 months). Thus in group B patients showed a decrease in symptom score.

In comparison of both the groups, we found patients in Group A showed a statistically significant decrease in sign score as compared to Group B. (p<0.05)

An assessment of visual acuity, IOP, pupil diameter, and clinical findings for the iris, lens, anterior chamber, and fundus, no abnormal change related to testing drugs was observed. In our study, 8 patients from group A developed side effect (7 had transient burning sensation one patient developed burning sensation)which was managed with the addition of lubricating eye drop.

 Discussion:

In our study, we studied 60 patients with refractory VKC for testing the efficacy of tacrolimus 0.1% ointment. Previous studies have used different concentrations. A study by Joseph MA12 used 0.02% concentration while a study by  Müller GG  used 0.03% concentration13. Kheirkhah A  used topical 0.005% tacrolimus eye drop for the treatment of VKC14. The good safety profile of 0.1% tacrolimus ophthalmic suspension based on the low blood concentration of tacrolimus, coupled with demonstrated better efficacy, make it an important tool for treating severe allergic conjunctivitis15. Not many studies have been done on Indian eyes to test the efficacy of tacrolimus 0.1% for the treatment of ocular allergic diseases. Therefore we chose 0.1% tacrolimus ointment in this study

Topical tacrolimus has been used for different durations in previous studies. Duration ranged from 1-7 months. In our study, we followed the patients for 6 months.

The mean age of the patients in group A was 14.5±2.4 years and in group B was 15.4±3.1 years. Males predominated females in both the groups. Both the groups were comparable with respect to age and sex.

In group A mean score of symptoms at baseline was 10.56±1.73. It decreased over follow up and found to be 5.93±0.78 (2 weeks), 4.23±0.67 (1 month), 2.86±0.68 (3 months) and 1.7±0.65 (6 months). In Group B, mean symptom score at baseline was 10.53±1.67. At 2 weeks it was 8.73±1.28. Score decreased to 7.93±1.04 at 1 month, 7.13±0.77 at 3 months and 6.8±0.71 at 6 months.

Patients with tacrolimus treatment showed a statistically significant decrease in symptom score(p<.05) 

In Group A, the mean sign score at baseline was 19.56±1.95 and it decreased to 1.66±0.6 at 6 months. In group, B the mean score of symptoms at baseline was 19.5±1.94 which decreased to 13.6±1.52 at 6 months. Patients with tacrolimus treatment showed a statistically significant decrease in sign score over 6 months. (p<0.05).

Similar to our study, in the study by Ohashi Yand others, 0.1% twice-daily dose of tacrolimus showed improvement in symptoms of VKC16.

A study by Miyazaki N and others studied effects of 0.02% Tacrolimus ointment for refractory ocular surface inflammatory diseases and found that there was a lower incidence of elevated intraocular pressure and no adverse side effects during 2–26 months of continuous treatment18.

Muller and Jose 13 reported no difference in the improvement of symptoms or signs in 2 groups of patients with severe VKC treated with tacrolimus and olopatadine or tacrolimus alone.

In contrast to a study by Muller GG,13  Tam PMK 19 reported the additional use of mast cell stabilizers in 2 of 5 patients. A study by Fukushima 20  reported the continued requirement of steroids in nearly half of their patients.

In our study tacrolimus ophthalmic ointment 0.1% was well-tolerated, 8 patients from group A developed side effect(7 had transient burning sensation one patient developed burning sensation) which was managed with the addition of lubricating eye drop. Previous studies have also reported burning sensation upon application of topical tacrolimus.21This study findings suggest the usefulness of topical tacrolimus 0.1% as a steroid-sparing substitute for treating severe allergic conjunctivitis due to its potent immunosuppressive effect,

Conclusion:  In this study, we conclude that Tacrolimus ophthalmic ointment 0.1% is well tolerated and effective in improving objective signs and subjective symptoms in cases of severe VKC who are refractory to other topical antiallergic agents.

Conflict of interest-NIL

The Source of the funding-The study was carried out at Saraswathi Institute Of Medical Sciences, Hapur and no extra financial support was required

Ethical Clearance-Ethics committee approval was obtained before the study.IECSIMS/FMT/ETHI/22/19

Acknowledgement-Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of manuscript.

References:

  1. Kumar S. Vernal keratoconjunctivitis: a major review. Acta Ophthalmol. 2009;87:133–147.

  2. Abu El-Asrar AM, Tabbara KF, Geboes K, Missotten L, Desmet V. An immunohistochemical study of topical cyclosporine in vernal keratoconjunctivitis. Am J Ophthalmol. 1996;121:156–161.

  3. Bielory L, Frohman LP. Allergic and immunologic disorders of the eye. J All Clin Immunol. 1992;89:1–15.

  4. Buckley DC, Coldwell DR & Reaves TA (1993): Treatment of vernal keratoconjunctivitis with superfan, a topical non-steroidal anti-inflammatory agent. Invest OphthalmolVis Sci 38: 133–140.

  5. Sechhi AG, Tognon MS & Leonard A (1990): Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis. Am J Ophthalmol 110: 641–64.

  6. Sawada S, Suzuki G, Kawase Y, Takaku F. Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation. J Immunol 1987; 139(6): 1797–1803.

  7. Kobayashi C, Kanai A, Nakajima A, Okumura K. Suppression of corneal graft rejection in rabbits by a new immunosuppressive agent, FK-506. Transplant Proc. 1989; 21(1 Part 3): 3156–3158.

  8. Kawashima H, Fujino Y, Mochizuki M. Effects of a new immunosuppressive agent, FK506, on experimental autoimmune uveoretinitis in rats. Invest Ophthalmol Vis Sci. 1988; 29(8): 1265–1271.

  9. Iwamoto H, Yoshida H, Yoshida O, Fukushima A, Ueno H. Inhibitory effects of FK506 on the development of experimental allergic/immune-mediated blepharoconjunctivitis in Lewis rats by systemic but not by topical administration. Graefes Arch Clin Exp Ophth. 1999; 237(5):407–414.

  10. ZribiH, Descamps V, Hoang-Xuan T, Crickx B, Doan S. Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. J Eur Acad Dermatol Venereol. 2009; 23(4): 489–490.

  11. Joseph MA, Kaufman HE, Insler M. Topical tacrolimus ointment for the treatment of refractory anterior segment inflammatory disorders. Cornea. 2005; 24(4): 417–420.

  12. Müller GG,  José NK, Castro RS. Topical Tacrolimus 0.03% as Sole Therapy in Vernal Keratoconjunctivitis. Eye Contact Lens. 2014;40:79-83.

  13. Kheirkhah A,  Zavareh MK, Farzbod F, Fukushima A, Kumagai N, Nakagawa Y et al. Topical 0.005% tacrolimus eye drop for refractory vernal keratoconjunctivitis. Eye. 2011;25:872–880.

  14. Ebihara N. Blood level of tacrolimus in patients with severe allergic conjunctivitis treated by 0.1% tacrolimus ophthalmic suspension doi: 10.2332/allergolint.11-OA-0349. Epub 2012 Feb 25.

  15. Ohashi Y, Ebihara N, Fujishima H, Fukushima A, Kumagai N, Nakagawa Y et al. A randomized, placebo-controlled clinical trial of tacrolimus ophthalmic suspension 0.1% in severe allergic conjunctivitis. J Ocul Pharmacol Ther. 2010;26:165–174.

  16. Al-Amri AM. Long-term follow-up of tacrolimus ointment for the treatment of atopic keratoconjunctivitis. Am J Ophthalmol. 2014;157:280–286.

  17. Miyazaki D, Tominaga T, Kakimaru- Hasegawa A, Nagata Y. Therapeutic effects of tacrolimus ointment for refractory ocular surface inflammatory diseases. Ophthalmology 2008;115:988–92.

  18. Tam PMK, Young AL, Chen LL. Topical tacrolimus 0.03% monotherapy for vernal keratoconjunctivitis—case series. Br J Ophthalmol. 2010;94:1405–1406.

  19. Fukushima A, Ohashi Y, Ebihara N. Therapeutic effects of 0.1% tacrolimus eye drops for refractory allergic ocular diseases with a proliferative lesion or corneal involvement. Br J Ophthalmol. 2014;98:1023–1027

  20. Kymionis GD, Goldman D, Ide T, Yoo SH. Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. Cornea. 2008;27:228–229.

  21. Rikkers SM, Holland GN, Drayton GE, Michel FK, Torres MF, Takahashi S. Topical tacrolimus treatment of atopic eyelid disease. Am J Ophthalmol. 2003;135:297–302.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2022 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions