International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 13 Issue 13, July, 2021

Pages: 33-38

Date of Publication: 05-Jul-2021


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The Role of Phytoconstituents in the Development of Newer Drug Compounds

Author: Gakhar A, Singla N

Category: Healthcare

Abstract:Introduction: Natural products have been used in clinical therapeutics since time immemorial. It has been estimated that 56% of the lead compounds for medicines in the British National Formulary are natural products or are derived from natural products. Materials: Despite the achievements of synthetic chemistry and the advances towards rational drugs design, 50 important natural products are described which continue to be essential in providing medicinal compounds and as starting points for the development of synthetic analogues. Result: This article describes the phytoconstituents which are being used as lead compounds for the design, synthesis and development of Novel Drug Compounds. Conclusion: Despite the achievements of synthetic chemistry and the advances towards rational drugs design, natural products will continue to be important in three areas of drug discovery: they can be used as a target for production by biotechnology, as a source of new lead compounds of the novel chemical structure and as active ingredients for useful treatments following the traditional system of medicines. Moreover, along with biologically active primary plant metabolites, secondary compounds also serve additionally as chemical models or templates for the design and total synthesis of new drug entities.

Keywords: Natural products, Lead compounds, Therapeutics, Medicinal compounds, Phytoconstituents

Full Text:

Introduction

Naturalproductshavebeenamajorsourceofdrugsforcenturies.1Withmorethan25%of the pharmaceuticals in use today are derived from natural products. Pharmaceutical scientists are experiencing difficulty in identifying new lead structure, templates and scaffold in the finite world of chemical diversity. Although interest in natural products as a source of new biologically active compounds have decreased in the last few decades as synthetic

chemistry programs have expanded1. But numbers of synthetic drugs have adverse and unacceptable side effects. Natural Products Still Continue to form a significant proportion of drugs in current use. It has been estimated that 56% of the lead compounds for medicines in the British National Formulary are natural products or are derived from natural products.2 Of the top 20 best-selling pharmaceutical products in 1990, four were derived from natural products (amoxicillin, cefaclor, ceftriaxone, and lovastatin) and two others (captopril and enalapril) resulted from leads provided by a natural product.3 In 1991, 42 new agents were introduced to medical practice; of these, 16 were natural products or were derived from the natural product. Similarly, there were 43 new chemical entities introduced in 1992, and 18 were natural products or their derivatives.4 This article summarizes the natural products that have been used as lead compounds for the designsynthesis and development of Novel Drug Compounds.

Natural products in drug discovery

Plant products are useful as starting materials for the semi-synthetic preparation of other drugs. The main examples are plant steroids for the manufacture of oral contraceptives and other steroidal hormones. Diosgenin from several species of yams (Dioscorea deltoidea) and echogenic from sisal leaves (Agave sisalana) are the main compounds used.5 There has been an impressive success with botanical medicine, most notably quing-has and artemisinin from Chinese medicine.6 Considerable research in pharmacognosy, chemistry, pharmacology and clinical therapeutics has been carried out on ayurvedic medicinal plants.7 Natural compounds of pharmaceutical importance that were once obtained from higher plant sources, but which are now produced commercially largely by synthesis, include caffeine, theophylline, theobromine, ephedrine, pseudoephedrine, emetine, papaverine, L- dopa, salicylic acid and A-tetrahydrocananbinol.9 Biologically active plant-derived metabolites have found direct medicinal application as drug entities. Bioactive plant compounds have proven useful as 'leads' or model compounds for drug synthesis or semisynthesis. For eg. Beta-carotene, a plant primary metabolite that is useful in the prevention and/or treatment of certain cancers is currently produced synthetically on a commercial scale8. Despite that numerous examples of economically synthesizable natural product (Table no. 1), it is frequently forgotten that plant secondary compound can, and often do serve additionally as chemical models or templates for the design and total synthesis of new drug entities.24,25 For example, atropine for tropicamide, quinine for chloroquine,  cocaine for procaine and tetracaine, opium alkaloids for codeine and morphine have served as models for the design and synthesis of anticholinergic, antimalarial drugs.2, 8 Similarly, the study of the synthetic analogue of khellin, a Furano chrome derived from the fruits of Ammi visnaga(L.) Lam. is formally marketed in the United States as a bronchodilator and a coronary medication that led to the preparation and development of disodium cromolyn, also known as cromolyn sodium. Cromolyn is now a major drug used as a bronchodilator and for its antiallergenic property. Related synthetic studies based on the benzofur and moiety eventually led to the development of amiodarone, which was originally introduced in Europe as a coronary vasodilator of angina, but which was subsequently found to have a more useful application in the treatment of the specific type of arrhythmias, the wolf-Parkinson syndrome, and for arrhythmias resistant to other drugs.9

In still another example, the guanidine type alkaloids, galegins, the active principle of goat's rue (Galega officinalis L.), were used clinically for the treatment of diabetics. It had been known for some times previous to this discovery that guanidine itself had anti-diabetic properties, but was too toxic for human use. After hundreds of synthetic compounds were prepared, metformin, a close relative to galegin was developed and marketed as a useful antidiabetic drug.10 Despite the achievements of synthetic chemistry and the advances towards rational drugs design, natural products continue to be essential in providing medicinal compounds and as starting points for the development of synthetic analogues. Plant-derived drug thus represent stable markets upon which both physicians and patients rely. In addition, worldwide markets in plant-derived drugs are difficult to estimate, but undoubtedly amount to many additional billions of dollars.11,12,13

Plants continue to be an Important Source of Drugs, as the recent approval in the United States, of several new plant-derived drugs, and semi-synthetic and synthetic drugs based on plant secondary compounds. For example taxol (paclitaxel), an anticancer taxane diterpenoid derived from the relatively scarce Pacific or western yew tree, Taxus brevifolia Nutt., was approved in the United States for the treatment of refractory ovarian cancer12. Etoposide is a relatively new semisynthetic antineoplastic agent based on podophyllotoxin, a constituent of the mayapple (also known as American mandrake), Podophyllum peltatum.17,18,19 which is useful in the chemotherapeutic treatment of refractory testicular carcinoma, small cell lung carcinoma, non-lymphatic leukaemia, and non-

Hodgkin's lymphoma.13 Atracurium besylate is a relatively new synthetic relaxant, which is structurally and pharmacologically related to the curare alkaloids. In addition, synthetic A9-tetrahydrocannabinol(originally derived from the marijuana plant, Cannabis sativa L.) and some of its synthetic analogues (e.g., nabilone) has recently been approved in the The U.S.    for treatment of nausea associated with cancer chemotherapy.15,16

Cannabinoidsarealsobeingdevelopedfortheuseinglaucomaand in neurological disorders (e.g. epilepsy and dystonia), and as antihypertensives (cardiovascular agents), antiasthmatics(bronchodilator), and potentanalgesics.3, 20-24

Plant-derived drugs which are currently undergoing development and testing include the Chinese drug artemisinin(qinghaosu) and several of its derivatives, which are newly, discovered rapidly acting antimalarial agents derived from Artemisia annua and forskolin, a naturally occurring labdane diterpene with antihypertensive, positive inotropic, and adenylyl cyclase-activating properties. Forskolin is derived from the root of Coleus forskohlii plant used in East Indian folk medicine and cited in ancient Hindu and Ayruvedictexts6,10.Inadditiontothecompoundsmentionedabove, several other bioactive plant secondary metabolites are being investigated for their potential utility. 25,26 For example, the medicinally active organosulphur compounds of garlic and onion are being investigated and evaluated as potentially useful cardiovascular agents and ellagic acid, Beta-carotene, and vitamin (tocopherol) are being tested and evaluated for there possible utility as prototype anti-mutagenic and cancer prevention agents.12,14

Conclusion:

Experimentalagentsfromnaturalproductsareofferingusagreat the opportunity to evaluate new chemical classes of medicinal agents, as well as novel and potentially relevant mechanisms of action. Despite the achievements of synthetic chemistry and the advances towards rational drugs design, natural products will continue to be important in three areas of drug discovery: they can be used as a target for production by biotechnology, as a source of new lead compounds of the novel chemical structure and as active ingredients for useful treatments following the traditional system of medicines. Moreover, along with biologically active primary plant metabolites, secondary compounds also serve additionally as chemical models or templates for the design and total synthesis of new drug entities.

Conflict of Interest : None

Source Of Funding: None

 

 

References:

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  2. Sumantran VN. Experimental approaches for studying uptake and action of herbal medicines. Phytoth Res. 2007; 21: 210.

  3. Hobden AN and Harris TJ, The impact of biotechnology and molecular biology on the pharmaceutical industry. Soc Edinburgh Sect B. 1992; 99:37.

  4. Davis J, New chemical entities disappoint in 1992, Scrip review 1992.PJB publications.1993; 21:20-21.

  5. Rollinger JM. Strategiesforefficientleadstructurediscovery from natural products, Curr Med Chem. 2006;13: 1491.

  6. Jan P, Coelmont L, Vliegen I, Hemel JV.Heminpotentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin, Biochem Biophy Res Comm. 2006;348:139-144.

       7 John AP, Healing plant of peninsular India, CABI Publishing, 2001, 217.

  1. Foye WO, Principles of Medicinal Chemistry, Lea and Febiger: Philadelphia, PA, 3rdEd, 1989,64.

  2. Dahanukar SA, Kulkarni RA and Rege NN. Pharmacology of medicinal plants and natural products. Ind J Pharmac. 2000;37: 231.

  3. Sneader W, Drug Discovery: The Evolution of Modern Medicines, John Wiley and Sons: Chichester. 1985;12:165.

  4. Mukherjee P. Quality control of herbal drugs, Horizons publishers, Istedition, 2002, 35.

  5. Tabata H. Paclitaxel production by plant cell culture technology, Adv Biochem Engg Biotech. 2004; 87,1-23.

  6. Ariga T and Seki T, Antithrombotic and anticancer effects of garlic derived sulphur compounds. Biofactors. 2006, 26,93-103.

  7. Griebenow R, Pittrow DB, Weidinger G and Mutschler E, Antihypertensive efficacy and tolerability of low-dose reserpine/thiazide combination compared anace- inhibitor in first-line treatment. Am J Hypert. 1996; 9: 119.

  1. Kunio S, Isolation and characterization of angiotensin I-converting enzyme inhibitor dipeptides derived from Allium sativum L (garlic). J  Nutrit Biochem. 2017;9: 415-419.

  2. Lindsay B, Erland E and Richard T, Digitalis structure-activity relationship analysis :Conclusions from indirect binding studies with cardiac (Na+ + K+)-ATPase. Biochem Pharmac.1983; 32: 2767-2774.

  3. Sumitra M, Manikandan P, Kumar DA, Balakrishnan K, Manohar BM and Puvana Krishnan R, Experimental myocardial Necrosis in Rats – Role of ArjunolicAcid on Platelet aggregation, coagulation and Antioxidant status. J Molec Cell Biochem. 2001; 224:135-142.

  4. GiuffreG,CaputoGandPelusoF,Plateletrichplasmatreatmentandheomatasisinpatients with hemorrhagic risk. Minerva Stomatol. 2006; 55:599-609.

  5. Duxbury BM and Poller L, The oral anticoagulant saga: past, present, and future, Clin Appl ThrombHemost. 2001; 7,269-75.

  6. Power I, and McCormack J, Postoperative pain management: new, convenient analgesic therapies. Expert OpinPharmacother. 2007; 8:391-9.

  7. Simasek M and Blandino DA, Treatment of the common cold. Am Fam Physician, 2007; 75: 515-20.

  8. Jasjeet K and Gurvinder SS, Diuretic activity of organomercury(II) complexes of theophylline and theobromine. J Inorg Biochem. 1992; 48:305-310.

  9. Misso S, The Theobromine class of diuretics. The Lancet. 1907; 169:602-603.

  10. Lachkar Y and Bouassida W, Drug induced acute angle glaucoma, Curr Opin Ophthalmol. 2007; 18:129-33

  11. Ishida N, Odani-Kawabata N, Shimazaki A and Hara H, Prostanoids in treatment of glaucoma. Cardiovasc Drug Rev. 2006; 24:1-10.

  12.   Noedl H, Krud Sood S, Laowattana W. In Vitro Antimalarial Activity Of Azithromycin,artesunate, and quinine in combination and correlation with clinical outcome. Antimicrob Agents Chemother. 2007; 51: 651-6.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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